Objective To explore the efficacy of DSA-guided intrathecal drug delivery system combined with Zi Wu Liu Zhu Acupoint Therapy for management of cancer pain and provide reference for its standardized clinical application.Methods and Results Recommendations were formulated based on literature review and expert group discussion,and consensus was reached following expert consultation.The consensus recommendations are comprehensive,covering the entire treatment procedures from preoperative assessment and preparation,surgical operation process,postoperative management and traditional Chinese medicine treatment to individualized treatment planning.The study results showed that the treatment plans combining traditional Chinese with Western medicine effectively alleviated cancer pain,reduced the use of opioid drugs,and significantly improved the quality of life and enhanced immune function of the patients.Postoperative follow-up suggested good treatment tolerance among the patients without serious complications.Conclusion The formulated consensus is comprehensive and can provide reference for clinicians to use DSA-guided intrathecal drug delivery system combined with Zi Wu Liu Zhu Acupoint Therapy.The combined treatment has a high clinical value with a good safety profile for management of cancer pain.

Objective:To explore the direction of the association between smartphone multitasking behavior and comorbid symptoms of anxiety and depression (CAD) among college students.Methods:College students from one college located in Shanxi, Chongqing, and Shenzhen were selected between October and December 2021 using a multistage random cluster sampling method, and a follow-up visit was conducted in May 2022. The Assessment of Smartphone Multitasking for Adolescents, the Patient Health Questionnaire-9 Items, and the Generalized Anxiety Disorder Questionnaire-7 Items were used to assess the smartphone multitasking behaviors and CAD of college students. Multivariate logistic regression models were used to analyze the associations between smartphone multitasking behavior and CAD. Autoregressive cross-lagged models (ARCLM) were used to analyze the bidirectional associations between smartphone multitasking behavior and CAD.Results:A total of 953 college students were included in this study, including 323 (33.9%) males and 630 (66.1%) females, with an age of (18.89±1.33) years. The detection rates of CAD at baseline and follow-up were 25.5% and 27.5%, respectively. The mean of the total smartphone multitasking index at baseline was 2.11±0.48. The mean of smartphone and non-media activity multitasking index was 2.00±0.55. The mean of smartphone and other media activity multitasking index was 1.92±0.67. The mean of smartphone functional use multitasking index was 2.18±0.54. The multivariate logistic regression models showed that smartphone and non-media activity multitasking index ( OR=1.85, 95% CI: 1.39-2.45), smartphone and other media activity multitasking index ( OR=1.42, 95% CI: 1.10-1.83), and total smartphone multitasking index ( OR=1.66, 95% CI: 1.21-2.28) were positively associated with the risk of CAD among college students at baseline. The smartphone and non-media activity multitasking index ( OR=1.74,95% CI: 1.30-2.32), smartphone and other media activity multitasking index ( OR=1.37, 95% CI: 1.04-1.79) and total smartphone multitasking index ( OR=1.48, 95% CI: 1.06-2.06) were positively associated with the risk of CAD at follow-up. There was no statistical association between smartphone functional use multitasking index at baseline and CAD. The ARCLM showed that smartphone and non-media activity multitasking index ( β=0.974, P=0.029), smartphone and other media multitasking index ( β=0.798, P=0.003), and the total smartphone multitasking index ( β=1.379, P=0.011) at baseline could positively predict the risk of CAD at follow-up. The CAD at baseline could positively predict smartphone and other media multitasking index ( β=0.004, P=0.016) and smartphone functional use multitasking index at follow-up ( β=0.004, P=0.016). Conclusion:There is a bidirectional association between smartphone and other media activity multitasking and CAD among college students.

OBJECTIVES: To explore the efficacy of DSA-guided intrathecal drug delivery system combined with Zi Wu Liu Zhu Acupoint Therapy for management of cancer pain and provide reference for its standardized clinical application. Methods and. RESULTS: Recommendations were formulated based on literature review and expert group discussion, and consensus was reached following expert consultation. The consensus recommendations are comprehensive, covering the entire treatment procedures from preoperative assessment and preparation, surgical operation process, postoperative management and traditional Chinese medicine treatment to individualized treatment planning. The study results showed that the treatment plans combining traditional Chinese with Western medicine effectively alleviated cancer pain, reduced the use of opioid drugs, and significantly improved the quality of life and enhanced immune function of the patients. Postoperative follow-up suggested good treatment tolerance among the patients without serious complications. CONCLUSIONS The formulated consensus is comprehensive and can provide reference for clinicians to use DSA-guided intrathecal drug delivery system combined with Zi Wu Liu Zhu Acupoint Therapy. The combined treatment has a high clinical value with a good safety profile for management of cancer pain.
Humans ; Medicine, Chinese Traditional ; Cancer Pain/therapy* ; Drugs, Chinese Herbal/therapeutic use* ; Drug Delivery Systems ; Pain Management/methods* ; China

Objective:To explore the direction of the association between smartphone multitasking behavior and comorbid symptoms of anxiety and depression (CAD) among college students.Methods:College students from one college located in Shanxi, Chongqing, and Shenzhen were selected between October and December 2021 using a multistage random cluster sampling method, and a follow-up visit was conducted in May 2022. The Assessment of Smartphone Multitasking for Adolescents, the Patient Health Questionnaire-9 Items, and the Generalized Anxiety Disorder Questionnaire-7 Items were used to assess the smartphone multitasking behaviors and CAD of college students. Multivariate logistic regression models were used to analyze the associations between smartphone multitasking behavior and CAD. Autoregressive cross-lagged models (ARCLM) were used to analyze the bidirectional associations between smartphone multitasking behavior and CAD.Results:A total of 953 college students were included in this study, including 323 (33.9%) males and 630 (66.1%) females, with an age of (18.89±1.33) years. The detection rates of CAD at baseline and follow-up were 25.5% and 27.5%, respectively. The mean of the total smartphone multitasking index at baseline was 2.11±0.48. The mean of smartphone and non-media activity multitasking index was 2.00±0.55. The mean of smartphone and other media activity multitasking index was 1.92±0.67. The mean of smartphone functional use multitasking index was 2.18±0.54. The multivariate logistic regression models showed that smartphone and non-media activity multitasking index ( OR=1.85, 95% CI: 1.39-2.45), smartphone and other media activity multitasking index ( OR=1.42, 95% CI: 1.10-1.83), and total smartphone multitasking index ( OR=1.66, 95% CI: 1.21-2.28) were positively associated with the risk of CAD among college students at baseline. The smartphone and non-media activity multitasking index ( OR=1.74,95% CI: 1.30-2.32), smartphone and other media activity multitasking index ( OR=1.37, 95% CI: 1.04-1.79) and total smartphone multitasking index ( OR=1.48, 95% CI: 1.06-2.06) were positively associated with the risk of CAD at follow-up. There was no statistical association between smartphone functional use multitasking index at baseline and CAD. The ARCLM showed that smartphone and non-media activity multitasking index ( β=0.974, P=0.029), smartphone and other media multitasking index ( β=0.798, P=0.003), and the total smartphone multitasking index ( β=1.379, P=0.011) at baseline could positively predict the risk of CAD at follow-up. The CAD at baseline could positively predict smartphone and other media multitasking index ( β=0.004, P=0.016) and smartphone functional use multitasking index at follow-up ( β=0.004, P=0.016). Conclusion:There is a bidirectional association between smartphone and other media activity multitasking and CAD among college students.

Objective: To explore the longitudinal correlation between smartphone multitasking and depressive symptoms, so as to provide an evidence based basis for promoting the mental health of college students. Methods: A total of 967 college students were recruited from one university in Taiyuan, Chongqing, and Shenzhen cities, China, by using multi stage randomized cluster sampling from October to December 2021 at baseline, and a follow up survey was conducted in May 2022. Smartphone multitasking behaviors were assessed by means of the Assessment of Smartphone Multitasking for Adolescents (ASMA), and depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) among college students. Chi square tests were performed to compare the differences in depressive symptoms between different groups of demographic characteristics, and binary Logistic regression models were employed to analyze the associations between smartphone multitasking and depressive symptoms among college students. Results: The rates of depressive symptoms among college students at baseline and follow up were 35.2% and 42.3%, respectively. Compared to the low level smartphone multitasking index group at baseline, the moderate and high level groups were more likely to experience depressive symptoms at baseline (moderate level group: OR=1.74, 95%CI =1.22-2.50, high level group: OR=2.77, 95%CI =1.94-3.95) and followup (moderate level group: OR=1.41, 95%CI =1.01-1.95, high level group: OR=1.64, 95%CI =1.17-2.29) ( P <0.05). In addition, compared to the persistently low smartphone multitasking index, increased risk of depressive symptoms was associated with maintaining a moderate to high ( OR=2.94, 95%CI =1.83-4.71), and a higher ( OR=2.07, 95%CI =1.31-3.27) or lower smartphone multitasking index ( OR=2.02, 95%CI =1.27-3.19) ( P <0.05). Moreover, higher smartphone multitasking index scores were positively associated with the risk of new-onset depressive symptoms at follow up ( OR=1.87, 95%CI=1.07-3.27, P <0.05). Conclusions Smartphone multitasking behaviors are find to be associated with an increased risk of depressive symptoms in college students. There is a need to reduce smartphone multitasking in order to decrease depressive symptoms and promote students mental health.

Objective: To explore the association among neck-shoulder pain (NSP), low back pain (LBP) and co occurring symptoms with mental sub health in adolescents, so as to provide evidence for improving physical and mental health of adolescents. Methods: Stratified cluster random sampling method was used to select 7 986 students from 12 middle and high schools in Shenzhen, Nanchang, and Shenyang cities from October to December 2019. The Assessment of Spinal Health of Youth (ASHY) and the Brief Instrument on Psychological Health of Youth (BIOPHY) were used to assess NSP, LBP and mental sub health. Binary Logistic regression model was used to analyze the association between NSP, LBP and co occurring symptoms with mental sub health in adolescents. Results: The detection rates of adolescents with NSP, LBP and co occurring symptoms and mental sub health were 9.1% , 9.8%, 9.5%, and 10.0%, respectively. The co occurring rate of neck shoulder pain, low back pain and mental sub health was 3.2%. After adjusting for confounding variables such as gender, age, being an only child, family residence, and parental education level, NSP ( OR=6.01, 95%CI =5.02-7.19), LBP ( OR=5.08, 95%CI =4.25-6.07), and co occurring symptoms ( OR= 5.96 , 95%CI =4.98-7.12) in adolescents were positively correlated with mental sub health risk ( P <0.01). Stratifying the gender, boys with NSP, LBP and co occurring symptoms ( OR =6.84, 5.80, 6.74)had a higher risk of mental sub health compared to girls ( OR =5.52, 4.65, 5.49) ( P <0.01). Conclusions NSP, LBP and co occurring symptoms in adolescents are associated with mental sub health. The mental health status of boys is more affected by NSP, LBP and their co occurring symptoms. Measures should be taken to improve spinal health in adolescents to reduce the incidence of mental sub health.

Objective: To describe the prevalence and association of dietary rhythm and depressive symptoms among adolescents, so as to provide a basis for improving unhealthy behavioral habits,and to promote adolescent physical and mental health. Methods: From October to December 2021, a total of 22 868 students were selected from one middle school and high school in urban and rural areas of eight cities, namely, Shenyang, Xuzhou, Shenzhen, Taiyuan, Nanchang, Zhengzhou, Chongqing, and Kunming cities, China, using a combination of purposive sampling and stratified cluster random sampling. A self administered questionnaire was used to assess adolescents dietary rhythm, and the Patient Health Questionnaire-9 (PHQ-9) was used to assess depressive symptoms. Binary Logistic regression model was employed to analyze the associations between adolescent dietary rhythm and depressive symptoms, while the associations between adolescent dietary rhythm and depressive symptoms across gender and physical activity levels were stratified by gender and physical activity levels. Results: The detection rate of depressive symptoms in adolescents was 44.4%. The respective differences in the detection rates of depressive symptoms among adolescents of different genders, physical activity levels, and dietary rhythm disorders were statistically significant ( χ 2=157.51, 105.02, 3 282.50, P <0.01). Taking the low disordered dietary rhythm group as the reference, binary Logistic regression analyses showed that after adjusting for confounding factors such as age, gender，family location, family economic situation, whether only child, parental education level, and learning burden, physical activity levels, depressive symptoms were positively correlated with adolescents in the moderate disordered dietary rhythm group ( OR=2.63, 95%CI =2.45-2.83) and the high disordered dietary rhythm group ( OR=6.38, 95%CI = 5.93- 6.86). In addition, after stratifying by gender, dietary rhythm were positively correlated with depressive symptoms. The moderate disordered group (male: OR=2.62, 95%CI =2.37-2.89, female: OR=2.67, 95%CI =2.40-2.97) and the highly disordered group (male: OR=5.74, 95%CI =5.19-6.35, female: OR=7.11, 95%CI =6.40-7.89) were positively correlated with depressive symptoms. After stratification by physical activity levels, low, moderate and above physical activity levels among adolescents in the disordered dietary rhythm group (low physical activity: OR=2.91, 95%CI =2.58-3.29, moderate and above physical activity: OR= 2.50, 95%CI =2.28-2.74), high disordered group (low physical activity: OR=6.51, 95%CI =5.94- 7.13 , moderate and higher physical activity: OR=6.18, 95%CI =5.47-6.97) were positively associated with depressive symptoms ( P <0.01). There was an interaction between dietary rhythm and physical activity levels in regard to the development of depressive symptoms in adolescents, taking the group with moderate and above physical activity levels and low disordered dietary rhythm as the reference,the detection rate of which was higher in adolescents with low levels of physical activity and those in the moderate or high disordered dietary rhythm group ( OR=1.50, 3.90, 95%CI=1.39-1.61, 3.63-4.19, P <0.01). Conclusions Dietary rhythm disorders were found to be positively associated with depressive symptoms in adolescents. Regular dietary behaviors and increased physical activity play an important positive role in promoting adolescent mental health.

Trillions of microbes inhabit the human intestinal tract as a complex ecological community.They impact the host's normal physiological activities and disease susceptibility through their collective metabolic activities and interactions with the host.Gut microbes participate in immune regulation and nutrient metabolism and are closely related to aging.In recent years,the role of gut microbes in ophthalmic diseases has received much attention.This paper reviews the relation-ship between gut microbes and various ophthalmic diseases,aiming to provide new insights into the diagnosis and treatment of ophthalmic diseases.

Objective:To provide warning information for early renal injury in pilots by investigating the relationship between serum cystatin C (Cys-C) level and renal blood flow parameters in healthy pilots.Methods:A total of 347 military pilots who underwent annual physical examination in the Air Service Department of the 960th Hospital of Joint Logistics Support Force from July of 2019 to December of 2021 were selected as the pilot group, and 347 healthy subjects who were in same age span and examined at same period were selected as the control group. Color Doppler flow imaging was used to qualitatively analyze renal artery blood flow parameters, including the peak systolic velocity (PSV), end-diastolic blood flow velocity (EDV) and resistance index (RI) of the main renal artery, segmental artery and interlobar arteries. The serum urea nitrogen, serum creatinine and uric acid of subjects were measured. Both pilot group and the control group were divided into 21-30 years old, 31-40 years old and 41-50 years old groups. According to the median level of serum Cys-C, the pilots were divided into high Cys-C group and low Cys-C group. The Cys-C level and renal blood flow parameters of each group were compared, and the correlation between Cys-C level and renal blood flow parameters of pilots was analyzed.Results:There were no significant differences on serum Cys-C level between the pilot group and the control group at all ages (all P>0.05). There was a significant difference on Cys-C levels among the pilots of different ages ( H=8.24, P=0.045). There was no significant difference in Cys-C levels among control groups at different ages ( P>0.05). The levels of endogenous creatinine clearance and uric acid in the high Cys-C group were higher than those in the low Cys-C group, and the differences were significant ( Z=-4.17, -2.98, P<0.001, =0.003). The EDV of main renal artery in high Cys-C group was lower than that in low Cys-C group, and the difference was significant ( t=4.82, P=0.021). The EDV of interlobar arteries in high Cys-C group was lower than that in low Cys-C group, and the difference was significant ( Z=-5.48, P=0.030). Correlation analysis showed that the Cys-C level of pilots was positively correlated with age, flying hours and uric acid level ( r=0.381, 0.165, 0.359, P=0.001, 0.002, 0.003). Cys-C level was negatively correlated with EDV of main renal artery and interlobar arteries ( r=-0.306, -0.321, P=0.048, 0.024), and positively correlated with RI of main renal artery ( r=0.417, P=0.029). Conclusions:The serum Cys-C of pilots could reflect certain basic data of renal function and is hopeful to provide warning for early renal injury due it correlated to the EDV of main renal artery and interlobar arteries and the RI of main renal artery.

Objective:To provide warning information for early renal injury in pilots by investigating the relationship between serum cystatin C (Cys-C) level and renal blood flow parameters in healthy pilots.Methods:A total of 347 military pilots who underwent annual physical examination in the Air Service Department of the 960th Hospital of Joint Logistics Support Force from July of 2019 to December of 2021 were selected as the pilot group, and 347 healthy subjects who were in same age span and examined at same period were selected as the control group. Color Doppler flow imaging was used to qualitatively analyze renal artery blood flow parameters, including the peak systolic velocity (PSV), end-diastolic blood flow velocity (EDV) and resistance index (RI) of the main renal artery, segmental artery and interlobar arteries. The serum urea nitrogen, serum creatinine and uric acid of subjects were measured. Both pilot group and the control group were divided into 21-30 years old, 31-40 years old and 41-50 years old groups. According to the median level of serum Cys-C, the pilots were divided into high Cys-C group and low Cys-C group. The Cys-C level and renal blood flow parameters of each group were compared, and the correlation between Cys-C level and renal blood flow parameters of pilots was analyzed.Results:There were no significant differences on serum Cys-C level between the pilot group and the control group at all ages (all P>0.05). There was a significant difference on Cys-C levels among the pilots of different ages ( H=8.24, P=0.045). There was no significant difference in Cys-C levels among control groups at different ages ( P>0.05). The levels of endogenous creatinine clearance and uric acid in the high Cys-C group were higher than those in the low Cys-C group, and the differences were significant ( Z=-4.17, -2.98, P<0.001, =0.003). The EDV of main renal artery in high Cys-C group was lower than that in low Cys-C group, and the difference was significant ( t=4.82, P=0.021). The EDV of interlobar arteries in high Cys-C group was lower than that in low Cys-C group, and the difference was significant ( Z=-5.48, P=0.030). Correlation analysis showed that the Cys-C level of pilots was positively correlated with age, flying hours and uric acid level ( r=0.381, 0.165, 0.359, P=0.001, 0.002, 0.003). Cys-C level was negatively correlated with EDV of main renal artery and interlobar arteries ( r=-0.306, -0.321, P=0.048, 0.024), and positively correlated with RI of main renal artery ( r=0.417, P=0.029). Conclusions:The serum Cys-C of pilots could reflect certain basic data of renal function and is hopeful to provide warning for early renal injury due it correlated to the EDV of main renal artery and interlobar arteries and the RI of main renal artery.