Highly migrated disc herniations are difficult to treat using standard surgical procedures. Even minimally invasive techniques require more than the usual degree of bone and soft tissue resection to effectively remove these herniations safely. The authors present a retrospective analysis of results for 10 patients who were treated with the full-endoscopic translaminar technique, for upward and downward migrated disc herniations. The mean follow-up period was 24.7 months. All patients experienced significant relief from their preoperative symptoms, with an 86% reduction from preoperative pain levels and a 77% improvement from preoperative Oswestry Disability Index values. No long-term complications were noted in this series of patients. In this article, we present our modified translaminar endoscopic technique to treat this difficult subset of patients.