Objective:To explore the association between perceived social support,TMEM161B gene rs768705 polymorphism,and their interaction with incidence of depressive symptoms in the freshmen.Methods:A total of 9928 freshmen from two medical universities were investigated at baseline and follow-up two years later during 2018-2020 by cluster sampling.A self-report demographic characteristics questionnaire was used to collect information of general demographic characteristics.Perceived Social Support Scale,Beck Depression Inventory,Beck Anxiety Inventory and Adolescent Self-Rating Life Events Check List were used to measure the level of perceived social support,depressive symptoms,anxiety symptoms and the number of negative life events of individuals.Blood sam-ples were collected and typed for DNA by professionals.Results:Family support and other support were all nega-tively associated with depressive symptoms in the freshmen(OR=0.96,95％CI:0.93-0.99;OR=0.94,95％CI:0.91-0.98).There was no correlation between friend support and depressive symptoms in the freshmen(OR=0.99,95％CI:0.95-1.02).TMEM161B gene rs768705 polymorphism(AG)was positively associated with de-pressive symptoms in the freshmen(OR=1.58,95％CI:1.12-2.23).The interactions of friend support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95％CI:1.02-1.26)and other support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95％CI:1.02-1.25)had significant effects on the incidence of depressive symptoms in the females and no significant effect in the males.Conclusion:The perceived social support,TMEM161B gene rs768705 polymorphism and their interaction are associated with influence of de-pressive symptoms,and have sex difference in the freshmen.

Objective:To explore the risk factors of suicidal ideation in community residents in Shandong province,China,and to establish a prediction model and a nomogram for the risk of suicidal ideation.Methods:To-tally 11 087 community residents in Jining City,Zoucheng City,and Weifang City,Shandong Province,were recrui-ted as the study subjects.The general information questionnaire,Composite International Diagnostic Interview-3.0,General Anxiety Disorder-7,were used to collect demographic information,mental health status,family information,and lifestyle using a computer-assisted interview system to conduct face-to-face interview.LASSO regression and binary logistic regression analyses were used to develop a nomogram model of the risk of suicidal ideation.Results:Young people,female,smoking,non-new town residents,no physical exercise,difficulty approaching people,anxiety symptoms and depression were effective predictors of suicidal ideation.The area under the curve(AUC)of the training set(AUC)was 0.89(95％CI:0.85-0.93)and AUC of the validation set(AUC)was 0.83(95％CI:0.75-0.92).Conclusion:The nomogram prediction model constructed in this study on suicidal ideation in com-munity residents has a high degree of differentiation and accuracy.It could be used to screen people at high risk of suicide and provide intervention to suicidal ideation in community residents.

Objective:To explore the latent class characteristics of fear of childbirth among expectant fathers of third trimester based on latent profile analysis, and to analyze the differences in characteristics among different classes and influencing factors.Methods:Convenience sampling was used to select expectant fathers accompanying their partners for prenatal check-ups at Obstetrics and Gynecology Hospital Affiliated to Zhejiang University School of Medicine from March to September 2024 as the subjects of the investigation. A General Information Questionnaire, Fathers' Fear of Childbirth Scale, Perceived Social Support Scale, Connor-Davidson Resilience Scale, and Edinburgh Postnatal Depression Scale were used for the survey; latent profile analysis was employed to explore the latent typing of fear of childbirth among expectant fathers of third trimester, and univariate analysis and multiple logistic regression analysis were used to investigate related influencing factors.Results:A total of 269 expectant fathers were included in the final analysis, aged 31 (29, 34) years old. The score of Fathers' Fear of Childbirth Scale was (49.58 ± 13.28); the scores of Perceived Social Support Scale was 64.00 (51.00, 71.50); the scores of Connor-Davidson Resilience Scale was 29.00 (26.00, 33.00); the score of Edinburgh Postnatal Depression Scale was 7.00 (5.00, 9.00). Latent profile analysis showed that the level of fear of childbirth among expectant fathers of third trimester could be divided into four latent classes: "low fear of childbirth-pain fear group" (19.0%, 51/269), "moderate fear of childbirth-maternal and infant safety concern group" (24.5%, 66/269), "moderate fear of childbirth-medical trust group" (32.0%, 86/269), and "high fear of childbirth-comprehensive group" (24.5%, 66/269). Multiple logistic regression analysis showed that expectant fathers with high psychological resilience were more likely to be classified into the low fear of childbirth-pain fear group ( OR values ranged from 0.863 to 0.909, all P<0.05); expectant fathers with higher levels of prenatal depression were more likely to be classified into the high fear of childbirth-comprehensive group ( OR values ranged from 1.286 to 1.366, all P<0.05); compared with the low fear of childbirth-pain fear group, younger expectant fathers were more likely to be classified into the moderate fear of childbirth-medical trust group ( OR=0.871, P<0.05); compared with the moderate fear of childbirth-medical trust group, expectant fathers with lower family monthly income were more likely to be classified into the high fear of childbirth-comprehensive group ( OR=3.093, P<0.05). Conclusions:There are significant class characteristics in the level of fear of childbirth among expectant fathers of third trimester, and it is recommended that medical staff implement targeted personalized intervention measures based on the characteristics of each class to reduce the level of fear of childbirth among expectant fathers.

Objective:To explore the association between perceived social support,TMEM161B gene rs768705 polymorphism,and their interaction with incidence of depressive symptoms in the freshmen.Methods:A total of 9928 freshmen from two medical universities were investigated at baseline and follow-up two years later during 2018-2020 by cluster sampling.A self-report demographic characteristics questionnaire was used to collect information of general demographic characteristics.Perceived Social Support Scale,Beck Depression Inventory,Beck Anxiety Inventory and Adolescent Self-Rating Life Events Check List were used to measure the level of perceived social support,depressive symptoms,anxiety symptoms and the number of negative life events of individuals.Blood sam-ples were collected and typed for DNA by professionals.Results:Family support and other support were all nega-tively associated with depressive symptoms in the freshmen(OR=0.96,95％CI:0.93-0.99;OR=0.94,95％CI:0.91-0.98).There was no correlation between friend support and depressive symptoms in the freshmen(OR=0.99,95％CI:0.95-1.02).TMEM161B gene rs768705 polymorphism(AG)was positively associated with de-pressive symptoms in the freshmen(OR=1.58,95％CI:1.12-2.23).The interactions of friend support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95％CI:1.02-1.26)and other support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95％CI:1.02-1.25)had significant effects on the incidence of depressive symptoms in the females and no significant effect in the males.Conclusion:The perceived social support,TMEM161B gene rs768705 polymorphism and their interaction are associated with influence of de-pressive symptoms,and have sex difference in the freshmen.

Objective:To explore the risk factors of suicidal ideation in community residents in Shandong province,China,and to establish a prediction model and a nomogram for the risk of suicidal ideation.Methods:To-tally 11 087 community residents in Jining City,Zoucheng City,and Weifang City,Shandong Province,were recrui-ted as the study subjects.The general information questionnaire,Composite International Diagnostic Interview-3.0,General Anxiety Disorder-7,were used to collect demographic information,mental health status,family information,and lifestyle using a computer-assisted interview system to conduct face-to-face interview.LASSO regression and binary logistic regression analyses were used to develop a nomogram model of the risk of suicidal ideation.Results:Young people,female,smoking,non-new town residents,no physical exercise,difficulty approaching people,anxiety symptoms and depression were effective predictors of suicidal ideation.The area under the curve(AUC)of the training set(AUC)was 0.89(95％CI:0.85-0.93)and AUC of the validation set(AUC)was 0.83(95％CI:0.75-0.92).Conclusion:The nomogram prediction model constructed in this study on suicidal ideation in com-munity residents has a high degree of differentiation and accuracy.It could be used to screen people at high risk of suicide and provide intervention to suicidal ideation in community residents.

Objective:To investigate the symptom network structure of subjective cognitive decline(SCD)and its associated factors in middle-aged and older adults.Methods:A cross-sectional study was conducted among 8,262 community residents aged 45 years and over in Shandong Province(Jining,Weifang,and Zoucheng).SCD was assessed using the 8-item Ascertain Dementia(AD8)questionnaire,while mental health status was evaluated with Patient Health Questionnaire-9 and General Anxiety Disorder-7.SPSS and R were applied to construct the SCD symptom network model and examine its association with psychological factors.Results:The prevalence of SCD was 24.53％."Difficulty using household appliances"emerged as the core symptom,with the strongest connections to"forgetting appointments"(edge=2.13)and"declining daily memory and thinking ability".Additionally,"poor self-rated mental health"was most strongly linked to"loss of interest,change in hobbies and reduced activities"(edge=0.38).Conclusion:SCD symptoms in middle-aged and older adults exhibits strong interconnections and are closely linked to the individual's mental health condition.

Objective:To investigate the symptom network structure of subjective cognitive decline(SCD)and its associated factors in middle-aged and older adults.Methods:A cross-sectional study was conducted among 8,262 community residents aged 45 years and over in Shandong Province(Jining,Weifang,and Zoucheng).SCD was assessed using the 8-item Ascertain Dementia(AD8)questionnaire,while mental health status was evaluated with Patient Health Questionnaire-9 and General Anxiety Disorder-7.SPSS and R were applied to construct the SCD symptom network model and examine its association with psychological factors.Results:The prevalence of SCD was 24.53％."Difficulty using household appliances"emerged as the core symptom,with the strongest connections to"forgetting appointments"(edge=2.13)and"declining daily memory and thinking ability".Additionally,"poor self-rated mental health"was most strongly linked to"loss of interest,change in hobbies and reduced activities"(edge=0.38).Conclusion:SCD symptoms in middle-aged and older adults exhibits strong interconnections and are closely linked to the individual's mental health condition.

Objective:To explore the latent class characteristics of fear of childbirth among expectant fathers of third trimester based on latent profile analysis, and to analyze the differences in characteristics among different classes and influencing factors.Methods:Convenience sampling was used to select expectant fathers accompanying their partners for prenatal check-ups at Obstetrics and Gynecology Hospital Affiliated to Zhejiang University School of Medicine from March to September 2024 as the subjects of the investigation. A General Information Questionnaire, Fathers' Fear of Childbirth Scale, Perceived Social Support Scale, Connor-Davidson Resilience Scale, and Edinburgh Postnatal Depression Scale were used for the survey; latent profile analysis was employed to explore the latent typing of fear of childbirth among expectant fathers of third trimester, and univariate analysis and multiple logistic regression analysis were used to investigate related influencing factors.Results:A total of 269 expectant fathers were included in the final analysis, aged 31 (29, 34) years old. The score of Fathers' Fear of Childbirth Scale was (49.58 ± 13.28); the scores of Perceived Social Support Scale was 64.00 (51.00, 71.50); the scores of Connor-Davidson Resilience Scale was 29.00 (26.00, 33.00); the score of Edinburgh Postnatal Depression Scale was 7.00 (5.00, 9.00). Latent profile analysis showed that the level of fear of childbirth among expectant fathers of third trimester could be divided into four latent classes: "low fear of childbirth-pain fear group" (19.0%, 51/269), "moderate fear of childbirth-maternal and infant safety concern group" (24.5%, 66/269), "moderate fear of childbirth-medical trust group" (32.0%, 86/269), and "high fear of childbirth-comprehensive group" (24.5%, 66/269). Multiple logistic regression analysis showed that expectant fathers with high psychological resilience were more likely to be classified into the low fear of childbirth-pain fear group ( OR values ranged from 0.863 to 0.909, all P<0.05); expectant fathers with higher levels of prenatal depression were more likely to be classified into the high fear of childbirth-comprehensive group ( OR values ranged from 1.286 to 1.366, all P<0.05); compared with the low fear of childbirth-pain fear group, younger expectant fathers were more likely to be classified into the moderate fear of childbirth-medical trust group ( OR=0.871, P<0.05); compared with the moderate fear of childbirth-medical trust group, expectant fathers with lower family monthly income were more likely to be classified into the high fear of childbirth-comprehensive group ( OR=3.093, P<0.05). Conclusions:There are significant class characteristics in the level of fear of childbirth among expectant fathers of third trimester, and it is recommended that medical staff implement targeted personalized intervention measures based on the characteristics of each class to reduce the level of fear of childbirth among expectant fathers.

Objective:To investigate the associated factors of depressive symptoms among patients with neo-plasms.Methods:Nationwide(excluding Hong Kong,Macao,and Taiwan),30 505 residents were selected by a combination of stratified sampling and quota sampling according to the proportion of the seventh national population census.Patient Health Questionnaire-9(PHQ-9),General Anxiety Disorder-7(GAD-7),self-made questionnaire,and simplified perceived social support scale used to evaluate depressive symptoms,anxiety symptoms,behaviors,and perceived social support among patients with neoplasms.Results:Totally 359(1.2％)patients with self-repor-ted clinically diagnosed neoplasms were included,of which 151(42.1％)patients with malignant neoplasms and 208(57.9％)patients with benign neoplasms.The detection rate of depressive symptoms in patients with neo-plasms was 76.6％.Less than three days of walking for more than 10 minutes per day in the past week(OR=6.63),4-6 days of walking for more than 10 minutes per day in the past week(OR=5.00),the low(OR=4.80)or medium(OR=3.06)overall sleep quality,the lower perceived friend support(OR=4.66),and anxiety symp-toms(OR=1.74)among patients with neoplasms were risk factors for depressive symptoms.Conclusion:Patients with neoplasms generally might be at a high risk of depressive symptoms,especially for those patients with less ex-ercise,poor sleep quality,and low perceived social support.

Objective:Analyzing the relationship between negative life events and depressive symptoms in university freshmen,and the mediating effects of neuroticism and the moderating role of exercise frequency.Meth-ods:A sampling of 8 079 university freshmen,and the Patient Health Questionnaire was used to assess depressive symptoms,the Eysenck Personality Inventory-Neuroticism subscale to assess neuroticism,the self-administered questionnaire to assess the number of negative life events that the participants had experienced and the exercise fre-quency.Model 4 in the Process plug-in was used to test the mediating effect of neuroticism,and Model 7 to test the moderating role of exercise frequency.Results:The numbers of negative life events were positively correlated with the depressive symptoms scores(r=0.16,P＜0.01),and were positively correlated with the neuroticism scores(r=0.26,P＜0.01).The neuroticism scores were positively correlated with the depressive symptoms scores(r=0.52,P＜0.01).Neuroticism score partially mediated between negative life events and depressive symptoms score,with a mediating effect of 78.4％,and exercise frequency score moderated between negative life events and neuroti-cism scores(β=-0.05,P=0.032).Conclusion:Negative life events are associated with depressive symptoms,neuroticism plays a mediating role,and exercise frequency could moderate negative life events and neuroticism.