[Objective]To discuss the clinical efficacy of moxibustion at the back-Shu points in preventing chemotherapy-induced nausea and vomiting,based on the theory of"regulating Shu points to regulate the pivot".[Methods]A total of 94 patients who received chemotherapy at The First Affiliated Hospital of Zhejiang Chinese Medical University from September 2021 to December 2023 were selected.The patients were divided into experimental group and control group using a random number table,with 47 patients in each.The control group received conventional treatment and care,while the experimental group received additional moxibustion treatment at the back-Shu points(specific acupoints)along with the conventional treatment and care.The incidence of nausea and vomiting in both groups from the 1st to the fifth day,seventh day,and the 14th day after chemotherapy were compared,as well as the incidence of adverse reactions to chemotherapy-related drugs including constipation,headache,fatigue and drowsiness.[Results]Statistical analysis shows,the incidence of nausea in the experimental group was lower than that in the control group on the first day after chemotherapy,but the difference was not significant(P>0.05).However,on the third day to the fifth day and the seventh day after chemotherapy,incidence of nausea in the experimental group was significantly lower than that in the control group(P<0.05).Similarly,on the second day to the fifth and the seventh day after chemotherapy,the incidence of vomiting in the experimental group was also lower than that in the control group(P<0.05).Additionally,the incidence of adverse reactions caused by chemotherapy such as constipation,headache,fatigue and somnolence in the experimental group was 23.4%,4.3%,34.0%,and 10.6%,respectively,all of which were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).[Conclusion]Moxibustion at the back-Shu points can be used as effective adjunctive therapy to reduce the incidence of nausea and vomiting during chemotherapy,while also alleviate other common side effects caused by chemotherapy.

[Objective]To discuss the clinical efficacy of moxibustion at the back-Shu points in preventing chemotherapy-induced nausea and vomiting,based on the theory of"regulating Shu points to regulate the pivot".[Methods]A total of 94 patients who received chemotherapy at The First Affiliated Hospital of Zhejiang Chinese Medical University from September 2021 to December 2023 were selected.The patients were divided into experimental group and control group using a random number table,with 47 patients in each.The control group received conventional treatment and care,while the experimental group received additional moxibustion treatment at the back-Shu points(specific acupoints)along with the conventional treatment and care.The incidence of nausea and vomiting in both groups from the 1st to the fifth day,seventh day,and the 14th day after chemotherapy were compared,as well as the incidence of adverse reactions to chemotherapy-related drugs including constipation,headache,fatigue and drowsiness.[Results]Statistical analysis shows,the incidence of nausea in the experimental group was lower than that in the control group on the first day after chemotherapy,but the difference was not significant(P>0.05).However,on the third day to the fifth day and the seventh day after chemotherapy,incidence of nausea in the experimental group was significantly lower than that in the control group(P<0.05).Similarly,on the second day to the fifth and the seventh day after chemotherapy,the incidence of vomiting in the experimental group was also lower than that in the control group(P<0.05).Additionally,the incidence of adverse reactions caused by chemotherapy such as constipation,headache,fatigue and somnolence in the experimental group was 23.4%,4.3%,34.0%,and 10.6%,respectively,all of which were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).[Conclusion]Moxibustion at the back-Shu points can be used as effective adjunctive therapy to reduce the incidence of nausea and vomiting during chemotherapy,while also alleviate other common side effects caused by chemotherapy.

OBJECTIVE： To establish a method for simultaneous determination of eleven active constituents in Zhenwutang decoction， such as 5-hydroxymethylfurfural， （+）-cianidanol， paeoniflorin， benzoylaconitine， benzoylhypacoitine， benzoylpaeoniflorin， 6-gingerol， 8-gingerol， atractylenolide Ⅱ， 6-shogaol and pachymic acid. METHODS： HPLC method was adopted. The separation was performed on Phenomenex Kinetex C18 column with mobile phase consisted of acetonitrile-0.2 ％ phosphoric acid solution（gradient elution） at flow rate of 1.0 mL/min. The detection wavelength was set at 285 nm （4.4-7 min， 5-hydroxymethylfurfural）， 203 nm [7-12 min，（+）-cianidanol]， 233 nm （12-50 min，paeoniflorin， benzoylaconitine， benzoylhypacoitine， benzoylpaeoni- florin）， 200 nm （50-62.3 min， 6-gingerol， 8-gingerol； 62.9-90 min， 6-shogaol， pachymic acid） and 222 nm （62.3-62.9 min， atractylenolide Ⅱ）. The column temperature was set at 35 ℃， and the sample size was 20 μL. RESULTS： The linear ranges of 5-hydroxymethylfurfural， （+） -cianidanol， paeoniflorin， benzoylaconitine， benzoylhypacoitine， benzoylpaeoniflorin， 6-gingerol， 8-gingerol， atractylenolide Ⅱ， 6-shogaol， pachymic acid were 0.62-12.47 μg/mL （r＝0.999 6），2.36-47.25 μg/mL （r＝0.999 7），200.80-4 016 μg/mL （r＝0.999 7），4.45-89.04 μg/mL （r＝0.999 6），4.28-85.54 μg/mL （r＝0.999 5），5.16-103.13 μg/mL （r＝0.999 9），5.53-110.66 μg/mL （r＝0.999 9），0.84-16.89 μg/mL （r＝0.999 8），0.60-12.04 μg/mL （r＝0.999 9），0.53-10.62 μg/mL （r＝0.999 5），1.04-20.78 μg/mL （r＝0.999 7）， respectively. The limits of quantitation were 0.155， 0.590， 1.210， 1.112， 1.070， 0.258， 0.553， 0.421， 0.153， 0.354， 0.431 μg/mL， respectively. The limits of detection were 0.047， 0.179， 0.134， 0.337， 0.324， 0.078， 0.168， 0.128， 0.046， 0.107， 0.131 μg/mL， respectively. RSDs of precision， stability and reproducibility tests were all lower than 3％. The average recovery rates were 96.06％-103.01％（RSD＝2.64％，n＝6）， 95.11％-101.57％（RSD＝2.58％，n＝6）， 97.22％-102.11％（RSD＝1.93％，n＝6）， 96.43％-102.78％（RSD＝2.35％，n＝6）， 96.42％-101.43％（RSD＝2.15％，n＝6）， 96.86％-102.05％（RSD＝2.10％，n＝6）， 95.32％-100.55％（RSD＝1.87％，n＝6）， 97.04％-103.25％（RSD＝2.22％，n＝6）， 96.78％-103.22％（RSD＝2.62％，n＝6）， 97.04％-103.14％（RSD＝2.28％，n＝6）， 97.08％-103.51％（RSD＝2.94％，n＝6）， respectively. CONCLUSIONS： The method is accurate and specific， and suitable for simultaneous determination 11 active components of Zhenwutang decoction.