1.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
2.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
3.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
4.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
5.Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Syedda AYESHA ; Masood Muhammad KARIM ; Maria ALI ; Abdul Hadi SHAHID ; Salman Naseem ADIL
The Korean Journal of Gastroenterology 2025;85(1):73-77
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange.This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.
6.Unraveling the Sugar Rush: A Cross-sectional Study of Knowledge, Attitudes, and Practices Related to Sugar- Sweetened Beverages Consumption among Malaysian Young Adults
Siti Nur Athirah Aisyah Abu Bakar ; Asma&rsquo ; Ali ; Abdul Rais Abdul Rahman ; Abbe Maleyki Mhd Jalil ; Noor Salihah Zakaria
Malaysian Journal of Medicine and Health Sciences 2024;20(No.1):152-160
Introduction: The consumption of sugar-sweetened beverages (SSBs) among young adults in Malaysia has witnessed
a notable increase in recent years, giving rise to concerns regarding the potential adverse health effects, including
obesity and diabetes. Despite the urgent need for targeted interventions, there is a dearth of research examining the
knowledge, attitudes, and practices (KAP) related to SSBs among Malaysian young adults. To address this research
gap, the present study aims to assess the level of KAP concerning SSB intake and its associated factors in this specific
population. Methods: A cross-sectional study was conducted involving 408 Malaysian young adults aged between
15 and 29 years. Respondents completed an online questionnaire survey, which encompassed the assessment of
socio-demographic characteristics and KAP regarding SSB consumption. The collected data were analyzed using
IBM’s Statistical Package for the Social Sciences (SPSS) version 22.0. Spearman correlation tests were performed
at a significance level of 0.05. Results: The majority of respondents demonstrated moderate knowledge (60%) and
practices (60%), while exhibiting a high positive attitude (100%) towards reducing SSB consumption. Significant
correlations were observed between knowledge and attitude (p = 0.003, rs = 0.148) and between knowledge and
practice (p = 0.005, rs = 0.138). Moreover, the attitude scores were found to be significantly associated with gender
(χ2
(1, N = 408) = 10.421, p = 0.001) and locality (χ2
(1, N = 408) = 4.106, p = 0.043), while the practice scores
exhibited a significant association with ethnicity (p = 0.006). Conclusion: This study provides valuable insights into
the relationship between KAP related to SSB consumption and socio-demographic factors among Malaysian young
adults. The findings underscore the importance of utilizing these insights to develop strategic interventions that aim
to curtail SSB consumption and promote a healthy lifestyle, ultimately contributing to the reduction of non-communicable diseases. Health authorities are encouraged to capitalize on these findings to design targeted interventions
tailored to the unique needs and circumstances of this population.
7.Anatomical study of variations in the configurations of the circle of Willis in relation to age, sex, and diameters of the components
Yasser ALHARBI ; Radi Ali M. Al SAFFAR
Anatomy & Cell Biology 2024;57(4):579-591
The circle of Willis (COW) refers to the anastomotic arterial network found on the brain base, tasked with provision of collateral circulation aimed at prevention of ischemia. The COW is of immense clinical importance especially with regard to the assessment of neurovascular diseases. Individuals portray significant variations in the COW’s anatomical configuration. The present study seeks to evaluate the existing anatomical variations of the COW and within the anterior and posterior segments of the COW. Thus, the study seeks to evaluate the different anatomical variations of the COW and its segments and components within the study population. To attain the set objectives, the present study has utilized the angiographic images for studying the COW variants in patients who underwent cerebral angiography during assessment of different types of cerebral anomalies and conditions. Therefore, this study used conventional angiography as an important tool in the evaluation of the different variations in the COW, and is most appropriate for evaluation of smaller anatomical variations owing to its perfect spatial resolution and portrayal of COW anatomy. The study findings indicated the existence between age and sex, and anatomical variations of the COW, particularly with regard to diameters of COW components like basilar artery (BA), P1, and internal carotid arterys (ICAs). Males had bigger BA, P1 and ICA diameters than females, while individuals aged below 40 years had bigger BA, A1, posterior communicating artery, and ICA diameters than those aged above 40 years.
8.Anatomical study of variations in the configurations of the circle of Willis in relation to age, sex, and diameters of the components
Yasser ALHARBI ; Radi Ali M. Al SAFFAR
Anatomy & Cell Biology 2024;57(4):579-591
The circle of Willis (COW) refers to the anastomotic arterial network found on the brain base, tasked with provision of collateral circulation aimed at prevention of ischemia. The COW is of immense clinical importance especially with regard to the assessment of neurovascular diseases. Individuals portray significant variations in the COW’s anatomical configuration. The present study seeks to evaluate the existing anatomical variations of the COW and within the anterior and posterior segments of the COW. Thus, the study seeks to evaluate the different anatomical variations of the COW and its segments and components within the study population. To attain the set objectives, the present study has utilized the angiographic images for studying the COW variants in patients who underwent cerebral angiography during assessment of different types of cerebral anomalies and conditions. Therefore, this study used conventional angiography as an important tool in the evaluation of the different variations in the COW, and is most appropriate for evaluation of smaller anatomical variations owing to its perfect spatial resolution and portrayal of COW anatomy. The study findings indicated the existence between age and sex, and anatomical variations of the COW, particularly with regard to diameters of COW components like basilar artery (BA), P1, and internal carotid arterys (ICAs). Males had bigger BA, P1 and ICA diameters than females, while individuals aged below 40 years had bigger BA, A1, posterior communicating artery, and ICA diameters than those aged above 40 years.
9.Anatomical study of variations in the configurations of the circle of Willis in relation to age, sex, and diameters of the components
Yasser ALHARBI ; Radi Ali M. Al SAFFAR
Anatomy & Cell Biology 2024;57(4):579-591
The circle of Willis (COW) refers to the anastomotic arterial network found on the brain base, tasked with provision of collateral circulation aimed at prevention of ischemia. The COW is of immense clinical importance especially with regard to the assessment of neurovascular diseases. Individuals portray significant variations in the COW’s anatomical configuration. The present study seeks to evaluate the existing anatomical variations of the COW and within the anterior and posterior segments of the COW. Thus, the study seeks to evaluate the different anatomical variations of the COW and its segments and components within the study population. To attain the set objectives, the present study has utilized the angiographic images for studying the COW variants in patients who underwent cerebral angiography during assessment of different types of cerebral anomalies and conditions. Therefore, this study used conventional angiography as an important tool in the evaluation of the different variations in the COW, and is most appropriate for evaluation of smaller anatomical variations owing to its perfect spatial resolution and portrayal of COW anatomy. The study findings indicated the existence between age and sex, and anatomical variations of the COW, particularly with regard to diameters of COW components like basilar artery (BA), P1, and internal carotid arterys (ICAs). Males had bigger BA, P1 and ICA diameters than females, while individuals aged below 40 years had bigger BA, A1, posterior communicating artery, and ICA diameters than those aged above 40 years.
10.Anatomical study of variations in the configurations of the circle of Willis in relation to age, sex, and diameters of the components
Yasser ALHARBI ; Radi Ali M. Al SAFFAR
Anatomy & Cell Biology 2024;57(4):579-591
The circle of Willis (COW) refers to the anastomotic arterial network found on the brain base, tasked with provision of collateral circulation aimed at prevention of ischemia. The COW is of immense clinical importance especially with regard to the assessment of neurovascular diseases. Individuals portray significant variations in the COW’s anatomical configuration. The present study seeks to evaluate the existing anatomical variations of the COW and within the anterior and posterior segments of the COW. Thus, the study seeks to evaluate the different anatomical variations of the COW and its segments and components within the study population. To attain the set objectives, the present study has utilized the angiographic images for studying the COW variants in patients who underwent cerebral angiography during assessment of different types of cerebral anomalies and conditions. Therefore, this study used conventional angiography as an important tool in the evaluation of the different variations in the COW, and is most appropriate for evaluation of smaller anatomical variations owing to its perfect spatial resolution and portrayal of COW anatomy. The study findings indicated the existence between age and sex, and anatomical variations of the COW, particularly with regard to diameters of COW components like basilar artery (BA), P1, and internal carotid arterys (ICAs). Males had bigger BA, P1 and ICA diameters than females, while individuals aged below 40 years had bigger BA, A1, posterior communicating artery, and ICA diameters than those aged above 40 years.


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