Spinal cord injury (SCI), as a serious traumatic disease of the central nervous system, often leads to irreversible damage to neurological function and has a high disability rate. Induced pluripotent stem cells (iPSCs) have the ability of self-renewal capacity and multilineage differentiation potential, and thus show broad application prospects and research value in the repair of SCI. iPSCs can replace damaged cells by directionally differentiating into neurons, oligodendrocytes, etc., secrete neurotrophic factors to optimize the microenvironment, promote myelin regeneration, and regulate immune responses. In recent years, research has concentrated on refining the directional differentiation protocol of iPSCs, improving survival rate and functional integration of transplanted cells, and actively exploring combined treatment strategies with biomaterial scaffolds, electrical stimulation, etc., to enhance the repair effect. Preclinical studies substantiate that iPSC transplantation can improve motor function, and early-phase clinical trials have also demonstrated its biological safety. Furthermore, iPSCs avoid ethical controversies and can be applied to disease modeling and mechanism research.

Spinal cord injury (SCI), as a serious traumatic disease of the central nervous system, often leads to irreversible damage to neurological function and has a high disability rate. Induced pluripotent stem cells (iPSCs) have the ability of self-renewal capacity and multilineage differentiation potential, and thus show broad application prospects and research value in the repair of SCI. iPSCs can replace damaged cells by directionally differentiating into neurons, oligodendrocytes, etc., secrete neurotrophic factors to optimize the microenvironment, promote myelin regeneration, and regulate immune responses. In recent years, research has concentrated on refining the directional differentiation protocol of iPSCs, improving survival rate and functional integration of transplanted cells, and actively exploring combined treatment strategies with biomaterial scaffolds, electrical stimulation, etc., to enhance the repair effect. Preclinical studies substantiate that iPSC transplantation can improve motor function, and early-phase clinical trials have also demonstrated its biological safety. Furthermore, iPSCs avoid ethical controversies and can be applied to disease modeling and mechanism research.

Objective To systematically analyze the World Health Organization Rehabilitation Competency Framework (RCF) theoretical framework, methodology and its application in the field of rehabilitation.Methods We systematically analyzed RCF conceptual framework and key characteristics, and discussed how to apply the RCF in the fields of human resource planning, education program and curriculum system, and vocational competency standards and certification criteria for rehabilitation human resources.Results The RCF encompasses five domains, naming practice, professionalism, learning and development, management and leadership, and research. Rehabilitation professionals' performance is the result of the interaction of their core values and beliefs, competencies, activities, knowledge, and skills. The RCF can be used to plan rehabilitation human resources, establish competency-based rehabilitation education programs and curriculum systems, and develop competency certification standards and licensure accreditation standards.Conclusion This study analyzed background, content and implementation framework of RCF, and systematically discussed the theories and methods related to how to use the RCF to construct national rehabilitation human resources development plans, develop rehabilitation education programs and curriculum systems based on the RCF, and establish certification and assessment standards for rehabilitation human resources.