Radiochemotherapy-induced oral mucositis (OM) is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy. Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment. To date, differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties, which has increased the uncertainty of treatment effects. On the basis of current research evidence, this expert consensus outlines risk factors, clinical manifestations, clinical grading, ancillary examinations, diagnostic basis, prevention and treatment strategies and efficacy indicators for OM. In addition to strategies such as basic oral care, anti-inflammatory and analgesic agents, anti-infective agents, pro-healing agents, and photobiotherapy recommended in previous guidelines, we also emphasize the role of traditional Chinese medicine in OM prevention and treatment. This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention, diagnosis, and treatment, standardizing clinical practice, reducing OM occurrence, promoting healing, and improving the quality of life of patients.
Humans ; Chemoradiotherapy/adverse effects* ; Consensus ; Risk Factors ; Stomatitis/etiology*

Approximately 60% of colorectal cancer (CRC) patients exhibit TP53 mutations, which are strongly associated with tumor progression, chemotherapy resistance, and an unfavorable prognosis. However, targeting p53 has historically been challenging, and currently, there are no approved p53-based therapeutics for clinical use worldwide. In this study, we discovered that ubiquitin carboxyl terminal hydrolase L3 (UCHL3) plays a crucial role in high-level glycolysis, enhanced stem-like properties, and 5-fluorouracil (5-FU) chemoresistance in TP53-mutant CRC by exerting its deubiquitinating enzyme activity to stabilize α-enolase (ENO1) protein. Notably, we identified a newly Food and Drug Administration (FDA)-approved drug, pacritinib, that potently suppresses UCHL3 expression by blocking the janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway in TP53-mutant CRC. Furthermore, Pacritinib was demonstrated to effectively inhibit glycolysis and improve the sensitivity to 5-FU chemotherapy in TP53-mutant CRC. Our findings suggest that targeting the JAK2-STAT3-UCHL3-ENO1 axis is a promising strategy to suppress glycolysis and enhance the efficacy of 5-FU chemotherapy in TP53-mutant CRC. Pacritinib shows potential for clinical application in the treatment of TP53-mutant CRC.

Objective:To construct a multi-benefit evaluation index system about the operational quality of medical imaging equipment,so as to optimize the management path for imaging equipment and improve the operational quality of equipment.Methods:A multi-benefit evaluation index system was jointly constructed by the Department of Medical Equipment,Department of Medical Imaging,Benefit Group and Quality Control Group of Medical Affairs Division,Department of Occupational Disease Management of Shanghai Pulmonary Hospital.The multi-criteria decision-making method was used to conduct combined weight analysis and multi-attribute boundary approximate region comparison(MABAC)evaluation for carrying out the evaluation management of operational quality of medical imaging equipment.The used twenty-six medical imaging equipment in the radiology department of hospital from July 2020 to June 2024 were selected.The conventional evaluation method with performance target list was adopted for 25 equipment during the period from July 2020 to June 2022.From July 2022 to June 2024,25 equipment(including used 24 equipment that were evaluated by evaluation method with performance target list and 1 new equipment)were evaluated and managed by adopting multi-benefit evaluation method.The operational quality,medical safety and clinical benefits of medical imaging equipment were compared and analyzed by the two methods.Results:The average utilization rate,qualified rate of quality detection and effective rate of maintenance for medical imaging equipment of using the multi-benefit evaluation method were respectively(96.98±1.42)%,(97.37±1.17)%and(96.05±2.33)%,all of which were higher than those of using evaluation method with performance target list.Its averagely failure frequency was(0.63±0.39)times per quarter,which was lower than that of evaluation method with performance target list,and the differences were statistically significant(t=2.618,3.136,2.848,2.753,P<0.05).The qualified rates of radiation protection devices and radiation protection supplies,and the effective rate of patients'protection of medical imaging equipment of using the multi-benefit evaluation method were higher than those of using evaluation method with performance target list,and the differences were significant(x2=5.657,10.699,10.350,P<0.05).The average values of growth ranges of cost-effectiveness,scientific research achievements,teaching applications and team cultivation about equipment of using the multi-benefit evaluation method were all higher than those of using the evaluation method with performance target list,and the differences were statistically significant(t=5.467,6.236,5.032,4.724,P<0.05),respectively.Conclusion:The application of the multi-benefit evaluation index system for the operational quality of medical imaging equipment can improve the operational quality of equipment,and enhance the medical safety and benefit of operating equipment.

Objective:To construct a multi-benefit evaluation index system about the operational quality of medical imaging equipment,so as to optimize the management path for imaging equipment and improve the operational quality of equipment.Methods:A multi-benefit evaluation index system was jointly constructed by the Department of Medical Equipment,Department of Medical Imaging,Benefit Group and Quality Control Group of Medical Affairs Division,Department of Occupational Disease Management of Shanghai Pulmonary Hospital.The multi-criteria decision-making method was used to conduct combined weight analysis and multi-attribute boundary approximate region comparison(MABAC)evaluation for carrying out the evaluation management of operational quality of medical imaging equipment.The used twenty-six medical imaging equipment in the radiology department of hospital from July 2020 to June 2024 were selected.The conventional evaluation method with performance target list was adopted for 25 equipment during the period from July 2020 to June 2022.From July 2022 to June 2024,25 equipment(including used 24 equipment that were evaluated by evaluation method with performance target list and 1 new equipment)were evaluated and managed by adopting multi-benefit evaluation method.The operational quality,medical safety and clinical benefits of medical imaging equipment were compared and analyzed by the two methods.Results:The average utilization rate,qualified rate of quality detection and effective rate of maintenance for medical imaging equipment of using the multi-benefit evaluation method were respectively(96.98±1.42)%,(97.37±1.17)%and(96.05±2.33)%,all of which were higher than those of using evaluation method with performance target list.Its averagely failure frequency was(0.63±0.39)times per quarter,which was lower than that of evaluation method with performance target list,and the differences were statistically significant(t=2.618,3.136,2.848,2.753,P<0.05).The qualified rates of radiation protection devices and radiation protection supplies,and the effective rate of patients'protection of medical imaging equipment of using the multi-benefit evaluation method were higher than those of using evaluation method with performance target list,and the differences were significant(x2=5.657,10.699,10.350,P<0.05).The average values of growth ranges of cost-effectiveness,scientific research achievements,teaching applications and team cultivation about equipment of using the multi-benefit evaluation method were all higher than those of using the evaluation method with performance target list,and the differences were statistically significant(t=5.467,6.236,5.032,4.724,P<0.05),respectively.Conclusion:The application of the multi-benefit evaluation index system for the operational quality of medical imaging equipment can improve the operational quality of equipment,and enhance the medical safety and benefit of operating equipment.

Through the report of 4 cases of occupational heatstroke among sanitation workers working in high-temperature weather, this study analyzes the risk of occupational heatstroke among workers in the environmental sanitation industry working in high-temperature weather, and provides scientific suggestions for standardizing occupational health management, safeguarding the health rights and interests of workers, and preventing the occurrence of occupational heatstroke in summer. Through case analysis, we aim to raise high awareness of the occupational health of sanitation workers in the whole society, in order to provide a scientific and healthy working environment for sanitation workers and promote their physical and mental health.

Through the report of 4 cases of occupational heatstroke among sanitation workers working in high-temperature weather, this study analyzes the risk of occupational heatstroke among workers in the environmental sanitation industry working in high-temperature weather, and provides scientific suggestions for standardizing occupational health management, safeguarding the health rights and interests of workers, and preventing the occurrence of occupational heatstroke in summer. Through case analysis, we aim to raise high awareness of the occupational health of sanitation workers in the whole society, in order to provide a scientific and healthy working environment for sanitation workers and promote their physical and mental health.

OBJECTIVE: To analyze the relationship between hemoglobin(Hb) level on admission and survival prognosis of patients with hip fracture. METHODS: From February 2016 to October 2018, 249 elderly patients with hip fracture were surgically treated including 62 males and 187 females;the age ranged from 60 to 91(73.67±10.52) years;the time from injury to operation was (6.79±2.27) d. The clinical and laboratory examination results were collected. The Hb level at admission and the mortality at 30, 90, 180 and 360 days after operation were observed. According to the Hb level at admission, the patients were divided into Hb<120 g/L and Hb≥120 g/L groups. The survival conditions of the two groups at 30, 90, 180 and 360 days after operation were compared and analyzed. Logistic regression was used to analyze the effect of Hb level on death 30, 90, 180 and 360 days after operation. RESULTS: The mortality rates at 30, 90, 180 and 360 days after operation were 5.22%, 9.24%, 16.87% and 20.48% respectively. The level of Hb at admission was a risk factor for prognosis and death 30, 90, 180 and 360 days after operation(P<0.05). The OR(95% CI) were 2.431(1.475-4.006), 2.625(1.468-4.695), 2.276(1.320-3.925) and 2.082(1.221-3.551) respectively. CONCLUSION The level of Hb at admission can affect the survival and prognosis of elderly patients with hip fracture. We should further study how to manage the level of Hb before operation.
Aged ; Aged, 80 and over ; Female ; Hemoglobins/analysis* ; Hip Fractures/surgery* ; Hospitalization ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors

Objective:To explore the effect of scenario simulation nursing in fundus fluorescein angiography (FFA) examination of preschool children.Methods:From January 2017 to March 2021, 98 preschool children who underwent FFA examination in the Fluorescence Contrast Room of Shanxi Eye Hospital were selected as the research object. Children from 2017 to December 2018 were in the control group with routine nursing, and children from January 2019 to March 2021 were in the experimental group with scenario simulation nursing. The incidence of adverse reactions and satisfaction with cooperation were compared between the two groups of children.Results:The incidence of adverse reactions in children in the experimental group was 2.00%, which was lower than 16.67% in children in the control group. The satisfaction with cooperation in the experimental group was 94.0%, which was higher than 79.2% in the control group. The differences were all statistically significant ( P<0.05) . Conclusions:The application of scenario simulation nursing in FFA examination of preschool children can effectively reduce the incidence of adverse reactions in children and improve the satisfaction of children with cooperation during the examination.

Objective:To investigate the features of chest computed tomography (CT) imaging and dynamic changes of severe corona virus disease 2019 (COVID-19).Methods:The clinical and CT data of 17 patients diagnosed with severe COVID-19 admitted to Chongqing Public Health Medical Center from January 24 to February 6, 2020 were collected. The first chest CT manifestations and the dynamic changes of imaging during treatment were retrospectively analyzed.Results:The first chest CT manifestations of the 17 patients showed that 16 cases presented with peripheral and subpleural distributions, and two cases presented with three lobes involved, one case with four lobes involved and 14 cases with five lobes involved, and 17 cases presented with ground-glass opacities, ten cases with consolidation, seven cases with subpleural line, nine cases with air bronchogram, three cases with thickened lobular septum, two cases with bronchiectasis, two cases with pleural effusion, three cases with lymphadenopathy with the short diameter of 1.0-1.2 cm.Among 16 patients who underwent repeated CT examination, the lesions of eight patients showed continuous improvement, and those of the other eight patients showed fluctuating changes.Conclusions:The CT findings of severe COVID-19 patients are mainly ground-glass opacities and consolidation, with the peripheral distribution. The range of lesions is wide, with five-lobe involvement mostly. Lymphadenopathy or pleural effusion is rare. Pynamic monitoring chest CT is useful for the evaluation for the therapeutic effects.