Objective To explore the predictive value of a model established by combining MRI radiomics with clinical features for lymphovascular space invasion(LVSI)and lymph node metastasis(LNM)in early-stage cervical cancer.Methods A retrospective analysis was conducted on relevant data from 123 patients with early-stage cervical cancer confirmed by surgical pathology.They were randomly divided into training set(n=74)and testing set(n=49)in a 6∶4 ratio.The tumor regions in the T2WI-fat suppression(FS),diffusion weighted imaging(DWI),and T1WI with enhancement sequences were segmented and radiomics features were extracted.After screening and dimensionality reduction,the most relevant features were retained.The effectiveness of the model was evaluated using the area under the curve(AUC)of the receiver operating characteristic(ROC)curve.Results The combined model of MRI radiomics-clinical-MRI features had the best predictive performance for early-stage cervical cancer LVSI,with AUC of 0.848 and 0.821 in the training and testing sets,respectively.The predictive performance of various MRI radiomics models for early-stage cervical cancer LNM was superior to the clinical model.Conclusion The MRI radiomics model and clinical model have certain predictive value for early-stage cervical cancer LVSI and LNM,and the combined model performs the best.Radiomics will provide a basis for developing individualized treatment plans in clinical practice.

Objective To explore the predictive value of a model established by combining MRI radiomics with clinical features for lymphovascular space invasion(LVSI)and lymph node metastasis(LNM)in early-stage cervical cancer.Methods A retrospective analysis was conducted on relevant data from 123 patients with early-stage cervical cancer confirmed by surgical pathology.They were randomly divided into training set(n=74)and testing set(n=49)in a 6∶4 ratio.The tumor regions in the T2WI-fat suppression(FS),diffusion weighted imaging(DWI),and T1WI with enhancement sequences were segmented and radiomics features were extracted.After screening and dimensionality reduction,the most relevant features were retained.The effectiveness of the model was evaluated using the area under the curve(AUC)of the receiver operating characteristic(ROC)curve.Results The combined model of MRI radiomics-clinical-MRI features had the best predictive performance for early-stage cervical cancer LVSI,with AUC of 0.848 and 0.821 in the training and testing sets,respectively.The predictive performance of various MRI radiomics models for early-stage cervical cancer LNM was superior to the clinical model.Conclusion The MRI radiomics model and clinical model have certain predictive value for early-stage cervical cancer LVSI and LNM,and the combined model performs the best.Radiomics will provide a basis for developing individualized treatment plans in clinical practice.

This is our first time report of S-180 cell handled with various voltages, capacity and pulse number. Many pores on the S-180 cell membrane can be observed under scanning electron microscope. By the stains of trypan blue, we have known the influence of electric parameters on the ratio of poration. The results show that the ratio of electroporation has positive correlation with the voltages and the pulse number while negative correlation with the capacity.
Animals ; Cell Membrane Permeability ; Electromagnetic Fields ; Electroporation ; methods ; Mice ; Sarcoma 180 ; ultrastructure ; Tumor Cells, Cultured

This study evaluated the effects of electric pulses combined with antitumor drugs on S180 tumor cells. It was found that the growth of S180 sarcoma was inhibited with a maximum inhibition ratio of 95.5% after the use of electric pulses in combination with the injection of bleomycin (BLM), and the blood vessels of tumor were obviously fewer than those of the untreated tumor in vivo. The mitochondria of S180 tumor cells were swollen after the use of electric pulses in combination with adriamycin. The results showed that electrochemotherapy has evident inhibitory effect on the growth of S180 sarcoma and the mechanism may involve the suppression of tumor angiogenesis and changes in the ultrastructures of tumor cells.
Animals ; Antimetabolites, Antineoplastic ; administration & dosage ; Bleomycin ; administration & dosage ; Combined Modality Therapy ; Electric Stimulation Therapy ; methods ; Electrochemistry ; Mice ; Neovascularization, Pathologic ; prevention & control ; Sarcoma 180 ; blood supply ; therapy