Objective To explore the expression of peripheral blood Nod-like receptor protein 3(NLRP3)inflammasomes,serum caveolin-1(Cav-1),and sphingosine 1-phosphate receptor 1(S1P1)in children with Kawasaki disease(KD),and to elucidate their associations with coronary artery lesion(CAL).Methods A total of 223 children diagnosed with KD were recruited from our hospital between March 2023 and December 2024 and served as the KD study group.These children were classified into the CAL group(n=71)and the non-CAL group(n=152)based on their CAL status.Additionally,223 healthy children who underwent physical examinations at our hospital were selected as the healthy control group.Clinical data,levels of routine laboratory test indices,peripheral blood NLRP3 inflammasomes,serum Cav-1,and S1P1 were compared among the groups.Risk factors for CAL in children with KD were analyzed,and the diagnostic value of peripheral blood NLRP3 inflammasomes,serum Cav-1,and S1P1 levels for CAL in children with KD was evaluated.Results The levels of NLRP3,caspase-1,ASC in peripheral blood and messenger ribonucleic acid(mRNA)of serum Cav-1 were significantly higher in the KD study group than in the healthy control group(P<0.05).Conversely,the serum level of S1P1 was significantly lower in the KD study group compared to the healthy control group(P<0.05).In the CAL group,the levels of peripheral blood white blood cell count(WBC),NLRP3,caspase-1,ASC mRNA,serum C-reactive protein(CRP),and Cav-1 were all higher than those in the non-CAL group(P<0.05),while the serum level of S1P1 was lower than that in the non-CAL group(P<0.05).The levels of NLRP3,caspase-1,ASC mRNA in peripheral blood,along with serum Cav-1 and S1P1,were identified as independent risk factors for CAL in children with KD(P<0.05).The results of receiver operating characteristic(ROC)analysis indicated that the combined test of the levels of NLRP3,caspase-1,ASC mRNA in peripheral blood,serum Cav-1,and S1P1 for diagnosing CAL in children with KD had an area under the curve(AUC)value of 0.926.This value was significantly higher than that of each individual index(0.844,0.785,0.821,0.843,0.833,P<0.05).Conclusions The levels of NLRP3 inflamma-tory vesicles in peripheral blood and serum Cav-1 were highly expressed in children with KD,whereas the serum S1P1 was poorly expressed.These indices may be involved in the development process of CAL in children with KD.Moreover,the combination of these indices is more beneficial for the diagnosis of CAL in children with KD.

Objective To explore the expression of peripheral blood Nod-like receptor protein 3(NLRP3)inflammasomes,serum caveolin-1(Cav-1),and sphingosine 1-phosphate receptor 1(S1P1)in children with Kawasaki disease(KD),and to elucidate their associations with coronary artery lesion(CAL).Methods A total of 223 children diagnosed with KD were recruited from our hospital between March 2023 and December 2024 and served as the KD study group.These children were classified into the CAL group(n=71)and the non-CAL group(n=152)based on their CAL status.Additionally,223 healthy children who underwent physical examinations at our hospital were selected as the healthy control group.Clinical data,levels of routine laboratory test indices,peripheral blood NLRP3 inflammasomes,serum Cav-1,and S1P1 were compared among the groups.Risk factors for CAL in children with KD were analyzed,and the diagnostic value of peripheral blood NLRP3 inflammasomes,serum Cav-1,and S1P1 levels for CAL in children with KD was evaluated.Results The levels of NLRP3,caspase-1,ASC in peripheral blood and messenger ribonucleic acid(mRNA)of serum Cav-1 were significantly higher in the KD study group than in the healthy control group(P<0.05).Conversely,the serum level of S1P1 was significantly lower in the KD study group compared to the healthy control group(P<0.05).In the CAL group,the levels of peripheral blood white blood cell count(WBC),NLRP3,caspase-1,ASC mRNA,serum C-reactive protein(CRP),and Cav-1 were all higher than those in the non-CAL group(P<0.05),while the serum level of S1P1 was lower than that in the non-CAL group(P<0.05).The levels of NLRP3,caspase-1,ASC mRNA in peripheral blood,along with serum Cav-1 and S1P1,were identified as independent risk factors for CAL in children with KD(P<0.05).The results of receiver operating characteristic(ROC)analysis indicated that the combined test of the levels of NLRP3,caspase-1,ASC mRNA in peripheral blood,serum Cav-1,and S1P1 for diagnosing CAL in children with KD had an area under the curve(AUC)value of 0.926.This value was significantly higher than that of each individual index(0.844,0.785,0.821,0.843,0.833,P<0.05).Conclusions The levels of NLRP3 inflamma-tory vesicles in peripheral blood and serum Cav-1 were highly expressed in children with KD,whereas the serum S1P1 was poorly expressed.These indices may be involved in the development process of CAL in children with KD.Moreover,the combination of these indices is more beneficial for the diagnosis of CAL in children with KD.

Objective:To explore the application effect of staged health education combined with respiratory function exercise in patients undergoing esophageal cancer surgery.Methods:Using the convenient sampling method, a total of 200 patients with esophageal cancer who were admitted to Affiliated Cancer Hospital of Zhengzhou University from February 2019 to February 2020 were selected as the research objects. The patients were divided into the control group (81 cases) and the observation group (119 cases) according to their hospitalization time. The control group was given respiratory function exercise and routine nursing, while the observation group was given staged health education combined with respiratory function exercise on the basis of routine nursing. The cognition level and lung function of patients of the two groups before and 7 days after operation were compared.Results:The levels of vital capacity (VC) , maximum ventilation (MVV) and forced vital capacity in the first second (FEV1) in the observation group were higher than those in the control group at 7 days after operation, and the difference was statistically significant ( P<0.05) . The cognitive score of the observation group was higher than that of the control group at 7 days after operation, and the difference was statistically significant ( P<0.05) . Conclusions:Staged health education combined with respiratory function exercise can improve postoperative cognitive level and lung function of patients with esophageal cancer.

Objective To explore the effects of protection motivation theory (PMT) in functional training among breast cancer patients. Methods From January 2018 to December 2018, we selected 110 breast cancer patients with modified radical mastectomy in the Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital) by convenience sampling as subjects. A total of 55 inpatients between January 2018 and June 2018 were in control group, and 55 inpatients between July 2018 to December 2018 were in experimental group. Control group carried out routine functional training guidance for patients before discharge, while experimental group implemented intervention based on PMT. Intervention effects of two groups were compared with the Functional Exercise Compliance Scale for Postoperative Breast Cancer Patients, the Quick Disabilities of the Arm, Shoulder, and Hand (DASH) Questionnaire and the Self-rating Anxiety Scale (SAS). Results A total of 50 complete data were collected in control group and 52 in experimental group. After intervention, the scores of physical exercise compliance and compliance actively seeking advice of patients in experimental group were higher than those in control group with statistical differences (P<0.05); the score of upper limb disorder questionnaire of patients in experimental group was lower than that in control group with a statistical difference (P<0.05);the score of anxiety of patients in experimental group was lower than that in control group with a statistical difference (P< 0.05). Conclusions PMT-based intervention can improve the functional exercise compliance and upper limb function of breast cancer patients,and reduce their anxiety.

Objective:To investigate the relationship between urinary polycyclic aromatic hydrocarbons(PAHs) metabolites and pulmonary function in community population.Methods:A total of 4 812 participants were recruited from two communities in Wuhan city from April to May 2011 and two communities in Zhuhai city in May 2012. Information of demographic characteristics and life style was collected by semi-structural questionnaire. Physical examination was performed and pulmonary function was measured. Morning urine was also collected. The concentration of 12 urinary PAHs metabolites was tested and classified into four types by chemical structure, including hydroxynaphthalene, hydroxyfluorene, hydroxyphenanthrene and hydroxypyrene. The level of pulmonary function in different group of urinary PAHs metabolites was compared by using covariance analysis. The association of the urinary PAHs metabolites and pulmonary function was analyzed by using generalized linear model, and the interaction of different population characteristics and life style on the association was analyzed.Results:The age of participants was(51.99±13.64) years old, and 67.66% ( n=2 565) of the population were women. The M ( P25, P75) of concentration of total urinary PAHs metabolites was 5.72 (3.91,8.72) μg/mmol Cr. After controlling for variables including age, gender, city, Waist-to-Hip Ratio, smoking status, drinking situation, physical activity, cooking meals at home or not, kitchen ventilation and exposure to dust as confounding factors, generalized linear model showed that each 1-unit increase in log-transformed levels of hydroxynaphthalene, hydroxyfluorene, hydroxyphenanthrene, hydroxypyrene and total PAHs was associated with 26.83 (95% CI: -48.18, -5.48) , 21.86 (95% CI: -40.49, -3.23), 26.18(95% CI: -48.27, -4.09), 34.95 (95% CI: -55.95, -13.94), and 35.23 (95% CI: -58.93, -11.54) ml reduction of FVC and 29.36 (95% CI: -47.23, -11.48), 20.79 (95% CI: -36.39, -5.19), 22.65 (95% CI: -41.15, -4.15), 31.44(95% CI: -49.03, -13.85), and 33.20 (95% CI: -53.04, -13.36) ml reduction of FEV 1 respectively (all P values<0.05). Compared to non-alcohol users and participants with home cooking, the association was more evident in alcohol users and participants without home cooking( P for interaction<0.05). Conclusion:The exposure to PAHs was associated with decreased pulmonary function, and the association was more evident in alcohol users and participants without home cooking.

Objective:To investigate the relationship between urinary polycyclic aromatic hydrocarbons(PAHs) metabolites and pulmonary function in community population.Methods:A total of 4 812 participants were recruited from two communities in Wuhan city from April to May 2011 and two communities in Zhuhai city in May 2012. Information of demographic characteristics and life style was collected by semi-structural questionnaire. Physical examination was performed and pulmonary function was measured. Morning urine was also collected. The concentration of 12 urinary PAHs metabolites was tested and classified into four types by chemical structure, including hydroxynaphthalene, hydroxyfluorene, hydroxyphenanthrene and hydroxypyrene. The level of pulmonary function in different group of urinary PAHs metabolites was compared by using covariance analysis. The association of the urinary PAHs metabolites and pulmonary function was analyzed by using generalized linear model, and the interaction of different population characteristics and life style on the association was analyzed.Results:The age of participants was(51.99±13.64) years old, and 67.66% ( n=2 565) of the population were women. The M ( P25, P75) of concentration of total urinary PAHs metabolites was 5.72 (3.91,8.72) μg/mmol Cr. After controlling for variables including age, gender, city, Waist-to-Hip Ratio, smoking status, drinking situation, physical activity, cooking meals at home or not, kitchen ventilation and exposure to dust as confounding factors, generalized linear model showed that each 1-unit increase in log-transformed levels of hydroxynaphthalene, hydroxyfluorene, hydroxyphenanthrene, hydroxypyrene and total PAHs was associated with 26.83 (95% CI: -48.18, -5.48) , 21.86 (95% CI: -40.49, -3.23), 26.18(95% CI: -48.27, -4.09), 34.95 (95% CI: -55.95, -13.94), and 35.23 (95% CI: -58.93, -11.54) ml reduction of FVC and 29.36 (95% CI: -47.23, -11.48), 20.79 (95% CI: -36.39, -5.19), 22.65 (95% CI: -41.15, -4.15), 31.44(95% CI: -49.03, -13.85), and 33.20 (95% CI: -53.04, -13.36) ml reduction of FEV 1 respectively (all P values<0.05). Compared to non-alcohol users and participants with home cooking, the association was more evident in alcohol users and participants without home cooking( P for interaction<0.05). Conclusion:The exposure to PAHs was associated with decreased pulmonary function, and the association was more evident in alcohol users and participants without home cooking.

Objective? To explore the effects of mindfulness-based stress reduction on post-traumatic growth and quality of life among postoperative breast cancer patients. Methods? From June 2017 to December 2017, we selected 112 postoperative breast cancer patients of breast department at a classⅢ grade A cancer hospital in He'nan Province as subjects by convenience sampling. All of the patients were divided into control group and observation group with the method of random number table, 56 cases in each group. Control group adopted routine nursing intervention. On the basis of routine nursing, observation group carried out mindfulness-based stress reduction for 8 weeks. The intervention effects were evaluated with the Posttraumatic Growth Inventory (PTGI) and the Functional Assessment of Cancer Therapy-Breast (FACT-B). Results? Before intervention, there were no statistical differences in the total score and dimension scores of PTGI of patients between two groups (P＞ 0.05). After intervention, the total score and dimension scores of PTGI of patients in observation group were higher than those in control group with statistical differences (P＜0.01). Before intervention, there were also no statistical differences in the total score and dimension scores of life quality of patients between two groups (P＞0.05). After intervention, the total score and dimension scores of life quality of patients in observation group were higher than those in control group with statistical differences (P＜0.01). Conclusions? Mindfulness-based stress reduction can improve post-traumatic growth and quality of life among postoperative breast cancer patients.

Objective To explore the efficacy of fluconazole mouthwash by means of oxygen-driven atomizing inhalation for treating the pediatric oral fungal infections. Methods A total of 60 cases of child patient from the department of Pediatrics of Jiaozhou People's Hospital have been selected and divided into control group and test group with 30 cases for each group by the method of random number table. The sodium bicarbonate solutions as well as the fluconazole capsules were used for the two groups of children patients. Everyday there were five doses of sodium bicarbonate solution as follows:one after getting up in the morning, one after breakfast/lunch/dinner, and one before bedtime by gargling for three minutes followed by spitting. Daily dose of fluconazole capsules was 3 mg/kg, with 50 ml of NS added for preparing a solution of 1-3 mg/ml. Differences between the two groups are as follows. The control group used the traditional method of gargling. The prepared fluconazole solution was divided into five doses for gargling followed by swallowing which were carried out two hours after the sodium bicarbonate solution. The test group used the oxygen-driven atomizing inhalation therapy. The intervals with the sodium bicarbonate solution were two hours. Before the oxygen-driven atomizing inhalation therapy, the children patients had gargled with water to remove the food debris inside the mouth. Next, the daily dose was divided into five doses to be added into the nebulizers for carrying out the oxygen-driven atomizing inhalation therapy focusing on the exposed ulcer areas. The difference in healing time of oral fungal infection of different position and degree between both groups of child patient has been observed. Results The healing time of oral mucositis at different position of both groups has been compared with each other, with the exception of gingival position, the healing time of child patients in test group at the position of cheek, palate, tongue, pharynx, lips and so on was respectively (6.67±1.68) d, (6.38±1.80) d, (6.36±1.96) d, (6.50±1.60) d and (5.00±0.82) d, which were all better than that of the control group, which was (8.13 ± 2.13) d,(8.00 ± 2.14) d,(8.23 ± 2.13) d, (8.67 ± 1.75) d and (7.20 ± 1.48) d, the difference between both groups was statistically significant(t=2.14-2.64, P<0.05);the healing time of child patients in test group with a degree ranging from I to IV was respectively (5.10±0.88) d, (7.92±1.32) d,(8.00±1.00 )d and (10.25±0.96)d,which were all better than that of the control group, which was(6.36±0.81)d,(9.00±1.29) d,(10.33 ± 0.58)d and(12.33 ± 0.58)d,the difference between both groups was statistically significant(t=2.10-3.50,P<0.05). Conclusions It's suitable for oral care of children patients if we replace the fluconazole mouthwash with the oxygen-driven atomizing inhalation therapy which can reduce the severity of oral mucositis and shorten the healing time.

Objective To explore effects of group education based on transactional analysis in patients with esophageal squamous cell carcinoma underwent radiotherapy to find an effective education method and provide a theoretical basis for the clinical application. Methods A number of 69 cases of esophageal squamous cell carcinoma patients underwent radiotherapy from August 2014 to July 2015 were recruited in the control group. The other 77 cases of esophageal squamous cell carcinoma patients underwent radiotherapy from August 2015 to July 2016 were included into the observation group. The control group was managed by routine group education, while the observation group was managed by group education based on transactional analysis model. GQOLI-74 quality of life scale, the amount of self efficacy scale (SUPPH) and the Hamilton Depression Scale (HRSD), and Hamilton Anxiety Scale (HAMA) were used to investigate the survival quality, self-efficacy and negative emotional status of patients. The patient's compliance was investigated by asking the health care providers. Meanwhile, the complications of patients were collected. Results After the intervention, scores of quality of life including physical function, psychological function and material function of patients in the observation group were significantly higher than those in the control group (P<0.05). In the observation group, scores of self-efficacy prognosis were higher than those in the control group; the level of depression and anxiety was lower than that in the control group; treatment compliance rate was higher than that in the control group; the incidence of complication was lower than that in the control group; the differences were statistically significant (P<0.05). Conclusions Group education based on transactional analysis model can improve the quality of life and self-efficacy of patients, and reduce their negative emotions and complication rates.

Objective To analyze the constitution of in-patient death causes in Sharxi Cancer Hospital from 2005 to 2010. Method Statistical analysis of 1277 hospitalized cases from 2005 to 2010 in Shanxi Cancer Hospital was retrospectively conducted. Results The overall case fatality rate of hospitalized patients from 2005 to 2010 was 0.86 ％ (1277/146820),the rates were 1.16 ％,1.05 ％,0.99 ％,0.85 ％,0.84 ％, 0.64 ％, respectively, with a declining trend, and the differences among them was statistically significance (x2 =45.763,P ＜0.001).Total mortality rate of male hospitalized patients (1.26％) was higher than that of women (0.53％),and the difference was statistically significant (x2=215.367,P＜ 0.001).Analysis of cancer death cause revealed that lung cancer possessed the leading cause of cancer death with the ratio of 36.4％(456/1253). The analysis of top 10 death causes showed that the majority of the population in cancer death causes were men,cadres of staff and workers,secondary school education level people,and people over the age of 60. Conclusion The consitution of in-patient deaths in Shanxi Cancer Hospital is defined, which could provide a scientific basis for disease prevention and control.