Liposuction abdominoplasty is a prevalent procedure in plastic surgery, with common complications including infection and bleeding. However, cases leading to intestinal rupture accompanied by extensive abdominal wall infection are extremely infrequent. One such case was reported in this article. The patient was a 37-year-old female who developed symptoms of abdominal pain, vomiting, and fever after undergoing liposuction abdominoplasty at another hospital. She was admitted to the First Affiliated Hospital of Wenzhou Medical University on October 27, 2023. CT scan revealed a right lower abdominal wall hernia, intestinal obstruction, and abdominal wall infection. Intra-operative exploration demonstrated that a portion of the ileum had herniated subcutaneously, with multiple small perforations. There was also widespread soft-tissue infection in the subcutaneous area, along with partial skin necrosis. Emergency surgery was performed to repair the ruptured intestine. Biological dressing were used to cover and protect the exposed intestinal wall and the defective abdominal wall. Multiple debridement procedures and vacuum sealing drainage were performed for the extensive subcutaneous soft-tissue infection. Bacterial culture of the drainage fluid indicated Escherichia coli infection, and imipenem-cilastatin was administered for anti-infective treatment. After the infection was controlled, the wound was repaired with local flaps and fascia lata. During the six-month follow-up after discharge, the patient’s general condition remained satisfactory, with normal dietary intake and a well-healed wound. This case report particularly highlights that for patients with a prior history of abdominal surgery should undergo preoperative abdominal CT and other relevant examinations before liposuction to exclude potential risk factors such as incisional hernias and ensure patient safety.

Liposuction abdominoplasty is a prevalent procedure in plastic surgery, with common complications including infection and bleeding. However, cases leading to intestinal rupture accompanied by extensive abdominal wall infection are extremely infrequent. One such case was reported in this article. The patient was a 37-year-old female who developed symptoms of abdominal pain, vomiting, and fever after undergoing liposuction abdominoplasty at another hospital. She was admitted to the First Affiliated Hospital of Wenzhou Medical University on October 27, 2023. CT scan revealed a right lower abdominal wall hernia, intestinal obstruction, and abdominal wall infection. Intra-operative exploration demonstrated that a portion of the ileum had herniated subcutaneously, with multiple small perforations. There was also widespread soft-tissue infection in the subcutaneous area, along with partial skin necrosis. Emergency surgery was performed to repair the ruptured intestine. Biological dressing were used to cover and protect the exposed intestinal wall and the defective abdominal wall. Multiple debridement procedures and vacuum sealing drainage were performed for the extensive subcutaneous soft-tissue infection. Bacterial culture of the drainage fluid indicated Escherichia coli infection, and imipenem-cilastatin was administered for anti-infective treatment. After the infection was controlled, the wound was repaired with local flaps and fascia lata. During the six-month follow-up after discharge, the patient’s general condition remained satisfactory, with normal dietary intake and a well-healed wound. This case report particularly highlights that for patients with a prior history of abdominal surgery should undergo preoperative abdominal CT and other relevant examinations before liposuction to exclude potential risk factors such as incisional hernias and ensure patient safety.

BACKGROUNDWhat benefits and toxicities patients acquire from the use of bevacizumab combined with firstline chemotherapy remains controversial. This study was performed to evaluate the efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer (mCRC).

METHODSSeveral databases, including PubMed, Embase, and Cochrane Library, were searched up to April 30, 2013. Eligible studies were only randomized, controlled trials (RCTs) with a direct comparison between mCRC patients treated with and without bevacizumab. Overall risk ratio (RR), hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CI) were calculated employing fixed or random-effects models depending on the heterogeneity of the included trials.

RESULTSSix RCTs, including 1582 patients in chemotherapy plus bevacizumab group and 1484 patients in chemotherapyalone group, were included. Overall, the addition of bevacizumab to first-line chemotherapy increased overall response rate (ORR) by 4.5%, prolonged both progression-free survival (PFS) and overall survival (OS), and increased the rate of total Grades 3 or 4 adverse events (G3/4AEs) by 6.9%. Significant differences were found in ORR (RR = 1.22 (95% CI 1.01-1.46), P = 0.03), PFS (HR = 0.60 (95% CI 0.47-0.77), P < 0.0001), OS (HR = 0.83 (95% CI 0.70-0.97), P = 0.02), and any G3/4AEs (OR = 1.56 (95% CI 1.29-1.89), P < 0.00001).

CONCLUSIONBevacizumab is a valuable addition to the current first-line chemotherapy regimens used in patients with mCRC, because of conferring a significant improvement in ORR, PFS, and OS, even though it increased adverse events.

Angiogenesis Inhibitors ; therapeutic use ; Antibodies, Monoclonal, Humanized ; therapeutic use ; Bevacizumab ; Colorectal Neoplasms ; drug therapy ; Humans ; Odds Ratio

[Objective] To confirm the effects of Neiguan massaged to prevent ache nausea and vomit after laparoscopic cholecystectomy(LC).[Methods] 400 patients were randomly divide into 2 groups;the group 1 were treated by Neiguan massage during the LC,the group 2 nothing during the operation.[Results]Group 1 suffered the same ache in the 1st hour as group 2,but less in the last 24h,and less nausea and vomit too.[Conclusions ]Neiguan massage could obviously prevent ache nausea and vomit after LC.