Assisted reproductive technology (ART) is considered to be an important means to help infertile women get pregnant. With the development of technology, the safety of ART has been paid more and more attention. However, the neonatal pregnancy outcome of ART is worse than that of natural conception. The operation of ART may affect the development and health of offspring through epigenetic mechanisms. DNA methylation is the most studied epigenetic regulatory mechanism. This article briefly reviewed the research progress of DNA methylation in ART embryo and fetal development, aiming to provide a new idea for clinical treatment.

Assisted reproductive technology (ART) is considered to be an important means to help infertile women get pregnant. With the development of technology, the safety of ART has been paid more and more attention. However, the neonatal pregnancy outcome of ART is worse than that of natural conception. The operation of ART may affect the development and health of offspring through epigenetic mechanisms. DNA methylation is the most studied epigenetic regulatory mechanism. This article briefly reviewed the research progress of DNA methylation in ART embryo and fetal development, aiming to provide a new idea for clinical treatment.