Objective To assess the effect of cardiac rehabilitation on symptoms and quality of life in patients with coronary artery disease(Non-obCAD)living at high altitudes who have positive results for cardiopulmonary exercise testing.Methods A randomized controlled study was conducted.Hospitalized patients with suspected coronary heart disease were enrolled for coronary angiography.Based on the angiography findings,patients with Non-obCAD underwent cardiopulmonary exercise testing,and those with positive results were included in the study.With a random number table,patients with positive results for cardiopulmonary exercise testing were assigned to two groups,an experimental group receiving cardiac rehabilitation(individualized exercise plan)plus standard treatment and a control group receiving standard treatment alone.At enrollment and the 3-months follow-up,Seattle Angina Questionnaire(SAQ)and the 36-item Short-Form Health Survey(SF-36)were used to evaluate the patients.The data of the two groups were analyzed and compared to evaluate the effect of cardiac rehabilitation on the symptoms and quality of life in Non-obCAD patients living at high altitudes who have positive results for cardiopulmonary exercise testing.Results A total of 100 patients were included in the study,with 50 patients in the experimental group and 50 in the control group.The mean age in the experimental group was(55.0±6.8)years,while that in the control group was(56.6±9.1)years.Notably,at the time of enrollment,no significant differences were found between the two groups across all the SAQ measures.However,after 3 months of follow-up,the experimental group scored higher than the control group did in terms of physical limitation(75.6±5.0 vs.72.1±5.9),angina stability(69.6±6.4 vs.62.5±9.6),angina frequency(70.8±9.1 vs.65.3±9.3),treatment satisfaction(79.5±5.0 vs.76.3±4.7),and disease perception(84.9±5.2 vs.80.4±3.8),with statistically significant differences between the two groups(P＜0.05).At the time of enrollment,the two groups showed no significant differences in any of the SF-36 measures.However,at the 3-month follow-up,the experimental group had better scores than the control group did in physiological functioning(27.4±2.4 vs.25.8±3.0),role—physical(6.6±1.2 vs.6.0±0.8),bodily pain(4.7±1.3 vs.4.1±1.0),general health(20.2±2.2 vs.19.0±1.8),vitality(15.8±2.1 vs.14.5±2.1),social functioning(7.2±1.3 vs.6.4±1.1),role—emotional(5.2±1.1 vs.4.7±1.2),and mental health(22.9±2.7 vs.20.8±2.1)(P＜0.05).Conclusion Cardiac rehabilitation is conducive to improvements in symptom and quality of life in Non-obCAD patients in high altitude areas with positive results for cardiopulmonary exercise testing.No adverse cardiovascular events occurred during the rehabilitation period,which validates preliminarily the safety and efficacy of cardiac rehabilitation in this patient population.

Coronary artery involvement in cardiovascular syphilis is infrequent and often overlooked, especially in patients with latent syphilis. Herein, we present the case of myocardial infarction largely related to cardiovascular syphilis in a 63-year-old man. Invasive coronary angiography and contrast-enhanced computed tomography scan revealed a critical ostial narrowing of the left main trunk, an occlusive right coronary artery, and moderate-to-severe ostial stenosis of multiple major branches of the abdominal aorta. Syphilis screening and confirmatory tests were positive. Cardiovascular syphilis was considered. Percutaneous coronary intervention (PCI) was performed uneventfully, and a coronary stent was implanted in the ostium of the left main coronary artery. However, on day 3 after PCI, the patient died suddenly, likely because of stent thrombosis. In conclusion, severe coronary lesions confined to the ostia suggest rheumatologic large-vessel vasculitis or infectious aortitis.

Coronary artery involvement in cardiovascular syphilis is infrequent and often overlooked, especially in patients with latent syphilis. Herein, we present the case of myocardial infarction largely related to cardiovascular syphilis in a 63-year-old man. Invasive coronary angiography and contrast-enhanced computed tomography scan revealed a critical ostial narrowing of the left main trunk, an occlusive right coronary artery, and moderate-to-severe ostial stenosis of multiple major branches of the abdominal aorta. Syphilis screening and confirmatory tests were positive. Cardiovascular syphilis was considered. Percutaneous coronary intervention (PCI) was performed uneventfully, and a coronary stent was implanted in the ostium of the left main coronary artery. However, on day 3 after PCI, the patient died suddenly, likely because of stent thrombosis. In conclusion, severe coronary lesions confined to the ostia suggest rheumatologic large-vessel vasculitis or infectious aortitis.

OBJECTIVE:To systematically review the efficacy and safety of Kanglaite injection combined with radiothreapy in the treatment of the non-small cell lung cancer (NSCLC),and provide evidence-based reference for clinical treatment. METH-ODS:Retrieved from PubMed,Cochrane Library,EMBase,VIP,CJFD,Wanfang database and CBM,randomized controlled tri-als(RCT)about the efficacy and safety of Kanglaite injection combined with radiothreapy in the treatment of NSCLC were collect-ed. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation with modified Jadad scale. RESULTS:Totally 9 RCTs were included,involving 561 patients. Results of Meta-analysis showed,Kanglaite injection com-bined with radiothreapy can significantly improve the effective rate [OR=2.99,95%CI(2.07,4.31),P<0.001] and improvement rate of life quality [OR=3.74,95%CI(2.36,5.92),P<0.001],and reduce the incidence of radiation pneumonitis [OR=0.23,95%CI (0.12,0.47),P<0.001] and radiation esophagitis [OR=0.10,95%CI(0.05,0.21),P<0.001] of NSCLC patients,the differences were statistically significant. CONCLUSIONS:Both the efficacy and safety of Kanglaite injection combined with radiothreapy in the treatment of NSCLC are superior to radiothreapy alone.

We sought to explore the feasibility of global area strain to assess left ventricular global systolic function in patients with essential hypertension and normal ventricular geometry. Thirty-five essential hypertensive patients with normal ventricular geometry and 30 normally healthy persons as controls were enrolled in this study. The two groups were comparable for age, sex ratio, height, weight, body mass index (BMI), and heart rate. Blood pressures (BPs) were significantly higher in the hypertension group than the control group. Two-dimensional echocardiography and three-dimensional speckle tracking imaging were performed. Left ventricular global area strain (GAS), global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), LV volumes, ejection fraction (EF), sphericity index (SPI), left ventricular end-diastolic and end-systolic mass (EDmass and ESmass) and LV mass index (EDmassI and ESmassI) were obtained. Compared with those of the controls, GAS, GLS, GCS, GRS were significantly reduced in hypertensive patients Call P < 0.001). GAS (r = 0.672, P < 0. 001), GLS (r = 0.587, P < 0.001), GCS (r = 0.639, P < 0.001) and GRS (r = 0.685, P < 0.001) were correlated with EF in the pooled population. GAS showed an excellent correlation with GCS (r = 0.905, P < 0.001), GLS (r = 0.892, P < 0.001) and GRS (r = 0.990, P < 0.001). EF measured with 3D-STI was significantly lower in group of hypertension (P < 0.001) than that in the controls. There were no significant differences between the two groups in cardiac output, sphericity index, EDmass and ESmass, LV mass index (EDmassI and ESmassI) calculated with 3D-STI. The study showed that GAS could identify early changes of left ventricular global systolic function in hypertensive patients with normal ventricular geometry.
Adult ; Aged ; Case-Control Studies ; Echocardiography, Three-Dimensional ; methods ; Female ; Humans ; Hypertension ; diagnostic imaging ; physiopathology ; Male ; Middle Aged ; Myocardial Contraction ; physiology ; Ventricular Function, Left ; physiology ; Young Adult