1.A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation
Ryo Sasaki ; Yoshio Omote ; Koh Tadokoro ; Namiko Matsumoto ; Emi Nomura ; Mami Takemoto ; Nozomi Hishikawa ; Toru Yamashita ; Yasuyuki Ohta ; Koji Abe
Neurology Asia 2020;25(3):415-418
Palmoplantar pustulosis is a chronic inflammatory skin disease involving the palms and soles where
mild accumulation of helper T cells and neutrophils in the dermis histologically are observed.
Leukoencephalopathy is a brain disease affecting white matter but is rarely accompanied by skin lesion.
Here we report a unique case of leukoencephalopathy accompanied by palmoplantar pustulosis with
identical pathological feature of helper T cell accumulation in both the brain and skin, suggesting a
possible link in the pathogenesis.
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