This study aims to investigate the association of lifestyle values with lifestyle and quality of life among community-dwelling late middle-aged and older adults. Methods: This retrospective cross-sectional study analyzed secondary data of 200 late middle-aged and older adults. Lifestyle and lifestyle values were measured by Yonsei Lifestyle Profile (YLP) and YLP-Value, respectively. The mediator was quality of life, and a mediation analysis was conducted to examine the relationship between lifestyle values, lifestyle, and quality of life. Our study then repeated the analysis by dividing lifestyle into three components: physical activity, nutrition/eating habit, and activity participation. Results: Mediation analysis revealed significant associations across all pathways (all p<.001). The lifestyle values were associated with lifestyle (β=.40). Both lifestyle value (β=.40) and lifestyle (β=.18) were positively associated with quality of life. The indirect effect of lifestyle values on quality of life, mediated by lifestyle, accounted for 14.58% of the total effect, with the direct effect constituting 85.42%. Conclusion: Among the three components of lifestyle, a mediation effect was observed between lifestyle values, nutrition/eating habit, and quality of life. Our results indicate the need for education to increase lifestyle values within lifestyle programs, emphasizing the significance of lifestyle values in enhancing both lifestyle and quality of life among late middle-aged and older adults. Health professionals may integrate the results into interventions by recognizing the importance of lifestyle values.

Purpose: Radiotherapy (RT) remains a cornerstone of curative treatment for localized and locally advanced prostate cancer. However, dose escalation to improve tumor control is often constrained by the proximity of the rectum, which increases the risk of gastrointestinal (GI) and genitourinary toxicities. Biodegradable rectal spacers inserted between the prostate and rectum have emerged as an effective approach to reduce rectal radiation exposure. This guideline provides evidence-based recommendations on indications, contraindications, procedural standards, and clinical management for biodegradable rectal spacer insertion during prostate cancer RT. Materials and Methods: This guideline was developed by a multidisciplinary expert panel through a systematic review of the literature, analysis of international guidelines (National Comprehensive Cancer Network, European Association of Urology, American Society for Radiation Oncology), and expert consensus among radiation oncologists, radiologists, and urologists with clinical experience in spacer insertion. The strength of each recommendation and the level of evidence were classified according to the modified GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) system. Results: Spacer insertion is conditionally recommended (Grade C, Level I) for patients receiving definitive external-beam RT without rectal invasion. It reduces the high-dose rectal irradiation volume (V70–75) by >50%, decreases acute GI toxicity, and helps maintain bowel-related quality of life. However, the benefit for late severe toxicity (grade 2 or higher) remains debated in recent meta-analyses. Contraindications include rectal invasion, anatomical inaccessibility, infection, and material hypersensitivity. Procedures should be performed under local anesthesia in a sterile environment by trained physicians. Short-course antibiotics and simulator-based training, including completion of multiple supervised cases, are advised. Conclusion Biodegradable rectal spacer insertion is clinically validated and effective in reducing acute rectal toxicity. Although pivotal trials demonstrated a favorable procedural safety profile, real-world postmarket data include reports of rare but severe procedural complications. This guideline provides standardized recommendations tailored to Korean clinical practice while remaining consistent with international standards, emphasizing the importance of operator training and careful patient selection.

Background and Objectives: Acute decompensated heart failure (ADHF) often necessitates invasive mechanical ventilation (MV) due to respiratory failure. Positive end-expiratory pressure (PEEP) is a critical component in MV management; however, the optimal PEEP level for patients with ADHF remains unclear. The High vErsus Low Positive end-expiratory pressure in mechanically ventilated patients with Acute Heart Failure (HELP-AHF) trial is a multicenter, open-label, randomized controlled study designed to compare the efficacy and safety of high versus low PEEP strategies in this population. Methods: A total of 120 patients with ADHF requiring MV within 24 hours of initiation will be randomized 1:1 to a high PEEP group (target: 10 cmH2 O) or a low PEEP group (target: 3 cmH2 O). Results: The primary outcome is ventilator-free days at day 28. Key secondary outcomes include in-hospital mortality, duration of intensive care unit and hospital stay, vasoactive-inotropic support, and rates of heart transplantation or left ventricular assist device implantation. Safety outcomes include hemodynamic instability requiring mechanical circulatory support, pulmonary complications, and weaning-related adverse events. Conclusions This HELP-AHF trial aims to provide valuable insights into optimal PEEP strategies in ADHF patients receiving invasive MV. Findings from this study have the potential to inform ventilatory management practices and improve outcomes in this high-risk population.

Purpose: This study aims to evaluate the treatment approaches and locoregional patterns for adenoid cystic carcinoma (ACC) in the breast, which is an uncommon malignant tumor with limited clinical data. Materials and Methods: A total of 93 patients diagnosed with primary ACC in the breast between 1992 and 2022 were collected from multi-institutions. All patients underwent surgical resection, including breast-conserving surgery (BCS) or total mastectomy (TM). Recurrence patterns and locoregional recurrence-free survival (LRFS) were assessed. Results: Seventy-five patients (80.7%) underwent BCS, and 71 of them (94.7%) received post-operative radiation therapy (PORT). Eighteen patients (19.3%) underwent TM, with five of them (27.8%) also receiving PORT. With a median follow-up of 50 months, the LRFS rate was 84.2% at 5 years. Local recurrence (LR) was observed in five patients (5.4%) and four cases (80%) of the LR occurred in the tumor bed. Three of LR (3/75, 4.0%) had a history of BCS and PORT, meanwhile, two of LR (2/18, 11.1%) had a history of mastectomy. Regional recurrence occurred in two patients (2.2%), and both cases had a history of PORT with (n=1) and without (n=1) irradiation of the regional lymph nodes. Partial breast irradiation (p=0.35), BCS (p=0.96) and PORT in BCS group (p=0.33) had no significant association with LRFS. Conclusion BCS followed by PORT was the predominant treatment approach for ACC of the breast and LR mostly occurred in the tumor bed. The findings of this study suggest that partial breast irradiation might be considered for PORT in primary breast ACC.

Objectives: Given the rapidly growing expectations for large language models (LLMs) in healthcare, this study systematically collected perspectives from Korean experts on the potential benefits and risks of LLMs, aiming to promote their safe and effective utilization. Methods: A web-based mini-Delphi survey was conducted from August 27 to October 14, 2024, with 20 selected panelists. The expert questionnaire comprised 84 judgment items across five domains: potential applications, benefits, risks, reliability requirements, and safe usage. These items were developed through a literature review and expert consultation. Participants rated their agreement or perceived importance on a 5-point scale. Items meeting predefined thresholds (content validity ratio ≥0.49, degree of convergence ≤0.50, and degree of consensus ≥0.75) were prioritized. Results: Seventeen participants (85%) responded to the first round, and 16 participants (80%) completed the second round. Consensus was achieved on several potential applications, benefits, and reliability requirements for the use of LLMs in healthcare. However, significant heterogeneity was found regarding perceptions of associated risks and criteria for safe usage of LLMs. Of the 84 total items, 52 met the criteria for statistical validity, confirming the diversity of expert opinions. Conclusions Experts reached a consensus on certain aspects of LLM utilization in healthcare. Nonetheless, notable differences remained concerning risks and requirements for safe implementation, highlighting the need for further investigation. This study provides foundational insights to guide future research and inform policy development for the responsible introduction of LLMs into the healthcare field.

Purpose: This study aims to evaluate the treatment approaches and locoregional patterns for adenoid cystic carcinoma (ACC) in the breast, which is an uncommon malignant tumor with limited clinical data. Materials and Methods: A total of 93 patients diagnosed with primary ACC in the breast between 1992 and 2022 were collected from multi-institutions. All patients underwent surgical resection, including breast-conserving surgery (BCS) or total mastectomy (TM). Recurrence patterns and locoregional recurrence-free survival (LRFS) were assessed. Results: Seventy-five patients (80.7%) underwent BCS, and 71 of them (94.7%) received post-operative radiation therapy (PORT). Eighteen patients (19.3%) underwent TM, with five of them (27.8%) also receiving PORT. With a median follow-up of 50 months, the LRFS rate was 84.2% at 5 years. Local recurrence (LR) was observed in five patients (5.4%) and four cases (80%) of the LR occurred in the tumor bed. Three of LR (3/75, 4.0%) had a history of BCS and PORT, meanwhile, two of LR (2/18, 11.1%) had a history of mastectomy. Regional recurrence occurred in two patients (2.2%), and both cases had a history of PORT with (n=1) and without (n=1) irradiation of the regional lymph nodes. Partial breast irradiation (p=0.35), BCS (p=0.96) and PORT in BCS group (p=0.33) had no significant association with LRFS. Conclusion BCS followed by PORT was the predominant treatment approach for ACC of the breast and LR mostly occurred in the tumor bed. The findings of this study suggest that partial breast irradiation might be considered for PORT in primary breast ACC.

Objectives: Given the rapidly growing expectations for large language models (LLMs) in healthcare, this study systematically collected perspectives from Korean experts on the potential benefits and risks of LLMs, aiming to promote their safe and effective utilization. Methods: A web-based mini-Delphi survey was conducted from August 27 to October 14, 2024, with 20 selected panelists. The expert questionnaire comprised 84 judgment items across five domains: potential applications, benefits, risks, reliability requirements, and safe usage. These items were developed through a literature review and expert consultation. Participants rated their agreement or perceived importance on a 5-point scale. Items meeting predefined thresholds (content validity ratio ≥0.49, degree of convergence ≤0.50, and degree of consensus ≥0.75) were prioritized. Results: Seventeen participants (85%) responded to the first round, and 16 participants (80%) completed the second round. Consensus was achieved on several potential applications, benefits, and reliability requirements for the use of LLMs in healthcare. However, significant heterogeneity was found regarding perceptions of associated risks and criteria for safe usage of LLMs. Of the 84 total items, 52 met the criteria for statistical validity, confirming the diversity of expert opinions. Conclusions Experts reached a consensus on certain aspects of LLM utilization in healthcare. Nonetheless, notable differences remained concerning risks and requirements for safe implementation, highlighting the need for further investigation. This study provides foundational insights to guide future research and inform policy development for the responsible introduction of LLMs into the healthcare field.

Objectives: Given the rapidly growing expectations for large language models (LLMs) in healthcare, this study systematically collected perspectives from Korean experts on the potential benefits and risks of LLMs, aiming to promote their safe and effective utilization. Methods: A web-based mini-Delphi survey was conducted from August 27 to October 14, 2024, with 20 selected panelists. The expert questionnaire comprised 84 judgment items across five domains: potential applications, benefits, risks, reliability requirements, and safe usage. These items were developed through a literature review and expert consultation. Participants rated their agreement or perceived importance on a 5-point scale. Items meeting predefined thresholds (content validity ratio ≥0.49, degree of convergence ≤0.50, and degree of consensus ≥0.75) were prioritized. Results: Seventeen participants (85%) responded to the first round, and 16 participants (80%) completed the second round. Consensus was achieved on several potential applications, benefits, and reliability requirements for the use of LLMs in healthcare. However, significant heterogeneity was found regarding perceptions of associated risks and criteria for safe usage of LLMs. Of the 84 total items, 52 met the criteria for statistical validity, confirming the diversity of expert opinions. Conclusions Experts reached a consensus on certain aspects of LLM utilization in healthcare. Nonetheless, notable differences remained concerning risks and requirements for safe implementation, highlighting the need for further investigation. This study provides foundational insights to guide future research and inform policy development for the responsible introduction of LLMs into the healthcare field.

Purpose: This study aims to evaluate the treatment approaches and locoregional patterns for adenoid cystic carcinoma (ACC) in the breast, which is an uncommon malignant tumor with limited clinical data. Materials and Methods: A total of 93 patients diagnosed with primary ACC in the breast between 1992 and 2022 were collected from multi-institutions. All patients underwent surgical resection, including breast-conserving surgery (BCS) or total mastectomy (TM). Recurrence patterns and locoregional recurrence-free survival (LRFS) were assessed. Results: Seventy-five patients (80.7%) underwent BCS, and 71 of them (94.7%) received post-operative radiation therapy (PORT). Eighteen patients (19.3%) underwent TM, with five of them (27.8%) also receiving PORT. With a median follow-up of 50 months, the LRFS rate was 84.2% at 5 years. Local recurrence (LR) was observed in five patients (5.4%) and four cases (80%) of the LR occurred in the tumor bed. Three of LR (3/75, 4.0%) had a history of BCS and PORT, meanwhile, two of LR (2/18, 11.1%) had a history of mastectomy. Regional recurrence occurred in two patients (2.2%), and both cases had a history of PORT with (n=1) and without (n=1) irradiation of the regional lymph nodes. Partial breast irradiation (p=0.35), BCS (p=0.96) and PORT in BCS group (p=0.33) had no significant association with LRFS. Conclusion BCS followed by PORT was the predominant treatment approach for ACC of the breast and LR mostly occurred in the tumor bed. The findings of this study suggest that partial breast irradiation might be considered for PORT in primary breast ACC.

Studies on the association between pleural effusion (PE) and left ventricular assist devices (LVADs) are limited. This study aimed to examine the characteristics and the clinical impact of PE following LVAD implantation. Methods: This study is a prospective analysis of patients who underwent LVAD implantation from June 2015 to December 2022. We investigated the prognostic impact of therapeutic drainage (TD) on clinical outcomes. We also compared the characteristics and clinical outcomes between early and late PE and examined the factors related to the development of late PE. Results: A total of 71 patients was analyzed. The TD group (n=45) had a longer ward stay (days; median [interquartile range]: 31.0 [23.0–46.0] vs. 21.0 [16.0–34.0], P=0.006) and total hospital stay (47.0 [36.0–82.0] vs. 31.0 [22.0–48.0], P=0.002) compared to the no TD group (n=26). Early PE was mostly exudate, left-sided, and neutrophil-dominant even though predominance of lymphocytes was the most common finding in late PE. Patients with late PE had a higher rate of reintubation within 14 days (31.8% vs. 4.1%, P=0.004) and longer hospital stays than those without late PE (67.0 [43.0–104.0] vs. 36.0 [28.0–48.0], P<0.001). Subgroup analysis indicated that female sex, low body mass index, cardiac resynchronization therapy, and hypoalbuminemia were associated with late PE. Conclusions: Compared to patients not undergoing TD, those undergoing TD had a longer hospital stay but not a higher 90-day mortality. Patients with late PE had poor clinical outcomes. Therefore, the correction of risk factors, like hypoalbuminemia, may be required.