1.Research progress on mechanism of gut microbiota-host DNA methylation interaction in the pathogenesis of inflammatory bowel disease
Yanzhe GUO ; Mingfei CHEN ; Abudurexiti WARESI ; Zhongyuan WANG ; Song LI ; Jianfeng GONG
Chinese Journal of Inflammatory Bowel Diseases 2025;09(2):164-169
Inflammatory bowel disease (IBD) is an intestinal disease with uncertain etiology and complex mechanism. The interaction between environment and gene is a risk factor of IBD, which includes abnormal DNA methylation. In this review, we discuss the abnormal DNA methylation in IBD patients, and illustrate the interaction between gut microbiota and host through DNA methylation and its mechanism. Finally, we look forward to the prospect of regulating the interaction between gut microbiota and host through DNA methylation in the treatment of IBD.
2.Research progress on mechanism of gut microbiota-host DNA methylation interaction in the pathogenesis of inflammatory bowel disease
Yanzhe GUO ; Mingfei CHEN ; Abudurexiti WARESI ; Zhongyuan WANG ; Song LI ; Jianfeng GONG
Chinese Journal of Inflammatory Bowel Diseases 2025;09(2):164-169
Inflammatory bowel disease (IBD) is an intestinal disease with uncertain etiology and complex mechanism. The interaction between environment and gene is a risk factor of IBD, which includes abnormal DNA methylation. In this review, we discuss the abnormal DNA methylation in IBD patients, and illustrate the interaction between gut microbiota and host through DNA methylation and its mechanism. Finally, we look forward to the prospect of regulating the interaction between gut microbiota and host through DNA methylation in the treatment of IBD.
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