1.Prevalence of shoulder pain and influencing factors
Munkhdelger M ; Baasanjav N ; Munkhsaikhan T ; Baatarjav S
Mongolian Medical Sciences 2024;208(2):61-65
After low back pain and knee pain, shoulder pain has been estimated to be the third most common
musculoskeletal presentation in primary care. The prognosis for people presenting with musculoskeletal
shoulder pain varies widely between individuals with, on average, 50% of people with shoulder pain
still reporting symptoms 6months after presenting in primary care. In addition to pain, functional
disabilities are common and can interfere with work, hobbies, social, and sporting activities and may
also be associated with psychological distress and reduced quality of life. Shoulder pain consequences
generate high costs to society.
2.A study of tissue biomarkers in gastric cancer and its precursors
Nyam-Erdene N ; Tsogzolmaa Sh ; Batchimeg B ; Nomin-Erdene D ; Tuul B ; Оyunbileg N ; Zorigoo Sh ; Ganchimeg D ; Munkhbayar S ; Baasanjav N ; Tulgaa L
Mongolian Medical Sciences 2024;209(3):21-28
Background:
Specifically, stomach cancer ranks as the fifth leading cause of cancer morbidity
and mortality worldwide. Early-stage detection significantly improves survival rates,
with over 90% of patients diagnosed at stages I and II living beyond five years. To
improve the early detection of gastric cancer, it is necessary to complement the
conventional method of endoscopic examination with biomarker analysis. We aimed
to compare biomarkers such as pepsinogen C (PGC), matrix metalloproteinase 2
(MMP2), matrix metalloproteinase 9 (MMP9), and the cell proliferation marker Ki-67
with immunohistochemical analysis.
Purpose:
A comparative study and evaluation of biomarkers for the early detection of gastric
cancer.
Materials and Methods:
The study was conducted using a retrospective cohort design. Research ethics
issues were discussed at the meeting of the Medical Ethics Control Committee of
the Ministry of Health on October 13, 2023, and permission to start the research
was obtained (Resolution No. 23/051). The information was gathered based on the
criteria for K29.3, K29.4, K31, and C1 diagnoses according to the international ICD
10 classification, and participants were selected accordingly. Proteins such as PGC,
MMP2, MMP9, and Ki-67 were examined using a tissue microarray kit and evaluated
through immunohistochemical analysis.
Results:
Negative gastric tumor markers PGC, Ki-67, MMP2 and MMP9 were evaluated
by immunohistochemical analysis. The mean PGC protein staining values were
6.20±2.61 for chronic superficial gastritis, 5.45±2.47 for atrophic gastritis, 3.61±2.0 for
metaplasia, and 3.31±1.75 for gastric cancer, with statistically significant differences
between the groups (P<0.001). The mean Ki-67 protein staining values were 0.1 ±
0.4 for chronic superficial gastritis, 0.33 ± 0.55 for atrophic gastritis, 0.09 ± 0.39 for
metaplasia, and 2.62 ± 0.78 for gastric cancer, also showing statistically significant
differences (P<0.001). The mean MMP2 and MMP9 protein staining values were
0.2±0.76 and 1.2±2.04, respectively, for chronic superficial gastritis; 0.28±0.52
and 3.28±2.82 for atrophic gastritis; 0.35±1.04 and 1.12±1.45 for metaplasia; and
1.38±2.11 and 5.29±2.51 for gastric cancer, with all differences being statistically
significant (P<0.001).
Conclusion
PGC protein, a negative tumor marker, decreases during the transition
from a gastric cancer precursor to cancer. MMP2 protein, a marker of cell migration
and metastasis, has little diagnostic value, while the expression of MMP9 and the Ki
67 are highly effective in gastric cancer. Immunohistochemical analysis of endoscopic
biopsy tissue to detect the negative tumor marker PGC, the positive marker Ki-67,
and MMP9 can be used for early detection of gastric cancer.
3.Risk factors profile for cardioembolic stroke: A case-control study
Uurtsaikh G ; Batmyagmar K ; Dosjan E ; Saruul Ts ; Ariyasuren L ; Nandintsetseg B ; Baasanjav N ; Lkhamtsoo N
Mongolian Medical Sciences 2021;196(2):13-20
Introduction:
In Mongolia, data on the etiology and risk factors of cardioembolic stroke (CES) is scarce and few
clinical studies have been performed to date. Timely identification and control of cardiovascular risk
factors are priority objectives for adequate primary and secondary prevention of CES.
Goal:
The goal of this study was to describe risk factors for CES in our setting.
Results:
The case-control study enrolled a total of 525 subjects. CES was detected in 63 (35.7%) out of
176 (33.5%) ischemic stroke patients with a predominance in age group of 60-69 and men (33%).
The main risk factor of CES was non-valvular atrial fibrillation (AF). AF especially paroxysmal AF
increased the risk of CES by 4.6 times (p=<0.0001, OR 4.6, 95% CI 1.4-44.6). The second main
cerebrovascular risk factors were hypertension and dyslipidemia.
Conclusion
CES accounted for 1/3 of ischemic stroke. The commonest underlying medical conditions were non-valvular atrial fibrillation, hypertension, dyslipidemia, alcohol consumption and obesity. Hence, all
patients with hypertension and non-valvular AF should be meticulously screened for prevention of
CES.
4.Planned endoscopic examination of the abdomen for pancreatic necrosis and advanced peritonitis
Lochin Ts ; Baasanjav N ; Byambakhuu B ; Erdenechimeg J
Mongolian Medical Sciences 2021;196(2):32-36
Introduction:
We classify peritonitis as end-stage if it lasts for more than 72 hours or more than three days. At this
point, the pleural effusion of the posterior abdominal wall, the pleural layer of the gastrointestinal
tract, and the dimples of the esophagus are all scattered with pus. During the first operation, it is very
difficult to completely cleanse these abscesses. After the operation, pus will collect in the abdomen
and abscesses will form, which will require another operation. If this postoperative complication is
not diagnosed in time and operated again (relaparotomy), many other complications can occur and
the risk of death is high. 48-hour relaparotomy mortality is higher than early surgery (21.8% -76.8%).
Necrotic pancreatitis is chronic peritonitis (an abscess of the lower extremities) in which only non-pancreatic adipose tissue, sebum glands, pericardial effusions, pericardial effusions, and kidney
adipose tissue become necrotic.
Purpose:
Endoscopic surveillance for chronic pleurisy with pancreatic necrosis
Objectives:
1. Endoscopic monitoring of the postoperative course of pancreatic necrosis.
2. Calculate the results of washing and cleaning using binoculars.
Method:
Patients with advanced peritoneal inflammation and necrotizing pancreatitis should be selected for
reoperation. After removing the dead pancreatic tissue (necrosectomy), all layers of the abdomen are
temporarily closed. A 6 mm short tube with surgical rubber is cut into the small pancreas, inserted 2
cm deep into the standard abdomen and sutured to the skin. Or use a silicone tube 4 - 5 cm long.
Result:
The study was carried out on 56 patients in 2016-2020. The mean age was 50 (89%) for men, 6 (11%)
for women, and 47.5 ± 8.6.
Conclusion
1. Endoscopic follow-up showed 19 (76%) persistent postoperative peritonitis and re-clearance,
and 6 (24%) patients were not diagnosed with persistent peritonitis.
2. 25 (50%) cases of persistent peritonitis after surgery were washed 1-3 times. This method has
proven to be a safe and easy procedure and can be used in any urban or rural hospital.
5.Improving diagnosis of alcohol-induced acute necrotizing pancreatitis
Erdenebold D ; Baasanjav N ; Batbold B ; Puntsag Ch ; Ganbaatar M ; Altankhuyag S
Mongolian Medical Sciences 2021;195(1):25-30
Introduction:
About 20-30% of patients with acute pancreatitis have a severe disease and mortality rate among
inpatients were 15%. There are many causes of acute pancreatitis (AP), but most common cause of
AP is an alcohol. According to some studies in our country, alcohol is the number one cause of acute
pancreatitis and the mortality rate is 15.3%. Very important for prognosis of disease optimal choice
of treatment tactics, detection of infectious evidence of necrotizing pancreatitis. Therefore, based on
the above, there is an urgent need to conduct research to address important issues and to improve
the diagnosis and treatment of acute alcohol-induced pancreatic necrosis.
Goal:
Determine the importance of early diagnostic assessment of alcohol induced severe acute necrotizing
pancreatitis.
Materials and Methods:
Research model and research method. We conducted our research using an observational research
model and a factual research method.Sampling of research materials will be carried out by targeted
sampling. From November 1, 2008 to January 1, 2020, 122 patients who were hospitalized with
alcohol-inducedAP were selected and archival documents or medical histories were selected.
Statistical analysis was performed using averages and regression analysis methods to calculate the
laboratory parameters in the analysis related to the new evaluation system.
Results:
The minimum age of patients with ANP was 25 and the maximum was 71, with the majority (87.4%)
aged 26 to 60 years. When the Person Correlation method calculates the relationship between
alcohol consumption and mortality, it is assumed that the weaker the correlation, the higher the
amount of alcohol consumed, the lower the cure and the higher the mortality. Of the 31 deaths
reported in the study, 24 (77.4%) were hospitalized more than 72 hours after the onset of the disease.
Late hospitalization and late treatment of patients with acute necrotizing pancreatitis (ANP) disease
have been shown to adversely affect the prognosis of the disease. In our study, all parameters were
significant, but procalcitonin, serum amylase, serum lipase, serum LDG8 C-reactive protein, serum
glucose was found to be higher than the value specified in the evaluation system for the variable (in determining pancreatic necrosis). АNOVA analysis test showed that white blood cells, procalcitonin,
serum amilza, serum lipaza, serumglucose, serum LDG, C-reactive protein were higher than those
specified in the evaluation system, and that the level of significance for the variable (indicating a
severe pancreatitis or poor prognosis) was higher than other test results (P <0.01). According to
the new evaluation system, 12 out of 122 patients were classified as A class or 0-3, 69 (56.5%)
patients were class B or 4-6, and 41 (33.6%) patients were class C or >7 points. Of the total cases,
90.1% were rated as severe form of ANP and pancreatic necrosis by the classification system we
developed. When we assessed the prognosis with the new assessment system, we found that 100
percent of patients in category A were cured, 89.8 percent of patients in category B were cured, and
41.5 percent of patients in category C were cured and 58.5 percent died. Statistical calculations using
the correlation analysis method for the correlation between the score and the cure of the evaluation
system shows negative correlation (P <0.01) other words, the higher the score of the evaluation
system, the lower the cure rate and the higher the mortality rate.
Conclusion
In Mongolia, relatively young men suffer from alcohol-induced pancreatitis.Factors contributing to the
development of necrosis in acute pancreatitis include alcohol abuse, prolonged alcohol use, delayed
hospitalization, and delayed treatment.In our study, following clinical signs and laboratory findings are
effective in distinguishing severe forms of acute necrotizing pancreatitis, early diagnosis, assessment
of prognosis. Laboratorytests include: increase in white blood cells, procalcitonin, serum amylase,
serum LDH, serum lipase, C-reactive protein and a decrease in hematocrit, serum calcium.
6.First case of endovascular surgery with rotablation
Lhagvasuren Z ; Baasanjav N ; Batmyagmar Kh ; Narantuya D ; Erdembileg D ; Batzaya Ts ; Gereltuya Ch
Mongolian Medical Sciences 2020;191(1):96-99
Introduction
In 1987 Jerome Ritchie, David Auth and colleagues first introduced rotational atherectomy (rotablation)
as a technique for the endovascular treatment of obstructive atherosclerotic disease. Rotational
atherectomy covers 3-5% of all procedures in big PCI centers, while <1% in smaller centers. By
study of Warth DC et al. in 1994, at early period when it was first introduced, procedure complication
of rotablation was about 40%, those with coronary dissection 29%, coronary artery occlusion 11.2%,
side branch occlusion 1.8%, distal occlusion 0.9%, no relow phenomenon 6.1%, severe vasospasm
13.8% and vascular perforation 1-2%.
By advanced techniques and technologies that kind of complications reduced significantly, it occurs
as same as other PCI procedures.
In our country PCI procedure was first introduced in Third State Central Hospital in 2000, since then
20 years has passed. During this period coronary intravascular diagnosis and treatment developed
progressively performing 14751 PTCA procedures, of those 8355(56,6%) PCI cases. By statistics
of 2017, myocardial infarction occurred 1145.6 in 10000 population, showing sharp increase, and
cardiovascular mortality became number one cause and has tendency to increase further.
To inform first outcome of rotational atherectomy of atherosclerosis that is severely calcified and
unavailable to introduce balloon catheter or stent. To conduct atherectomy treatment methods,
accustoming professionals, order and get ready the treatment materials for necessity.
We successfully performed rotablation in severely calcified mLAD of 56 years of male patient by
staged PCI, whose infarct related artery Lcx was revascularized 3 months previously. As a result the
patient was fully revascularized, the balloon catheter passed through the narrowing and stent was
implanted successfully.
7.Results of laparoscopic pyeloplasty for ureteropelvic junctional stricture
Ganbold G ; Bayan-Undur D ; Nyamsuren D ; Baasanjav N
Mongolian Medical Sciences 2020;194(4):10-16
Background:
An aim of this study was to evaluate the long-term functional outcomes of laparoscopic
ureteropyeloplasty compared to that of open surgery at the Urology and Andrology Center of the First
Central Hospital of Mongolia. Ureteropelvic junction (UPJ) is the most common site for upper urinary
tract obstruction occurring 1 in 750 - 1500 births. Laparoscopic pyeloplasty was first reported in 1993
by Schuessler WW and its technique was dismembered pyeloplasty.
Material and Methods:
In the period from June 2018 to September 2019, we have operated 91 ureteropyeloplasty
cases. Patients were randomized into Group I (45 laparoscopy) operated by the laparoscopic
ureteropyeloplasty and Group II (46 open surgery) operated by the open ureteropyeloplasty. All the
patients had ureteropelvic junction obstruction and ureteropyeloplasty was performed. Both groups
were compared according to the operative time, and recovery duration. We studied restoration of
renal function and causes of conditions. Demographic data including age, gender and complications
were recorded. Renal diethylenetriamine penta-acetate scintigraphy was respectively performed 6
months after surgery.
Results:
Mean age was 32±12.05 ranging 16-62 in all the study population. A total of 91 (55 men and 36
women) were participated. Ureteropelvic junction stricture was occurred 75.66% in laparoscopic
cases and 84.78% in open cases which leads to hydronephrosis and it was statistically different
(p<0.028). Compared to that of open surgery, wound size was 6 time smaller, blood loss and hospital
stay less than 2 fold and wound healing is 5 days shorter than open surgery. There was statistical
different (p<0.001) between parameters of 2 groups. In laparoscopic and open group respectively,
renal function was 41.78±10.02ml/min, 42.15±11.34 ml/min (1.73м2). After intervention, renal function
was increased by (46±10.17ml/min, 46.09±11.50ml/min) and there was difference between 2 groups
(p<0.003). In laparoscopic group, renal function was more improved than open group (p=0.05).
Conclusion
Laparoscopic surgery had less blood, less analgesics usage, fewer hospital stays, and faster wound
healing. Renal function was improved 6 months after surgery.
8.Treatment for movement rehabilitation results after knee surgery
Mongolian Medical Sciences 2020;194(4):32-37
Intruduction:
Since 1990, joint surgery techniques and implants have changed dramatically and results have
improved. Today knee implants and surgical treatment of knee injuries are commonplace at the
National Center for Trauma and Orthopedics.
Rehabilitation after knee surgery can help maintain joint range of motion, muscle strength, and daily
function. However, inadequate rehabilitation can lead to increased pain, reduced mobility and, in
some cases, reoperation.
Material and Methods:
The study included 90 patients who responded to an AM-34 form using a random sampling method
for pain assessment using VAS, daily activity ability using the Barthel index, gait analysis using gait
analysis, and muscle strength rating of joint amplitude using by ICF 10.
Result
A study was conducted on 90 patients who had postoperative physical surgery in 2016-2019 in the
Arthritis Surgery Department of the National Center for Trauma and Orthopedics. The study included
patients aged 19 to 45 years with a mean age of 28.98 ± 5.47 years, 58 years for men (64%) and 32
years for women (36%).
Rehabilitation and postoperative treatment after knee surgery can help maintain freedom of movement,
muscle strength, and daily joint function, while inadequate rehabilitation can lead to increased pain,
reduced mobility and, in some cases, reoperation. confirmed by research.
Studies have shown that endoscopic surgery is 30 to 40% more effective than open surgery in
normalizing joint function in postoperative knee surgery.
The sooner you start mobile surgery after knee surgery, the sooner your joint function will be normal.
It was effective to do the 6 movement exercises that we used together.
9.Minimally Invasive Approaches to Ureteropelvic Junction Obstruction
Ganbold G ; Bayan-Undur D ; Nyamsuren D ; Baasanjav N
Mongolian Medical Sciences 2019;190(4):52-59
There are many treatment options for the management of ureteropelvic junction obstruction (UPJO).
Open pyeloplasty has a high success rate and has been considered as a gold standard. Minimally
invasive surgical techniques are associated with reduced morbidity, improved cosmetic result and
better convalescence than open pyeloplasty. For endopyelotomy, these advantages for minimally
invasive surgery such as laparoscopic pyeloplasty and robot assisted pyeloplasty have superior
success rate than open pyeloplasty. However, the success rate for laparoscopic surgery could
potentially be improved by careful selection of patients, using the criteria of stricture <2 cm, renal
function >25% and the absence of severe hydronephrosis. Laparoscopic pyeloplasty and robot-assisted pyeloplasty have similar success rates to open pyeloplasty (>90%) and the best outcomes
have been reported for robot-assisted pyeloplasty although this treatment option is less readily
available than laparoscopic pyeloplasty. Retrograde endopyelotomy is a simple, safe, and effective
therapeutic option for primary and secondary symptomatic UPJO.
Retrograde endopyelotomy should be considered a viable first-line treatment option for the
management of patients with UPJO. These include balloon dilation, antegrade endopyelotomy,
retrograde endopyelotomy, Acucise endopyelotomy and laparoscopic pyeloplasty. During last decade,
advances in endourological techniques have resulted in significant progress in the development of
minimally invasive surgical procedures to treat UPJO.
Surgeons described their modification of Kusters dismembered procedure that involved anastomosis
of the spatulated ureter to a projection of the lower aspect of the pelvis after a redundant portion
was excised. Laparoscopic pyeloplasty was first reported in 1993 both by Schuessler and others
and by Kavoussi and Peters, who utilized dismembered pyeloplasty technique. During last decade,
advances in endourological techniques have resulted in significant progress in the development
of minimally invasive surgical procedures to treat UPJO. The combination of less postoperative
morbidity, improved cosmesis, shorter convalescence and comparable operative success rates has
lured many patients away from gold standard of open pyeloplasty. Only few retrospective studies have
been conducted regarding laparoscopic versus open pyeloplasty. Success rates are comparable for
laparoscopic pyeloplasty.
The number of minimally invasive surgeries performed by us increased from year to year. Therefore
the characteristics and performance of the surgeries should be studied in detail and based on the
finding the evidence based medicine should be placed in.
10.Investigation of the Surgical Methods in the “Secret History of the Mongols”
Khaliunaa B ; Baasanjav N ; Bold Sh
Mongolian Medical Sciences 2019;187(1):48-51
In the 13th century, a wound caused by an arrowhead was healed by scorching the surface of the injury. For instance, in the early 13th century during a battle, Ugudei Khaan was shot in the neck. One of his knights, Borokhul, sucked a blood clot from the wound and carried him on his horse. When Chinggis Khaan saw them, he grieved, wept, and ordered a fire to be made. After scorching Ugudei’s wound, he gave him something to drink and waited to fight their enemies. We came across instances of curing injuries with dairy products in the Secret History of Mongolia. In one case, when he was wounded in the neck, Chinggis Khaan traveled with difficulty and camped in a battle field at sunset.
One of Chinggis’ knights, Zelme, nursed him by sucking blood until midnight. He cared for the unconscious Khaan by himself, not trusting others. When midnight passed, Chinggis Khaan woke up and said “blood has dried and I am thirsty.” Zelme took off his hat, boots and deel (dressing-gown), leaving only underwear and entered their enemy’s camp. He searched for eseg (mare’s milk) on carriages of commoners who camped behind the military camp. However, he couldn’t find any eseg because the refugees hadn’t milked their mares. Therefore, he stole a leather sack of tarag (a drink made by fermenting the milk of sheep, goat, or cow) and carried it back to his camp.
Nobody saw Zelme, God might have blessed him. Zelme gave Chinggis Khaan the tarag mixing it with water to drink. Chinggis Khaan had the drink and said he felt relieved. At that time it was dawn.
One of the achievements of Traditional Mongolian Medicine of that time was curing wounds with the help of surgical means. In the beginning, the Mongolians got much knowledge of animal anatomy by dismembering joints and internal organs of different animals while slaughtering. Afterwards, based on their knowledge of animal anatomy, they set bones and cured wounds. Additionally, they broadened their knowledge by performing autopsies on dead bodies, etc. In 1263, during one of the battles between the Mongolian and South Sun nation troops, which the Sun lost, Zuukhar was hit by 3 arrows. The arrowhead in his left shoulder could not be removed. Hyavtsag opened the wound with the help of two men who were sentenced to death (these people were Sun nation) and examined if the arrow could possibly be removed. Finally, he was able to remove the arrow from Zuukhar’s body. Thence, the
Mongolians of that time performed autopsies as well as surgical treatment along with medical treatment.
In the mid-13th century, Traditional Mongolian curing methods were rapidly developing. The Mongolian army had special doctors to cure injured soldiers. According to some sources, in the early 13th century, there was a position of “military doctor,” among Chinggis Khaan’s army. When generals or troops got injured, the military doctor was ordered to cure them by a fixed deadline.
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