Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of reproductive age. Its etiology is complex and its clinical heterogeneity is high. Metabolic abnormality is an important characteristic of PCOS and plays a crucial role in the pathogenesis of PCOS. This paper mainly reviews the reproductive endocrine disorders and metabolic abnormalities of rodent models induced by various modeling methods, discusses the applicable research of various models and provides a reference for the selection of PCOS rodent models, which matter in the etiology research and therapy exploration of PCOS.

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of reproductive age. Its etiology is complex and its clinical heterogeneity is high. Metabolic abnormality is an important characteristic of PCOS and plays a crucial role in the pathogenesis of PCOS. This paper mainly reviews the reproductive endocrine disorders and metabolic abnormalities of rodent models induced by various modeling methods, discusses the applicable research of various models and provides a reference for the selection of PCOS rodent models, which matter in the etiology research and therapy exploration of PCOS.

[Objective] To investigate the clinical characteristics and blood transfusion status of patients of liver cirrhosis and analyze its rationality.[Methods] We designed questionnaires to collect the data of patients admitted with liver cirrhosis including clinical features,blood transfusion,smoking,drinking and other living habits.We follow up the patients and analyze the blood transfusion rationality.[Results] Data on 198 patients was collected.34.8％ (69/198) of all patients were transfused at least one blood component.Total blood transfusion was 371 times,of which 52.2％ of the blood transfusion cases (36/69) were transfused with two or more blood during hospitalization.Among the 69 cases of blood transfusion,11 cases were treated with the first blood transfusion for the purpose of treatment and 58 cases for prevention.18 of those cases were infused with red blood cells of 90.5 units.54.55 ％ (60/110) and 60.91％ (67/110) of patients who had a pre-transfusion INR＞1.3 did not receive plasma.2.27％ (2/88) of patients who had a pre-transfusion INR≤1.3 received plasma.29.41％ (5/17)who had a pre-transfusion fib≤1.0 received cryoprecipitate.3.87％(7/181) who had a pre-transfusion fib＞1.0 received cryoprecipitate.[Conclusions] Blood transfusion is common in patients with liver cirrhosis.Empirical and preventive blood transfusion is common also.We should take a more scientific restrictive blood transfusion strategy.