Polylactic acid-glycolic acid copolymer(PLGA)is a widely used and studied drug delivery system.The favorable characteristics of PLGA,such as good bioavailability,controlled release,and excellent safety due to the biodegradable polymer skeleton,have allowed PLGA to be approved by authorities as a human drug delivery platform.Immunoprophylaxis will be one of the most poten-tial and ideal prevention and control measures to control the epidemic of parasitic diseases.Howev-er,vaccines often have many limitations,such as relatively weak immunogenicity,easy degrada-tion,dose and mode of administration challenges,stability and storage issues.The use of PLGA as a vaccine carrier can improve the stability of the vaccine,reduce the storage and transportation prob-lems of the vaccine and reduce the number of doses,improve the therapeutic effect and reduce the side effects;These characteristics make PLGA an ideal platform for vaccine delivery.This paper re-views the latest progress,feasibility and challenges of PLGA in the field of parasite immunopro-phylaxis,in order to provide new ideas for the development and development of more effective pre-vention and treatment strategies for parasitic diseases.

Polylactic acid-glycolic acid copolymer(PLGA)is a widely used and studied drug delivery system.The favorable characteristics of PLGA,such as good bioavailability,controlled release,and excellent safety due to the biodegradable polymer skeleton,have allowed PLGA to be approved by authorities as a human drug delivery platform.Immunoprophylaxis will be one of the most poten-tial and ideal prevention and control measures to control the epidemic of parasitic diseases.Howev-er,vaccines often have many limitations,such as relatively weak immunogenicity,easy degrada-tion,dose and mode of administration challenges,stability and storage issues.The use of PLGA as a vaccine carrier can improve the stability of the vaccine,reduce the storage and transportation prob-lems of the vaccine and reduce the number of doses,improve the therapeutic effect and reduce the side effects;These characteristics make PLGA an ideal platform for vaccine delivery.This paper re-views the latest progress,feasibility and challenges of PLGA in the field of parasite immunopro-phylaxis,in order to provide new ideas for the development and development of more effective pre-vention and treatment strategies for parasitic diseases.

An animal biosafety level-3 laboratory(ABSL-3)is a high-level biosafety installation that can conduct experiments on animals infected with highly pathogenic microorganisms.In recent years,with the continuous characterization of emerging and re-emerging infectious diseases,high-level biosafety laboratories have played increasingly important roles in pathogenic mechanism and drug and vaccine research and development.The demand for ABSL-3 is increasing year by year.At the same time,there is also a growing demand for personnel who are competent in working in ABSL-3.The systematization,normalization,and standardization of pre-service training have become important to guarantee a reduction in the risks to personnel working in ABSL-3.Training of ABSL-3 staff needs to be carried out in specific simulated laboratories.Therefore,it is necessary to construct simulated ABSL-3 and establish scientific and effective operating standards and mechanisms.This paper comprehensively introduces the design,construction,operation,and functions of a simulated ABSL-3 installation.