INTRODUCTION: Brucellosis is an important zoonotic disease and a major cause of morbidity worldwide presenting with varying clinical manifestations. We aimed to investigate the epidemiological characteristics and complications of brucellosis at the Van Training and Research Hospital from January 2018 to December 2018. MATERIALS AND METHODS: 210 patients with brucellosis were assessed retrospectively. The clinical histories and signs, laboratory findings, therapeutic features and complications of these patients were obtained by examining their medical files. RESULTS: Of the 210 patients;, the most common symptoms were myalgia (87.6%), arthralgia (76.2%) and fever (72.4%). The most frequent clinical signs were fever (72.4%) and arthritis (21.9%). Out of 210 patients, standard tube agglutination (STA) tests were positive in 208 (99%). Osteoarticular involvement (34.3%) was common, and a combination of rifampicin and doxycycline was the most frequently used antimicrobial regimen. CONCLUSION It should be kept in mind that brucellosis may occur in patients presenting with fever, sweating, arthralgia and leukopenia, especially in endemic areas where dairy livestock is prevalent. People living in these areas should be educated about proper animal care and the handling of dairy products.

OBJECTIVE: The prevalence of schizophrenia is 1%, and it is a debilitating disorder that often results in a shortened lifespan. Peripheral blood samples are good candidates to investigate because they can be easily drawn, and they are widely studied in psychiatric disorders. MicroRNAs are small non-coding RNA transcripts. They regulate the expression of genes by binding to the 3'-untranslated region (UTR) of mRNAs and pointing them to degrade. In this study, we aimed to investigate the expression of miR-9-5p, miR-29a-3p, miR-106-5p, miR-106b-5p, miR-107, miR-125a-3p, and miR-125b-3p in schizophrenia patients and healthy controls. METHODS: We collected blood samples from 16 patients with schizophrenia and 16 healthy controls. MicroRNAs were measured with reverse transcriptase polymerase chain reaction. RESULTS: Schizophrenia patients showed statistically significant upregulation of five microRNAs: miR9-5p (p=0.002), miR29a-3p (p<0.001), miR106b-5p (p=0.002), miR125a-3p (p<0.001), and miR125b-3p (p=0.018). CONCLUSION: Our results increased the value of the miR106 and miR29 families as potentially and consistently dysregulated in psychiatric disorders. Our results should be considered preliminary, and they need confirmation in future studies with larger sample sizes.
Humans ; MicroRNAs* ; Prevalence ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger ; RNA, Small Untranslated ; Sample Size ; Schizophrenia* ; Up-Regulation