Objective:To study the level of resilience and influencing factors in patients with Crohn′s disease (CD) .Methods:A cross-sectional survey was conducted. The convenience sampling method was used to select CD patients admitted to Ruijin Hospital of Shanghai Jiao Tong University School of Medicine from November 2021 to July 2022. An electronic questionnaire was distributed for investigation, including general information, Connor-Davidson resilience scale, simplified coping style scale, general self-efficacy scale, emotion regulation questionnaire, family care index scale and perceived social support scale. The influencing factors of resilience in CD patients were analyzed through univariate analysis, Pearson correlation analysis, and multiple linear stepwise regression analysis.Results:A total of 155 valid questionnaires were collected. Among the 155 CD patients, there were 92 males (59.4%) and 63 females (40.6%). The average age was (36.82 ± 12.22) years, with a disease duration of 4.5 (2.0, 10.0) years. The Crohn′s disease activity index score was 70.25 (30.12, 115.19) points, and 38 patients (24.5%) had undergone intestinal surgery. The total score of resilience was (64.25 ± 15.12) points and at a moderate level. Univariate analysis showed that there were significant differences in resilience among CD patients with different genders, employment statuses, medical insurance forms, and whether they had undergone intestinal surgery (all P<0.05). And there were significant differences in the optimism dimension of resilience among CD patients with different education levels and monthly household incomes (all P<0.05). Correlation analysis found that resilience in CD patients was positively correlated with self-efficacy ( r = 0.715, P<0.01), positive coping ( r = 0.553, P<0.01) and negative coping ( r = 0.172, P=0.033) in coping styles, family support ( r = 0.448, P<0.01), friend support ( r = 0.434, P<0.01), and other support ( r = 0.478, P<0.01) in perceived social support, and expression suppression ( r = 0.431, P<0.01) and reappraisal ( r = 0.606, P<0.01) in emotion regulation. Multiple linear stepwise regression analysis revealed that self-efficacy, positive coping, negative coping, gender, whether they had undergone intestinal surgery, and monthly household income were independent influencing factors for resilience in CD patients (all P<0.05), and the influence decreased in sequence. Conclusions:The CD patients with high self-efficacy, more positive coping, less negative coping, high monthly household income, history of intestinal surgery, and being male may have higher level of resilience. And self-efficacy has the greatest impact.

Objective:To study the level of resilience and influencing factors in patients with Crohn′s disease (CD) .Methods:A cross-sectional survey was conducted. The convenience sampling method was used to select CD patients admitted to Ruijin Hospital of Shanghai Jiao Tong University School of Medicine from November 2021 to July 2022. An electronic questionnaire was distributed for investigation, including general information, Connor-Davidson resilience scale, simplified coping style scale, general self-efficacy scale, emotion regulation questionnaire, family care index scale and perceived social support scale. The influencing factors of resilience in CD patients were analyzed through univariate analysis, Pearson correlation analysis, and multiple linear stepwise regression analysis.Results:A total of 155 valid questionnaires were collected. Among the 155 CD patients, there were 92 males (59.4%) and 63 females (40.6%). The average age was (36.82 ± 12.22) years, with a disease duration of 4.5 (2.0, 10.0) years. The Crohn′s disease activity index score was 70.25 (30.12, 115.19) points, and 38 patients (24.5%) had undergone intestinal surgery. The total score of resilience was (64.25 ± 15.12) points and at a moderate level. Univariate analysis showed that there were significant differences in resilience among CD patients with different genders, employment statuses, medical insurance forms, and whether they had undergone intestinal surgery (all P<0.05). And there were significant differences in the optimism dimension of resilience among CD patients with different education levels and monthly household incomes (all P<0.05). Correlation analysis found that resilience in CD patients was positively correlated with self-efficacy ( r = 0.715, P<0.01), positive coping ( r = 0.553, P<0.01) and negative coping ( r = 0.172, P=0.033) in coping styles, family support ( r = 0.448, P<0.01), friend support ( r = 0.434, P<0.01), and other support ( r = 0.478, P<0.01) in perceived social support, and expression suppression ( r = 0.431, P<0.01) and reappraisal ( r = 0.606, P<0.01) in emotion regulation. Multiple linear stepwise regression analysis revealed that self-efficacy, positive coping, negative coping, gender, whether they had undergone intestinal surgery, and monthly household income were independent influencing factors for resilience in CD patients (all P<0.05), and the influence decreased in sequence. Conclusions:The CD patients with high self-efficacy, more positive coping, less negative coping, high monthly household income, history of intestinal surgery, and being male may have higher level of resilience. And self-efficacy has the greatest impact.

In recent years, the research on boron-containing drugs, especially boric acid drugs, has been increasing gradually.Boron-containing drugs, which have been a new area of research for pharmaceutical chemists in the development of new drugs, play an increasingly important anti-inflammatory, antibacterial, and anti-tumor role.At present, five boron-containing drugs have been approved, many are under clinical trials, and more are under investigation around the world, which has greatly expanded the application of boron in the research of new drugs.This paper introduces the characteristics of boron, and reviews the indications of representative boron-containing drugs in various research stages, their binding mechanisms with targets, and their progress after entering clinical trials, aiming to provide reference for further research on boron-containing drugs.

Objective:To analyze and discuss the psychological needs of family members of critically ill burn inpatients in semi-closed wards and their related influence factors.Methods:A cross-sectional survey was conducted among the 82 burn patients, who met the inclusion criteria and were admitted to the Department of Burns and Plastic Surgery of Ruijin Hospital of Shanghai Jiao Tong University School of Medicine from October 2018 to April 2019, and their family members. A general condition questionnaire of 15 indexes was applied to investigate the general data of burn patients and their family members including cause of burn, gender, age, total burn area, burn depth, burn severity, burn site, and type of medical insurance of patients, kinship with the patients, gender, age, experience of accompanying in intensive care isolation wards, occupation, education level, and monthly income of their family members. The Critical Care Family Needs Inventory (CCFNI) was used to assess each item, each factor, and total scores of the family members of patients including 5 factors and 45 items such as support scale (SS), comfort scale (CS), information scale (IS), proximity scale (PS), assurance scale (AS). CCFNI was used to assess the total scores of patients and their family members after classification according to the general data, the data were statistically analyzed with one-way analysis of variance or independent sample t test. Indicators with statistical significance in the above analysis were selected for multiple linear regression analysis to screen the independent influence factors of psychological needs of patients' family members. CCFNI was used to assess each dimension scores of patients and their family members after classification according to the aforementioned selected independent influence factors including age and burn area of patients, gender, educational level, and experience of accompanying in intensive care isolation wards of their family members, and the data were statistically analyzed with one-way analysis of variance or independent sample t test. Results:A total of 82 questionnaires were sent out in this study, and 80 were effectively received, with s a recovery rate of 97.6%. In 80 patients, there were 45 males and 35 females; 35 cases (43.75%) were ≤14 years; most of the patients had flame and thermal burns; 33 patients (41.25%), 21 patients (26.25%), and 26 patients (32.50%) had moderate, severe, and extremely severe burns, respectively; and only 3 patients (3.75%) had no health insurance. In 80 family members of patients, 34 (42.50%) were males and 46 (57.50%) were females; 62.50% in the family members of patients were concentrated between 18 and 45 years old; and 12 family members of patients had experience of accompanying in intensive care isolation wards, accounting for 15.00%. The total CCFNI score of the family members was (141±14) points, and the scores of AS, PS, IS, CS, and SS were (3.77±0.23), (3.43±0.37), (3.53±0.34), (2.50±0.59), and (2.69±0.45) points, respectively. The top five items of the psychological needs of family members of patients were concentrated in three factors (AS, PS, and IS), and the item "ensuring that patients receive the best treatment" ranked the first, with a score of (3.99±0.11) points. There were significant differences on the CCFNI total scores of patients with different age, total burns area, and severity of burns and of their family members with different gender, education level, and whether or not experience of accompanying in intensive care isolation unit ( F=4.378, 5.481, 5.913, t=4.027, 14.339, 7.265, P<0.05 or P<0.01). Multiple linear regression analysis showed that the patient's age (≤14, 15-45 years) and total burn area (11%-30%, 31%-49%, ≥50% TBSA) and the patient's family members' gender, educational level, experience of accompanying in intensive care isolation unit could affect the psychological needs of family members of patients ( t=3.133, 2.260, 2.297, 2.433, 3.015, 2.200, 2.102, 2.463, P<0.05 or P<0.01). There was statistically significant difference in AS score of the patients' family members with different age ( F=4.390, P<0.05). There were significant differences in both IS and AS scores of the patients' family members of patients with different burn area ( F=5.042, 3.131, P<0.05 or P<0.01). The AS score of the patients' family members with experience of accompanying in intensive care isolation unit was significantly lower than those without ( t=-1.040, P<0.05). The SS score of the patients' family members with college education or above was significantly higher than those with high school (technical secondary school) or below ( t=0.657, P<0.05). The IS score of the patients' family members with college education or above was significantly lower than those with high school (technical secondary school) or below ( t=-1.438, P<0.05). The SS score of male family members of patients was significantly lower than those of female patients ( t=4.149, P<0.05). Conclusions:The family members of burn patients in semi-closed ward have the most urgent need to ensure the patients receive the best treatment. Patients' age, total burn area, and their family members' gender, education level, experience of accompanying in intensive care isolation unit are the main factors affecting the psychological needs of family members of patients.