Objective To investigate the diagnostic value of plasma heparin-binding protein(HBP)in the bloodstream infection of tumor patients.Methods The tumor patients treated at Ruijin Hospital,Shanghai Jiao Tong University School of Medicine from Janu-ary 2023 to December 2023 were selected and further divided into the following three groups:124 patients with positive blood cultures(bloodstream infection group),95 with negative blood cultures but positive cultures from other body fluids(culture-positive group),and 100 with negative bacterial cultures(culture-negative group).The levels of HBP,procalcitonin(PCT),C-reactive protein(CRP),interleukin 6(IL-6),white blood cell(WBC),and neutrophil(NE)in the three groups were detected.The level differences of each indicator among three groups were compared.The differences in the expression levels of HBP in the bloodstream infection group with different pathogens such as Gram-negative bacteria,Gram-positive bacteria,and fungi were also compared.The Logistic regression analysis was used to evaluate the predictive efficacy of each indicator for the risk of bloodstream infection.The receiver operating char-acteristics(ROC)curve was used to assess the diagnostic value of each indicator alone and in combination for the bloodstream infection of tumor patients.Results The expression level of HBP in the bloodstream infection group(32.14[14.01,110.40]ng/mL)was sig-nificantly higher than that in the culture-positive group(23.00[5.90,54.87]ng/mL,t=5.39,P＜0.05),and both of them were sig-nificantly higher than that in the culture-negative group(6.80[5.90,16.05]ng/mL,Z=47.248,P＜0.05).HBP had a certain clini-cal predictive value for the occurrence of bloodstream infection in tumor patients(OR=1.017,95％CI:1.008～1.027,P＜0.001).In addition,the levels of HBP in the Gram-negative bacterial infection group(78.04[21.60,157.20]ng/mL)were significantly higher than that in the Gram-positive bacterial infection group(51.00[18.45,106.50]ng/mL,t=2.01,P＜0.05),and both of them were significantly higher than that in the fungal infection group(5.90[5.90,14.17]ng/mL,Z=3.40,P＜0.05).The area under the ROC curve(AUCROC),sensitivity,and specificity of HBP for the diagnosis of bloodstream infection in tumor patients were 0.717,67.37％,and 67.26％,respectively,which were superior to those of PCT(0.700,77.17％,and 52.14％),CRP(0.667,63.16％,and 62.39％),and IL-6(0.629,60.47％,and 60.47％).The AUCROC,sensitivity,and specificity of the combination of HBP,CRP,PCT,and IL-6 were 0.739,70.24％,and 68.42％,respectively,which were better than those of each indicator alone.Conclusion The detection of HBP has high clinical application value in the diagnosis of bloodstream infections of tumor patients and may serve as a potential biomarker for the bloodstream infection of tumor patients.

Objective To investigate the diagnostic value of plasma heparin-binding protein(HBP)in the bloodstream infection of tumor patients.Methods The tumor patients treated at Ruijin Hospital,Shanghai Jiao Tong University School of Medicine from Janu-ary 2023 to December 2023 were selected and further divided into the following three groups:124 patients with positive blood cultures(bloodstream infection group),95 with negative blood cultures but positive cultures from other body fluids(culture-positive group),and 100 with negative bacterial cultures(culture-negative group).The levels of HBP,procalcitonin(PCT),C-reactive protein(CRP),interleukin 6(IL-6),white blood cell(WBC),and neutrophil(NE)in the three groups were detected.The level differences of each indicator among three groups were compared.The differences in the expression levels of HBP in the bloodstream infection group with different pathogens such as Gram-negative bacteria,Gram-positive bacteria,and fungi were also compared.The Logistic regression analysis was used to evaluate the predictive efficacy of each indicator for the risk of bloodstream infection.The receiver operating char-acteristics(ROC)curve was used to assess the diagnostic value of each indicator alone and in combination for the bloodstream infection of tumor patients.Results The expression level of HBP in the bloodstream infection group(32.14[14.01,110.40]ng/mL)was sig-nificantly higher than that in the culture-positive group(23.00[5.90,54.87]ng/mL,t=5.39,P＜0.05),and both of them were sig-nificantly higher than that in the culture-negative group(6.80[5.90,16.05]ng/mL,Z=47.248,P＜0.05).HBP had a certain clini-cal predictive value for the occurrence of bloodstream infection in tumor patients(OR=1.017,95％CI:1.008～1.027,P＜0.001).In addition,the levels of HBP in the Gram-negative bacterial infection group(78.04[21.60,157.20]ng/mL)were significantly higher than that in the Gram-positive bacterial infection group(51.00[18.45,106.50]ng/mL,t=2.01,P＜0.05),and both of them were significantly higher than that in the fungal infection group(5.90[5.90,14.17]ng/mL,Z=3.40,P＜0.05).The area under the ROC curve(AUCROC),sensitivity,and specificity of HBP for the diagnosis of bloodstream infection in tumor patients were 0.717,67.37％,and 67.26％,respectively,which were superior to those of PCT(0.700,77.17％,and 52.14％),CRP(0.667,63.16％,and 62.39％),and IL-6(0.629,60.47％,and 60.47％).The AUCROC,sensitivity,and specificity of the combination of HBP,CRP,PCT,and IL-6 were 0.739,70.24％,and 68.42％,respectively,which were better than those of each indicator alone.Conclusion The detection of HBP has high clinical application value in the diagnosis of bloodstream infections of tumor patients and may serve as a potential biomarker for the bloodstream infection of tumor patients.