Objective:To investigate the characteristics of the population of skeletal fluorosis patients in drinking-tea-borne endemic fluorosis (referred to as drinking-tea-borne fluorosis) areas in Inner Mongolia Autonomous Region (referred to as Inner Mongolia) and the influencing factors of treatment willingness, and to provide a basis for improving the prevention and control measures of drinking-tea-borne fluorosis and the treatment plan of skeletal fluorosis.Methods:From August to October 2022, a face-to-face questionnaire survey was conducted in key areas of drinking-tea-borne fluorosis in Inner Mongolia (administrative villages with an average daily intake of tea fluoride > 3.5 mg and skeletal fluorosis patients identified by the general survey of drinking-tea-borne fluorosis in Inner Mongolia in 2019), and to investigate the demographic, severity, and treatment status of patients with skeletal fluorosis, analyze the demographic characteristics of patients with skeletal fluorosis and the influencing factors of treatment willingness.Results:A total of 734 patients with skeletal fluorosis were investigated, including 543 mild cases, 125 moderate cases and 66 severe cases. The gender ratio of patients with skeletal fluorosis was 0.71 ∶ 1.00 (305/429), the age was concentrated in > 50 - 70 years old (70.57%, 518/734), the proportion of Mongolians was 94.28% (692/734), the proportion of herders was 97.68% (717/734), the educational level was mainly primary school (54.63%, 401/734), and the proportion of poor households and immigrants who had moved to their current residence was 7.08% (52/734) and 8.04% (59/734), respectively. The distribution of the severity of skeletal fluorosis in patients of different ages, genders, and educational levels was compared, and the differences were statistically significant ( P < 0.05). Fifty-three point two seven percent (391/734) of the patients had a willingness to undergo non-pharmacological treatment, of which 69.82% (273/391) had already started non-pharmacological treatment, with a treatment effectiveness rate of 73.99% (202/273). Sixty-five point two six percent (479/734) of the patients had a willingness to receive medication treatment, of which 7.31% (35/479) had already started medication treatment, with a treatment effectiveness rate of 54.29% (19/35). Zero point two seven percent (2/734) of the patients expressed a willingness to undergo surgical treatment, while no patients underwent surgical treatment. Multivariate logistic regression analysis showed that the age, ethnicity, occupation, educational level, poverty status, immigrants status, and the severity of skeletal fluorosis were all influencing factors of non-pharmacological treatment willingness ( P < 0.05). Occupation, educational level, poverty status, immigrants status, and the severity of skeletal fluorosis were all influencing factors of medication treatment willingness ( P < 0.05). Conclusions:Patients with skeletal fluorosis caused by tea drinking in Inner Mongolia are mainly from Mongolian ethnic groups, herders, middle-aged and elderly people, and those with a lower educational levels. The willingness of patients to receive treatment is influenced by various factors, and corresponding intervention measures can be formulated and taken based on these influencing factors to effectively improve the disease prevention awareness and treatment willingness of patients and the public.

Objective:To study the relationship between urinary arsenic methylation metabolism patterns and skin keratinization and pigmentation abnormalities in population exposed to arsenic through drinking water.Methods:Using a cross-sectional study method, a survey on endemic arsenic poisoning was conducted among permanent residents of drinking water endemic arsenic poisoning areas in Bayannur City, Inner Mongolia Autonomous Region in 2004 (before water improvement). In 2017 (after water improvement), 71 arsenic exposed individuals were followed up as survey subjects. According to the "Diagnosis of Endemic Arsenism" (WS/T 211-2015), the clinical grading of skin injuries (skin keratinization, pigmentation abnormalities) in the survey subjects was evaluated. Urine samples were collected for detection of arsenic methylation metabolite levels by high-performance liquid chromatography inductively coupled plasma mass spectrometry and calibrated with urinary creatinine. The changes and amplitudes of urinary arsenic methylation indicators before and after water improvement were calculated and analyzed according to the outcome of skin keratinization and pigmentation abnormalities which were divided into reduced, unchanged, and added groups.Results:(1) The changes in urinary total arsenic (TAs), inorganic arsenic (iAs), monomethyl arsenic (MMA), and dimethyl arsenic (DMA) levels in different outcome groups of skin keratinization were compared, and the differences were statistically significant ( H = 9.08, 8.77, 9.28, 8.57, P < 0.05). The changes in urinary TAs, iAs, MMA, DMA levels, iAs percentage (iAs%), DMA percentage (DMA%), and primary methylation index (PMI) in different outcome groups of skin pigmentation abnormalities were compared, and the differences were statistically significant ( H = 8.04, 10.67, 8.29, 9.14, 6.30, 9.10, 7.20, P < 0.05). (2) The comparison of amplitudes in urinary TAs, iAs, MMA, and DMA levels in different outcome groups of skin keratinization showed statistically significant differences ( H = 6.92, 7.34, 6.66, 6.16, P < 0.05). The amplitudes in urinary iAs level, iAs%, DMA%, and PMI in different outcome groups of skin pigmentation abnormalities were compared, and the differences were statistically significant ( H = 7.94, 7.61, 9.95, 7.22, P < 0.05). Conclusion:The changes pattern of urinary TAs, iAs, MMA, DMA, iAs%, DMA%, and PMI in population exposed to arsenic through drinking water is related to the transformation of skin keratinization and pigmentation abnormalities.

Objective:To understand the current status and trends of domestic research on esophageal cancer in the elderly.Methods:In the three major databases of CNKI, Wanfang, and VIP, studies related to elderly esophageal cancer were retrieved using the keywords "elderly" and "esophageal cancer" from the inception of the databases until December 7, 2024.Following the manual screening of the extracted studies, CiteSpace and VOSviewer software were employed to perform a visual analysis of publication trends, authors, institutions, and keywords.Results:A total of 1, 165 articles were included in the study.The first article appeared in 1989, and the number of publications has been increasing year by year, reaching a peak in 2014.The author with the highest number of publications is Zhu Shuchai, and the institution is The Fourth Hospital of Hebei Medical University.Keyword clustering formed ten clusters including "esophageal cancer, elderly, nedaplatin, nursing, thoracoscopic, prognosis, risk factors, enteral nutrition, treatment, and esophageal stenosis." Emerging keywords include surgical treatment, thoracoabdominal laparoscopy, prognosis, and apatinib.Conclusions:Currently, targeted therapy is a research hot spot and frontier.It is anticipated that ongoing advancements in treatment methods will contribute to improved outcomes and quality of life for elderly patients with esophageal cancer.

Objective:To understand the current status and trends of domestic research on esophageal cancer in the elderly.Methods:In the three major databases of CNKI, Wanfang, and VIP, studies related to elderly esophageal cancer were retrieved using the keywords "elderly" and "esophageal cancer" from the inception of the databases until December 7, 2024.Following the manual screening of the extracted studies, CiteSpace and VOSviewer software were employed to perform a visual analysis of publication trends, authors, institutions, and keywords.Results:A total of 1, 165 articles were included in the study.The first article appeared in 1989, and the number of publications has been increasing year by year, reaching a peak in 2014.The author with the highest number of publications is Zhu Shuchai, and the institution is The Fourth Hospital of Hebei Medical University.Keyword clustering formed ten clusters including "esophageal cancer, elderly, nedaplatin, nursing, thoracoscopic, prognosis, risk factors, enteral nutrition, treatment, and esophageal stenosis." Emerging keywords include surgical treatment, thoracoabdominal laparoscopy, prognosis, and apatinib.Conclusions:Currently, targeted therapy is a research hot spot and frontier.It is anticipated that ongoing advancements in treatment methods will contribute to improved outcomes and quality of life for elderly patients with esophageal cancer.

Objective:To investigate the characteristics of the population of skeletal fluorosis patients in drinking-tea-borne endemic fluorosis (referred to as drinking-tea-borne fluorosis) areas in Inner Mongolia Autonomous Region (referred to as Inner Mongolia) and the influencing factors of treatment willingness, and to provide a basis for improving the prevention and control measures of drinking-tea-borne fluorosis and the treatment plan of skeletal fluorosis.Methods:From August to October 2022, a face-to-face questionnaire survey was conducted in key areas of drinking-tea-borne fluorosis in Inner Mongolia (administrative villages with an average daily intake of tea fluoride > 3.5 mg and skeletal fluorosis patients identified by the general survey of drinking-tea-borne fluorosis in Inner Mongolia in 2019), and to investigate the demographic, severity, and treatment status of patients with skeletal fluorosis, analyze the demographic characteristics of patients with skeletal fluorosis and the influencing factors of treatment willingness.Results:A total of 734 patients with skeletal fluorosis were investigated, including 543 mild cases, 125 moderate cases and 66 severe cases. The gender ratio of patients with skeletal fluorosis was 0.71 ∶ 1.00 (305/429), the age was concentrated in > 50 - 70 years old (70.57%, 518/734), the proportion of Mongolians was 94.28% (692/734), the proportion of herders was 97.68% (717/734), the educational level was mainly primary school (54.63%, 401/734), and the proportion of poor households and immigrants who had moved to their current residence was 7.08% (52/734) and 8.04% (59/734), respectively. The distribution of the severity of skeletal fluorosis in patients of different ages, genders, and educational levels was compared, and the differences were statistically significant ( P < 0.05). Fifty-three point two seven percent (391/734) of the patients had a willingness to undergo non-pharmacological treatment, of which 69.82% (273/391) had already started non-pharmacological treatment, with a treatment effectiveness rate of 73.99% (202/273). Sixty-five point two six percent (479/734) of the patients had a willingness to receive medication treatment, of which 7.31% (35/479) had already started medication treatment, with a treatment effectiveness rate of 54.29% (19/35). Zero point two seven percent (2/734) of the patients expressed a willingness to undergo surgical treatment, while no patients underwent surgical treatment. Multivariate logistic regression analysis showed that the age, ethnicity, occupation, educational level, poverty status, immigrants status, and the severity of skeletal fluorosis were all influencing factors of non-pharmacological treatment willingness ( P < 0.05). Occupation, educational level, poverty status, immigrants status, and the severity of skeletal fluorosis were all influencing factors of medication treatment willingness ( P < 0.05). Conclusions:Patients with skeletal fluorosis caused by tea drinking in Inner Mongolia are mainly from Mongolian ethnic groups, herders, middle-aged and elderly people, and those with a lower educational levels. The willingness of patients to receive treatment is influenced by various factors, and corresponding intervention measures can be formulated and taken based on these influencing factors to effectively improve the disease prevention awareness and treatment willingness of patients and the public.

Objective:To study the relationship between urinary arsenic methylation metabolism patterns and skin keratinization and pigmentation abnormalities in population exposed to arsenic through drinking water.Methods:Using a cross-sectional study method, a survey on endemic arsenic poisoning was conducted among permanent residents of drinking water endemic arsenic poisoning areas in Bayannur City, Inner Mongolia Autonomous Region in 2004 (before water improvement). In 2017 (after water improvement), 71 arsenic exposed individuals were followed up as survey subjects. According to the "Diagnosis of Endemic Arsenism" (WS/T 211-2015), the clinical grading of skin injuries (skin keratinization, pigmentation abnormalities) in the survey subjects was evaluated. Urine samples were collected for detection of arsenic methylation metabolite levels by high-performance liquid chromatography inductively coupled plasma mass spectrometry and calibrated with urinary creatinine. The changes and amplitudes of urinary arsenic methylation indicators before and after water improvement were calculated and analyzed according to the outcome of skin keratinization and pigmentation abnormalities which were divided into reduced, unchanged, and added groups.Results:(1) The changes in urinary total arsenic (TAs), inorganic arsenic (iAs), monomethyl arsenic (MMA), and dimethyl arsenic (DMA) levels in different outcome groups of skin keratinization were compared, and the differences were statistically significant ( H = 9.08, 8.77, 9.28, 8.57, P < 0.05). The changes in urinary TAs, iAs, MMA, DMA levels, iAs percentage (iAs%), DMA percentage (DMA%), and primary methylation index (PMI) in different outcome groups of skin pigmentation abnormalities were compared, and the differences were statistically significant ( H = 8.04, 10.67, 8.29, 9.14, 6.30, 9.10, 7.20, P < 0.05). (2) The comparison of amplitudes in urinary TAs, iAs, MMA, and DMA levels in different outcome groups of skin keratinization showed statistically significant differences ( H = 6.92, 7.34, 6.66, 6.16, P < 0.05). The amplitudes in urinary iAs level, iAs%, DMA%, and PMI in different outcome groups of skin pigmentation abnormalities were compared, and the differences were statistically significant ( H = 7.94, 7.61, 9.95, 7.22, P < 0.05). Conclusion:The changes pattern of urinary TAs, iAs, MMA, DMA, iAs%, DMA%, and PMI in population exposed to arsenic through drinking water is related to the transformation of skin keratinization and pigmentation abnormalities.

Objective:Based on the investigation on the advantages of Traditional Chinese Medicine(TCM)participation in the field of basic public health services,exploring how TCM participates in public health.Methods:It searched for policies related to basic public health services and conducted a questionnaire survey on 2 995 people working in public health-related jobs in Beijing to conduct an empirical study on the advantages of Chinese medicine and the current status of participation.Results:2 982 valid questionnaires were collected,and practitioners in the field of public health services in Beijing had a high level of attention and recognition towards the participation of TCM.TCM is generally considered to have obvious advantages in basic public health services such as responding to epidemics,preventing and treating chronic diseases,and managing the health of Children 0-6 Years and the elderly.However,TCM shows overall shortcomings in emphasis,talent allocation,infrastructure construction,public perception and resource balance.Conclusion:To play the ascendant role and enhance the service capacity of TCM,basic public health services can be further developed by optimizing mechanisms related to the participation of TCM in disease prevention and control,chronic disease management,children's,and elderly health management.Basic public health services can enhance the service capacity of TCM from several aspects such as increasing financial support,strengthening the cultivation and management of TCM talents,and emphasizing grassroots and balanced resource allocation of TCM.

Objective:Based on the investigation on the advantages of Traditional Chinese Medicine(TCM)participation in the field of basic public health services,exploring how TCM participates in public health.Methods:It searched for policies related to basic public health services and conducted a questionnaire survey on 2 995 people working in public health-related jobs in Beijing to conduct an empirical study on the advantages of Chinese medicine and the current status of participation.Results:2 982 valid questionnaires were collected,and practitioners in the field of public health services in Beijing had a high level of attention and recognition towards the participation of TCM.TCM is generally considered to have obvious advantages in basic public health services such as responding to epidemics,preventing and treating chronic diseases,and managing the health of Children 0-6 Years and the elderly.However,TCM shows overall shortcomings in emphasis,talent allocation,infrastructure construction,public perception and resource balance.Conclusion:To play the ascendant role and enhance the service capacity of TCM,basic public health services can be further developed by optimizing mechanisms related to the participation of TCM in disease prevention and control,chronic disease management,children's,and elderly health management.Basic public health services can enhance the service capacity of TCM from several aspects such as increasing financial support,strengthening the cultivation and management of TCM talents,and emphasizing grassroots and balanced resource allocation of TCM.

Objective:Based on the investigation on the advantages of Traditional Chinese Medicine(TCM)participation in the field of basic public health services,exploring how TCM participates in public health.Methods:It searched for policies related to basic public health services and conducted a questionnaire survey on 2 995 people working in public health-related jobs in Beijing to conduct an empirical study on the advantages of Chinese medicine and the current status of participation.Results:2 982 valid questionnaires were collected,and practitioners in the field of public health services in Beijing had a high level of attention and recognition towards the participation of TCM.TCM is generally considered to have obvious advantages in basic public health services such as responding to epidemics,preventing and treating chronic diseases,and managing the health of Children 0-6 Years and the elderly.However,TCM shows overall shortcomings in emphasis,talent allocation,infrastructure construction,public perception and resource balance.Conclusion:To play the ascendant role and enhance the service capacity of TCM,basic public health services can be further developed by optimizing mechanisms related to the participation of TCM in disease prevention and control,chronic disease management,children's,and elderly health management.Basic public health services can enhance the service capacity of TCM from several aspects such as increasing financial support,strengthening the cultivation and management of TCM talents,and emphasizing grassroots and balanced resource allocation of TCM.

Objective:Based on the investigation on the advantages of Traditional Chinese Medicine(TCM)participation in the field of basic public health services,exploring how TCM participates in public health.Methods:It searched for policies related to basic public health services and conducted a questionnaire survey on 2 995 people working in public health-related jobs in Beijing to conduct an empirical study on the advantages of Chinese medicine and the current status of participation.Results:2 982 valid questionnaires were collected,and practitioners in the field of public health services in Beijing had a high level of attention and recognition towards the participation of TCM.TCM is generally considered to have obvious advantages in basic public health services such as responding to epidemics,preventing and treating chronic diseases,and managing the health of Children 0-6 Years and the elderly.However,TCM shows overall shortcomings in emphasis,talent allocation,infrastructure construction,public perception and resource balance.Conclusion:To play the ascendant role and enhance the service capacity of TCM,basic public health services can be further developed by optimizing mechanisms related to the participation of TCM in disease prevention and control,chronic disease management,children's,and elderly health management.Basic public health services can enhance the service capacity of TCM from several aspects such as increasing financial support,strengthening the cultivation and management of TCM talents,and emphasizing grassroots and balanced resource allocation of TCM.