[Purpose]To analyze the trends of incidence and age of onset of ovarian cancer in can-cer registration areas of Jiangsu Province from 2009 to 2019.[Methods]Based on data reported by 16 cancer registries in Jiangsu Province,the average annual change percentage(AAPC)of ovarian cancer crude rate(CR),age-standardized incidence rate by Chinese standard population(ASIRC),proportion of cases in people over 60 years old of age were calculated by Joinpoint software.The linear regression model was used to calculate the trend of the mean age of onset and the standardi-zed average age of onset.The change trend of ovarian cancer incidence rate among people born in different periods using the birth cohort from 1929 to 2019.[Results]The CR(AAPC=4.18％,P＜0.001)and ASIRC(AAPC=2.11％,P=0.010)of ovarian cancer from 2009 to 2019 showed a significant increasing trend.The CR of ovarian cancer in urban areas was higher than that in rural areas,however,the CR in rural areas showed a significant upward trend(AAPC=4.85％,P＜0.05),while it was not significantly changed in urban areas.The incidence of ovarian cancer first increased and then decreased with age,and peaked at the age group of 60～69 years old.From 2009 to 2019,the incidence trend of different age groups varied,but the age group over 50 years showed an up-ward trend,and the upward trend became more significantly as age increased.From 2009 to 2019,the crude mean age of onset and the standardized mean age of onset in Jiangsu Province showed a significant upward trend,with an average annual increase of 0.572 years and 0.380 years,respectively(P＜0.05).The average age of onset in both urban and rural areas showed a sig-nificant upward trend,and the annual increase in urban areas was higher than that in rural areas.However,there was no significant change in rural areas after adjusting the population composi-tion.Compared with 2009,the standardized age proportion of ovarian cancer in Jiangsu Province in 2019 showed a backward trend.Standardized proportion of ovarian cancer among people over 60 years old showed a significant upward trend(AAPC=2.78％,P=0.010).[Conclusion]From 2009 to 2019,the incidence rate of ovarian cancer in Jiangsu Province showed an upward trend.Compared with urban areas,the increase in rural areas was more pronounced.The average age of onset of ovarian cancer has shifted later with the increasing cases in older individuals.

[Purpose]To analyze the trends of incidence and age of onset of ovarian cancer in can-cer registration areas of Jiangsu Province from 2009 to 2019.[Methods]Based on data reported by 16 cancer registries in Jiangsu Province,the average annual change percentage(AAPC)of ovarian cancer crude rate(CR),age-standardized incidence rate by Chinese standard population(ASIRC),proportion of cases in people over 60 years old of age were calculated by Joinpoint software.The linear regression model was used to calculate the trend of the mean age of onset and the standardi-zed average age of onset.The change trend of ovarian cancer incidence rate among people born in different periods using the birth cohort from 1929 to 2019.[Results]The CR(AAPC=4.18％,P＜0.001)and ASIRC(AAPC=2.11％,P=0.010)of ovarian cancer from 2009 to 2019 showed a significant increasing trend.The CR of ovarian cancer in urban areas was higher than that in rural areas,however,the CR in rural areas showed a significant upward trend(AAPC=4.85％,P＜0.05),while it was not significantly changed in urban areas.The incidence of ovarian cancer first increased and then decreased with age,and peaked at the age group of 60～69 years old.From 2009 to 2019,the incidence trend of different age groups varied,but the age group over 50 years showed an up-ward trend,and the upward trend became more significantly as age increased.From 2009 to 2019,the crude mean age of onset and the standardized mean age of onset in Jiangsu Province showed a significant upward trend,with an average annual increase of 0.572 years and 0.380 years,respectively(P＜0.05).The average age of onset in both urban and rural areas showed a sig-nificant upward trend,and the annual increase in urban areas was higher than that in rural areas.However,there was no significant change in rural areas after adjusting the population composi-tion.Compared with 2009,the standardized age proportion of ovarian cancer in Jiangsu Province in 2019 showed a backward trend.Standardized proportion of ovarian cancer among people over 60 years old showed a significant upward trend(AAPC=2.78％,P=0.010).[Conclusion]From 2009 to 2019,the incidence rate of ovarian cancer in Jiangsu Province showed an upward trend.Compared with urban areas,the increase in rural areas was more pronounced.The average age of onset of ovarian cancer has shifted later with the increasing cases in older individuals.

[Purpose]To analyze the trend of gastric cancer incidence and age characteristics in Jiangsu cancer registration areas from 2009 to 2019.[Methods]Cancer registration data from 2009 to 2019 meeting quality control requirements were collected from 16 cancer registries in Jiangsu Province.The crude incidence rate and age-standardized incidence rate by Chinese standard population in 2000(ASIRC)were calculated by gender,urban/rural areas and age groups.The inci-dence trends were analyzed by Joinpoint.A birth cohort model was constructed to calculate the in-cidence rate of gastric cancer for men and women born between 1929 and 2019.The age composi-tion of gastric cancer incidence in Jiangsu Province between 2009 and 2019 was calculated and compared.[Results]The crude incidence rate and ASIRC of gastric cancer in Jiangsu cancer regi-stration areas from 2009 to 2019 showed a significant decreasing trend in both male and female or urban and rural areas,in which the decrease in male(AAPC=-1.28％,P＜0.001)was higher than that of female(AAPC=-1.17％,P=0.030),and the decrease in urban(AAPC=-1.66％,P＜0.001)was higher than that of rural(AAPC=-0.72％,P＜0.001).The incidence rates of gastric cancer in age groups of 40～79 years old showed a significant decreasing trend from 2009 to 2019 with the AAPC ranging from-6.75％to-3.54％(all P＜0.05).In age groups of 40～79 years old,the inci-dence rates of gastric cancer among people with different years of birth showed a decreasing trend with the increase of the birth year.For ASIRC,the composition of patients aged 60 years old above increased by 0.63％(95％CI:0.46％～0.81％)per year from 2009 to 2019.[Conclusion]The inci-dence rate of gastric cancer in cancer registration areas of Jiangsu Province from 2009 to 2019 showed a decreasing trend,the average age of incidence showed a trend of backward moving,and for age-standardized incidence the proportion of patients over 60 years old was increased.

Objective:To observe the effect of anti-lymphocyte globulin(ALG)combined with cyclosporin A(CsA)in treatment of severe aplastic anemia(SAA).Methods:Forty-three patients with SAA received ALG [15mg/(kg?d)once a day for5d],CsA [5mg/(kg?d)for6months]and androgen(80mg,tid)for more than6months.Results:After6months,the blood corpuscle counts of patients increased(P