Mitochondria act as the main energy supply station for cardiomyocytes and are thus crucial for maintaining normal cardiac function.Mitochondrial autophagy plays an important positive role in maintaining cardiomyocyte homeostasis and coping with stress.The progressive exacerbation of cardiovascular diseases presents a challenge to the homeostasis of mitochondrial autophagy through as-yet-unidentified pathological mechanisms,leading to mitochondrial damage,which may in turn trigger damage to cardiomyocytes.In addition,when mitochondrial autophagy fails to meet the physiological needs of the body,mitochondrial dysfunction may be triggered,which may in turn accelerate the progression of heart failure.In this review,we explore the specific roles of mitochondrial autophagy and mitochondrial dynamics in the heart,and discuss the mechanisms in the context of major cardiovascular diseases,focusing on the latest advances and important discoveries in this field.

Mitochondria act as the main energy supply station for cardiomyocytes and are thus crucial for maintaining normal cardiac function.Mitochondrial autophagy plays an important positive role in maintaining cardiomyocyte homeostasis and coping with stress.The progressive exacerbation of cardiovascular diseases presents a challenge to the homeostasis of mitochondrial autophagy through as-yet-unidentified pathological mechanisms,leading to mitochondrial damage,which may in turn trigger damage to cardiomyocytes.In addition,when mitochondrial autophagy fails to meet the physiological needs of the body,mitochondrial dysfunction may be triggered,which may in turn accelerate the progression of heart failure.In this review,we explore the specific roles of mitochondrial autophagy and mitochondrial dynamics in the heart,and discuss the mechanisms in the context of major cardiovascular diseases,focusing on the latest advances and important discoveries in this field.

Objective To investigate the significance of T-bet and GATA-3 in the pathogenesis of pityriasis rosea.Methods SYBR Green Ⅰ real-time fluorescence quantitative PCR was performed to detect the expressions of T-bet and GATA-3 mRNA in peripheral blood mononuclear cells (PBMCs) from 17 patients with pityriasis rosea and 20 normal human controls.Results The average delta Ct value of T-bet mRNA and GATA-3 mRNA was 3.33 ± 0.94 and 5.22 ± 0.69 respectively in the patients,4.31 ± 1.11 and 4.36 ± 1.02respectively in the controls.There was a higher expression of T-bet mRNA but a lower expression of GATA-3 mRNA in the patients compared with the controls (both P ＜ 0.05).Conclusions Patients with pityriasis rosea show an increased ratio of T-bet to GATA3 expression and predominant expression of Th1-type cytokines.Abnormal cellular immunity may play an important role in the pathogenesis of pityriasis rosea.