1.Recent Trends in Cytomegalovirus IgG Seropositivity in the Adult Population of Korea: A Cross-Sectional Study and Literature Review
Changhee HA ; Anna LEE ; Hee-Won MOON
Annals of Laboratory Medicine 2026;46(2):171-179
Background:
Cytomegalovirus (CMV) infection is prevalent worldwide. Although Korea has historically shown high CMV IgG seropositivity ( > 95%), declines have been reported recently. We assessed current CMV IgG seropositivity and analyzed prevailing trends in the Korean population.
Methods:
Residual samples from individuals undergoing regular health checkups were analyzed. We assessed 1,978 samples (from 937 men and 1,041 women) where the age group distribution was relatively balanced. CMV IgG levels were measured at two institutions using a commercial immunoassay (Alinity i CMV IgG Reagent Kit, Abbott) following the manufacturer’s instructions. Results were interpreted as “reactive” when the CMV IgGconcentration was ≥ 6.0 arbitrary units (AU)/mL or “nonreactive” when the CMV IgG con-centration was < 6.0 AU/mL. Seropositivity was compared by sex and across age groups (20–29, 30–39, 40–49, and 50–59 yrs).
Results:
The overall CMV IgG seropositivity was 89.9% (1,778/1,978) and was significantly higher in men (91.7%, 859/937) than in women (88.3%, 919/1,041) (difference:3.4%; 95% confidence interval: 0.8%–6.0%; P = 0.012, chi-square test). No significant differences with regard to sex were found within each age group. Seropositivity increased with age, from 76.3% (347/455, 20–29 yrs) to 99.8% (448/449, 50–59 yrs) (P for trend < 0.001), consistently in both sexes.
Conclusions
Our findings provide the most up-to-date estimate of CMV IgG seropositivity in the Korean adult population. Because of lower seropositivity in younger adults, continued monitoring and further education are essential for CMV control and prevention.
2.Association of Lipoprotein(a) with Progression of Coronary Artery Calcification: Retrospective Longitudinal Study
Anna LEE ; Hyun-Min KOH ; Ji-Yong JANG ; Hye-Rang BAK ; Hye-Jin JANG ; Jun-Young HUH ; Nak-Gyeong KO
Korean Journal of Family Medicine 2025;46(3):176-184
Background:
Atherosclerotic cardiovascular disease (ASCVD) is a major health concern, and lipoprotein(a) (Lp(a)) is an independent risk factor. However, there is limited evidence regarding Lp(a) and the risk of ASCVD in Asian populations. This study aimed to assess the predictive value of changes in coronary artery calcification (CAC) for ASCVD risk associated with Lp(a) level.
Methods:
Participants (n=2,750) were grouped according to their Lp(a) levels, and the association between Lp(a) and CAC progression was examined. CAC progression was defined as the occurrence of incident CAC or a difference ≥2.5 between the square root (√) of baseline and follow-up coronary artery calcium scores (CACSs) (Δ√transformed CACS). To adjust for differences in follow-up periods, Δ√transformed CACS was divided by the follow- up period (in years).
Results:
Over an average follow-up of 3.07 years, 18.98% of participants experienced CAC progression. Those with disease progression had notably higher Lp(a) levels. Higher Lp(a) tertiles correlated with increased baseline and follow-up CACS, CAC progression (%), and Δ√transformed CACS. Even after adjustment, higher Lp(a) levels were associated with CAC progression. However, annualized Δ√transformed CACS analysis yielded no significant results.
Conclusion
This study demonstrated an association between elevated Lp(a) levels and CAC progression in a general population without ASCVD. However, longer-term follow-up studies are needed to obtain meaningful results regarding CAC progression. Further research is necessary to utilize Lp(a) level as a predictor of cardiovascular disease and to establish clinically relevant thresholds specific to the Korean population.
3.Childbearing intentions and influencing factors among single young adults in South Korea: a cross-sectional study
Hyewon SHIN ; Anna LEE ; Sunyeob CHOI ; Minjeong JO
Child Health Nursing Research 2025;31(1):15-27
Purpose:
To identify the childbearing intentions of young adults in South Korea and examine the factors influencing them using a social-ecological model (SEM).
Methods:
A descriptive cross-sectional study design was used. Unmarried employed men and women (n=181) aged 25–40 years completed an online survey. The data included socio-demographic characteristics and responses at four levels: (1) intrapersonal (perception of parenthood and fertility knowledge), (2) interpersonal (quality of family relationships), (3) institutional (work-family culture), and (4) community and public policy (adequacy of government policies and social support systems). Data were analyzed using descriptive statistics, correlations, and multiple logistic regression.
Results:
Approximately 77% of the participants planned to have children, and more than 60% wanted to have two or more children. Among the four levels of SEM, only intrapersonal factors, including intention to marry, fertility knowledge, and attitudes toward parenthood, were statistically significant in influencing childbearing intentions. The model explaining the intention to have a child demonstrated an explanatory power of 59.6%, incorporating factors such as marital intention, perceptions of parenthood, and fertility knowledge.
Conclusion
A noticeable gap exists between childbearing intentions and childbirth in South Korea. These findings provide insights into the nursing educational content needed for delivering family planning education to young adults. Targeted interventions such as counseling services and community education should be integrated into nursing practice. Moreover, nursing curricula should discuss factors influencing childbearing intentions to equip future nurses better to support young adults' family planning decisions.
4.Prognostic factors and outcomes of extremity necrotising fasciitis in Singapore.
Shaun Kai Kiat CHUA ; Noah Tian Run LIM ; Anna Hien Anh TRAN ; Liang SHEN ; Choon Chiet HONG ; Joel Yong Hao TAN ; Mark Edward PUHAINDRAN ; Jonathan Jiong Hao TAN
Annals of the Academy of Medicine, Singapore 2025;54(10):679-681
5.Motivating and hindering factors affecting muslim mothers' Infant and Young Child Feeding (IYCF) practices in select municipalities of Maguindanao, BARMM, Philippines
Paul Alteo A. Bagabaldo ; Maria Theresa M. Talavera ; Divine Grace C. Domingo ; Angelina R. Bustos ; Leila S. Africa ; Angelina Dr. Felix ; Anna Teresa O. Orillo ; Nancy A. Tandang ; Warren Tk Lee ; Maria Cecilia F. Pastores
Acta Medica Philippina 2025;59(5):19-29
OBJECTIVES
This study aimed to determine the motivating and hindering factors affecting the Infant and Young Child Feeding (IYCF) practices of Muslim mothers in select municipalities of Maguindanao.
METHODSA pretested questionnaire was administered through face-to-face interviews conducted among 320 randomly selected Muslim mothers with a child aged 6-23 months.
RESULTSResults revealed that prelacteal feeding was practiced by 16.6% of the Muslim mothers, giving mostly plain water. Solid/semi-solid foods were introduced at a mean age of 6.1 ± 1.4 months, with home-cooked lugao (porridge) (55.0%) and commercial baby food (31.3%) as the top foods introduced. The majority of Muslim mothers (82.5%) fed processed foods as complementary food to their children, including instant noodles (85.2%) and canned goods (51.5%). These processed foods were mostly obtained from sari-sari stores, with TV as the top source of information. More than 80% of the Muslim mothers cited food availability, economic reasons, and convenience in food preparation as the top three motivating factors in the practice of complementary feeding (CF). In addition, almost all the Muslim mothers (~97%) mentioned seeing their children grow healthy as the top reason for improving their food preparation practices, followed by positive feedback from their families. Meanwhile, household duties, low milk output, and a new pregnancy make it difficult to continue breastfeeding, while high complementary food costs, a limited budget, and a lack of food make it difficult to provide complementary food. The preparation of food for infants and young children is hindered by an increased workload and a lack of understanding.
CONCLUSIONThe results revealed suboptimal practices in prelacteal feeding and the reliance on processed foods among Muslim mothers, with economic factors, availability, and convenience as motivating factors in complementary feeding practices. Challenges such as household duties, low milk output, and financial constraints hinder breastfeeding and nutritious food provision for infants and young children. The study reinforced the necessity for holistic strategies in IYCF promotion among Muslim mothers.
Breast Feeding ; Malnutrition ; Islam
6.Association of Lipoprotein(a) with Progression of Coronary Artery Calcification: Retrospective Longitudinal Study
Anna LEE ; Hyun-Min KOH ; Ji-Yong JANG ; Hye-Rang BAK ; Hye-Jin JANG ; Jun-Young HUH ; Nak-Gyeong KO
Korean Journal of Family Medicine 2025;46(3):176-184
Background:
Atherosclerotic cardiovascular disease (ASCVD) is a major health concern, and lipoprotein(a) (Lp(a)) is an independent risk factor. However, there is limited evidence regarding Lp(a) and the risk of ASCVD in Asian populations. This study aimed to assess the predictive value of changes in coronary artery calcification (CAC) for ASCVD risk associated with Lp(a) level.
Methods:
Participants (n=2,750) were grouped according to their Lp(a) levels, and the association between Lp(a) and CAC progression was examined. CAC progression was defined as the occurrence of incident CAC or a difference ≥2.5 between the square root (√) of baseline and follow-up coronary artery calcium scores (CACSs) (Δ√transformed CACS). To adjust for differences in follow-up periods, Δ√transformed CACS was divided by the follow- up period (in years).
Results:
Over an average follow-up of 3.07 years, 18.98% of participants experienced CAC progression. Those with disease progression had notably higher Lp(a) levels. Higher Lp(a) tertiles correlated with increased baseline and follow-up CACS, CAC progression (%), and Δ√transformed CACS. Even after adjustment, higher Lp(a) levels were associated with CAC progression. However, annualized Δ√transformed CACS analysis yielded no significant results.
Conclusion
This study demonstrated an association between elevated Lp(a) levels and CAC progression in a general population without ASCVD. However, longer-term follow-up studies are needed to obtain meaningful results regarding CAC progression. Further research is necessary to utilize Lp(a) level as a predictor of cardiovascular disease and to establish clinically relevant thresholds specific to the Korean population.
7.Childbearing intentions and influencing factors among single young adults in South Korea: a cross-sectional study
Hyewon SHIN ; Anna LEE ; Sunyeob CHOI ; Minjeong JO
Child Health Nursing Research 2025;31(1):15-27
Purpose:
To identify the childbearing intentions of young adults in South Korea and examine the factors influencing them using a social-ecological model (SEM).
Methods:
A descriptive cross-sectional study design was used. Unmarried employed men and women (n=181) aged 25–40 years completed an online survey. The data included socio-demographic characteristics and responses at four levels: (1) intrapersonal (perception of parenthood and fertility knowledge), (2) interpersonal (quality of family relationships), (3) institutional (work-family culture), and (4) community and public policy (adequacy of government policies and social support systems). Data were analyzed using descriptive statistics, correlations, and multiple logistic regression.
Results:
Approximately 77% of the participants planned to have children, and more than 60% wanted to have two or more children. Among the four levels of SEM, only intrapersonal factors, including intention to marry, fertility knowledge, and attitudes toward parenthood, were statistically significant in influencing childbearing intentions. The model explaining the intention to have a child demonstrated an explanatory power of 59.6%, incorporating factors such as marital intention, perceptions of parenthood, and fertility knowledge.
Conclusion
A noticeable gap exists between childbearing intentions and childbirth in South Korea. These findings provide insights into the nursing educational content needed for delivering family planning education to young adults. Targeted interventions such as counseling services and community education should be integrated into nursing practice. Moreover, nursing curricula should discuss factors influencing childbearing intentions to equip future nurses better to support young adults' family planning decisions.
8.Association of Lipoprotein(a) with Progression of Coronary Artery Calcification: Retrospective Longitudinal Study
Anna LEE ; Hyun-Min KOH ; Ji-Yong JANG ; Hye-Rang BAK ; Hye-Jin JANG ; Jun-Young HUH ; Nak-Gyeong KO
Korean Journal of Family Medicine 2025;46(3):176-184
Background:
Atherosclerotic cardiovascular disease (ASCVD) is a major health concern, and lipoprotein(a) (Lp(a)) is an independent risk factor. However, there is limited evidence regarding Lp(a) and the risk of ASCVD in Asian populations. This study aimed to assess the predictive value of changes in coronary artery calcification (CAC) for ASCVD risk associated with Lp(a) level.
Methods:
Participants (n=2,750) were grouped according to their Lp(a) levels, and the association between Lp(a) and CAC progression was examined. CAC progression was defined as the occurrence of incident CAC or a difference ≥2.5 between the square root (√) of baseline and follow-up coronary artery calcium scores (CACSs) (Δ√transformed CACS). To adjust for differences in follow-up periods, Δ√transformed CACS was divided by the follow- up period (in years).
Results:
Over an average follow-up of 3.07 years, 18.98% of participants experienced CAC progression. Those with disease progression had notably higher Lp(a) levels. Higher Lp(a) tertiles correlated with increased baseline and follow-up CACS, CAC progression (%), and Δ√transformed CACS. Even after adjustment, higher Lp(a) levels were associated with CAC progression. However, annualized Δ√transformed CACS analysis yielded no significant results.
Conclusion
This study demonstrated an association between elevated Lp(a) levels and CAC progression in a general population without ASCVD. However, longer-term follow-up studies are needed to obtain meaningful results regarding CAC progression. Further research is necessary to utilize Lp(a) level as a predictor of cardiovascular disease and to establish clinically relevant thresholds specific to the Korean population.
9.Childbearing intentions and influencing factors among single young adults in South Korea: a cross-sectional study
Hyewon SHIN ; Anna LEE ; Sunyeob CHOI ; Minjeong JO
Child Health Nursing Research 2025;31(1):15-27
Purpose:
To identify the childbearing intentions of young adults in South Korea and examine the factors influencing them using a social-ecological model (SEM).
Methods:
A descriptive cross-sectional study design was used. Unmarried employed men and women (n=181) aged 25–40 years completed an online survey. The data included socio-demographic characteristics and responses at four levels: (1) intrapersonal (perception of parenthood and fertility knowledge), (2) interpersonal (quality of family relationships), (3) institutional (work-family culture), and (4) community and public policy (adequacy of government policies and social support systems). Data were analyzed using descriptive statistics, correlations, and multiple logistic regression.
Results:
Approximately 77% of the participants planned to have children, and more than 60% wanted to have two or more children. Among the four levels of SEM, only intrapersonal factors, including intention to marry, fertility knowledge, and attitudes toward parenthood, were statistically significant in influencing childbearing intentions. The model explaining the intention to have a child demonstrated an explanatory power of 59.6%, incorporating factors such as marital intention, perceptions of parenthood, and fertility knowledge.
Conclusion
A noticeable gap exists between childbearing intentions and childbirth in South Korea. These findings provide insights into the nursing educational content needed for delivering family planning education to young adults. Targeted interventions such as counseling services and community education should be integrated into nursing practice. Moreover, nursing curricula should discuss factors influencing childbearing intentions to equip future nurses better to support young adults' family planning decisions.
10.Association of Lipoprotein(a) with Progression of Coronary Artery Calcification: Retrospective Longitudinal Study
Anna LEE ; Hyun-Min KOH ; Ji-Yong JANG ; Hye-Rang BAK ; Hye-Jin JANG ; Jun-Young HUH ; Nak-Gyeong KO
Korean Journal of Family Medicine 2025;46(3):176-184
Background:
Atherosclerotic cardiovascular disease (ASCVD) is a major health concern, and lipoprotein(a) (Lp(a)) is an independent risk factor. However, there is limited evidence regarding Lp(a) and the risk of ASCVD in Asian populations. This study aimed to assess the predictive value of changes in coronary artery calcification (CAC) for ASCVD risk associated with Lp(a) level.
Methods:
Participants (n=2,750) were grouped according to their Lp(a) levels, and the association between Lp(a) and CAC progression was examined. CAC progression was defined as the occurrence of incident CAC or a difference ≥2.5 between the square root (√) of baseline and follow-up coronary artery calcium scores (CACSs) (Δ√transformed CACS). To adjust for differences in follow-up periods, Δ√transformed CACS was divided by the follow- up period (in years).
Results:
Over an average follow-up of 3.07 years, 18.98% of participants experienced CAC progression. Those with disease progression had notably higher Lp(a) levels. Higher Lp(a) tertiles correlated with increased baseline and follow-up CACS, CAC progression (%), and Δ√transformed CACS. Even after adjustment, higher Lp(a) levels were associated with CAC progression. However, annualized Δ√transformed CACS analysis yielded no significant results.
Conclusion
This study demonstrated an association between elevated Lp(a) levels and CAC progression in a general population without ASCVD. However, longer-term follow-up studies are needed to obtain meaningful results regarding CAC progression. Further research is necessary to utilize Lp(a) level as a predictor of cardiovascular disease and to establish clinically relevant thresholds specific to the Korean population.


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