Addressing the enduring challenge of evaluating traditional Chinese medicines (TCMs), the integrated evidence chain-based effectiveness evaluation of TCMs (Eff-iEC) has emerged. This paper explored its capacity through a demonstration study that evaluated the effectiveness evidence of six commonly used anti-hepatic fibrosis Chinese patent medicines (CPMs), including Biejiajian Pill (BP), Dahuang Zhechong Pill (DZP), Biejia Ruangan Compound (BRC), Fuzheng Huayu Capsule (FHC), Anluo Huaxian Pill (AHP), and Heluo Shugan Capsule (HSC), using both Eff-iEC and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. The recognition of these CPMs within the TCM academic community was also assessed through their inclusion in relevant medical documents. Results showed that the evidence of BRC and FHC received higher assessments in both Eff-iEC and GRADE system, while the assessments for others varied. Analysis of community recognition revealed that Eff-iEC more accurately reflects the clinical value of these CPMs, exhibiting superior evaluative capabilities. By breaking through the conventional pattern of TCMs effectiveness evaluation, Eff-iEC offers a novel epistemology that better aligns with the clinical realities and reasoning of TCMs, providing a coherent methodology for clinical decision-making, new drug evaluations, and health policy formulation.

Objective: To describe screening situation and associated factors of early warning signals in psychopathology in kindergarten children, so as to provide reference for effective prevention and treatment strategies. Methods: From October to December 2021, a cross sectional study was conducted in kindergartens in Jinniu District of Chengdu. The age appropriate early warning signals were screened among 20 417 kindergarten children for developmental problems. Chi square test and Logistic regression were used for univariate and multivariate analysis of positive early warning signs screening, respectively. Results: The positive screening of early warning signals among 2 year old children was mainly distributed in the language domain (6.12%), personal social domain for 2.5 year old (1.70%) and 3 year old children (1.76%), and fine motor domain for 4 year old (2.04%) and 5 year old children (1.03%). Univariate and multivariate analysis showed that factors associated with positive screening of early warning signals included gender, family structure, history of diseases, electronic screen exposure >2 h/d, sleep duration at night, and age of children( P < 0.05). Conclusion It is necessary to carry out regular screening for early warning signals for psychopathology in kindergartens. Age appropriate health education for early childhood development should be carried out against nurses and kindergarten teaching staff. Similarly, more attention should be paid to healthy sleep and media usage to improve physical and mental wellness among preschool children.