1.Analysis of radiosensitivity indicators for radiation workers at a nuclear power plant
Nan MA ; Junchao FENG ; Yulong LIU ; Jie LI ; Yu GAO
Chinese Journal of Radiological Health 2025;34(2):264-269
Objective To analyze the health effects of long-term occupational exposure to ionizing radiation on radiation workers in a nuclear power plant, and to provide a scientific basis for their occupational health monitoring. Methods In 2023, 183 radiation workers in a nuclear power plant were subjected to the analysis of blood cell parameters such as mean red blood cell count, white blood cell count (WBC), lymphocyte count, and hemoglobin count, thyroid function indicators such as serum triiodothyronine, thyroxine, and thyrotropin, as well as the chromosomal aberration rate and micronucleus rate of the lymphocytes in the peripheral blood. Results The blood cell parameters, thyroid function indicators, chromosomal aberration rate, and micronucleus rate of these radiation workers in the nuclear power plant were within normal reference ranges. Comparison among radiation workers with different ages showed statistically significant differences in triiodothyronine (H = 6.98, P < 0.05) and micronucleus rate (H = 48.44, P < 0.05). Among the three groups of radiation workers with different working years, WBC was significantly different (χ2 = 3.87, P < 0.05), with the lowest WBC observed in radiation workers with ≥ 20 years of service. Thyroxine (χ2 = 4.01, P < 0.05) and micronucleus rate (H = 40.95, P < 0.05) also varied significantly among these three groups. Conclusion Thyroid triiodothyronine level and micronucleus rate were affected by age, while WBC, thyroid thyroxine level, and micronucleus rate were related to working years. Targeted health management should be carried out for radiation workers in nuclear power plants to improve the awareness of radiation protection and continuously enhance their health status.
2.Exploring the Diagnosis and Treatment of Vascular Cognitive Impairment Based on the Relationship Between "Kidney Governing Water" and the Glymphatic System
Senlin CHEN ; Yu CHEN ; Yulong ZOU ; Zhichen WANG ; Gengzhao CHEN ; Qianhong ZHU ; Saie HUANG
Journal of Traditional Chinese Medicine 2025;66(11):1114-1118
Starting from the intrinsic relationship between the glymphatic system and the core pathogenesis of vascular cognitive impairment (VCI), including internal dampness, phlegm turbidity, and blood stasis, this paper explores clinical approaches to the diagnosis and treatment of VCI. Dysfunction of the kidney's role in governing water leads to the accumulation of dampness, phlegm turbidity, and blood stasis, which are key pathological mechanisms underlying the onset and progression of VCI. The glymphatic system participates in the circulation of cerebrospinal fluid within the central nervous system, and its impairment can result in reduced clearance of soluble metabolic waste products in the brain, a crucial factor contributing to VCI. It is proposed that the "kidney governing water" function is related to the glymphatic system, and that the cerebral collaterals correspond structurally to the glymphatic pathways. Clinically, therapies aimed at tonifying the kidney, resolving phlegm, activating blood circulation, and unblocking collaterals, such as modified Kaixin Powder (开心散), which eliminates dampness and turbidity, transforms phlegm, restores consciousness, enhances cognition, and strengthens the brain, are commonly employed. These treatments may improve VCI prognosis by regulating glymphatic system function, providing a theoretical basis for the prevention and treatment of VCI with traditional Chinese medicine.
3.Feasibility study on automatic dicentric chromosome detection and dose estimation using an artificial intelligence-based chromosome image scanning and processing system
Junchao FENG ; Chang LIU ; Yulong LIU ; Jie LI ; Yu GAO
Chinese Journal of Radiological Health 2025;34(4):571-577
Objective To compare the results obtained from an artificial intelligence (AI)-based chromosome image scanning and processing system, the Metafer 4 chromosome scanning and analysis system, and manual analysis of dicentric chromosomes, and to explore the feasibility of applying AI technology for dicentric chromosome detection and biological dose estimation. Methods Healthy human elbow vein blood was collected and subjected to 60Co in vitro irradiation. Chromosome samples were prepared using conventional methods. The slides were scanned and automatically analyzed using the AI-based system and the Metafer 4 system. The results were manually analyzed and confirmed. Results The number of cells was comparable between the AI-based system and the Metafer 4 system. However, the scanning speed of the AI-based system was 4.5 seconds per image, which was significantly faster than the 7.3 seconds per image of the Metafer 4 system (t = −6.19, P < 0.05). At a confidence level of 0.7, the AI-based system demonstrated a true positive rate of 96.7% and a false positive rate of 6.5%, which were significantly better than the true positive rate (45.4%-54.5%) and false positive rate (22.2%-29.2%) of the Metafer 4 system (all P < 0.05). In the biological dose estimation, the deviation of the dose-response curve was ≤ ± 10% in the automatic analysis using the Metafer 4 system. Due to the use of the manual dose-response curve, the deviation of the AI-based System was ≤ ± 15%. However, there were no significant differences in the estimated doses when the two systems were compared with the manual analysis (P > 0.05). Conclusion Both the AI-based chromosome image scanning and processing system and the Metafer 4 chromosome scanning and analysis system greatly improved the analysis speed of chromosome aberrations. However, the scanning speed, true positive rate, and false positive rate of the AI-based system were superior to those of the Metafer 4 system. Therefore, the AI-based system is more suitable for rapid and high-throughput biological dose estimation in large-scale radiation accidents.
4.Efficacy and safety of using an enteral immunonutrition formula in the enhanced recovery after surgery protocol for Chinese patients with gastrointestinal cancers undergoing surgery: A randomized, open-label, multicenter trial (healing trial).
Jianchun YU ; Gang XIAO ; Yanbing ZHOU ; Yingjiang YE ; Han LIANG ; Guole LIN ; Qi AN ; Xiaodong LIU ; Bin LIANG ; Baogui WANG ; Weiming KANG ; Tao YU ; Yulong TIAN ; Chao WANG ; Xiaona WANG
Chinese Medical Journal 2025;138(21):2847-2849
5.Off-the-shelf human umbilical cord mesenchymal stromal cell product in acute-on-chronic liver failure: A multicenter phase I/II clinical trial.
Lina CUI ; Huaibin ZOU ; Shaoli YOU ; Changcun GUO ; Jundong GU ; Yulong SHANG ; Gui JIA ; Linhua ZHENG ; Juan DENG ; Xiufang WANG ; Ruiqing SUN ; Dawei DING ; Weijie WANG ; Xia ZHOU ; Guanya GUO ; Yansheng LIU ; Zhongchao HAN ; Zhibo HAN ; Yu CHEN ; Ying HAN
Chinese Medical Journal 2025;138(18):2347-2349
6."Minimal harm"and"optimal care":the concepts and practices of medical humanities in enhanced recovery after surgery
Longwen FU ; Changhua ZHANG ; Honglu XU ; Yu CHENG ; Yulong HE
Chinese Medical Ethics 2024;37(8):932-940
In recent years,enhanced recovery after surgery(ERAS)has been widely used in clinical practice,aiming to optimize perioperative management measures through evidence-based medicine and reduce the physical and mental trauma,stress reactions,and complications of surgical patients through multidisciplinary collaboration.This paper examined the clinical practice of ERAS from the perspective of medical humanities,reviewed its development and characteristics,and first pointed out that the concept of"minimal harm"laid the medical humanities foundation for ERAS.However,the concept of"minimum harm"faced ethical and realistic challenges in practice,such as differentiated cognition between benefits and non-harm,the tension between generalization and personalization,and the gap between rehabilitation continuity and family care.This paper led into the caregiving perspective of social sciences,proposed"optimal care"as a supplement to the medical humanities concept of ERAS,and introduced its connotation and practice.The combination of"minimal harm"and"optimal care"can provide theoretical guidance for medical humanistic care in ERAS and innovate the practical path of medical humanities into clinical practice.
7.“Minimal harm”and“optimal care”:the concepts and practices of medical humanities in enhanced recovery after surgery
Longwen FU ; Changhua ZHANG ; Honglu XU ; Yu CHENG ; Yulong HE
Chinese Medical Ethics 2024;37(8):932-940
In recent years, enhanced recovery after surgery (ERAS) has been widely used in clinical practice, aiming to optimize perioperative management measures through evidence-based medicine and reduce the physical and mental trauma, stress reactions, and complications of surgical patients through multidisciplinary collaboration. This paper examined the clinical practice of ERAS from the perspective of medical humanities, reviewed its development and characteristics, and first pointed out that the concept of “minimal harm” laid the medical humanities foundation for ERAS. However, the concept of “minimum harm” faced ethical and realistic challenges in practice, such as differentiated cognition between benefits and non-harm, the tension between generalization and personalization, and the gap between rehabilitation continuity and family care. This paper led into the caregiving perspective of social sciences, proposed “optimal care” as a supplement to the medical humanities concept of ERAS, and introduced its connotation and practice. The combination of “minimal harm” and “optimal care” can provide theoretical guidance for medical humanistic care in ERAS and innovate the practical path of medical humanities into clinical practice.
8."Minimal harm"and"optimal care":the concepts and practices of medical humanities in enhanced recovery after surgery
Longwen FU ; Changhua ZHANG ; Honglu XU ; Yu CHENG ; Yulong HE
Chinese Medical Ethics 2024;37(8):932-940
In recent years,enhanced recovery after surgery(ERAS)has been widely used in clinical practice,aiming to optimize perioperative management measures through evidence-based medicine and reduce the physical and mental trauma,stress reactions,and complications of surgical patients through multidisciplinary collaboration.This paper examined the clinical practice of ERAS from the perspective of medical humanities,reviewed its development and characteristics,and first pointed out that the concept of"minimal harm"laid the medical humanities foundation for ERAS.However,the concept of"minimum harm"faced ethical and realistic challenges in practice,such as differentiated cognition between benefits and non-harm,the tension between generalization and personalization,and the gap between rehabilitation continuity and family care.This paper led into the caregiving perspective of social sciences,proposed"optimal care"as a supplement to the medical humanities concept of ERAS,and introduced its connotation and practice.The combination of"minimal harm"and"optimal care"can provide theoretical guidance for medical humanistic care in ERAS and innovate the practical path of medical humanities into clinical practice.
9."Minimal harm"and"optimal care":the concepts and practices of medical humanities in enhanced recovery after surgery
Longwen FU ; Changhua ZHANG ; Honglu XU ; Yu CHENG ; Yulong HE
Chinese Medical Ethics 2024;37(8):932-940
In recent years,enhanced recovery after surgery(ERAS)has been widely used in clinical practice,aiming to optimize perioperative management measures through evidence-based medicine and reduce the physical and mental trauma,stress reactions,and complications of surgical patients through multidisciplinary collaboration.This paper examined the clinical practice of ERAS from the perspective of medical humanities,reviewed its development and characteristics,and first pointed out that the concept of"minimal harm"laid the medical humanities foundation for ERAS.However,the concept of"minimum harm"faced ethical and realistic challenges in practice,such as differentiated cognition between benefits and non-harm,the tension between generalization and personalization,and the gap between rehabilitation continuity and family care.This paper led into the caregiving perspective of social sciences,proposed"optimal care"as a supplement to the medical humanities concept of ERAS,and introduced its connotation and practice.The combination of"minimal harm"and"optimal care"can provide theoretical guidance for medical humanistic care in ERAS and innovate the practical path of medical humanities into clinical practice.
10."Minimal harm"and"optimal care":the concepts and practices of medical humanities in enhanced recovery after surgery
Longwen FU ; Changhua ZHANG ; Honglu XU ; Yu CHENG ; Yulong HE
Chinese Medical Ethics 2024;37(8):932-940
In recent years,enhanced recovery after surgery(ERAS)has been widely used in clinical practice,aiming to optimize perioperative management measures through evidence-based medicine and reduce the physical and mental trauma,stress reactions,and complications of surgical patients through multidisciplinary collaboration.This paper examined the clinical practice of ERAS from the perspective of medical humanities,reviewed its development and characteristics,and first pointed out that the concept of"minimal harm"laid the medical humanities foundation for ERAS.However,the concept of"minimum harm"faced ethical and realistic challenges in practice,such as differentiated cognition between benefits and non-harm,the tension between generalization and personalization,and the gap between rehabilitation continuity and family care.This paper led into the caregiving perspective of social sciences,proposed"optimal care"as a supplement to the medical humanities concept of ERAS,and introduced its connotation and practice.The combination of"minimal harm"and"optimal care"can provide theoretical guidance for medical humanistic care in ERAS and innovate the practical path of medical humanities into clinical practice.

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