Salvia miltiorrhiza (S. miltiorrhiza) represents a crucial component of traditional Chinese medicine, demonstrating effects on blood circulation activation and stasis removal, and has been widely utilized in asthma treatment. This study isolated a novel phenolic acid (S1) from S. miltiorrhiza and investigated its anti-asthmatic activity and underlying mechanisms for the first time. An allergic asthma (AA) model was established using ovalbumin (OVA). The mechanism of S1's effects on AA was investigated using multi-factor joint analysis, flow cytometry, and co-culture systems to facilitate clinical asthma treatment. S1 (10 or 20 mg·kg^-1) was administered daily to mice with OVA-induced AA (OVA-AA) during days 21-25. The study examined airway responsiveness, lung damage, inflammation, and levels of immunoglobulin E (IgE), PGD2, interleukins (IL-4, 5, 10, 13, 17A), tumor necrosis factor α (TNF-α), GM-CSF, CXCL1, CCL11, and mMCP-1. Additionally, mast cell (MC) activation and degranulation were explored, along with T helper type 17 (Th17)/Treg immune cells and TLR4 pathway biomarkers. The antagonistic activity of that specific antagonist of TLR4 (TAK-242) (1 µmol·L^-1), a specific TLR4 blocker, against S1 (10 µmol·L^-1) was examined in co-cultured 16HBE cells and bone marrow-derived cells (BMDCs) or splenic lymphocytes (SLs) induced with LPS (1 µg·mL^-1) to elucidate the TLR4 pathway's mediating role. S1 demonstrated reduced airway responsiveness, lung damage, and inflammation, with downregulation of IgE, PGD2, interleukins, TNF-α, GM-CSF, CXCL1, CCL11, and mMCP-1. It also impeded MC activation and degranulation, upregulated IL-10, and influenced Th17/Treg immune cell transformation following OVA challenge. Furthermore, S1 inhibited the TLR4 pathway in OVA-AA mice, and TLR4 antagonism enhanced S1's positive effects. Analysis using an OVA-AA mouse model demonstrated that S1 alleviates AA clinical symptoms, restores lung function, and inhibits airway response. S1's therapeutic effects occur through regulation of Th17/Treg immune cells and inflammation, attributable at least partially to the TLR4 pathway. This study provides molecular justification for S1 in AA treatment.

Objective To explore the effects of dexmedetomidine combined with desflurane anesthesia on cerebral oxygen metabolism,sedation depth and cerebral function in liver cancer patients undergoing partial hepatic lobectomy.Methods A total of 30 liver cancer patients undergoing partial hepatic lobectomy at the Affiliated Cancer Hospital of Zhengzhou University from March to September 2022 were selected as the research subjects,they were divided into control group(n=15)and observation group(n=15)according to different anesthesia methods.Patients in both groups underwent partial open hepatectomy,and they were given the same anesthesia induction method.The patients in the control group received desflurane for anesthesia mainte-nance,while patients in the observation group received dexmedetomidine combined with desflurane for anesthesia maintenance.The anesthesia recovery indexes including the postoperative recovery time,recovery time of spontaneous breathing,eye-opening time of patients between the two groups were compared.The arterial oxygen saturation(SaO2),cervical vein oxygen saturation(SjvO2),arterial partial pressure of oxygen(PaO2)and partial pressure of venous oxygen of patients were detected by blood gas analyzer before anesthesia induction(T0),at the completion of anesthesia induction(T,),at 10 minutes after hepatic portal occlusion(T2),after hepatic lobectomy(T3)and after surgery(T4),and arterio-venous oxygen content difference(AVDO2)and cerebral oxygen extraction rate(CEO2)were calculated.The sedation depth of patients was evaluated by bispectral index(BIS)and patient state index(PSI)at T0,T1,T2,T3 and T4.The cerebral function of patients was evaluated by the Glasgow-Pittsburgh cerebral performance category scale at 3 months after surgery.The incidence of postoperative adverse reactions of patients between the two groups was compared.Results The postoperative recovery time,recovery time of sponta-neous breathing and eye-opening time of patients in the observation group were significantly shorter than those in the control group(P＜0.05).There was no significant difference in SaO2 of patients between the two groups at different time points(P＞0.05).At T2 and T3,SjvO2,AVDO2 and CEO2 of patients in the observation group were significantly lower than those in the control group(P＜0.05),but there was no significant difference in SjvO2,AVDO2 and CEO2 of patients between the two groups at the other time points(P＞0.05).At T2,T3 and T4,BIS and PSI of patients in the observation group were significantly lower than those in the control group(P＜0.05),but there was no significant difference in BIS and PSI of patients between the two groups at T0 and T1(P＞0.05).In the control group,there were 11 patients with postoperative brain function in grade 1,3 patients in grade Ⅱ and 1 patient in grade Ⅲ;in the observation group,there were 12 patients in grade Ⅰ and 3 patients in gradeⅡ.There was no significant difference in postoperative grading of brain function between the two groups(x2=1.044,P＞0.05).There was no significant difference in the total incidence of postoperative adverse reactions between the control group and observation group[20.00％(3/15)vs 26.67％(4/15),x2=0.186,P＞0.05].Conclusion Dexmedetomidine combined with desflurane anesthesia can shorten anesthesia recovery time,improve anesthesia depth and reduce cerebral oxygen metabolism in patients undergoing liver cancer surgery,which has no effect on cerebral function,showing good safety.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective: To analyze the impact of parental sports concept and behavior on physical activity in preschool children, so as to provide a foundation for future guidance on fostering childrens physical activity within the family context. Methods: From November to December 2020, a clustered convenience sampling method was employed to conduct surveys, and a total of 283 children were selectal from one kindergarten each in Beijing, Shenyang, and Xian. Participating children wore ActiGraph GT9X accelerometers continuously for one week to collect data on different intensity levels of physical activity. Physical Activity afterschool Questionnaire for Preschooler (P-PAQ) was utilized to assess parental sports concept and behavior. The gender differences in physical activity level and physical activity compliance rate were analyzed by using ttest, Mann-Whitney U test, and Chisquare test; and the relationship between parental exercise concepts and behaviors and physical activity of preschool children was analyzed using Spearman rank correlation analysis and multiple linear regression analysis. Results: Parental sports concept was significantly positively correlated with average daily moderatetovigorous physical activity (MVPA) and total physical activity (TPA) in children (r=0.12-0.16, P<0.05). Parental sports behavior was significantly positively correlated with childrens average daily TPA (r=0.25, P<0.05). Multiple linear regression revealed that parental sports concept was positively correlated with average daily MVPA and TPA in both boys and girls (B=0.65-0.83), while parental sports behavior only was positively correlated with boys average daily MVPA and TPA (B=0.24-0.25)(P<0.05). Conclusions Parental sports concept and behavior can impact physical activity levels in preschool children, exhibiting gender differences. Future guidance on physical activity in family upbringing should consider both parental sports concept and behavior, and pay attention to the influence of childrens gender.

Objective:To study the clinical value of enhanced recovery after surgery(ERAS) strategy combined with early intestinal fluid reinfusion among neonates receiving jejunostomy due to intestinal obstruction.Methods:From December 2018 to December 2022, neonates with intestinal obstruction receiving jejunostomy in the Department of Neonatal Surgery of our hospital were prospectively enrolled. They were randomly assigned into ERAS group and traditional treatment (TT) group after surgery. The ERAS group was treated with ERAS strategy plus early intestinal fluid reinfusion. The TT group was treated with conventional gastrointestinal decompression, analgesia as needed and enteric fluid reinfusion according to the amount of defecation. The postoperative parenteral nutrition (PN) duration (T pn), central venous catheter (CVC) duration (T cvc), daily weight gain, duration of postoperative hospital stay (T hos), complications and readmission rate within 30 days were compared between the two groups. Results:A total of 22 cases were included in the ERAS group and 20 cases were in the TT group. T pn [(22.6±9.4) d vs. (30.7±11.3) d], T cvc [(5.9±0.8) d vs. (9.9±2.1) d] and T hos [(26.8±9.8) d vs. (33.8±11.5) d] in the ERAS group were significantly shorter than the TT group ( P<0.05). No significant difference existed in daily weight gain between the two groups ( P>0.05). The incidence of postoperative gastrointestinal mucosal bleeding in the ERAS group was significantly lower than the TT group (13.6% vs. 45.0%)( P<0.05). No significant differences existed in the following items between the two groups: feeding intolerance, PN-associated cholestasis, CVC-related bloodstream infection, intestinal fluid reinfusion-related complications, premature closure of fistula and readmission rate within 30 days (all P>0.05). Conclusions:The application of ERAS strategy plus early intestinal fluid reinfusion in neonates with enterostomy is safe and feasible, which can reduce the postoperative durations of PN, CVC and hospital stay and accelerate the recovery.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.