Objective To investigate the epidemiological characteristics and risk factors of non-alcoholic fatty liver disease in Jincheng between 2015 and 2020. Methods Clinical data of 8,578 medical check-ups at Physical Examination Center of ou hospital from January 2015 to December 2020 were retrospectively selected. The prevalence of non-alcoholic fatty liver disease in the last 5 years was recorded, and Logistic regression was utilized to identify the risk factors for the development of non-alcoholic fatty liver disease. Results The overall prevalence of non-alcoholic fatty liver disease in Jincheng was 14.57% in 2015-2020. The prevalence of non-alcoholic fatty liver disease was higher in men than in women (16.99% vs 10.98%) and highest in the 40-59 age group (18.76%). No statistical difference was reported in blood urea nitrogen (BUN) and serum creatinine (Scr) between groups (P>0.05), while statistical difference was found in diabetes, hypertension, body mass index (BMI), waist circumference, weekly exercise frequency, daily vegetable intake, triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT) and uric acid (UA) between two groups (P<0.05). Multivariate Logistic regression analysis denoted that BMI (OR=2.794, 95% CI: 1.745-4.550), waist circumference (OR=2.586, 95% CI: 1.585-4.299), diabetes (OR=0.644, 95% CI: 1.425-2.781), hypertension (OR=1.479, 95% CI: 1.121-2.290), weekly exercise ≥6h (OR=0.617, 95% CI: 0.519-0.709), daily vegetable intake ≥300g (OR=0.590, 95% CI: 0.467-0.652), TG (OR=1.481, 95% CI: 1.122-1.996), TC (OR=1.562, 95% CI:1.143-2.135), LDL-C (OR=1.440, 95% CI: 1.139-2.048), HDL-C (OR=0.656 , 95% CI: 0.587-0.783) , ALT (OR=1.591, 95% CI: 1.056-2.183), and UA (OR=1.412, 95% CI: 1.009-1.887) were risk factors for non-alcoholic fatty liver disease (P<0.05) . Conclusion The prevalence of non-alcoholic fatty liver disease in Jincheng City from 2015 to 2020 is 14.57%, the prevalence of males is higher than that of females, and the prevalence rate is the highest in the 40-59 age group. Moreover , diabetes mellitus , hypertension , BMI , waist circumference , weekly exercise , daily vegetable intake , serum TG, TC, LDL-C, HDL-C, ALT, and UA are all associated with the risk of the disease.

Objective:To analyze the short-term clinical efficacy and safety of arsenic trioxide (ATO) combined with a modified N7 induction regimen in the treatment of children with high-risk neuroblastoma (NB).Methods:This study was a prospective, single-arm, multicenter phase Ⅱ clinical study. Sixty-seven high-risk NB children from eight units of Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Wuhan Children′s Hospital of Tongji Medical College of Huazhong University of Science and Technology, First Affiliated Hospital of Guangxi Medical University, Hainan General Hospital, Affiliated Hospital of Guangdong Medical University, Kunming Children′s Hospital, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, and Guangdong Provincial Agricultural Reclamation Center Hospital were enrolled from January 2019 to August 2023 and were treated with ATO combined with a modified N7 induction regimen. The efficacy and adverse effects at the end of induction chemotherapy were assessed and analyzed, and the differences in the clinical characteristics were further compared between the treatment-responsive and treatment-unresponsive groups by using the Fisher′s exact test.Results:Among 67 high-risk NB children, there were 40 males (60%) and 27 females (40%), with the age of disease onset of 3.5 (2.6, 4.8) years. Primary NB sites were mostly in retroperitoneum (including adrenal gland) (56/67, 84%) and the common metastases sites at initial diagnosis were distant lymph node in 25 cases (37%),bone in 48 cases (72%),bone marrow in 56 cases (84%) and intracalvarium in 3 cases (4%). MYCN gene amplification were detected in 28 cases (42%). At the end of induction, 33 cases (49%) achieved complete remission, 29 cases (43%) achieved partial remission, 1 case (1%) with stable disease, and 4 cases (6%) were assessed as progressive disease (PD). The objective remission rate was 93% (62/67) and the disease control rate was 94% (63/67). The percentage of central system metastases at the initial diagnosis was higher in the treatment-unresponsive group than in the treatment-responsive group (2/5 vs. 2% (1/62), P=0.013), whereas the difference in MYCN gene amplification was not statistically significant between two groups (3/5 vs.40% (25/62), P=0.786). Grade Ⅲ or higher adverse reactions during the induction chemotherapy period were myelosuppression occurred in 60 cases (90%), gastrointestinal symptoms occurred in 33 cases (49%), infections occurred in 20 cases (30%), hepatotoxicity occurred in 4 cases (6%), and cardiovascular toxicity occurred in 1 case (2%). There were no chemotherapy-related deaths. Conclusion:ATO combined with N7-modified induction regimen had a superiority in efficacy and safety, which deserved further promotion in clinical practice.

Objective:To investigate the effect of oral contraceptive pretreatment on pregnancy outcome of modified long down-regulation protocol in in vitro fertilization and embryo transfer and intracytoplasmic sperm injection cycles. Methods:Totally 13 542 cycles were retrospectively analyzed in Reproductive Medicine Center of the 73th Group Military Hospital of PLA from January 2012 to December 2017. According to whether use oral contraceptives (OC) before down-regulation, they were divided into OC group (591 cases) and non-OC group (12 951 cases). After the variables between the two groups were balanced by the propensity score matching method, the number of oocytes obtained, number of mature oocytes, number of fertilized oocytes, number of high-quality embryos, estradiol level on human chorionic gonadotropin (hCG) trigger day, endometrial thickness on hCG trigger day, the clinical pregnancy rate and the live birth rate of the two groups were compared.Results:Before matching, the estradiol level on hCG triger day in OC group [3 118.00(2 529.00) ng/L] was lower than that in non-OC group [3 422.00(2 733.00) ng/L], with statistically significant difference ( P=0.001), there was no significant difference between OC group and non-OC group in the number of harvested oocytes and mature oocytes, fertilization number, number of viable embryos, endometrial thickness on hCG trigger day, the clinical pregnancy rate and the live birth rate. However, after adjusting for confounding factors through multi-factor logistics regression analysis, OC group was the negative factor to reduce the live birth rate compared with non-OC group (clinical pregnancy rate OR=0.83, 95% CI=0.68-1.02; live birth rate OR=0.82, with 95% CI=0.88-0.99). After matching, the clinical pregnancy rate and the live birth rate of OC group and non-OC group had no statistically significant differences (clinical pregnancy rate OR=0.94, 95% CI=0.75-1.14, P=0.59; live birth rate OR=0.91, 95% CI=0.74-1.13, P=0.38). A post-hoc power caculation demonstrated that the study sample size yielded >80% power to detect a no less than 3.7% difference between groups in the primary outcome. Conclusion:The pretreatment of oral contraceptives has no significant effect on the outcome of modified long down-regulation protocol.

Objective:To investigate the effect of oral contraceptive pretreatment on pregnancy outcome of modified long down-regulation protocol in in vitro fertilization and embryo transfer and intracytoplasmic sperm injection cycles. Methods:Totally 13 542 cycles were retrospectively analyzed in Reproductive Medicine Center of the 73th Group Military Hospital of PLA from January 2012 to December 2017. According to whether use oral contraceptives (OC) before down-regulation, they were divided into OC group (591 cases) and non-OC group (12 951 cases). After the variables between the two groups were balanced by the propensity score matching method, the number of oocytes obtained, number of mature oocytes, number of fertilized oocytes, number of high-quality embryos, estradiol level on human chorionic gonadotropin (hCG) trigger day, endometrial thickness on hCG trigger day, the clinical pregnancy rate and the live birth rate of the two groups were compared.Results:Before matching, the estradiol level on hCG triger day in OC group [3 118.00(2 529.00) ng/L] was lower than that in non-OC group [3 422.00(2 733.00) ng/L], with statistically significant difference ( P=0.001), there was no significant difference between OC group and non-OC group in the number of harvested oocytes and mature oocytes, fertilization number, number of viable embryos, endometrial thickness on hCG trigger day, the clinical pregnancy rate and the live birth rate. However, after adjusting for confounding factors through multi-factor logistics regression analysis, OC group was the negative factor to reduce the live birth rate compared with non-OC group (clinical pregnancy rate OR=0.83, 95% CI=0.68-1.02; live birth rate OR=0.82, with 95% CI=0.88-0.99). After matching, the clinical pregnancy rate and the live birth rate of OC group and non-OC group had no statistically significant differences (clinical pregnancy rate OR=0.94, 95% CI=0.75-1.14, P=0.59; live birth rate OR=0.91, 95% CI=0.74-1.13, P=0.38). A post-hoc power caculation demonstrated that the study sample size yielded >80% power to detect a no less than 3.7% difference between groups in the primary outcome. Conclusion:The pretreatment of oral contraceptives has no significant effect on the outcome of modified long down-regulation protocol.

Objective To study normal hearing children's speech perception in Speech Spectrum -Shaped Noise (SSN) and Babble Noise (BN) using the Mandarin lexical neighborhood test .Methods Thirty -four children with normal hearing were included in this study and randomly assigned to the SSN group and the BN group .Each child was given the 12 lists of Mandarin lexical neighborhood test ,word recognition scores were acquired at different SNRs .Results SNR50 of dissyllablic easy word lists ,dissyllablic hard word lists ,monosyllable easy word lists , monosyllable hard word lists in SSN were -3 dB ,-0 .5 dB ,-1 dB and 3 .5 dB ,respectively ;SNR50 of the four categories lists in BN were -3 dB ,2 dB ,0 .5 dB and 10 dB ,respectively .Lexical effects had a significant influence on spoken word recognition in noise .Especially ,word recognition scores of easy words were higher than those of hard words ,dissyllablic words were better than monosyllable words .Conclusion The masking effects of babble noise on spoken speech perception are stronger than speech spectrum -shaped noise for 3-6 year-old normal hearing chil‐dren .Lexical effects also affet children's speech recognition in noise .

Objective-To-investigate-surgical-skills-and-safety-of-laparoscopic-hysterectomy-procedure-for-enlarged-uterus-in-woman-with-adenomyosis-.-Methods-Fourteen-cases-of-adenomyosis-with-uterus-larger-than-twelve-week-pregnancy-accepted-laparoscopic-hysterectomy-form-December-2012-to-December-2013-in-our-hospital-.-Some-operating-techniques-,-including-the-management-of-uterine-vessels-and-separation-of-cardinal-ligament-and-uterosacral-ligament-,-were-modified-.-Results-The-operation-was-performed-successfully-under-laparoscopy-in-all-the-cases-.No-conversion-to-open-surgery-was-required-.No-operating-complication-happened.The-operating-time-was-(160.7-±66.1)-min,-and-the-intraoperative-blood-loss-was-(184.3-±50.5)-ml.-Conclusion-Modified-laparoscopic-techniques-should-be-considered-as-an-acceptable-alternative-in-hysterectomy-for-the-management-of-large-uterus-in-woman-with-adenomyosis-.