Objective:To explore the chain mediating effect of coping style and illness perception between intolerance of uncertainty and fear of disease progression in patients with intracranial aneurysm.Methods:A total of 270 patients with intracranial aneurysms admitted to the neurosurgery department of 2 hospitals in Guangzhou from October 2023 to June 2024 were selected by convenience sampling method. The general information questionnaire, intolerance of uncertainty scale-12, the brief disease perception questionnaire, medical coping mode questionnaire(MCMQ) and fear of progression questionnaire-short form were used to investigate the subjects. Statistical description and Spearman correlation analysis were performed using IBM SPSS 25.0 software, and AMOS 23.0 software was used to test and correct the structural equation models.Results:The total score of fear of disease progression in patients with intracranial aneurysms was 27.50(20.00, 34.00). The total score of intolerance of uncertainty was 23.50(19.75, 29.00). The sores of confrontation, avoidance and submission in MCMQ were 18.69±5.44, 12.00(10.00, 15.00) and 7.00(5.00, 9.00), respectively.The total score of illness perception was 37.23±11.60. Fear of disease progression was positively correlated with intolerance of uncertainty, submission and illness perception ( r=0.614, 0.696, 0.680, all P<0.01). The direct effect of intolerance of uncertainty on fear of disease progression was significant in patients with intracranial aneurysms ( β=0.431, P<0.001). Intolerance of uncertainty indirectly affected fear of disease progression through submission ( β=0.181, P<0.001) and illness perception ( β=0.092, P<0.001). Submission and illness perception played chain-mediating effect in the relationship between intolerance of uncertainty and fear of disease progression ( β=0.103, P<0.001). Conclusion:The intolerance of uncertainty in patients with intracranial aneurysms can positively predict the fear of disease progression. Submission and illness perception played a chain mediating role between intolerance of uncertainty and fear of disease progression in patients with intracranial aneurysms.

Objective:To explore the chain mediating effect of coping style and illness perception between intolerance of uncertainty and fear of disease progression in patients with intracranial aneurysm.Methods:A total of 270 patients with intracranial aneurysms admitted to the neurosurgery department of 2 hospitals in Guangzhou from October 2023 to June 2024 were selected by convenience sampling method. The general information questionnaire, intolerance of uncertainty scale-12, the brief disease perception questionnaire, medical coping mode questionnaire(MCMQ) and fear of progression questionnaire-short form were used to investigate the subjects. Statistical description and Spearman correlation analysis were performed using IBM SPSS 25.0 software, and AMOS 23.0 software was used to test and correct the structural equation models.Results:The total score of fear of disease progression in patients with intracranial aneurysms was 27.50(20.00, 34.00). The total score of intolerance of uncertainty was 23.50(19.75, 29.00). The sores of confrontation, avoidance and submission in MCMQ were 18.69±5.44, 12.00(10.00, 15.00) and 7.00(5.00, 9.00), respectively.The total score of illness perception was 37.23±11.60. Fear of disease progression was positively correlated with intolerance of uncertainty, submission and illness perception ( r=0.614, 0.696, 0.680, all P<0.01). The direct effect of intolerance of uncertainty on fear of disease progression was significant in patients with intracranial aneurysms ( β=0.431, P<0.001). Intolerance of uncertainty indirectly affected fear of disease progression through submission ( β=0.181, P<0.001) and illness perception ( β=0.092, P<0.001). Submission and illness perception played chain-mediating effect in the relationship between intolerance of uncertainty and fear of disease progression ( β=0.103, P<0.001). Conclusion:The intolerance of uncertainty in patients with intracranial aneurysms can positively predict the fear of disease progression. Submission and illness perception played a chain mediating role between intolerance of uncertainty and fear of disease progression in patients with intracranial aneurysms.

Objective:To explore the current situation and influencing factors of home care needs of primary caregivers of stroke patients based on the existence-relatedness-growth (ERG) need theory, so as to provide reference for the development of effective intervention programs in the future.Methods:The supplemental sequential mixed methods design was adopted. From December 2023 to June 2024, convenience sampling was used to select the primary home caregivers ( n=210) of stroke patients as study subjects in community health service centers in Guangzhou. The survey was conducted using the General Information Questionnaire, Barthel Index, and Professional Care Needs Questionnaire for Family Caregivers of Stroke. Multiple linear regression was used to analyze the influencing factors of home care need scores. In July 2024, 11 primary home caregivers of stroke patients were selected for semi-structured interviews using purposive sampling method. NVivo14.0 software was used for data storage and processing, and Colaizzi 7-step method was used for extracting and summarizing interview data. Results:In the quantitative study, 210 questionnaires were distributed and 202 were effectively collected, with an effective response rate of 96.19%. The total score for home care needs of 202 primary caregivers was (117.31±13.64). Multiple linear regression analysis showed that patients' marital status, history of falls, activities of daily living, caregiver's educational level, average daily caregiving time, and number of caregivers were the influencing factors of home care need score ( P<0.05). In the qualitative study, three themes were distilled, namely the need for disease knowledge and rehabilitation skills, the need for emotional and psychological interventions, and the need for social resource utilization and economic support. Integrating the results of quantitative and qualitative studies revealed that primary caregivers of stroke patients were characterized by congruence, complementarity, and expansiveness in the three dimensions of ERG needs, respectively. Conclusions:The home care needs of primary caregivers of stroke patients present multidimensional and hierarchical characteristics and are influenced by multiple factors such as the functional status of the patients and the characteristics of the caregivers. The quality of community care services should be strengthened, community resource allocation should be optimized, and training programs based on the hierarchy of needs should be constructed to meet the home care needs of primary caregivers of stroke patients.

Objective:To explore the current situation and influencing factors of home care needs of primary caregivers of stroke patients based on the existence-relatedness-growth (ERG) need theory, so as to provide reference for the development of effective intervention programs in the future.Methods:The supplemental sequential mixed methods design was adopted. From December 2023 to June 2024, convenience sampling was used to select the primary home caregivers ( n=210) of stroke patients as study subjects in community health service centers in Guangzhou. The survey was conducted using the General Information Questionnaire, Barthel Index, and Professional Care Needs Questionnaire for Family Caregivers of Stroke. Multiple linear regression was used to analyze the influencing factors of home care need scores. In July 2024, 11 primary home caregivers of stroke patients were selected for semi-structured interviews using purposive sampling method. NVivo14.0 software was used for data storage and processing, and Colaizzi 7-step method was used for extracting and summarizing interview data. Results:In the quantitative study, 210 questionnaires were distributed and 202 were effectively collected, with an effective response rate of 96.19%. The total score for home care needs of 202 primary caregivers was (117.31±13.64). Multiple linear regression analysis showed that patients' marital status, history of falls, activities of daily living, caregiver's educational level, average daily caregiving time, and number of caregivers were the influencing factors of home care need score ( P<0.05). In the qualitative study, three themes were distilled, namely the need for disease knowledge and rehabilitation skills, the need for emotional and psychological interventions, and the need for social resource utilization and economic support. Integrating the results of quantitative and qualitative studies revealed that primary caregivers of stroke patients were characterized by congruence, complementarity, and expansiveness in the three dimensions of ERG needs, respectively. Conclusions:The home care needs of primary caregivers of stroke patients present multidimensional and hierarchical characteristics and are influenced by multiple factors such as the functional status of the patients and the characteristics of the caregivers. The quality of community care services should be strengthened, community resource allocation should be optimized, and training programs based on the hierarchy of needs should be constructed to meet the home care needs of primary caregivers of stroke patients.

Objective To evaluate the safety and effect of laryngeal mask airway (LMA) general anesthesia in neonatal laparoscopic pyloromyotomy. Methods The clinical data of 100 neonates who had underwent laparoscopic pyloromyotomy were retrospectively analyzed. The neonates were divided into LMA group (50 cases) and tracheal intubation group (50 cases) according to the anesthesia method. The heart rate and mean arterial pressure (MAP) were recorded at the time points of preanesthesia (T0), tracheal intubation (T1), 10 min after tracheal intubation (T2) and extubation (T3), and the extubation time, and consumption of sevoflurane and postoperative complications were also recorded. Results All the 2 groups had smooth intubation and LMA, and the operation was completed successfully under laparoscope. There was no conversion to laparotomy. In LMA group, there were no statistical difference in heart rate and MAP at all the time points (P>0.05). The heart rate and MAP at T1 and T3 in tracheal intubation group were significantly higher than those at T0, and there were statistical differences (P<0.05). The heart rate and MAP at T1 and T3 were significantly lower than those in tracheal intubation group, heart rate:(131.1 ± 11.0) times/min vs. (146.9 ± 13.7) times/min and (131.9 ± 9.8) times/min vs. (147.3 ± 14.6) times/min; MAP: (44.2 ± 5.5) mmHg (1 mmHg = 0.133 kPa) vs. (47.9 ± 8.4) mmHg and (45.1 ± 7.3) mmHg vs. (49.1 ± 9.4) mmHg, and there were statistical differences (P<0.01 or<0.05). The extubation time, consumption of sevoflurane and incidences of postoperative complications in LMA group were significantly lower than those in tracheal intubation group:(6.1 ± 2.2) min vs. (12.5 ± 3.6) min, (2.9 ± 1.1) ml vs. (5.1 ± 1.9) ml and 4％ (2/50) vs. 48％ (24/50), and there were statistical differences (P<0.01). Conclusions LMA anesthesia in neonatal laparoscopic surgery is activated to maintain the steadiness of hemodynamics, which has less stress, anesthetic drugs consumption and respiratory complications compared with tracheal intubation .

PURPOSE: Alendronate has been proposed as a local and systemic drug treatment used as an adjunct to scaling and root planing (SRP) for the treatment of periodontitis. However, its effectiveness has yet to be conclusively established. The purpose of the present meta-analysis was to assess the effectiveness of SRP with alendronate on periodontitis compared to SRP alone. METHODS: Five electronic databases were used by 2 independent reviewers to identify relevant articles from the earliest records up to September 2016. Randomized controlled trials (RCTs) comparing SRP with alendronate to SRP with placebo in the treatment of periodontitis were included. The outcome measures were changes in bone defect fill, probing depth (PD), and clinical attachment level (CAL) from baseline to 6 months. A fixed-effect or random-effect model was used to pool the extracted data, as appropriate. Mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using the Cochrane χ² and I2 tests. RESULTS: After the selection process, 8 articles were included in the meta-analysis. Compared with SRP alone, the adjunctive mean benefits of locally delivered alendronate were 38.25% for bone defect fill increase (95% CI=33.05–43.45; P<0.001; I²=94.0%), 2.29 mm for PD reduction (95% CI=2.07–2.52 mm; P<0.001; I²=0.0%) and 1.92 mm for CAL gain (95% CI=1.55–2.30 mm; P<0.001; I²=66.0%). In addition, systemically administered alendronate with SRP significantly reduced PD by 0.36 mm (95% CI=0.18–0.55 mm; P<0.001; I²=0.0%) and increased CAL by 0.39 mm (95% CI=0.11–0.68 mm; P=0.006; I²=6.0%). CONCLUSIONS: The collective evidence regarding the adjunctive use of alendronate locally and systemically with SRP indicates that the combined treatment can improve the efficacy of non-surgical periodontal therapy on increasing CAL and bone defect fill and reducing PD. However, precautions must be exercised in interpreting these results, and multicenter studies evaluating this specific application should be carried out.
Alendronate* ; Outcome Assessment (Health Care) ; Periodontitis* ; Population Characteristics ; Root Planing*