The disease of Fengfei is located in the brain and is a chronic debilitating disease characterized by symptoms of motor dysfunction.Based on the theory of"kidney similar to an official with great power and responsible for skills"in TCM ancient books,this article explored Professor Gao Ying's use of warming yang and transforming qi to treat ataxia;nourishing qi and warming yang can be used to treat multiple system atrophy mainly characterized by autonomic nervous system symptoms;nourishing yin and extinguishing wind can be used to treat multiple system atrophy mainly characterized by Parkinson's syndrome like symptoms;yin-yang dual supplementation can be used to treat multiple system atrophy mainly characterized by cerebellar ataxia symptoms.To treat Fengfei,it is necessary to focus on the traditional Chinese and Western medicine,pay attention to the patients'syndrome,think externally and internally,take analogies,under the guidance of analogical thinking,analyze the pathogenesis from a holistic perspective,adhere to the pathogenesis,distinguish yin and yang,and give early treatment with TCM to improve quality of life,delay disease progression,and prolong survival.

Objective:To explore the application of nursing intervention based on the capability, opportunity, motivation-behavior model (COM-B) in stroke patients during the rehabilitation period.Methods:Using the convenience sampling method, 146 stroke patients admitted to the First Affiliated Hospital of Zhengzhou University from February 2021 to February 2024 were selected as the research objects. According to the admission time sequence, they were divided into the COM-B group and the routine group, with 73 cases in each group. The routine group received routine nursing measures, and the COM-B group was intervened with the COM-B intervention, both for 3 months. The scores of the Health Education Self-Management Scale for Stroke Patients (HES-SP), the Exercise of Self-Care Agency Scale (ESCA), the Fugl-Meyer Assessment (FMA), and the Barthel Index of the two groups before and after the intervention were compared.Results:Finally, 72 patients in the COM-B group and 71 patients in the routine group completed the study. After 3 months of intervention, the scores of ESCA, HES-SP, FMA, and the Barthel Index of the two groups were all higher than those before the intervention, and the scores of COM-B group were all higher than those of the routine group, and the differences were statistically significant ( P<0.05) . Conclusions:The application of the COM-B intervention in stroke patients can improve patients' healthy behaviors and self-care abilities, and enhance their limb motor function and activities of daily living abilities, with a good application effect.

The disease of Fengfei is located in the brain and is a chronic debilitating disease characterized by symptoms of motor dysfunction.Based on the theory of"kidney similar to an official with great power and responsible for skills"in TCM ancient books,this article explored Professor Gao Ying's use of warming yang and transforming qi to treat ataxia;nourishing qi and warming yang can be used to treat multiple system atrophy mainly characterized by autonomic nervous system symptoms;nourishing yin and extinguishing wind can be used to treat multiple system atrophy mainly characterized by Parkinson's syndrome like symptoms;yin-yang dual supplementation can be used to treat multiple system atrophy mainly characterized by cerebellar ataxia symptoms.To treat Fengfei,it is necessary to focus on the traditional Chinese and Western medicine,pay attention to the patients'syndrome,think externally and internally,take analogies,under the guidance of analogical thinking,analyze the pathogenesis from a holistic perspective,adhere to the pathogenesis,distinguish yin and yang,and give early treatment with TCM to improve quality of life,delay disease progression,and prolong survival.

Objective:To explore the application of nursing intervention based on the capability, opportunity, motivation-behavior model (COM-B) in stroke patients during the rehabilitation period.Methods:Using the convenience sampling method, 146 stroke patients admitted to the First Affiliated Hospital of Zhengzhou University from February 2021 to February 2024 were selected as the research objects. According to the admission time sequence, they were divided into the COM-B group and the routine group, with 73 cases in each group. The routine group received routine nursing measures, and the COM-B group was intervened with the COM-B intervention, both for 3 months. The scores of the Health Education Self-Management Scale for Stroke Patients (HES-SP), the Exercise of Self-Care Agency Scale (ESCA), the Fugl-Meyer Assessment (FMA), and the Barthel Index of the two groups before and after the intervention were compared.Results:Finally, 72 patients in the COM-B group and 71 patients in the routine group completed the study. After 3 months of intervention, the scores of ESCA, HES-SP, FMA, and the Barthel Index of the two groups were all higher than those before the intervention, and the scores of COM-B group were all higher than those of the routine group, and the differences were statistically significant ( P<0.05) . Conclusions:The application of the COM-B intervention in stroke patients can improve patients' healthy behaviors and self-care abilities, and enhance their limb motor function and activities of daily living abilities, with a good application effect.

Objective:To analyze the mechanism of Kaixin Powder in intervening post-stroke cognitive impairment (PSCI) through network pharmacology and proteomics analysis.Methods:TCMSP, ETCM, TCMID, and BATMAN databases were used to retrieved the active components and gene targets of Kaixin Powder. Differential genes in PSCI patients' blood samples were determined using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). A protein-protein interaction network (PPI) was constructed using the STRING database, and a drug-PSCI-gene network was built with Cytoscape software. GO and KEGG enrichment analysis of targets were performed using the DAVID database, and the effective components were docked with targets using AutoDock software for molecular docking verification.Results:A total of 2 292 drug targets within Kaixin Powder were identified, with 248 differential genes found in clinical samples from PSCI patients, including 125 up-regulated and 123 down-regulated genes. KEGG enrichment analysis identified pathways including the TNF signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, and MAPK signaling pathway. The molecular docking results indicated that the three active components of Kaixin Powder, β-sitosterol, riboflavin, and musk ketone, had strong binding effects with four target proteins CXCR4, APOE, AGT, and SLC2A1.Conclusion:The active components of Kaixin Powder, such as β-sitosterol, riboflavin, and musk ketone, may treat PSCI by modulating the targets such as CXCR4, APOE, AGT, and SLC2A1, thereby activating or inhibiting pathways such as TNF signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, and MAPK signaling pathway.

The two injuries of fluid and qi are the pathological basis of atrophy syndrome,and also the result of the imbalance of"yang transforming into qi,yin forming shape".Deficiency of yang transforming into qi,imbalance of yin forming shape would result in dysfunction of visceral functions,internal generation of water,phlegm,and blood stasis,and loss of nourishment in limbs and nine orifices,and then later result in atrophy syndrome.Based on the theory of"yang transforming into qi,yin forming shape",this article discussed Professor Gao Ying's treatment of myasthenia gravis with insufficient yang transforming into qi by using the method of promoting yang transforming into qi;the method of tonifying the kidney and regulating the shape could be used to treat multiple sclerosis with imbalance in yin forming shape;yin-yang tonifying method could be used to treat motor neuron disease with both yin and yang damaged.In the treatment of atrophy syndrome,it is necessary to examine the syndrome and seek the cause,distinguish between yin and yang,adjust biases,and provide TCM treatment in the early stages of the disease to delay the progression of the disease and improve prognosis.

Objective: To search for biomarkers for human familial prion disease. Methods: Two-dimensional differential gel electrophoresis (2D-DIGE) proteomic analysis has been performed in frontal lobe tissues of 3 patients suffering from human familial prion disease (PrP) and 3 age-and sex-matched patients suffering from sudden death due to heart failure without neurological disease. Results: The maps revealed 14 polypeptide chains differentially modulated in the PrP samples, among those, 7 could be identified upon digestion and MALDI-TOF/MS analysis, of which 6 appeared to be up-regulated, 1 being down-regulated. Conclusions We highlight Galectin-1(Gal-1), ryanodine receptor 2 (RyR2), ubiquitin, Rab-interacting lysosomes protein-like protein 1 (RILPL-1) profillin 2 (PFN2), in the differential map. These proteins are related to neurogenesis, the clearance of misfolded proteins, stasis of calium channel, myoclonus and so on. These proteins are potential biomarkers or targets for treatment of prion disease.

Objective To investigate the clinical application and effecacy of ulnar-sided thumb ladder progressive flap in repairing grade Ⅰ and Ⅱ thumb oblique wound.Methods Between October 2009 and October 2013,ulnar-sided thumb ladder progressive flap with double blood supply was transferred to cover the grade Ⅰ and Ⅱ thumb oblique wound in 24 patients (12 males and 12 females).Mean age was 30 years (range,10-40 years).Mechanism of injury was machine twist injury in 8 patients,machine cutting injury in 6,sharp weapon injury in 6 and injury by a heavy object in 4.Twelve patients had grade Ⅰ defect and twelve patients grade Ⅱ defect.Flap ranged in size from 1.0 cm ×3.0 cm to 1.5 cm × 3.5 cm.Flap advancement distance was 1.5-2.5 cm.Donor area was sutured directly.Wound healing and color,swelling and temperature of the flap were observed after operation.Finger function was assessed with the upper limb function evaluation standard set up by hand surgery branch of Chinese Medical Association.Results Postoperatively,the flap survived and the fingertip had protective sensation.The wound healed by first intention.Two patients developed distal interphalangeal joint stiffness,and restored to normal after rehabilitation.All patients were followed up for 1-36 months (mean,20 months).Finger color,temperature,texture and pulp were restored.Finger function recovered satisfactorily,with excellent results in 22 patients and good results in 2 patients.Conclusion The procedure is easy and reliable,has affirmative effect and achieves maximal preservation of finger length and function.

Objective To analyze the PrP protein expression and the clinical degrees and pathological grade of head and neck squamous cell carcinomas.Methods Immunohistochemistry technique was used to test the PrP protein expression in the 92 head and neck squamous cell carcinomas cases.SPSS software was used to analyze the relationship between the PrP protein and the clinical degrees and pathological grade of head and neck squamous cell carcinomas.Results In the 92 head and neck squamous cell carcinomas cases,the positive rate of PrP protein was different with the sites of the carcinomas,the clinical degree and the pathological grade.Conclusion High expression of PrP protein related with the occurrence and development of head and neck squamous cell carcinomas.

Objective To investigate the clinical effect of inherent artery dorsal perforator flaps of thumb radial palmar for coverage of ipsilateral thumb degree Ⅰ and Ⅱ oblique defect of the fingertip.Methods The study included 6 males and 6 females,aged 10-40 years (mean 30 years),with thumb fingertip Ⅰ and Ⅱ degree defect treated between October 2009 and October 2013.Injury resulted from machinery cutting injury in 4 patients,machinery twist injury in 3,cutting by sharp weapons in 3,and crush injury in 2.There were 6 patients with Ⅰ degree defect and 6 patients with Ⅱ degree defect.Defects were all oblique involving more in the radial side rather than in the ulnar side and reconstructed with thumb radial palmar artery perforator flaps.Flap ranged in size from 1 cm × 2 cm to 1.5 cm × 2.5 cm.Donor site was covered with skin grafts.Observation indexes were wound healing condition,flap color,flap swelling degree,and flap temperature.Finger function was measured with upper extremity scoring system formulated by Hand Surgery Branch of Chinese Medical Association.Results All flaps survived and achieved good protective sensation.Wound healed primarily.Color,temperature and texture of the flap returned to almost normal.Moderate swelling of the flaps was detected and subsided around one week.All patients were followed up for 1-36 months (mean 20 months).At the final follow-up,two-point discrimination was 9-11 mm (mean 10 mm).Two patients developed distal interphalangeal joint stiffness and recovered after rehabilitation exercise.Finger function was rated as excellent in 10 cases and good in 2.Conclusion Inherent artery dorsal perforator flap of thumb radial palmar has affirmative effect and allows maximum preservation of finger length and function when applied to repair ipsilateral thumb degree Ⅰ and Ⅱ oblique defect of the fingertip.