Objective:To explore the optimum time of ambulation of atrial fibrillation patients after radiofrequency ablation, to provide basis for patients' early postoperative rehabilitation.Methods:By convenient sampling method, a total of 120 patients with atrial fibrillation after radiofrequency ablation were collected at Yanghu Branch and City Branch of Changzhou Second People's Hospital from January 2020 to May 2021. They were divided into the early group, middle group and late group according to the random number table method, each group were 40 cases. All patients received routine postoperative intervention, the time of ambulation were 4, 6 and 12 h after operation in the early group, middle group and late group, respectively. The complication rate within 24 h after operation was compared among the three groups, and the comfort level of the three groups at 24, 48 and 72 h after operation was evaluated with Comfort Status Scale (GCQ).Results:Finally, 111 patients were included, including 37 in the early group, 38 in the middle group and 36 in the late group. There was no significant difference in the incidence of bleeding or hematoma, urinary retention, lumbago within 24 h after operation among the three groups ( P>0.05). The incidence of postural hypotension within 24 h after operation in the early group was 2.7% (1/37), which was lower than 21.1% (7/38) and 25.0% (9/36) in the middle and late groups, with a statistically significant difference ( χ2=4.86, 7.67, both P<0.05). At 48 and 72 h after operation, the scores of physiological dimension, psychological dimension and the total score of GCQ in the early group were (20.68 ± 3.07), (22.54 ± 3.35), (81.68 ± 6.11) and (22.54 ± 3.73), (24.38 ± 2.49), (84.92 ± 6.37), higher than those in the middle group (19.16 ± 2.19), (21.32 ± 2.27), (78.24 ± 5.58), (20.93 ± 2.85), (22.32 ± 2.04), (81.66 ± 6.56), and those in the late group (18.44 ± 1.50) (21.31 ± 1.99), (78.06 ± 4.32), (20.89 ± 2.25), (21.58 ± 1.86), (80.28 ± 6.44), the differences were statistically significant ( t values were 2.19-4.15, all P<0.05). Conclusions:Ambulation at 4 h after operation does not increase peripheral vascular complications, but can reduce the incidence of postural hypotension and improve the comfort of patients with atrial fibrillation after radiofrequency ablation.

Objective To compare the efficacy and safety of long-term use of dabigatran and warfarin for prevention of stroke in elderly patients with atrial fibrillation. Methods The study was designed as a prospective randomized controlled trial. The subjects were outpatients or inpatients who were diagnosed as non-valvular atrial fibrillation and needed anticoagulant therapy in Changzhou No.2 People′s Hospital. The study started on March 20,2015. Patients in accordance with the inclusion criteria were randomly divided into the dabigatran group (dabigatran 110 mg,twice daily)and warfarin group (warfarin dose was adjusted by regular follow-up results to maintain INR in the range of 2.0-3.0). After two years of follow-up,effectiveness of preventing thromboembolism events and occurrence of hemorrhagic events were compared between the two groups;occurrence of extracranial hemorrhage was also compared in patients with different ages (＜60 years old group,60-＜80 years old group,≥80 years old group)between the two groups.Results Up to October 2015,a total of 180 patients were enrolled,including 114 males (63.3%) and 66 females (36.7%);65 patients (36.1%)were ＜60 years old,108 patients (60.0%)were 60-＜80 years old,and 7 (3.9%)were≥80 years old. There were 90 patients in the dabigatran group and in the warfarin group,respectively. During the period of 2-year follow-up,stroke and non-central nervous system embolism occurred in 6 patients and intracranial hemorrhage in 5 patients in each group,extracranial hemorrhage occurred respectively in 12 and 16 patients in the warfarin and dabigatran groups,without statistically significant differences (P ＞ 0. 05 for all comparisons ). Comparisons of the extracranial hemorrhage incidences in patients with different ages between the 2 groups showed that the incidence of extracranial hemorrhage in patients ＜60 years old in the dabigatran group was lower than that in the warfarin group (11.4% vs. 13.3%);the incidences of extracranial hemorrhage in patients aged 60-＜80 and ≥80 years in the dabigatran group were higher than those in the warfarin group (19.6% vs. 12.2%,50.0% vs. 33.3%,respectively ),without statistically significant differences (P ＞ 0. 05 for all comparisons ). Conclusions The effectivenessfor preventing stroke and the incidences of hemorrhagic events were respectively similar in elderly atrial fibrillation patients with long-term use of dabigatran and warfarin. The risk of extracranial hemorrhage in very elderly patients needs to be further studied by expanding the sample size.

Objective To compare the efficacy and safety of long-term use of dabigatran and warfarin for prevention of stroke in elderly patients with atrial fibrillation. Methods The study was designed as a prospective randomized controlled trial. The subjects were outpatients or inpatients who were diagnosed as non-valvular atrial fibrillation and needed anticoagulant therapy in Changzhou No.2 People′s Hospital. The study started on March 20,2015. Patients in accordance with the inclusion criteria were randomly divided into the dabigatran group (dabigatran 110 mg,twice daily)and warfarin group (warfarin dose was adjusted by regular follow-up results to maintain INR in the range of 2.0-3.0). After two years of follow-up,effectiveness of preventing thromboembolism events and occurrence of hemorrhagic events were compared between the two groups;occurrence of extracranial hemorrhage was also compared in patients with different ages (＜60 years old group,60-＜80 years old group,≥80 years old group)between the two groups.Results Up to October 2015,a total of 180 patients were enrolled,including 114 males (63.3%) and 66 females (36.7%);65 patients (36.1%)were ＜60 years old,108 patients (60.0%)were 60-＜80 years old,and 7 (3.9%)were≥80 years old. There were 90 patients in the dabigatran group and in the warfarin group,respectively. During the period of 2-year follow-up,stroke and non-central nervous system embolism occurred in 6 patients and intracranial hemorrhage in 5 patients in each group,extracranial hemorrhage occurred respectively in 12 and 16 patients in the warfarin and dabigatran groups,without statistically significant differences (P ＞ 0. 05 for all comparisons ). Comparisons of the extracranial hemorrhage incidences in patients with different ages between the 2 groups showed that the incidence of extracranial hemorrhage in patients ＜60 years old in the dabigatran group was lower than that in the warfarin group (11.4% vs. 13.3%);the incidences of extracranial hemorrhage in patients aged 60-＜80 and ≥80 years in the dabigatran group were higher than those in the warfarin group (19.6% vs. 12.2%,50.0% vs. 33.3%,respectively ),without statistically significant differences (P ＞ 0. 05 for all comparisons ). Conclusions The effectivenessfor preventing stroke and the incidences of hemorrhagic events were respectively similar in elderly atrial fibrillation patients with long-term use of dabigatran and warfarin. The risk of extracranial hemorrhage in very elderly patients needs to be further studied by expanding the sample size.