Objective: To learn the levels of thyroid hormone indicators among interventional and diagnostic radiologists, so as to provide insights into occupational health monitoring of radiologists. Methods: Demographic information, body mass index (BMI), thyroid hormone indicators and cumulative individual doses over 5 years among interventional and diagnostic radiologists were collected through the personal dosimetry monitoring database of Ningbo Center for Disease Control and Prevention and the Occupational Health Examination Center of a tertiary hospital in Ningbo City. The thyroid hormone indicators of different job types and cumulative individual doses over 5 years were analyzed, and factors affecting the thyroid hormone indicators were identified using a multivariable ordinal logistic regression model. Results: There were 159 interventional and 159 diagnostic radiologists included, and the proportions of abnormal thyroid hormone indicators were 9.43% and 12.26%, respectively, with no statistically significant difference (P>0.05). The levels of triiodothyronine and free triiodothyronine in interventional radiologists were lower than those in diagnostic radiologists [(1.54±0.41) vs. (1.68±0.34) nmol/L, (5.13±1.07) vs. (5.55±0.87) pmol/L; both P<0.05]. The levels of triiodothyronine and free triiodothyronine were significantly different among radiologists with cumulative individual doses over 5 years of <1.5 mSv, 1.5-<3.0 mSv and ≥3.0 mSv [(1.69±0.31), (1.69±0.40) vs. (1.52±0.41) nmol/L, (5.60±0.83), (5.32±0.94) vs. (5.14±1.09) pmol/L; both P<0.05]. Multivariable ordinal logistic regression analysis identified BMI (<18.5 kg/m2, OR=0.111, 95%CI: 0.028-0.436) and cumulative individual doses over 5 years (<1.5 mSv, OR=6.259, 95%CI: 2.368-16.547) as the factors affecting triiodothyronine, and job types (diagnostic radiologists, OR=3.171, 95%CI: 1.529-6.574), BMI (18.5-<24.0 kg/m2, OR=0.393, 95%CI: 0.184-0.842), and gender (men, OR=3.449, 95%CI: 1.294-9.190) as the factors affecting free triiodothyronine. Conclusion Occupational exposure has a certain impact on the thyroid hormone indicators among interventional and diagnostic radiologists, and the main influencing factors include BMI, radiation dose, job type and gender.

Objective:To investigate the values of two-dimensional and three-dimensional echocardiographic parameters in predicting pulmonary vascular resistance (PVR) in chronic pulmonary thromboembolic pulmonary hypertension (CTEPH).Methods:A total of 141 patients diagnosed with CTEPH in China-Japan Friendship Hospital from November 2015 to December 2022 were included. Two-dimensional echocardiographic indicators reflecting PVR were constructed according to the calculation formula of PVR: echocardiographic estimated systolic pulmonary artery pressure (sPAP Echo)/left ventricular end-diastolic diameter (LVIDd), echocardiographic estimated mean pulmonary artery pressure (mPAP Echo)/LVIDd. sPAP Echo/left ventricular end-diastolic volume (LVEDV), sPAP Echo/left ventricular cardiac output (LVCO) were measured by three-dimensional echocardiography. The correlations between two-dimensional and three-dimensional echocardiographic ratios and invasive PVR were then analyzed using the Spearman correlation method. Using receiver operating characteristic curve analysis, cut-off values for the ratios were generated to identify patients with PVR>1 000 dyn·s -1·cm -5. Pre- and postoperative hemodynamics and echocardiographic data were analyzed, as well as the correlation between the reduction rate of the echocardiographic index and PVR in 54 patients who underwent pulmonary endarterectomy (PEA). Results:sPAP Echo/LVIDd, sPAP Echo/LVEDV and sPAP Echo/LVCO were moderately correlated with PVR( rs=0.62, 0.52, 0.63, both P<0.001). The ratio of sPAP Echo to LVEDV, when greater than or equal to 1.41, had a sensitivity of 0.800 and a specificity of 0.930 for determining PVR >1 000 dyn·s -1·cm -5 (AUC=0.860, P<0.001). Similarly, the ratio of sPAP Echo to LVIDd, when greater than or equal to 2.14, had a sensitivity of 0.647 and a specificity of 0.861 for determining PVR >1000 dyn·s -1·cm -5 (AUC=0.830, P<0.001). The sPAP Echo/LVIDd and mPAP Echo/LVIDd significantly decreased after PEA (both P<0.001). The sPAP Echo/LVIDd and mPAP Echo/LVIDd reduction rate (ΔsPAP Echo/LVIDd and ΔmPAP Echo/LVIDd) were significantly correlated with PVR reduction rate (ΔPVR), respectively ( rs=0.61, 0.63, both P<0.05). Conclusions:Two-dimensional ratio sPAP Echo/LVIDd and three-dimensional ratio sPAP Echo/LVEDV can be used to noninvasively estimate PVR in CTEPH patients. The conventional ratio sPAP Echo/LVIDd is convenient and reproducibly suitable for monitoring the improvement of PVR before and after treatment, and its ratio of 2.14 can predict the significant increase of PVR in CTEPH patients (>1 000 dyn·s -1·cm -5).

Humans ; Soft Tissue Neoplasms ; Mesenchymoma/diagnostic imaging* ; Paraneoplastic Syndromes/pathology*

Objective:To investigate the regional homogeneity (ReHo) among the major depressive disorder patients without mixed features (MDD noMF), major depressive disorder with mixed features (MMF), bipolar disorder with mixed features (BMF) and bipolar disorder patients without mixed features (BD noMF) patients, and to explore the brain activity and functional connectivity patterns of the MMF and BMF patients. Methods:This was a cross-sectional study. The MDD noMF patients (MDD noMF group), MMF patients (MMF group), BMF patients (BMF group), BD noMF patients (BD noMF group), and age-and gender-matched healthy controls (HC group) were recruited from Beijing Anding Hospital, Capital Medical University between April, 2021 and June, 2022. All the participants underwent resting-state functional MRI scanning. The ReHo values was computed with the DPABI software based on the MATLAB. Firstly, the difference in ReHo among the patients with MDD noMF, MMF, BMF, BD noMF and HC group were estimated by the analysis of covariance and the post-hoc method (LSD or Games-Howell). And then, the brain regions with significant different ReHo values were selected as the seeds to calculate the functional connectivity with the whole brain. Results:A total of 29 cases in the MDD noMF group, 24 cases in the MMF group, 26 cases in the BMF group, 29 cases in the BD noMF group, and 42 in the HC group were included. The differences in ReHo values in the left fusiform and the left precuneus of the 5 groups were statistically significant ( P<0.05). Among of them, the ReHo values of the left fusiform were lower in the MMF, BMF and BD noMF groups compared with the HC group ( P<0.05), while the ReHo values of the left precuneus in MDD noMF, MMF, BMF and BD noMF groups were higher than that in the HC group ( P<0.05). The ReHo value of the left fusiform was lower in the MMF group compared with the MDD noMF group ( P=0.001); the ReHo value of the left fusiform was lower in the BMF group compared with the MDD noMF and BD noMF groups ( P<0.05). The functional connectivity between the left fusiform and vermis, left insula, right putamen, and left medial superior frontal gyrus, and functional connectivity between the left precuneus and right superior frontal gyrus (dorsolateral) showed significant difference among the MDD noMF, MMF, BMF, BD noMF and HC groups ( P<0.05). Compared with HC group, MDD noMF, MMF, BD noMF groups showed higher functional connectivity between the left fusiform and the vermis, and MDD noMF, MMF, BMF, BD noMF group showed higher functional connectivityy between the the left fusiform and the left insula, left medial superior frontal gyrus and right putamen ( P<0.05). Compared with the MDD noMF group, the MMF, BMF and BD noMF groups showed higher functional connectivity between the left fusiform and the left insula ( P<0.05). Compared with the MDD noMF group, the BMF and BD noMF groups had higher functional connectivity between the left fusiform and the left medial superior frontal gyrus ( P<0.05). The BMF group showed higher functional connectivity of the left fusiform with the right putamen than the MDD noMF and BD noMF groups. Additonally, the BMF and BD noMF groups showed higher functional connectivity between the left precuneus and the right superior frontal gyrus (dorsolateral) than HC, MDD noMF and MMF groups ( P<0.05). Conclusions:MMF and BMF patients have local abnormalities of functional activity synchronization in the left fusiform and precuneus and abnormal functional connectivity patterns with multiple brain regions. MMF and BMF patients have specific neuroimaging features compared to MDD noMF or BD noMF patients and also share similar neuroimaging pathogenesis.

Objective:To explore the effect of rhythm activation exercise on loneliness and physical activity ability of empty nest elderly.Methods:Using the convenient sampling method, a total of 90 empty nest elderly who were admitted to the elderly unaccompanied ward of the First People's Hospital of Hefei from January to June 2019 were selected as the research objects. They were randomly divided into the control group, the observation group 1 and the observation group 2, with 30 cases in every group. The patients in the control group took conventional nursing methods, the observation group 1 performed rehabilitation exercises, while the observation group 2 performed rhythm activation exercises under the guidance of nurses. After the intervention for 12 weeks, the differences in Barthel Index Scale, the short form of UCLA Lone lines scale (ULS-8) and the range of motion of each joint of limb movement were compared among the three groups.Results:After the intervention, the total score of Barthel index of the observation group 2 was (68.66±6.00) , which was higher than (58.00±8.16) of the control group and (60.00±6.64) of the observation group 1, and the differences were statistically significant ( P<0.05) . The total score of loneliness of the observation group 2 was (20.06±1.93) , which was lower than (27.11±1.77) of the control group and (26.32±1.74) of the observation group 1, and the differences were statistically significant ( P<0.05) . The scores of all dimensions of limb motor activity in observation group 2 were higher than those in the control group and the observation group 1, and the differences were statistically significant ( P<0.01) . Conclusions:Rhythm activation exercise can well improve the loneliness of empty-nest elderly, improve their self-care ability and improve physical mobility of the elderly to a certain extent.

Objective:To construct a systematic standardization system of combined medical care and elderly nursing service in general hospital-nursing home-community-family, so as to provide reference for the development of different forms of combined medical care and elderly nursing services.Methods:Delphi expert consultation method was used in the study. The expert consultation form of the standardized system of combined medical care and elderly nursing service in general hospital-nursing home-community-family was designed by discussing through the research group meeting on the basis of literature review from January to June 2020. A total of 15 experts who are engaged in geriatric nursing and management, geriatric nursing education, and geriatrics were selected to conduct two rounds of expert consultation.Results:The effective recovery rate of the questionnaires in the two rounds of expert consultation was 100.00%, and the expert authority coefficients were 0.875 and 0.848, and the expert opinions tended to be consistent. The standardized system of combined medical care and elderly nursing service was divided into 4 first-level indicators, 19 second-level indicators, 95 third-level indicators for general hospitals, 4 first-level indicators, 25 second-level indicators, and 96 third-level indicators for nursing homes, 4 first-level indicators, 16 second-level indicators and 88 third-level indicators for communities, 4 first-level indicators, 16 second-level indicators and 88 third-level indicators for families.Conclusions:The research method of the standardized system of combined medical care and elderly nursing service in general hospital-nursing home-community-family constructed in this study is scientific, reasonable and feasible, and the content is targeted, which can provide a reference for the development of different forms of combined medical care and elderly nursing services in the future.

Objective:To investigate the normal range of exhaled nitric oxide (FeNO) in 6-18-year-old children in China, so as to provide a data base for the establishment of FeNO standards for Chinese children.Methods:A multi-center study was conducted on 5 949 children aged 6-18 (3 101 males and 2 848 females) in 16 pro-vinces of 7 administrative districts in China.According to the technical standard recommended by American Thoracic Society/European Respiratory Association, FeNO was measured, and the relationship of FeNO with the sex, age, height, weight, body mass index and region was discussed.Results:The geometric mean FeNO value of Chinese children aged 6-18 was 14.1 ppb, and its 95% confidence interval (skewness distribution) was 1.0-38.2 ppb.The geometric mean FeNO values of children aged 6-11 and 12-18 were 13.1 ppb and 15.7 ppb, respectively, and their 95% confidence intervals (skewness distribution) were 1.0-38.1 ppb and 2.0-38.2 ppb.For children at and under 11 years old, FeNO decreased with age, with a mean decline of 1 ppb per year.The multiple linear regression results suggested that there was a significant correlation between FeNO and age for children aged 6-11, and FeNO of children aged 12-18 was significantly correlated with the gender, height, and region(all P<0.01). Conclusions:FeNO values of Chinese children and adolescents in this study are higher than those obtained by the previous study conducted from 2010 to 2012.For children aged 12-18, 16 ppb is recommended as the clinical cut-off point.For children at or under 11 years old, the influence of age on FeNO should be considered, and the cut-off point of FeNO decreases by 1 ppb as the age is reduced by one year.

Objective To explore the change patterns in the lumbar vertebral bone marrow fat content with age, analyze the interactions between lumbar vertebral bone marrow fat content, bone mineral density (BMD), and age, and compare the difference of lumbar vertebral bone marrow fat content between males and females in the same age groups. Methods According to the statistical sample size requirements that the minimum sample size of each group was 18, thus, we prospectively recruited healthy volunteers who met the inclusion criteria. Among them, there were 139 males and females, with age range of 21-70 years old. According to age, the patients were divided into group 1 (21-30-yr), group 2 (31-40-yr), group 3 (41-50-yr), group 4 (51-60-yr), and group 5 (61-70-yr). Quantitative computed tomography (QCT) was used to measure the lumbar vertebral BMD, and MR mDIXON-Quant technique was used to measure the marrow fat content of L3 lumbar vertebra. We compared the difference of lumbar vertebral bone marrow fat content and BMD between different age groups in males and females using one-way ANOVA, and compared the difference of lumbar vertebral bone marrow fat content and BMD between males and females in the same age groups using t-test. Correlation analysis was conducted between bone marrow fat content, BMD and age. Results Lumbar vertebral bone marrow fat content was generally increasing with the age. There were significant differences in the fat content of bone marrow at different age groups (male, F=13.598, P=0.000;female, F=73.419, P=0.000). Before the age of 50 years, lumbar vertebral bone marrow fat content in females was lower than one in males, and there was a significant difference between group 2 [females,(29.7± 7.1)%-(36.1 ± 6.6)%, males,(34.1 ± 8.4)%-(39.9 ± 5.9)%;21-30-yr, t=1.984, P=0.053;31-40-yr, t=5.699, P=0.000;41-50-yr, t=2.017, P=0.050]. Females older than 50 years had a higher marrow fat content than males, and there was a significant difference between group 5 [females,(48.3±8.8)%-(52.5±8.2)%, males, (45.5 ± 8.1)%-(46.2 ± 7.4)%;51-60-yr, t=-0.914, P=0.365;61-70-yr, t=-3.400, P=0.001]. For males, bone marrow fat content was positively correlated with age (r=0.527, P<0.05), and negatively correlated with BMD (r=-0.730, adjusted for age r=-0.584, P<0.05). For females, bone marrow fat content was positively correlated with age (r=0.761, P<0.05), and negatively correlated with BMD (r=-0.809, adjusted for age r=-0.473, P<0.05). Conclusions Lumbar vertebral bone marrow fat content was generally increasing with the age. Bone marrow fat content was positively correlated with age and negatively correlated with BMD for males and females.

Objective To explore the change patterns in the lumbar vertebral bone marrow fat content with age, analyze the interactions between lumbar vertebral bone marrow fat content, bone mineral density (BMD), and age, and compare the difference of lumbar vertebral bone marrow fat content between males and females in the same age groups. Methods According to the statistical sample size requirements that the minimum sample size of each group was 18, thus, we prospectively recruited healthy volunteers who met the inclusion criteria. Among them, there were 139 males and females, with age range of 21-70 years old. According to age, the patients were divided into group 1 (21-30-yr), group 2 (31-40-yr), group 3 (41-50-yr), group 4 (51-60-yr), and group 5 (61-70-yr). Quantitative computed tomography (QCT) was used to measure the lumbar vertebral BMD, and MR mDIXON-Quant technique was used to measure the marrow fat content of L3 lumbar vertebra. We compared the difference of lumbar vertebral bone marrow fat content and BMD between different age groups in males and females using one-way ANOVA, and compared the difference of lumbar vertebral bone marrow fat content and BMD between males and females in the same age groups using t-test. Correlation analysis was conducted between bone marrow fat content, BMD and age. Results Lumbar vertebral bone marrow fat content was generally increasing with the age. There were significant differences in the fat content of bone marrow at different age groups (male, F=13.598, P=0.000;female, F=73.419, P=0.000). Before the age of 50 years, lumbar vertebral bone marrow fat content in females was lower than one in males, and there was a significant difference between group 2 [females,(29.7± 7.1)%-(36.1 ± 6.6)%, males,(34.1 ± 8.4)%-(39.9 ± 5.9)%;21-30-yr, t=1.984, P=0.053;31-40-yr, t=5.699, P=0.000;41-50-yr, t=2.017, P=0.050]. Females older than 50 years had a higher marrow fat content than males, and there was a significant difference between group 5 [females,(48.3±8.8)%-(52.5±8.2)%, males, (45.5 ± 8.1)%-(46.2 ± 7.4)%;51-60-yr, t=-0.914, P=0.365;61-70-yr, t=-3.400, P=0.001]. For males, bone marrow fat content was positively correlated with age (r=0.527, P<0.05), and negatively correlated with BMD (r=-0.730, adjusted for age r=-0.584, P<0.05). For females, bone marrow fat content was positively correlated with age (r=0.761, P<0.05), and negatively correlated with BMD (r=-0.809, adjusted for age r=-0.473, P<0.05). Conclusions Lumbar vertebral bone marrow fat content was generally increasing with the age. Bone marrow fat content was positively correlated with age and negatively correlated with BMD for males and females.

Objective To analyze the CT and magnetic resonance imaging (MRI) manifestations of the pelvic osteosarcoma. Methods The CT and MRI manifestations of 15 cases with pelvic osteosarcoma from January, 2013 to December, 2015 proved by histology were ret-rospectively analyzed. Results There were 10 males and 5 females in them. The median age was 27.0 years. Ilium was involved in 11 cases. A mixed lytic/sclerotic pattern of bone destruction was found in 11 cases, and the sclerotic type in 2 cases, the osteolytic type in 2 cases. Ra-dial periosteal reaction was found in 5 cases and immature bone formation in 8 cases. Soft tissue masses were seen in 13 cases. MRI showed enhancement in 15 cases and the CT showed no enhancement in 2 cases with sclerotic type. Conclusion The typical imaging manifestations of pelvic osteosarcomainclude mixed lytic/sclerotic appearance, radial periosteal reaction, soft tissue masses and immature bone formation.