1.Differentiation of uterine fibroids and sarcomas by MRI and serum LDH levels: a multicenter study of the KAMOGAWA study
Yukio YAMANISHI ; Yasushi KOTANI ; Aki KIDO ; Tomoyuki OTANI ; Yuki HIMOTO ; Yasuhisa KURATA ; Kosuke MURAKAMI ; Hisamitsu TAKAYA ; Masahiro SUMITOMO ; Ikuko EMOTO ; Motonori MATSUBARA ; Naoki HORIKAWA ; Kana AKAGI ; Kentaro ISHIDA ; Aya TAKAORI ; Azusa SAKURAI ; Kaoru ABIKO ; Koji YAMANOI ; Masaki MANDAI ; Noriomi MATSUMURA
Journal of Gynecologic Oncology 2025;36(4):e58-
Objective:
In the differential diagnosis between uterine fibroids and uterine sarcomas, realworld magnetic resonance imaging (MRI) diagnostic information is scarce; furthermore, high diagnostic sensitivity is important in clinical practice. We previously developed a diagnostic algorithm to detect uterine sarcoma with high sensitivity using simple MRI images and serum lactate dehydrogenase (LDH) levels. In this multicenter study, we investigated the preoperative diagnosis of sarcoma in the real world and further validated the usefulness of our diagnostic algorithm.
Methods:
Of 154 uterine sarcomas and 154 uterine fibroids treated at 15 centers between January 2006 and December 2020, 139 sarcomas (16 smooth muscle tumors of uncertain malignant potential) and 141 fibroids with diffusion-weighted imaging information were included in the analysis. The diagnostic algorithm was validated by 3 radiologists who were blinded to the clinical information and pathologic diagnoses and who read the MRIs.
Results:
The sensitivity/specificity of preoperative diagnosis was 77.7%/92.9% for the preoperative report; 92.1%/72.3% for algorithm A; and 82.0%/85.8% for algorithm B (McNemar’s test p<0.05). Comparison of overall survival rates among 3 groups (Group 1: negative A, Group 2: positive A and negative B; Group 3: positive B) using algorithms A and B showed p=0.012. On multivariate analysis, stage, and serum LDH level were independent prognostic factors.
Conclusion
MRI is useful for preoperative diagnosis of uterine sarcoma, and the sarcoma diagnostic algorithm presented in this study is an option for diagnosing sarcoma with greater sensitivity. This information should be shared with patients.
2.A Questionnaire Survey on Acupuncture Practical Training for 5th Grade of Medical School
Akira MORITA ; Aya MURAKAMI ; Harumi HIRADI ; Yuki WATANABE ; Toshiya NAKAGUCHI ; Sadayuki OCHI ; Kazuho OKUDAIRA ; Yoshiro HIRASAKI ; Takao NAMIKI
Kampo Medicine 2023;74(2):175-179
To clarify the educational effect of the acupuncture and moxibustion practical training for a short time, we conducted a questionnaire survey of 112 fifth-year medical students gathering clinical experience for one hour of acupuncture and moxibustion practical training, including the therapeutic experience before and after the practical training. In 8 items out of 10, the percentage of “positively yes” responses after the practical training were significantly higher than before the practical training. The items that showed a large difference (range of change) in the percentage of “positively yes” responses before and after the practical training were “Do you think it is scientific? (+ 47.4% after the practical training),” “What is your general image? (+ 39.3%),” and “Do you want to use acupuncture and moxibustion in the future? (+ 39.3%).” Securing more opportunities to learn traditional medicine is desirable; however, the problem of limited time and personnel requires improvement. This survey showed a beneficial educational effect in a short time signifying the importance of implementing acupuncture and moxibustion practical training. Additionally, the possibility of expecting similar effects in other medical students and overall students in the medical field can also be expected.
3.Delphi Method Consensus-Based Identification of Primary Trauma Care Skills Required for General Surgeons in Japan
Kazuyuki HIROSE ; Soichi MURAKAMI ; Yo KURASHIMA ; Nagato SATO ; Saseem POUDEL ; Kimitaka TANAKA ; Aya MATSUI ; Yoshitsugu NAKANISHI ; Toshimichi ASANO ; Takehiro NOJI ; Yuma EBIHARA ; Toru NAKAMURA ; Takahiro TSUCHIKAWA ; Toshiaki SHICHINOHE ; Kazufumi OKADA ; Isao YOKOTA ; Naoto HASEGAWA ; Satoshi HIRANO
Journal of Acute Care Surgery 2023;13(2):58-65
Purpose:
General surgeons at regional hospitals should have the primary trauma care skills necessary to treat critically ill trauma patients to withstand transfer. This study was conducted to identify a consensus on primary trauma care skills for general surgeons.
Methods:
An initial list of acute care surgical skills was compiled, and revised by six trauma experts (acute care surgeons); 33 skills were nominated for inclusion in the Delphi consensus survey. Participants (councilors of the Japanese Society for Acute Care Surgery) were presented with the list of 33 trauma care skills and were asked (using web-based software) to rate how strongly they agreed or disagreed (using a 5-point Likert scale) with the necessity of each skill for a general surgeon. The reliability of consensus was predefined as Cronbach’s α ≥ 0.8, and trauma care skills were considered as primarily required when rated 4 (agree) or 5 (strongly agree) by ≥ 80% participants.
Results:
There were 117 trauma care specialists contacted to participate in the Delphi consensus survey panel. In the 1st round, 85 specialists participated (response rate: 72.6%). In the 2nd round, 66 specialists participated (response rate: 77.6%). Consensus was achieved after two rounds, reliability using Cronbach’s α was 0.94, and 34 items were identified as primary trauma care skills needed by general surgeons.
Conclusion
A consensus-based list of trauma care skills required by general surgeons was developed. This list can facilitate the development of a new trauma training course which has been optimized for general surgeons.
4.Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: findings from the NIPPON DATA2010.
Mieko NAKAMURA ; Toshiyuki OJIMA ; Tomomi NAGAHATA ; Imako KONDO ; Toshiharu NINOMIYA ; Katsushi YOSHITA ; Yusuke ARAI ; Takayoshi OHKUBO ; Keiko MURAKAMI ; Nobuo NISHI ; Yoshitaka MURAKAMI ; Naoyuki TAKASHIMA ; Nagako OKUDA ; Aya KADOTA ; Naoko MIYAGAWA ; Keiko KONDO ; Tomonori OKAMURA ; Hirotsugu UESHIMA ; Akira OKAYAMA ; Katsuyuki MIURA ; NIPPON DATA2010 Research Group
Environmental Health and Preventive Medicine 2019;24(1):1-1
BACKGROUND:
Oral health is thought to be associated with diet quality, and socioeconomic status (SES) affects both oral health and diet. The aim of this study was to investigate the association between the number of teeth and dietary intake as well as nutritional biomarker, considering the subjects' SES.
METHODS:
We conducted a cross-sectional analysis of data from 2049 individuals aged ≥ 50 years from the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010. The number of remaining teeth was categorized into age-specific quartiles (Q1 to Q4). We assessed the adjusted means and 95% confidence intervals for dietary variables by the number of teeth using analysis of covariance. Stratified analyses by SES were also conducted.
RESULTS:
The intake of grain products was 31 g higher, and those of vegetables and meat were 30 g and 8 g lower, respectively, in Q1 (fewer teeth) than in Q4 (more teeth). Carbohydrate intake was higher whereas protein, minerals (potassium, magnesium, and zinc), vitamins (vitamins A, E, B, B, β-carotene, and folic acid), and dietary fiber intakes were lower among individuals with fewer teeth. Adjusted mean serum albumin levels were low in Q1. The associations between the number of teeth and dietary intake were more evident in individuals with a low SES.
CONCLUSIONS
Having few remaining teeth was associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese adults, and these associations were more evident in individuals with low SES.
Aged
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Aged, 80 and over
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Carbohydrates
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Cross-Sectional Studies
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Diet
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Energy Intake
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physiology
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Female
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Humans
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Japan
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Male
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Middle Aged
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Nutrients
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Nutrition Surveys
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Nutritional Status
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Serum Albumin
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analysis
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Socioeconomic Factors
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Tooth
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Vegetables


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