Mitochondria are important organelles which produce the energy required to maintain cell activity.They can produce energy through oxidative phosphorylation(OXPHOS),tricarboxylic acid(TCA)cycle and other pathways,and play an essential role in cell metabolism and many physiological processes.However,mitochondrial dysfunction is associated with neurodegenerative diseases such as Alzheimer's disease(AD).Previous studies have confirmed that mitochondrial oxidative phosphorylation-related proteins,membrane transporters,fusion and fission proteins can affect mitochondrial function and participate in the pathophysiological process of AD via mechanisms such as oxidative stress injury.Therefore,this article reviews the involvement of mitochondrial proteins and its dysfunction in the pathogenesis of AD and the possibility of treating AD by regulating mitochondrial proteins and its functions.

Mitochondria are important organelles which produce the energy required to maintain cell activity.They can produce energy through oxidative phosphorylation(OXPHOS),tricarboxylic acid(TCA)cycle and other pathways,and play an essential role in cell metabolism and many physiological processes.However,mitochondrial dysfunction is associated with neurodegenerative diseases such as Alzheimer's disease(AD).Previous studies have confirmed that mitochondrial oxidative phosphorylation-related proteins,membrane transporters,fusion and fission proteins can affect mitochondrial function and participate in the pathophysiological process of AD via mechanisms such as oxidative stress injury.Therefore,this article reviews the involvement of mitochondrial proteins and its dysfunction in the pathogenesis of AD and the possibility of treating AD by regulating mitochondrial proteins and its functions.