With the rapid development of the healthcare industry and the deepening implementation of the Healthy China strategy,high-quality development has become the core goal of China's healthcare service system construction.As an important component of the healthcare service system,research-oriented hospitals undertake multiple missions such as technological innovation,clinical translation,and talent cultivation.A team of communication experts and lead authors jointly participated in the compilation of the expert group's related expert team to comprehensively analyze the current development status,existing problems,and future directions of research-oriented hospitals in China.After inviting well-known experts in hospital management from across the country to discuss and exchange ideas,it proposed a consensus on the construction mode and path of research-oriented hospitals in China under high-quality development,aiming to further guide and standardize the current construction work of research-oriented hospitals in China,and provide reference for the formulation and practice of relevant policies at the national and provincial levels.

With the rapid development of the healthcare industry and the deepening implementation of the Healthy China strategy,high-quality development has become the core goal of China's healthcare service system construction.As an important component of the healthcare service system,research-oriented hospitals undertake multiple missions such as technological innovation,clinical translation,and talent cultivation.A team of communication experts and lead authors jointly participated in the compilation of the expert group's related expert team to comprehensively analyze the current development status,existing problems,and future directions of research-oriented hospitals in China.After inviting well-known experts in hospital management from across the country to discuss and exchange ideas,it proposed a consensus on the construction mode and path of research-oriented hospitals in China under high-quality development,aiming to further guide and standardize the current construction work of research-oriented hospitals in China,and provide reference for the formulation and practice of relevant policies at the national and provincial levels.

Objective: Through the study of angiotensinⅡ- type 2 receptor agonist (AT2R) after pretreatment of mechanical ventilation lung injury (VILI) in rats model, to clarify the role of angiotensin Ⅱ - type 2 receptor agonist (C21) in alleviating VILI inflammation and the damage of immune function and its possible mechanism. Methods: In this experiment, the acute lung injury model was established by mechanical spring-volume ventilation in SD rats, and C21 pretreatment was performed to observe the pathological condition of lung tissue in rats with different ventilation duration, and to detect the inflammatory changes of BALF lavage fluid. Flow cytometry was used to detect the CD68+/iNOS+ labeled M1 type AMφ and the CD68+/Arg-1+ labeled M2 type AMφ in alveolar lavage fluid. Results: The mechanical VILI rat model was successfully established. The pathological injury score of the mechanical ventilation 4 h model, the wet/dry weight of lung tissue, the number of cells and protein in BALF lavage fluid were increased significantly, the levels of TNF-α and IL - 1 were increased significantly, the levels of IL-4 and IL-10 were decreased significantly, and the level of inflammatory reaction decreased with the increase of ventilation time. The M1/M2 ratio in the 4 h ventilation model group was the highest, which was significantly different from the control group (P<0.05). Compared to the model group, the C21 pretreatment significantly reduced the levels of proinflammatory factors TNF-αand IL-1, and increased the levels of anti-inflammatory factors IL-4 and IL-10 in BALF (P<0.01). After the intervention of AT2R agonist at 4 h, 6 h and 8 h, the M1/M2 ratio of the model was lower than that of the model without AT2R agonist at 4 h, 6 h and 8 h. Conclusion Mechanical ventilation for 4 h in SD rats can establish a mechanical ventilation lung injury model. AT2R agonist C21 can promote the polarization of macrophages to m2-type, and C21 pretreatment may alleviate VILI inflammation and immune damage by altering the polarization of macrophages.

Objective To study the chemical constituents of Phlomis medicinalis.Methods The constituents were isolated and purified by various modern chromatography techniques and the structures were elucidated by physicochemical properties and spectral analyses.Results Ten compounds were obtained and elucidated as 1-dehydroxyshanzhigenin methyl ester(Ⅰ),notohamosin A(Ⅱ),verbascoside(Ⅲ),3,4-dihydroxyphenyl ethanol(Ⅳ),succinic acid(Ⅴ),sucrose(Ⅵ),2,6-difructose(Ⅶ),butyl-?-D-fructopyanoside(Ⅷ),D-glucose(Ⅸ),and D-fructose(Ⅹ).Conclusion All the compounds are isolated from this plant for the first time,compound Ⅱ is obtained from the plants of Phlomis Linn.for the first time,and compound Ⅰ is a new one.

Objective To determine ecdysterone content in Radix Achyranthis Bidentalae by near-infrared diffuse reflectance spectroscopy (NIRDRS) combined with partial least squares (PLS). Methods NIRDRS and PLS. Results The correlation coefficient of the quantitative mathematics model between the prediction and the true values was 0.948 9. It is feasible to appling the above established method to determination of chemical constituents in Chinese materia medica. Conclusion Compared with other methods, the method is simple, rapid, high efficient, low expenditure, no pollution and with preparation undone and is suit for large quantity of unknown samples.