1.Research progress in natural N-glycosides and synthetic methodologies for the formation of N-glycosidic bonds
Yingting XIA ; Qingxia XU ; Alastair N. HERRON ; Wenjun WANG ; Lidong SHAO ; Guodong LI ; An LIU ; Jintang CHENG
Science of Traditional Chinese Medicine 2024;2(2):82-94
N-glycosides comprise a broad range of compounds, some of which have demonstrated a variety of bioactivities, such as antiviral, antitumor, and antibacterial activities. Serving as essential building blocks for DNA and RNA, nucleosides are a particularly important subclass of N-glycosides. Accordingly, natural N-glycosides and their analogs have garnered great interests of both organic and pharmaceutical chemists, who have developed numerous synthetic methods for the preparation of N-glycosides. By reviewing the natural N-glycosides published between 1980 and 2023, this article summarizes current strategies for synthesizing N-glycosides, aiming to provide support for the development and research of N-glycosides.
Result Analysis
Print
Save
E-mail