Objective:To explore the effect of Ephedrine on oxygen glucose deprivation/reoxygenation(OGD/R)induced neu-ronal injury by regulating receptor interacting protein-1/receptor interacting protein-3/mixed lineage kinase domain-like protein(RIP1/RIP3/MLKL)signaling pathway.Methods:OGD/R model was constructed by hypoxia/reoxygenation;human cortical neuron HCN cells were separated into control group,model group(OGD/R group),Ephedrine group(800 μg/ml),Compound 6i group(RIP1 acti-vator Compound 6i,0.94 μmol/L),Ephedrine+Compound 6i group(800 μg/ml Ephedrine+0.94 μmol/L Compound 6i),Nec-1 group(RIP1 specific inhibitor Nec-1,5 μmol/L)and Ephedrine+Nec-1 group(800 μg/ml Ephedrine+5 μmol/L Nec-1);CCK-8 method was applied to detect HCN cell proliferation;DCFH-DA method was applied to detect ROS level in HCN cells;flow cytometry was ap-plied to detect HCN cell apoptosis;ELISA was applied to detect levels of TNF-α and IL-6;Western blot was applied to detect RIP1/RIP3/MLKL signaling pathway and apoptotic proteins expressions in HCN cells.Results:Compared with control group,ROS level,apop-tosis rate,p-MLKL,RIP3,Bax,IL-6,TNF-α and RIP1 expressions of HCN cells in OGD/R group were significantly increased,A450 value and Bcl-2 protein were significantly decreased(P<0.05);compared with OGD/R group,ROS level,apoptosis rate,p-MLKL,RIP3,Bax,IL-6,TNF-α and RIP1 expressions of HCN cells in Ephedrine group and Nec-1 group were significantly reduced,A450 val-ue and Bcl-2 protein were significantly increased,the trend of Compound 6i group was opposite(P<0.05);Compound 6i was able to weaken the effect of Ephedrine in improving OGD/R induced neuronal injury,Nec-1 was able to enhance the effect of Ephedrine in im-proving OGD/R induced neuronal injury.Conclusion:Ephedrine attenuates OGD/R induced neuronal injury by inhibiting RIP1/RIP3/MLKL signaling pathway.

Depression is closely associated with a neuro-endocrine-immune(NEI)system imbalance.The"excessive vitality leading to restraint and counter-regulation(Kang Hai Cheng Zhi)"theory elucidates the self-regulating mechanism for maintaining dynamic equilibrium in the body,and serves as an importance principle guiding treatment formulation and medication selection.Based on the correlation between NEI system imbalance and the traditional Chinese medicine pathogenesis of depression,and integrating the"Kang Hai Cheng Zhi"theory,the author posits that the pathogenesis of depression lies in overactive liver invading spleen,earth dampness impeding wood′s ascendancy,and disharmony between body and mind,as well as imbalance in storage and discharge functions of liver and kidney,disharmony between Yin and Yang,and disrupted counter-regulation.This dosely aligns with two key pathological methanisms at the micro level:microglial-limbic system homeostatic imbalance and hypothalamic-pituitary-adrenal axis-inflammatory circuit dysregulation.Clinically,the treatment principle for depression adheres to supporting the counter-regulation to restrain excess,with herbal interventions using strategies such as restraining wood to support earth,dredging earth to unblock wood,and harmonizing pivotal functions,as well as nourishing water to nurture wood,warming kidney to tonify liver,and relieving depression to calm the spirit.These approaches aim to regulate the liver,spleen,and kidney,embodying the core therapeutic tenet of"striving for equilibrium,"thereby restoring the body′s self-regulating capability.

Depression is closely associated with a neuro-endocrine-immune(NEI)system imbalance.The"excessive vitality leading to restraint and counter-regulation(Kang Hai Cheng Zhi)"theory elucidates the self-regulating mechanism for maintaining dynamic equilibrium in the body,and serves as an importance principle guiding treatment formulation and medication selection.Based on the correlation between NEI system imbalance and the traditional Chinese medicine pathogenesis of depression,and integrating the"Kang Hai Cheng Zhi"theory,the author posits that the pathogenesis of depression lies in overactive liver invading spleen,earth dampness impeding wood′s ascendancy,and disharmony between body and mind,as well as imbalance in storage and discharge functions of liver and kidney,disharmony between Yin and Yang,and disrupted counter-regulation.This dosely aligns with two key pathological methanisms at the micro level:microglial-limbic system homeostatic imbalance and hypothalamic-pituitary-adrenal axis-inflammatory circuit dysregulation.Clinically,the treatment principle for depression adheres to supporting the counter-regulation to restrain excess,with herbal interventions using strategies such as restraining wood to support earth,dredging earth to unblock wood,and harmonizing pivotal functions,as well as nourishing water to nurture wood,warming kidney to tonify liver,and relieving depression to calm the spirit.These approaches aim to regulate the liver,spleen,and kidney,embodying the core therapeutic tenet of"striving for equilibrium,"thereby restoring the body′s self-regulating capability.

Objective:To compare the value of the fall risk self-assessment scale(FRSAS)and the modified falls efficacy scale(MFES)in the fall risk assessment of community-dwelling older adults.Method:A total of 1710 respondents aged 65 and above were recruited from four community health service centers in Beijing through convenient sampling.The general information questionnaire,FRSAS scale and MFES scale were used for data collection,and the fall incidence was obtained through telephone follow-up six months later.Result:Total 1686 subjects completed survey,1670 subjects received telephone follow-up,152 subjects report-ed falls.The total score of MFES was(127.77±24.39),with the full score accounting for 55.3％.Cronbach's α coefficient of MFES was 0.975.The total score of FRSAS was(9.62±5.01),Cronbach's α coefficient was 0.80.The correlation coefficient r of the two scales was-0.563,showing a moderate negative correlation.The AUC under the curve of MFES and FRSAS were 0.615 and 0.739,respectively.The diagnostic accuracy of FRSAS was better than MFES.When the cut off value of MFES was 134,Youdon index,sensitivity,specific-ity,positive predictive value,negative predictive value were 0.195,49.3％,70.2％,14.2％,93.3％,respectively.When the cut off value of FRSAS was 10,Youdon index,sensitivity,specificity,positive predictive value,negative predictive value were 0.399,80.9％,59.0％,16.5％,96.9％,respectively.The prediction accuracy of FR-SAS was better than that of MFES for individuals without falls.Conclusion:Compared with MFES,FRSAS has no ceiling effect and has more predictive value.It can be used as a fall risk screening tool for the elderly in the community.

Objective The aim was to explore a new method of tumor MDT management in a third-class comprehensive hospital by combining the experience of tumor MDT management in a certain hospital and the national medical quality and safety improvement goals of improving the rate of clinical TNM staging assessment before tumor treatment and improving the rate of pre-operative multidisciplinary discussion completion for grade Ⅳ surgery.Methods By retrospectively analyzing the quality control of MDT patients and the medical records of newly diagnosed malignant tumors from November 2021 to September 2024,the MDT rate and TN staging rate of newly diagnosed malignant tumors during this period were evaluated.Results By establishing expert and secretary teams,formulating work systems,and supervising their implementation within hospital,the MDT rate for newly di-agnosed malignant tumors reached 82.35％by September 2024,and the TNM staging rate reached 94.44％.Conclusion With the help of the system and team,the MDT rate and TNM staging rate of malignant tumor patients were continuously improved,the standardization and homogeneity of the diagnosis and treatment of malignant tumors were promoted,the level of tumor diagnosis and treatment services in a certain hospital was effectively improved and promoted,and the development of the diagnosis and treatment technology of malignant tumors in the field of multi-disciplinary intersection was promoted.

Objective:To compare the value of the fall risk self-assessment scale(FRSAS)and the modified falls efficacy scale(MFES)in the fall risk assessment of community-dwelling older adults.Method:A total of 1710 respondents aged 65 and above were recruited from four community health service centers in Beijing through convenient sampling.The general information questionnaire,FRSAS scale and MFES scale were used for data collection,and the fall incidence was obtained through telephone follow-up six months later.Result:Total 1686 subjects completed survey,1670 subjects received telephone follow-up,152 subjects report-ed falls.The total score of MFES was(127.77±24.39),with the full score accounting for 55.3％.Cronbach's α coefficient of MFES was 0.975.The total score of FRSAS was(9.62±5.01),Cronbach's α coefficient was 0.80.The correlation coefficient r of the two scales was-0.563,showing a moderate negative correlation.The AUC under the curve of MFES and FRSAS were 0.615 and 0.739,respectively.The diagnostic accuracy of FRSAS was better than MFES.When the cut off value of MFES was 134,Youdon index,sensitivity,specific-ity,positive predictive value,negative predictive value were 0.195,49.3％,70.2％,14.2％,93.3％,respectively.When the cut off value of FRSAS was 10,Youdon index,sensitivity,specificity,positive predictive value,negative predictive value were 0.399,80.9％,59.0％,16.5％,96.9％,respectively.The prediction accuracy of FR-SAS was better than that of MFES for individuals without falls.Conclusion:Compared with MFES,FRSAS has no ceiling effect and has more predictive value.It can be used as a fall risk screening tool for the elderly in the community.

Objective The aim was to explore a new method of tumor MDT management in a third-class comprehensive hospital by combining the experience of tumor MDT management in a certain hospital and the national medical quality and safety improvement goals of improving the rate of clinical TNM staging assessment before tumor treatment and improving the rate of pre-operative multidisciplinary discussion completion for grade Ⅳ surgery.Methods By retrospectively analyzing the quality control of MDT patients and the medical records of newly diagnosed malignant tumors from November 2021 to September 2024,the MDT rate and TN staging rate of newly diagnosed malignant tumors during this period were evaluated.Results By establishing expert and secretary teams,formulating work systems,and supervising their implementation within hospital,the MDT rate for newly di-agnosed malignant tumors reached 82.35％by September 2024,and the TNM staging rate reached 94.44％.Conclusion With the help of the system and team,the MDT rate and TNM staging rate of malignant tumor patients were continuously improved,the standardization and homogeneity of the diagnosis and treatment of malignant tumors were promoted,the level of tumor diagnosis and treatment services in a certain hospital was effectively improved and promoted,and the development of the diagnosis and treatment technology of malignant tumors in the field of multi-disciplinary intersection was promoted.

Objective:To systematically evaluate existing risk prediction models for anastomotic leakage after colorectal cancer surgery, and to provide theoretical support for clinical model selection and the future development of improved models.Methods:A comprehensive search was conducted across databases including China National Knowledge Infrastructure, Wanfang Data, VIP, CINAHL, PubMed, Embase, Web of Science, and the Cochrane Library from inception to December 31, 2024. Two researchers independently screened the literature and extracted relevant data. The prediction model risk of bias assessment tool was used to evaluate the risk of bias and applicability of included studies. A Meta-analysis of common predictive factors was performed using Stata 18.0.Results:A total of 28 studies were included. The identified predictive factors for anastomotic leakage after radical colorectal cancer surgery included preoperative diabetes, tumor size, preoperative chemoradiotherapy, tumor distance from the anal verge, body mass index, combined organ resection, Nutrition Risk Screening 2002 (NRS-2002) score, diverting stoma, preoperative bowel obstruction, and operative time.Conclusions:Future studies may reference the predictive factors summarized in this study and select appropriate methods in combination with clinical scenarios to develop and validate more effective risk prediction models for anastomotic leakage.

Objective:To explore the effect of Ephedrine on oxygen glucose deprivation/reoxygenation(OGD/R)induced neu-ronal injury by regulating receptor interacting protein-1/receptor interacting protein-3/mixed lineage kinase domain-like protein(RIP1/RIP3/MLKL)signaling pathway.Methods:OGD/R model was constructed by hypoxia/reoxygenation;human cortical neuron HCN cells were separated into control group,model group(OGD/R group),Ephedrine group(800 μg/ml),Compound 6i group(RIP1 acti-vator Compound 6i,0.94 μmol/L),Ephedrine+Compound 6i group(800 μg/ml Ephedrine+0.94 μmol/L Compound 6i),Nec-1 group(RIP1 specific inhibitor Nec-1,5 μmol/L)and Ephedrine+Nec-1 group(800 μg/ml Ephedrine+5 μmol/L Nec-1);CCK-8 method was applied to detect HCN cell proliferation;DCFH-DA method was applied to detect ROS level in HCN cells;flow cytometry was ap-plied to detect HCN cell apoptosis;ELISA was applied to detect levels of TNF-α and IL-6;Western blot was applied to detect RIP1/RIP3/MLKL signaling pathway and apoptotic proteins expressions in HCN cells.Results:Compared with control group,ROS level,apop-tosis rate,p-MLKL,RIP3,Bax,IL-6,TNF-α and RIP1 expressions of HCN cells in OGD/R group were significantly increased,A450 value and Bcl-2 protein were significantly decreased(P<0.05);compared with OGD/R group,ROS level,apoptosis rate,p-MLKL,RIP3,Bax,IL-6,TNF-α and RIP1 expressions of HCN cells in Ephedrine group and Nec-1 group were significantly reduced,A450 val-ue and Bcl-2 protein were significantly increased,the trend of Compound 6i group was opposite(P<0.05);Compound 6i was able to weaken the effect of Ephedrine in improving OGD/R induced neuronal injury,Nec-1 was able to enhance the effect of Ephedrine in im-proving OGD/R induced neuronal injury.Conclusion:Ephedrine attenuates OGD/R induced neuronal injury by inhibiting RIP1/RIP3/MLKL signaling pathway.

Objective:To systematically evaluate existing risk prediction models for anastomotic leakage after colorectal cancer surgery, and to provide theoretical support for clinical model selection and the future development of improved models.Methods:A comprehensive search was conducted across databases including China National Knowledge Infrastructure, Wanfang Data, VIP, CINAHL, PubMed, Embase, Web of Science, and the Cochrane Library from inception to December 31, 2024. Two researchers independently screened the literature and extracted relevant data. The prediction model risk of bias assessment tool was used to evaluate the risk of bias and applicability of included studies. A Meta-analysis of common predictive factors was performed using Stata 18.0.Results:A total of 28 studies were included. The identified predictive factors for anastomotic leakage after radical colorectal cancer surgery included preoperative diabetes, tumor size, preoperative chemoradiotherapy, tumor distance from the anal verge, body mass index, combined organ resection, Nutrition Risk Screening 2002 (NRS-2002) score, diverting stoma, preoperative bowel obstruction, and operative time.Conclusions:Future studies may reference the predictive factors summarized in this study and select appropriate methods in combination with clinical scenarios to develop and validate more effective risk prediction models for anastomotic leakage.