Objective: To analyze the epidemiological characteristics and influencing factors of severe fever with thrombocytopenia syndrome (SFTS) in Zhejiang Province from 2019 to 2023, so as to provide the reference for strengthening SFTS prevention and control. Methods: Data on laboratory-confirmed SFTS cases in Zhejiang Province from 2019 to 2023 were collected through the Infectious Disease Reporting Information System of Chinese Disease Prevention and Control Information System. Meteorological data, geographic environment and socioeconomic factors during the same period were collected from the fifth-generation European Centre for Medium-Range Weather Forecasts, Geospatial Data Cloud, and Zhejiang Statistical Yearbook, respectively. Descriptive epidemiological methods were used to analyze the epidemiological characteristics of SFTS from 2019 to 2023, and a Bayesian spatio-temporal model was constructed to analyze the influencing factors of SFTS incidence. Results: A total of 578 SFTS cases were reported in Zhejiang Province from 2019 to 2023, with an annual average incidence of 0.23/105. The peak period was from May to July, accounting for 52.60%. There were 309 males and 269 females, with a male-to-female ratio of 1.15∶1. The cases were mainly aged 50-<80 years, farmers, and in rural areas, accounting for 82.53%, 77.34%, and 75.43%, respectively. Taizhou City and Shaoxing City reported more SFTS cases, while Shaoxing City and Zhoushan City had higher annual average incidences of SFTS. The Bayesian spatio-temporal interaction model showed good goodness of fit. The results showed that mean temperature (RR=1.626, 95%CI: 1.111-2.378) and mean wind speed (RR=1.814, 95%CI: 1.321-2.492) were positively correlated with SFTS risk, while altitude (RR=0.432, 95%CI: 0.230-0.829) and population density (RR=0.443, 95%CI: 0.207-0.964) were negatively correlated with SFTS risk. Conclusions SFTS in Zhejiang Province peaks from May to July. Middle-aged and elderly people and farmers are high-risk populations. Taizhou City, Shaoxing City, and Zhoushan City are high-incidence areas. Mean temperature, mean wind speed, altitude, and population density can all affect the risk of SFTS incidence.

Objective: To investigate the epidemiological characteristics and influencing factors for hand, foot, and mouth disease (HFMD) incidence in Binzhou City, Shandong Province, so as to provide the evidence for developing HFMD prevention and control strategies. Methods: Data on HFMD cases in Binzhou City from 2017 to 2023 were collected through the Infectious Disease Reporting Information System of Chinese Disease Prevention and Control Information System. Meteorological data during the same period were collected from the fifth-generation European Centre for Medium-Range Weather Forecasts. The incidence of HFMD was calculated, and the temporal, population, and regional distribution characteristics of HFMD were analyzed descriptively. Bayesian spatiotemporal model was used to analyze the influencing factors for HFMD incidence Results: From 2017 to 2023, a total of 17 314 HFMD cases were reported in Binzhou City, with an annual average reported incidence of 62.57/105. The incidence peak was from June to September, and a secondary peak appeared from October to November in some years. The annual average reported incidences were higher in Bincheng District and Yangxin County, which were 107.41/105 and 72.95/105, respectively. There were 10 461 males and 6 853 females, with a male-to-female ratio of 1.53∶1. The age was mainly 1-3 years, with 11 713 cases accounting for 67.65%. Bayesian spatiotemporal model analysis showed that the risk of HFMD incidence had obvious seasonality and regionality. From 2017 to 2019 and in 2021, the peaks occurred in weeks 24-27 and 44-47 each year, with RR values of 1.771-6.747. From 2022 to 2023, it showed a single peak distribution. The RR values were all >1 in Bincheng District, Yangxin County, and Huimin County. Average temperature (RR=1.092, 95%CI: 1.080-1.105) and average relative humidity (RR=1.015, 95%CI: 1.008-1.022) were positively correlated with the risk of HFMD incidence, while average wind speed (RR=0.749, 95%CI: 0.655-0.856) was negatively correlated with the risk of HFMD incidence. Conclusions HFMD in Binzhou City mainly occurs in summer and in central areas. Males and children aged 1-3 years are high-risk populations. The risk of HFMD incidence increases with the increase of average temperature and average relative humidity, and decreases with the increase of average wind speed.

Objective To observe the effectiveness and safety of pirfenidone in the prevention and treatment of radiation-induced lung injury in esophageal cancer.Methods We retrospectively analyzed the data of 103 patients with esophageal cancer,of whom 53 in the combined group were treated with simultaneous chemoradiotherapy combined with pirfenidone and 50 in the control group were treated with simultaneous chemoradiotherapy only.The patients were followed up for three years to observe the treatment effects,adverse effects,and survival,as well as the incidence of radiation-induced lung injury,lung function,and changes in lung injury cytokine levels within one year after radiotherapy.Results Treatment efficiency in the combined group was higher than that in the control group(86.8%vs.70.0%,P＜0.05).The two-and three-year survival rates in the combined group were 84.9%and 71.7%,respectively,which were higher than those(68.0%and 52.0%)in the control group(P＜0.05).The one-,two-,and three-year disease-free survival rates in the combined group were 86.8%,67.9%,and 47.2%,respectively,which were higher than those(62.0%,46.0%,and 28.0%)in the control group(P＜0.05).The incidence rates of radiation pneumonitis at three months,pulmonary fibrosis at six months,and one year after radiotherapy in the combined group were 22.6%,13.2%,and 14.0%,respectively,which were lower than those(42.0%,30.0%,and 31.8%)in the control group at the same time(P＜0.05).At the end of radiotherapy and at three months,six months and one year after radiotherapy,the combined group showed higher levels of lung function indicators but lower levels of lung injury-related cytokines than the control group(P＜0.05).The incidence of rash in the combined group was 18.9%,which was higher than that(2.0%)in the control group(P＜0.05).However,no statistically significant difference in the incidence and severity of other adverse reactions was found between the two groups(P＞0.05).Conclusion Pirfenidone not only effectively reduces radiation-induced lung injury and improves lung function in esophageal cancer patients undergoing simultaneous chemoradiotherapy,but also helps improve tumor control rates and patient survival with a good safety profile.

Objective To observe the effectiveness and safety of pirfenidone in the prevention and treatment of radiation-induced lung injury in esophageal cancer.Methods We retrospectively analyzed the data of 103 patients with esophageal cancer,of whom 53 in the combined group were treated with simultaneous chemoradiotherapy combined with pirfenidone and 50 in the control group were treated with simultaneous chemoradiotherapy only.The patients were followed up for three years to observe the treatment effects,adverse effects,and survival,as well as the incidence of radiation-induced lung injury,lung function,and changes in lung injury cytokine levels within one year after radiotherapy.Results Treatment efficiency in the combined group was higher than that in the control group(86.8%vs.70.0%,P＜0.05).The two-and three-year survival rates in the combined group were 84.9%and 71.7%,respectively,which were higher than those(68.0%and 52.0%)in the control group(P＜0.05).The one-,two-,and three-year disease-free survival rates in the combined group were 86.8%,67.9%,and 47.2%,respectively,which were higher than those(62.0%,46.0%,and 28.0%)in the control group(P＜0.05).The incidence rates of radiation pneumonitis at three months,pulmonary fibrosis at six months,and one year after radiotherapy in the combined group were 22.6%,13.2%,and 14.0%,respectively,which were lower than those(42.0%,30.0%,and 31.8%)in the control group at the same time(P＜0.05).At the end of radiotherapy and at three months,six months and one year after radiotherapy,the combined group showed higher levels of lung function indicators but lower levels of lung injury-related cytokines than the control group(P＜0.05).The incidence of rash in the combined group was 18.9%,which was higher than that(2.0%)in the control group(P＜0.05).However,no statistically significant difference in the incidence and severity of other adverse reactions was found between the two groups(P＞0.05).Conclusion Pirfenidone not only effectively reduces radiation-induced lung injury and improves lung function in esophageal cancer patients undergoing simultaneous chemoradiotherapy,but also helps improve tumor control rates and patient survival with a good safety profile.

Objective To explore the effect of community pharmacy outpatient service on patients with type 2 diabetes mellitus. Methods A non-randomized controlled study was conducted, and type 2 diabetes patients managed in the community were divided into an intervention group of 112 cases and a control group of 110 cases. The control group received routine medication guidance during general practice outpatient visits, while the intervention group received comprehensive pharmacy outpatient service intervention based on routine medication guidance in general practice. Follow-up visits were conducted every 3 months. Repeated measurement analysis of variance and multivariate linear regression analysis were used to evaluate the intervention effect of the pharmacy outpatient service. Results Fasting blood glucose and glycosylated hemoglobin levels in the intervention group showed a decreasing trend with the increase of intervention time compared to pre-intervention time （P<0.01）, with increased duration of weekly exercise, decreased staple food intake, increased vegetable intake, and increased medication adherence score （P<0.01）. After adjusting for confounding factors through multivariate linear regression model, pharmacy outpatient intervention was found to be an independent protective factor for fasting blood glucose level （β=−0.891, P<0.01） and glycosylated hemoglobin level （β=−0.760, P<0.01） in the study subjects. Conclusion The community pharmacy outpatient service could enhance the self-management ability of patients with type 2 diabetes mellitus, and effectively improve patients’ fasting blood glucose and glycosylated hemoglobin.

BackgroundNon-suicidal self-injury （NSSI） behaviors are common among adolescents with depressive disorders， and school bullying is recognized as a major risk factor. Previous research has shown that self-esteem and alexithymia are closely associated with both school bullying and NSSI. However， the mediating roles of self-esteem and alexithymia in the link between school bullying and NSSI are unclear. ObjectiveTo explore the mediating roles of alexithymia and self-esteem in the relationship between school bullying and NSSI behaviors in adolescents with depressive disorders， in order to inform intervention strategies targeting NSSI in this population. MethodsA total of 335 adolescents diagnosed with depressive disorders and treated at the First Psychiatric Hospital of Harbin from July 2023 to October 2024 were enrolled. Assessments included a self-developed demographic questionnaire， Adolescent Non-suicidal Self-injury Assessment Questionnaire-Behavior （ANSAQ-B）， Delaware Bullying Victimization Scale-Student （DBVS-S）， Rosenberg Self-Esteem Scale （RSES）， and 26-item Toronto Alexithymia Scale （TAS-26）. Pearson correlation analysis was used to examine the relationship among variables. Controlling for gender and age at onset of depressive symptoms， mediation analysis was performed using the “mediation” package in R 4.4.2. ResultsScores on DBVS-S and TAS-26 were positively correlated with ANSAQ-B score （r=0.408， 0.417， P<0.01）， while RSES scores were negatively correlated（r=-0.300， P<0.01）. Regression analysis showed that school bullying and alexithymia significantly positively predicted NSSI behaviors （B=0.212， 0.333， P<0.01）， while self-esteem negatively predicted NSSI behaviors （B=-0.368， P<0.01）. Alexithymia was found to mediate the relationship between school bullying and NSSI behaviors， with an indirect effect of 0.040 （95% CI： 0.018~0.069） ，account for 17.17% of the total effect. The indirect effect through self-esteem was not statistically significant （95% CI： -0.004~0.069）. ConclusionExposure to school bullying and high levels of alexithymia are important predictors of NSSI behavior in adolescents with depressive disorders， and school bullying may indirectly influence NSSI behavior through alexithymia. ［Funded by Scientific Research Project of Health Commition of Heilongjiang Province，（number， 20230303090154］

The identification of suitable seed cells represents a critical scientific problem to be solved in the field of oral and maxillofacial bone tissue regeneration.The application of adipose-derived stem cells(ASCs)in tissue and organ repair and regeneration has been studied extensively.In recent years,dedifferentiated fat(DFAT)cells have also shown broad application prospects in the field of bone tissue engineering.DFAT cells express stem cell-related markers and have the potential to differentiate into adipocytes,osteoblasts,chondrocytes,nerve cells,cardiomyocytes and endothelial cells.In addition,DFAT cells also have the advantages of minimally invasive acquisition,strong proliferation and high homogeneity.Currently,all studies involving the application of DFAT cells in scaffold-based and scaffold-free bone tis-sue engineering can confirm their effectiveness in promoting bone regeneration.However,cytological research still faces some challenges,including relatively low cell culture purity,unclear phenotypic characteristics and undefined dediffer-entiation mechanisms.It is believed that with the continuous development and improvement of isolation,culture,identi-fication and directional induction of osteogenic differentiation methods,DFAT cells are expected to become excellent seed cells in the field of oral and maxillofacial bone tissue engineering in the future.

The identification of suitable seed cells represents a critical scientific problem to be solved in the field of oral and maxillofacial bone tissue regeneration.The application of adipose-derived stem cells(ASCs)in tissue and organ repair and regeneration has been studied extensively.In recent years,dedifferentiated fat(DFAT)cells have also shown broad application prospects in the field of bone tissue engineering.DFAT cells express stem cell-related markers and have the potential to differentiate into adipocytes,osteoblasts,chondrocytes,nerve cells,cardiomyocytes and endothelial cells.In addition,DFAT cells also have the advantages of minimally invasive acquisition,strong proliferation and high homogeneity.Currently,all studies involving the application of DFAT cells in scaffold-based and scaffold-free bone tis-sue engineering can confirm their effectiveness in promoting bone regeneration.However,cytological research still faces some challenges,including relatively low cell culture purity,unclear phenotypic characteristics and undefined dediffer-entiation mechanisms.It is believed that with the continuous development and improvement of isolation,culture,identi-fication and directional induction of osteogenic differentiation methods,DFAT cells are expected to become excellent seed cells in the field of oral and maxillofacial bone tissue engineering in the future.

The identification of suitable seed cells represents a critical scientific problem to be solved in the field of oral and maxillofacial bone tissue regeneration.The application of adipose-derived stem cells(ASCs)in tissue and organ repair and regeneration has been studied extensively.In recent years,dedifferentiated fat(DFAT)cells have also shown broad application prospects in the field of bone tissue engineering.DFAT cells express stem cell-related markers and have the potential to differentiate into adipocytes,osteoblasts,chondrocytes,nerve cells,cardiomyocytes and endothelial cells.In addition,DFAT cells also have the advantages of minimally invasive acquisition,strong proliferation and high homogeneity.Currently,all studies involving the application of DFAT cells in scaffold-based and scaffold-free bone tis-sue engineering can confirm their effectiveness in promoting bone regeneration.However,cytological research still faces some challenges,including relatively low cell culture purity,unclear phenotypic characteristics and undefined dediffer-entiation mechanisms.It is believed that with the continuous development and improvement of isolation,culture,identi-fication and directional induction of osteogenic differentiation methods,DFAT cells are expected to become excellent seed cells in the field of oral and maxillofacial bone tissue engineering in the future.

The identification of suitable seed cells represents a critical scientific problem to be solved in the field of oral and maxillofacial bone tissue regeneration.The application of adipose-derived stem cells(ASCs)in tissue and organ repair and regeneration has been studied extensively.In recent years,dedifferentiated fat(DFAT)cells have also shown broad application prospects in the field of bone tissue engineering.DFAT cells express stem cell-related markers and have the potential to differentiate into adipocytes,osteoblasts,chondrocytes,nerve cells,cardiomyocytes and endothelial cells.In addition,DFAT cells also have the advantages of minimally invasive acquisition,strong proliferation and high homogeneity.Currently,all studies involving the application of DFAT cells in scaffold-based and scaffold-free bone tis-sue engineering can confirm their effectiveness in promoting bone regeneration.However,cytological research still faces some challenges,including relatively low cell culture purity,unclear phenotypic characteristics and undefined dediffer-entiation mechanisms.It is believed that with the continuous development and improvement of isolation,culture,identi-fication and directional induction of osteogenic differentiation methods,DFAT cells are expected to become excellent seed cells in the field of oral and maxillofacial bone tissue engineering in the future.