Objective:To analyze the adverse drug reaction(ADR)signals of medication-related osteonecrosis of the jaw(MRONJ)through mining data from the USA FDA adverse event reporting system(FAERS),and to explore potential MRONJ-re-lated drug in order to provide a basis for clinical safety and rational drug use.Methods:The reporting odds ratio(ROR),propor-tional reporting ratio(PRR)and Bayesian Confidence interval Progressive Neural Network(BCPNN)methods were used for data mining and signal detection of MRONJ adverse event reports in FAERS for 80 quarters from the first quarter of 2004 to the fourth quarter of 2023.Results:A total of 22 214 adverse reaction reports of MRONJ were collected,with a male to female ratio of approximately 1∶2;The majority of patients is over 50 years old,with a total of 14 463 cases(65.10％).The United States and Japan were the countries with the most reports,6 589(29.66％)and 3 459(15.57％)respectively.China(including Taiwan)also reported cases.After screening,a total of 31 drugs were found to be associated with the occurrence of MRONJ,involving 19 757 reports,including 8 antiresorptive agents and 19 antineoplastic agents.Among them,there were 18 061 reports of antire-sorptive agents,and the drug label of 17 drugs did not list osteonecrosis as adverse reactions.Conclusion:Antiresorptive agents represented by bisphosphonates and some antineoplastic agents are the major risk medication for the occurrence of MRONJ.

Objective:To analyze the adverse drug reaction(ADR)signals of medication-related osteonecrosis of the jaw(MRONJ)through mining data from the USA FDA adverse event reporting system(FAERS),and to explore potential MRONJ-re-lated drug in order to provide a basis for clinical safety and rational drug use.Methods:The reporting odds ratio(ROR),propor-tional reporting ratio(PRR)and Bayesian Confidence interval Progressive Neural Network(BCPNN)methods were used for data mining and signal detection of MRONJ adverse event reports in FAERS for 80 quarters from the first quarter of 2004 to the fourth quarter of 2023.Results:A total of 22 214 adverse reaction reports of MRONJ were collected,with a male to female ratio of approximately 1∶2;The majority of patients is over 50 years old,with a total of 14 463 cases(65.10％).The United States and Japan were the countries with the most reports,6 589(29.66％)and 3 459(15.57％)respectively.China(including Taiwan)also reported cases.After screening,a total of 31 drugs were found to be associated with the occurrence of MRONJ,involving 19 757 reports,including 8 antiresorptive agents and 19 antineoplastic agents.Among them,there were 18 061 reports of antire-sorptive agents,and the drug label of 17 drugs did not list osteonecrosis as adverse reactions.Conclusion:Antiresorptive agents represented by bisphosphonates and some antineoplastic agents are the major risk medication for the occurrence of MRONJ.

Objective To explore the effect of the ongoing time of applying Musk Xiaochuan in the treatment of stable asthma and obtain the optimal therapy.Methods 129 cases of patients with stable asthma were randomly divided into 3h group (29 cases), 4h group (34 cases), 5h group (31 cases), 6h group (35 cases) according to the different applying time.The selection of points, applying frequency, treatment course remained the same, and then “dog day” was selected to apply Musk Xiaochuan paste for treatment.The asthma quality of life and asthma control pre-and post-treatment were observed.Results After applying, the asthma control questionnaire (ACQ) score difference value in 3h group was not preferable than the other groups, with no significant difference.The asthma quality life questionnaire (AQLQ) total score difference value in 4h group was significantly higher than the other 3 groups, with significant difference(P<0.05).The activity limitation score difference value and mental health difference value of AQLQ in 4h group were significantly higher than the other 3 groups, with significant difference(P <0.05), the asthma symptom score and stimulus response score difference values, health care for their own score difference value also showed significant effect (P<0.05).Conclusion The difference of the ongoing time of applying Musk Xiaochuan has different efficacy in the treatment of stable asthma, the efficacy of applying for 4h is better than 3, 5,6 h, while it could not determine the best time in asthma control.