Objective:To explore the association of induced abortion with subsequent stillbirth.Methods:The data collected from the National Free Pre-Pregnancy Health Examination Project in Yunnan Province between 2010 and 2017 were used in this analysis. Information on women's background characteristics, pregnant history, disease history, physical examination, etc. were recorded. After their pre-pregnancy health examination, women were routinely followed up and any pregnancies and pregnancy outcomes were recorded. By using SPSS20.0 and SAS9.4 software, we employed description analysis, Chi-square tests, stratified analysis and multivariate logistic regression for data analysis.Results:A total of 174 782 pregnancies were included in this analysis, and the total incidence rate of stillbirths was 0.64% (1119/174 782). The incidence rate of stillbirths in the group of women who had a previous history of induced abortion (exposed group) was 0.83% (333/40 216), which was significantly higher than 0.58% (786/134 566) in the non-induced abortion group (unexposed group). Results of unconditional multivariate logistic regression analysis demonstrated that, compared with unexposed group, the risk of stillbirth in exposed group was higher in those with 1 and 2 or more induced abortions ( OR=1.22, 95% CI=1.05-1.41; OR=1.33, 95% CI=1.08-1.64). The risk of stillbirth was significant lower in women who conceived in 2011-2016 than in 2010 ( OR=0.66, 95% CI=0.51-0.85). Mother's ethnicity, age, education level, parity and body mass index (BMI) before pregnancy were significantly associated with the risk of stillbirth. Women's occupation, previous histories of premature birth, stillbirth and natural abortion were not associated with subsequent stillbirth. Conclusion:Induced abortion is associated with an increase of the risk of subsequent stillbirth. Mother's ethnicity, age, education level, parity and BMI are significantly associated with the risk of stillbirth. Overweight and obesity before pregnancy increase the risk of stillbirth.

Objective:To explore the association of induced abortion with subsequent stillbirth.Methods:The data collected from the National Free Pre-Pregnancy Health Examination Project in Yunnan Province between 2010 and 2017 were used in this analysis. Information on women's background characteristics, pregnant history, disease history, physical examination, etc. were recorded. After their pre-pregnancy health examination, women were routinely followed up and any pregnancies and pregnancy outcomes were recorded. By using SPSS20.0 and SAS9.4 software, we employed description analysis, Chi-square tests, stratified analysis and multivariate logistic regression for data analysis.Results:A total of 174 782 pregnancies were included in this analysis, and the total incidence rate of stillbirths was 0.64% (1119/174 782). The incidence rate of stillbirths in the group of women who had a previous history of induced abortion (exposed group) was 0.83% (333/40 216), which was significantly higher than 0.58% (786/134 566) in the non-induced abortion group (unexposed group). Results of unconditional multivariate logistic regression analysis demonstrated that, compared with unexposed group, the risk of stillbirth in exposed group was higher in those with 1 and 2 or more induced abortions ( OR=1.22, 95% CI=1.05-1.41; OR=1.33, 95% CI=1.08-1.64). The risk of stillbirth was significant lower in women who conceived in 2011-2016 than in 2010 ( OR=0.66, 95% CI=0.51-0.85). Mother's ethnicity, age, education level, parity and body mass index (BMI) before pregnancy were significantly associated with the risk of stillbirth. Women's occupation, previous histories of premature birth, stillbirth and natural abortion were not associated with subsequent stillbirth. Conclusion:Induced abortion is associated with an increase of the risk of subsequent stillbirth. Mother's ethnicity, age, education level, parity and BMI are significantly associated with the risk of stillbirth. Overweight and obesity before pregnancy increase the risk of stillbirth.

No abstract available.
Hypokalemia* ; Leukoencephalopathies*

No abstract available.
POEMS Syndrome* ; Stroke*

A patient with multiple ischemic stroke due to spontaneous bilateral internal carotid artery dissection (ICAD) was reported and the epidemiology, neuroimaging, clinical characteristics and treatment of spontaneous bilateral ICAD were reviewed.Spontaneous bilateral ICAD mostly occurs in young and middle-aged individuals and the clinical manifestations are mainly stroke(71.1%), headache and neck pain(62.2%), Horner's syndrome(15.6%) and cranial nerve palsy(11.1%).Cervical axial T1-weighted fat-suppressed image is an alternative to DSA to make the definite diagnosis.Antithrombotic therapy is regularly used and the general clinical outcome is good.Cervical arterial dissection is one of the most common causes of stroke in young and middle-aged patients.Cervical MRI T1-weighted fat suppressed image is crucial for timely diagnosis and initiation of appropriate clinical intervention.

Objective To explore the effects of dehydroepiandrosterone (DHEA) on learning and memory ability and activities of choline acetyltransferase (ChAT),acetylcholinesterase (AchE),acetylcholine (Ach) in the frontal,temporal,hippocampal area of the aged rat.Methods Forty 24-month-old male SD rats were randomly divided into 4 groups (n=10,each group):control group,solvent group (intraperitoneal injection with equal volumes of DMSO),low-dose group (intraperitoneal injection with equal volumes of DHEA,1 mg/kg),and high-dose group (intraperitoneal injection with equal volumes of DHEA,5 mg/kg).The activities of ChAT,AchE,and Ach were measured by enzyme linked immunosorbent assay (ELISA) method.Learning and memory ability was detected by Morris water maze test.Results The levels of ChAT in frontal,temporal and hippocampal area were (118.5±1.3) U/mg,(120.6±1.5) U/mg,(130.8±1.5) U/mg,respectively in control group,(i39.5±1.6) U/mg,(137.4±1.4) U/mg,(141.46±1.9) U/mg,respectively in high-dose group,(131.8±1.9) U/mg,(132.4±1.2) U/mg,(139.9±1.3) U/mg,respectively in low-dose group.The levels of AchE in frontal,temporal and hippocampal area were (0.5±0.0) U/mg,(0.4±0.0) U/mg,(0.5±0.0) U/mg,respectively in control group,(0.4±0.0) U/mg,(0.4±0.0) U/mg,(0.4±0.0) U/mg,respectively in high-dose group,and (0.4±0.0) U/mg,(0.4±0.0) U/mg,(0.4±0.0) U/mg,respectively in low-dose group,and (0.5±0.0)U/mg.The Ach levels in frontal,temporal and hippocampal area were (26.0±0.8) U/mg,(24.5±1.4) U/mg,(30.1±0.8) U/mg respectively in control group,(28.7±0.9) U/mg,(28.9±1.3) U/mg,(35.9±1.4) U/mg,respectively in high-dose group,and (27.6±0.1) U/mg,(28.0±1.1) U/mg,(34.2± 1.0) U/mg,rcspectively in low dose group.The activities of ChAT in frontal,temporal and hippocampal area were higher in DHEA treatment group than in control group (P＜0.05).The activities of AchE in frontal,temporal and hippocampal area were much lower in DHEA treatment group than in control group (P＜ 0.05).The Ach levels in frontal,temporal and hippocampal area were much higher in DHEA treatment group than in control group (P＜0.05).There were significant differences in the activities of ChAT and AchE and Ach levels between low-dose group and high-dose group (P＜0.05).Compared with control group,the activities of ChAT and AchE and Ach levels had no significant differences in solvent group (P＞0.05).The escape latency was shorter in low-dose group and high-dose group than in control group (P＜0.05,P＜0.01,respectively),and there was a significant difference in escape latency between low-dose group and high dose group (P＜ 0.05).Conclusions DHEA administration can significantly increase the activity of cholinergic system,and improve the learning and memory ability in aged SD rats.