The application of research-oriented thinking to audit work represents a new-era requirement for audit practices.Research-based audit enhances audit effectiveness and strengthens oversight outcomes.Based on the characteristics of public hospitals,it expounds the connotation of research-based internal audit of public hospitals based on audit elements,and proposes three research-based internal audit models of public hospitals:policy-centered,project-centered,and fund-centered approaches.The characteristics and applicable conditions of the three modes are analyzed to provide references for public hospitals to conduct internal audits under the goal of achieving high-quality development.

Objective To investigate the predictive value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)radiomics combined with Magee equation 3(ME3)for pathological response following neoadjuvant chemotherapy(NAC)in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR+/HER2-)breast cancer.Methods A ret-rospective analysis was performed on 325 breast cancer patients diagnosed with HR+/HER2-in two hospitals.Patients from the first hospital were randomly divided into training and internal validation sets at a ratio of 7∶3.Patients from the second hospital served as external validation set.The volume of interest(VOI)of breast cancer was delineated on DCE-MRI images.Then the rele-vant radiomics features were extracted and selected,and the Radiomics score(Radscore)was calculated.The statistically significant clinical and pathological features and Radscore were incorporated into a multivariate analysis.The combined radiomics-clinical model and nomogram were established,and the prediction performance was evaluated by using the receiver operating characteristic(ROC)curve,calibration curve,and decision curve analysis(DCA).Results In the training set,seven radiomics features were selected to construct the radiomics model.ME3 score emerged as the independent factor for pathological complete response(pCR)(P＜0.001).By integrating ME3 score and Radscore,a combined radiomics-clinical model was developed.This model demonstrated robust predictive accuracy,with area under the curve(AUC)of 0.88[95％confidence interval(CI)0.80-0.95],0.90(95％CI 0.82-0.98),and 0.82(95％CI 0.70-0.93)in the training,internal validation,and external validation sets,respectively.The nomogram construc-ted from the combined model exhibited excellent discrimination and calibration,with P-values of 0.455,0.312 and 0.062 in the train-ing,internal validation,and external validation sets.Conclusion DCE-MRI radiomics combined with ME3 can be used to predict the pathological response of NAC in HR+/HER2-breast cancer.

Gastric cancer, a highly malignant tumor, has seen a persistent rise in global incidence in recent years. Claudin 18.2, a protein with highly specific expression in gastric cancer, has emerged as a prominent research target in therapeutic development. The overexpression of Claudin 18.2 in gastric cancer cells and its abnormal surface exposure provide novel opportunities for targeted and immunotherapeutic interventions. Therapeutic approaches targeting Claudin 18.2 have shown promising initial results in clinical trials, primarily including monoclonal antibodies and chimeric antigen receptor T-cell therapies. The authors systematically summarize the biological characteristics, mechanism of action, clinical research progress, and future treatment prospects and challenges of Claudin 18.2.

Objective To investigate the predictive value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)radiomics combined with Magee equation 3(ME3)for pathological response following neoadjuvant chemotherapy(NAC)in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR+/HER2-)breast cancer.Methods A ret-rospective analysis was performed on 325 breast cancer patients diagnosed with HR+/HER2-in two hospitals.Patients from the first hospital were randomly divided into training and internal validation sets at a ratio of 7∶3.Patients from the second hospital served as external validation set.The volume of interest(VOI)of breast cancer was delineated on DCE-MRI images.Then the rele-vant radiomics features were extracted and selected,and the Radiomics score(Radscore)was calculated.The statistically significant clinical and pathological features and Radscore were incorporated into a multivariate analysis.The combined radiomics-clinical model and nomogram were established,and the prediction performance was evaluated by using the receiver operating characteristic(ROC)curve,calibration curve,and decision curve analysis(DCA).Results In the training set,seven radiomics features were selected to construct the radiomics model.ME3 score emerged as the independent factor for pathological complete response(pCR)(P＜0.001).By integrating ME3 score and Radscore,a combined radiomics-clinical model was developed.This model demonstrated robust predictive accuracy,with area under the curve(AUC)of 0.88[95％confidence interval(CI)0.80-0.95],0.90(95％CI 0.82-0.98),and 0.82(95％CI 0.70-0.93)in the training,internal validation,and external validation sets,respectively.The nomogram construc-ted from the combined model exhibited excellent discrimination and calibration,with P-values of 0.455,0.312 and 0.062 in the train-ing,internal validation,and external validation sets.Conclusion DCE-MRI radiomics combined with ME3 can be used to predict the pathological response of NAC in HR+/HER2-breast cancer.

The application of research-oriented thinking to audit work represents a new-era requirement for audit practices.Research-based audit enhances audit effectiveness and strengthens oversight outcomes.Based on the characteristics of public hospitals,it expounds the connotation of research-based internal audit of public hospitals based on audit elements,and proposes three research-based internal audit models of public hospitals:policy-centered,project-centered,and fund-centered approaches.The characteristics and applicable conditions of the three modes are analyzed to provide references for public hospitals to conduct internal audits under the goal of achieving high-quality development.

Gastric cancer, a highly malignant tumor, has seen a persistent rise in global incidence in recent years. Claudin 18.2, a protein with highly specific expression in gastric cancer, has emerged as a prominent research target in therapeutic development. The overexpression of Claudin 18.2 in gastric cancer cells and its abnormal surface exposure provide novel opportunities for targeted and immunotherapeutic interventions. Therapeutic approaches targeting Claudin 18.2 have shown promising initial results in clinical trials, primarily including monoclonal antibodies and chimeric antigen receptor T-cell therapies. The authors systematically summarize the biological characteristics, mechanism of action, clinical research progress, and future treatment prospects and challenges of Claudin 18.2.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.

The modemization of medical and health governance is an integral part of the modernization of national govemance and a key livelihood issue.As an important part of the Party and state supervision system,audit supervision has played a positive role in the field of medical and health management.With the requirement of modernization of medical and health management,the medical and health system has undergone fundamental reform.On the basis of analyzing the modernization of medical and health governance and combining the needs of national audit for the modernization of medical and health governance,it builds a national audit supervi-sion system to promote the modernization of medical and health governance,explores the collaborative implementation path of audit business,in order to provide references and inspiration for carrying out audits in the field of medical and health governance.