Choledochojejunostomy is a common surgical method for the treatment of organ diseases such as hepatobiliary, gastrointestinal and pancreatic diseases, but there are many complications related to the operation. Benign biliary-enteric anastomosis stricture (BBES) is the most common long-term complication after operation, which seriously affects the quality of life of patients. At present, bile duct reconstruction and endoscopic treatment are the main methods to deal with BBES, but there are some limitations. The new interventional therapy has the advantages of small trauma, good repeatability, high success rate and few complications. It has been applied in many medical centers. The main treatment methods include percutaneous transhepatic biliary balloon dilatation, percutaneous temporary stent placement, percutaneous transhepatic choledochoscopy, magnetic compression anastomosis and intrabiliary ablation. Up to now, there is no uniform standard for the choice of interventional therapy for BBES at home and abroad, so it is of great clinical significance to establish a standardized interventional therapy strategy.

Objective:To investigate the cultural construction of Traditional Chinese Medicine(TCM) hospitals in Hunan province, for reference in their cultural construction.Methods:A questionnaire was designed according to TCM Hospital Cultural Construction Guidelines by the National Traditional Chinese Administration.From May to June 2020, the questionnaire was used to survey the present situation, existing problems and development suggestions of TCM cultural construction at TCM hospitals of and above the county level in Hunan province. The data were analyzed by descriptive analysis.Results:The survey covered 117 public TCM hospitals in the province and 87 questionnaires were recovered, a rate of 74.4%. In terms of cultural construction in these institutions, various programs were in place at a relatively high proportion in the core cultural value construction. The development of behavioral norms teaching and inheritance was in place at a relatively low proportion, namely 78.8% at tertiary TCM hospitals, 51.8% at secondary TCM hospitals, and only 16.7% at secondary level-B TCM hospitals. In terms of environmental image construction, various programs were in place at a relatively high proportion, yet focusing on themed cultural wall posters culturol bulletin board and other forms of display. At present, the main problems were insufficient funding(86.9%) and talents(82.1%).Conclusions:TCM hospitals in Hunan province highly value the construction of cultural core value and environmental image, but their development in the code of conduct system and other connotation was weak.

Objective:This study was aimed to explore the structural changes of grey matter (GM) in drug-naive patients with first-onset major depressive disorder (MDD) by using deformation-based morphometry (DBM) and the possible imaging biomarkers for early diagnosis of MDD.Methods:3D T 1-weighted structural MRI scans were performed on 38 MDD patients and 65 healthy controls (HCs), matched with age and gender. DBM and region of interests (ROIs) approaches were used to compare the gray matter (GM) Jacobian determinant and GM volume (GMV) between MDD group and HCs group. The receiver operating characteristic curve (ROC) was used to test the diagnostic value of the grey matter volume of statistically different regions for MDD. Results:MDD patients showed significant GM atrophy in the right anterior cingulate cortex (ACC), right precentral cortex and left paracentral cortex (voxel peak-level P<0.001,cluster size>120). The GMV of the right ACC, right precentral cortex and left paracentral cortex in MDD group were significantly smaller than those in HCs group ( P<0.01, two-tailed). The GMV of the right ACC showed a certain value for the diagnosis of MDD, with the area under curve (AUC) of 0.733, and a suggested cutoff value of 0.414. Conclusion:The DBM method can detect the GM atrophy and GMV reduction in the prefrontal and parietal regions, which reflect the changes in the GM microstructural of gray matter in early MDD. The GMV of the right ACC might be the imaging indicator for the early diagnosis of MDD.

Objective:This study was aimed to explore the structural changes of grey matter (GM) in drug-naive patients with first-onset major depressive disorder (MDD) by using deformation-based morphometry (DBM) and the possible imaging biomarkers for early diagnosis of MDD.Methods:3D T 1-weighted structural MRI scans were performed on 38 MDD patients and 65 healthy controls (HCs), matched with age and gender. DBM and region of interests (ROIs) approaches were used to compare the gray matter (GM) Jacobian determinant and GM volume (GMV) between MDD group and HCs group. The receiver operating characteristic curve (ROC) was used to test the diagnostic value of the grey matter volume of statistically different regions for MDD. Results:MDD patients showed significant GM atrophy in the right anterior cingulate cortex (ACC), right precentral cortex and left paracentral cortex (voxel peak-level P<0.001,cluster size>120). The GMV of the right ACC, right precentral cortex and left paracentral cortex in MDD group were significantly smaller than those in HCs group ( P<0.01, two-tailed). The GMV of the right ACC showed a certain value for the diagnosis of MDD, with the area under curve (AUC) of 0.733, and a suggested cutoff value of 0.414. Conclusion:The DBM method can detect the GM atrophy and GMV reduction in the prefrontal and parietal regions, which reflect the changes in the GM microstructural of gray matter in early MDD. The GMV of the right ACC might be the imaging indicator for the early diagnosis of MDD.

Objective To promote application and explore the old Chinese tradition of academic experience and their experience side mode.Methods In the study, the model of translational medicine was studied combined with the characteristics of Chinese medicine, taken the model from clinical to basic (experimental) to clinical research, combined with prospective and review of the clinical and research methods, with the modern information technology and other technological, and Tonifying Five Internal Organs(TFIO) byZhang-Chongquanfor treatment of coronary heart disease, vascular dementia.Results The article was Clarified the theory of TFIO byZhang-Chongquan,with clinical evidence.Conclusion The model of translational medicine can be used to summarize the academic experience.

OBJECTIVE:To establish a method for content determination of the total naphthoquinone in oil/water emul?sion of shikonin by ultraviolet spectrophotometry.METHODS:The content of the total naphthoquinone was counted in L-shikonin,methanol was used as solvent and the wavelength was set at516nm.RESULTS:The concentration of L-shikonin had good linear correlation with absorbance in the range of8.32～41.60?g/ml(r=1.0000,n=5),the average recovery was98.6%(RSD=0.53%).CONCLUSIONS:The present method is simple,precise and replicable resulting in high recovery and accuracy,it can be used to determine the content of total naphthoquinone in oil/water emulsion of shikonin.