Objective: This prospective study evaluated the effectiveness of clear aligner treatment (CAT) in achieving dentoalveolar upper arch expansion in patients with mixed dentition and transverse maxillary deficiency. Methods: Forty patients with mixed dentition and a transverse discrepancy of ≤ 5 mm were treated using clear aligners. Pre- and post-treatment digital dental models were measured using specific landmarks and compared with the programmed expansion in the virtual treatment plan. Statistical analyses included the inter-class correlation coefficient to evaluate inter-rater reliability. A paired t test was employed to compare pre- and post-treatment values and to examine the significance of the changes. Multiple regression analysis was conducted to estimate the relationship between the prescribed and observed measurements, stratified by inter-dental measurements (deciduous canines, first deciduous molars, and permanent molars, at cusp and gingival levels). Results: Excellent measurement reproducibility was observed. The accuracy of dentoalveolar maxillary arch expansion varied among different tooth regions. The inter-canine accuracy was 87.7% at the cusp level and 82.7% at the gingival level. The inter-first deciduous molars exhibited accuracies of 84.9% (cusp level) and 80.5% (gingival level). The inter-first molars showed accuracies of 77.8% (cusp level) and 67.9% (gingival level). Significant differences were observed between the planned and obtained measurements for specific tooth regions. Conclusions CAT demonstrated reliable predictability in achieving dentoalveolar expansion of the maxillary arch in patients with mixed dentition. A higher accuracy was observed in the anterior region than in the posterior region. These findings suggest that CAT could be an effective option for treating transverse maxillary deficiencies in patients with mixed dentition with moderate inter-arch transverse discrepancies, considering tooth-specific predictability differences.

Objective: This prospective study evaluated the effectiveness of clear aligner treatment (CAT) in achieving dentoalveolar upper arch expansion in patients with mixed dentition and transverse maxillary deficiency. Methods: Forty patients with mixed dentition and a transverse discrepancy of ≤ 5 mm were treated using clear aligners. Pre- and post-treatment digital dental models were measured using specific landmarks and compared with the programmed expansion in the virtual treatment plan. Statistical analyses included the inter-class correlation coefficient to evaluate inter-rater reliability. A paired t test was employed to compare pre- and post-treatment values and to examine the significance of the changes. Multiple regression analysis was conducted to estimate the relationship between the prescribed and observed measurements, stratified by inter-dental measurements (deciduous canines, first deciduous molars, and permanent molars, at cusp and gingival levels). Results: Excellent measurement reproducibility was observed. The accuracy of dentoalveolar maxillary arch expansion varied among different tooth regions. The inter-canine accuracy was 87.7% at the cusp level and 82.7% at the gingival level. The inter-first deciduous molars exhibited accuracies of 84.9% (cusp level) and 80.5% (gingival level). The inter-first molars showed accuracies of 77.8% (cusp level) and 67.9% (gingival level). Significant differences were observed between the planned and obtained measurements for specific tooth regions. Conclusions CAT demonstrated reliable predictability in achieving dentoalveolar expansion of the maxillary arch in patients with mixed dentition. A higher accuracy was observed in the anterior region than in the posterior region. These findings suggest that CAT could be an effective option for treating transverse maxillary deficiencies in patients with mixed dentition with moderate inter-arch transverse discrepancies, considering tooth-specific predictability differences.

Objective: This prospective study evaluated the effectiveness of clear aligner treatment (CAT) in achieving dentoalveolar upper arch expansion in patients with mixed dentition and transverse maxillary deficiency. Methods: Forty patients with mixed dentition and a transverse discrepancy of ≤ 5 mm were treated using clear aligners. Pre- and post-treatment digital dental models were measured using specific landmarks and compared with the programmed expansion in the virtual treatment plan. Statistical analyses included the inter-class correlation coefficient to evaluate inter-rater reliability. A paired t test was employed to compare pre- and post-treatment values and to examine the significance of the changes. Multiple regression analysis was conducted to estimate the relationship between the prescribed and observed measurements, stratified by inter-dental measurements (deciduous canines, first deciduous molars, and permanent molars, at cusp and gingival levels). Results: Excellent measurement reproducibility was observed. The accuracy of dentoalveolar maxillary arch expansion varied among different tooth regions. The inter-canine accuracy was 87.7% at the cusp level and 82.7% at the gingival level. The inter-first deciduous molars exhibited accuracies of 84.9% (cusp level) and 80.5% (gingival level). The inter-first molars showed accuracies of 77.8% (cusp level) and 67.9% (gingival level). Significant differences were observed between the planned and obtained measurements for specific tooth regions. Conclusions CAT demonstrated reliable predictability in achieving dentoalveolar expansion of the maxillary arch in patients with mixed dentition. A higher accuracy was observed in the anterior region than in the posterior region. These findings suggest that CAT could be an effective option for treating transverse maxillary deficiencies in patients with mixed dentition with moderate inter-arch transverse discrepancies, considering tooth-specific predictability differences.

Objective: This prospective study evaluated the effectiveness of clear aligner treatment (CAT) in achieving dentoalveolar upper arch expansion in patients with mixed dentition and transverse maxillary deficiency. Methods: Forty patients with mixed dentition and a transverse discrepancy of ≤ 5 mm were treated using clear aligners. Pre- and post-treatment digital dental models were measured using specific landmarks and compared with the programmed expansion in the virtual treatment plan. Statistical analyses included the inter-class correlation coefficient to evaluate inter-rater reliability. A paired t test was employed to compare pre- and post-treatment values and to examine the significance of the changes. Multiple regression analysis was conducted to estimate the relationship between the prescribed and observed measurements, stratified by inter-dental measurements (deciduous canines, first deciduous molars, and permanent molars, at cusp and gingival levels). Results: Excellent measurement reproducibility was observed. The accuracy of dentoalveolar maxillary arch expansion varied among different tooth regions. The inter-canine accuracy was 87.7% at the cusp level and 82.7% at the gingival level. The inter-first deciduous molars exhibited accuracies of 84.9% (cusp level) and 80.5% (gingival level). The inter-first molars showed accuracies of 77.8% (cusp level) and 67.9% (gingival level). Significant differences were observed between the planned and obtained measurements for specific tooth regions. Conclusions CAT demonstrated reliable predictability in achieving dentoalveolar expansion of the maxillary arch in patients with mixed dentition. A higher accuracy was observed in the anterior region than in the posterior region. These findings suggest that CAT could be an effective option for treating transverse maxillary deficiencies in patients with mixed dentition with moderate inter-arch transverse discrepancies, considering tooth-specific predictability differences.

Objective: This prospective study evaluated the effectiveness of clear aligner treatment (CAT) in achieving dentoalveolar upper arch expansion in patients with mixed dentition and transverse maxillary deficiency. Methods: Forty patients with mixed dentition and a transverse discrepancy of ≤ 5 mm were treated using clear aligners. Pre- and post-treatment digital dental models were measured using specific landmarks and compared with the programmed expansion in the virtual treatment plan. Statistical analyses included the inter-class correlation coefficient to evaluate inter-rater reliability. A paired t test was employed to compare pre- and post-treatment values and to examine the significance of the changes. Multiple regression analysis was conducted to estimate the relationship between the prescribed and observed measurements, stratified by inter-dental measurements (deciduous canines, first deciduous molars, and permanent molars, at cusp and gingival levels). Results: Excellent measurement reproducibility was observed. The accuracy of dentoalveolar maxillary arch expansion varied among different tooth regions. The inter-canine accuracy was 87.7% at the cusp level and 82.7% at the gingival level. The inter-first deciduous molars exhibited accuracies of 84.9% (cusp level) and 80.5% (gingival level). The inter-first molars showed accuracies of 77.8% (cusp level) and 67.9% (gingival level). Significant differences were observed between the planned and obtained measurements for specific tooth regions. Conclusions CAT demonstrated reliable predictability in achieving dentoalveolar expansion of the maxillary arch in patients with mixed dentition. A higher accuracy was observed in the anterior region than in the posterior region. These findings suggest that CAT could be an effective option for treating transverse maxillary deficiencies in patients with mixed dentition with moderate inter-arch transverse discrepancies, considering tooth-specific predictability differences.

Objective: Early iatrogenic menopause in gynecological cancer survivors and BRCA mutation (BRCAm) carriers undergoing risk-reducing salpingo-oophorectomy (RRSO) is a major health concern. Hormone replacement therapy (HRT) is the most effective remedy, but remains underused in clinical practice. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group promoted a national survey to investigate the knowledge and attitudes of healthcare professionals regarding the prescription of HRT. Methods: The survey consisted of a self-administered, multiple-choice 45-item questionnaire, available online to all MITO members for 2 months starting from January 2022. Results: A total of 61 participants completed the questionnaire (47 out of 180 MITO centers;compliance: 26.1%). Most respondents were female (73.8%), younger than 50 years (65.6%), and gynecologic oncologists (55.7%), working in public general hospitals (49.2%). An 84.4% of specialists actively discuss HRT with patients and 51.0% of patients ask the specialist for an opinion on HRT. The rate of specialists globally in favor of prescribing HRT was 22.9% for ovarian cancer, 49.1% for cervical cancer, and 8.2% for endometrial cancer patients. Most respondents (70.5%) believe HRT is safe for BRCA-mutated patients after RRSO. Nearly 70% of physicians prescribe systemic HRT, while 23.8% prefer local HRT. Most specialists recommend HRT for as long as there is a benefit and generally for up to 5 years. Conclusion Real-world data suggest that many healthcare professionals still do not easily prescribe HRT for gynecological cancer survivors and BRCA mutation carriers after RRSO.Further efforts are required to implement the use of HRT in clinical practice and to support both clinicians in recommending HRT and patients in accepting it.

Objective: Early iatrogenic menopause in gynecological cancer survivors and BRCA mutation (BRCAm) carriers undergoing risk-reducing salpingo-oophorectomy (RRSO) is a major health concern. Hormone replacement therapy (HRT) is the most effective remedy, but remains underused in clinical practice. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group promoted a national survey to investigate the knowledge and attitudes of healthcare professionals regarding the prescription of HRT. Methods: The survey consisted of a self-administered, multiple-choice 45-item questionnaire, available online to all MITO members for 2 months starting from January 2022. Results: A total of 61 participants completed the questionnaire (47 out of 180 MITO centers;compliance: 26.1%). Most respondents were female (73.8%), younger than 50 years (65.6%), and gynecologic oncologists (55.7%), working in public general hospitals (49.2%). An 84.4% of specialists actively discuss HRT with patients and 51.0% of patients ask the specialist for an opinion on HRT. The rate of specialists globally in favor of prescribing HRT was 22.9% for ovarian cancer, 49.1% for cervical cancer, and 8.2% for endometrial cancer patients. Most respondents (70.5%) believe HRT is safe for BRCA-mutated patients after RRSO. Nearly 70% of physicians prescribe systemic HRT, while 23.8% prefer local HRT. Most specialists recommend HRT for as long as there is a benefit and generally for up to 5 years. Conclusion Real-world data suggest that many healthcare professionals still do not easily prescribe HRT for gynecological cancer survivors and BRCA mutation carriers after RRSO.Further efforts are required to implement the use of HRT in clinical practice and to support both clinicians in recommending HRT and patients in accepting it.

Objective: Early iatrogenic menopause in gynecological cancer survivors and BRCA mutation (BRCAm) carriers undergoing risk-reducing salpingo-oophorectomy (RRSO) is a major health concern. Hormone replacement therapy (HRT) is the most effective remedy, but remains underused in clinical practice. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group promoted a national survey to investigate the knowledge and attitudes of healthcare professionals regarding the prescription of HRT. Methods: The survey consisted of a self-administered, multiple-choice 45-item questionnaire, available online to all MITO members for 2 months starting from January 2022. Results: A total of 61 participants completed the questionnaire (47 out of 180 MITO centers;compliance: 26.1%). Most respondents were female (73.8%), younger than 50 years (65.6%), and gynecologic oncologists (55.7%), working in public general hospitals (49.2%). An 84.4% of specialists actively discuss HRT with patients and 51.0% of patients ask the specialist for an opinion on HRT. The rate of specialists globally in favor of prescribing HRT was 22.9% for ovarian cancer, 49.1% for cervical cancer, and 8.2% for endometrial cancer patients. Most respondents (70.5%) believe HRT is safe for BRCA-mutated patients after RRSO. Nearly 70% of physicians prescribe systemic HRT, while 23.8% prefer local HRT. Most specialists recommend HRT for as long as there is a benefit and generally for up to 5 years. Conclusion Real-world data suggest that many healthcare professionals still do not easily prescribe HRT for gynecological cancer survivors and BRCA mutation carriers after RRSO.Further efforts are required to implement the use of HRT in clinical practice and to support both clinicians in recommending HRT and patients in accepting it.

Spontaneous canalith jam is an uncommon form of benign paroxysmal positional vertigo mimicking acute vestibular neuritis. We described for the first time a spontaneous horizontal semicircular canalith jam associated with a typical canalolithiasis involving contralateral posterior semicircular canal (PSC), illustrating how the latter condition modified direction-fixed nystagmus during head movements. An 81-year-old woman with persistent vertigo referred to our center. Video-Frenzel examination showed horizontal direction-fixed right-beating nystagmus in primary gaze position, inhibited by visual fixation. She exhibited corrective saccades after leftward head impulses. Chin-to-chest positioning at the head-pitch test did not modify spontaneous nystagmus, whereas slight torsional components with the top pole of the eye beating toward the right ear appeared in backward head-bending, resulting in mixed horizontal-torsional nystagmus. At supine positioning tests, direction-fixed nystagmus turned into direction-changing geotropic horizontal nystagmus, which was stronger on the left side, while overlapping upbeat nystagmus with torsional right-beating components appeared on the right. Primary clinical findings were consistent with a left horizontal semicircular canalith jam, inducing a persistent utriculofugal cupular displacement, combined with a typical right-sided PSC-canalolithiasis. Once canalith jam crumbled, resulting in a non-ampullary arm canalolithiasis of the horizontal semicircular canal, both involved canals were freed by debris with appropriate repositioning procedures.

Purpose: To analyze the characteristics of pediatric inflammatory bowel disease (IBD) over the past three decades in Argentina and determine if there are differences between the first two decades and the past decade. Methods: We conducted a retrospective multicenter analytical study in children with IBD between 0 and 18 years of age diagnosed between 1987 and 2017 in three tertiary health centers in Argentina. The evaluation included clinical characterization, endoscopy, histology, and imaging data together with therapeutic strategies. The patients were divided into two groups: Group 1, diagnosed between 1987 and 2007, and Group 2, diagnosed between 2008 and 2017. Results: Of the 756 patients included, 409 (54%) had ulcerative colitis (UC), 250 (33%) had Crohn’s disease (CD), and 97 (13%) had IBD-unclassified (IBD-U). The positive family history was 3.8%, which was more frequent among children under two years of age (6.7%). There were no significant differences in clinical presentation and extraintestinal manifestations between periods, with hepatic manifestations being the most frequent. In the last decade, we found an upward trend in CD, a downward trend in UC/IBD-U, even after adjustment for socioeconomic status, and a decrease of 50% in surgical treatments coinciding with the advent of biological therapy. Conclusion This is the first multicenter cohort study in a Latin American country to describe clinical, endoscopic, and therapeutic data across the past 30-year period. Although CD was responsible for the overall increase in incidence, UC was still prevalent in this region.