This consensus will introduce the characteristics of fillers used in the surgical cavities of domestic nasal surgery patients based on relevant literature and expert opinions. It will also provide recommendations for the selection of cavity fillers for different nasal diseases, with chronic sinusitis as a representative example.
Humans ; Nasal Cavity/surgery* ; Nasal Surgical Procedures ; China ; Consensus ; Sinusitis/surgery* ; Dermal Fillers

Objective:To analyze the epidemiological characteristics and survival rate of nasopharynx cancer (NPC) in Guangdong Province from 2011 to 2019.Methods:Based on the cancer registry data of Guangdong Province from 2011 to 2019, the crude rate, age-standardized rate (the standard population was the fifth Chinese national census of 2000) and age-specific rate of incidence and mortality of NPC were calculated, and the regional distribution characteristics were also explored. The average annual percentage change (AAPC) of the incidence and mortality rates were analyzed by using Joinpoint regression model. The observed survival rate was estimated by period survival method, and the expected survival rate was calculated by Ederer Ⅱ method.Results:The crude incidence rate and age standardized incidence rate of NPC showed a decreasing trend, and the AAPC was -1.9% and -2.1%, respectively ( P＜0.05). The crude mortality rate and age standardized mortality rate of NPC also showed a decreasing trend, and the AAPC was -4.8% and -4.6%, respectively ( P＜0.05). The incidence and mortality rates are both higher in men than those in women during the nine years. The age-specific incidence rate of NPC reached its peak in the 50-64 years old age group, and the mortality rate reached its peak in the 65-74 years old age group in Guangdong province. In 2019, the age-standardized incidence rate of NPC was 9.49/100 000 (13.89/100 000 in men and 5.19/100 000 in women). The incidence and mortality of NPC varied greatly among different areas, and the areas with highest incidence and mortality rate were both in Zhaoqing. In 2020, the five-year observed survival rate of NPC in Guangdong Province was 67.2%, the 5-year relative survival rate was 75.3% and the 5-year standardized relative survival rate was 68.9%. Conclusions:Both the incidence and mortality rates of NPC in Guangdong province show decreasing trend, and the decreasing level of the mortality rate is higher than that of the incidence rate, but the two rates are still at high levels. The prevention and control work should focus on male, middle-aged and elderly population and Zhaoqing, Zhongshan, Foshan areas.

Objective To establish an expert consensus on the management of low anterior resection syndrome(LARS)in patients with rectal cancer post-surgery(hereinafter referred to as"consensus"),aiming to standardize the related work of medical institutions in the context of post-operative LARS.Methods A comprehensive search of domestic and international databases was conducted to collect guidelines,expert consensuses,systematic reviews,evidence summaries,and original research related to post-operative LARS in rectal cancer published from the establishment of the databases until August 2024.Based on clinical practice experience,a preliminary draft of the"consensus"was formed.From September to November 2024,22 experts were invited to participate in 2 rounds of expert consultations,during which the draft content was revised and improved,and the final version of the"consensus"was determined through expert validation.Results A total of 22 experts responded,achieving a response rate of 100％.The effective recovery rate of the consultation questionnaires in both rounds was 100％,with an expert authority coefficient of 0.89,a judgment coefficient of 0.97,and a familiarity degree of 0.84.The Kendall harmony coefficients for the 2 rounds of expert consultations were 0.122 and 0.136,respectively(P＜0.001).This consensus covers 5 main aspects:definition,assessment,prevention,treatment,and follow-up management of LARS.Conclusion This consensus demonstrates a high level of scientific rigor and can provide a strong reference for clinical nursing personnel in the specialized care of rectal cancer patients with post-operative LARS.

AIM: To explore the efficacy and safety of repeated low-energy red light irradiation combined with visual training for the treatment of adolescent myopia based on vision and tear film function.METHODS: A total of 104 adolescent myopic patients(208 eyes)from the Second Hospital of Hebei Medical University from January 2022 to July 2023 were selected and randomly divided into two groups by random number table method, with 52 cases(104 eyes)in the control group and 52 cases(104 eyes)in the study group. Both groups were treated with orthokeratology lenses, while the control group received visual training and the study group received repeated low-energy red light treatment on top of visual training. Follow-up for 1 a, the improvement of vision, changes in the choroid, tear film function, adverse events, and visual acuity growth after 1 a were compared between the two groups before and after treatment.RESULTS: The uncorrected visual acuity(LogMAR)and axial length of the study group were lower than those of the control group after 6 mo and 1 a of treatment(all P<0.05). The thickness of the choroid under the center recess and the density of choroidal capillary blood flow were higher in the study group than in the control group at 6 mo and 1 a after treatment(all P<0.05); there was no statistically significant difference in the thickness of tear film lipid layer and tear film break-up time between the two groups at different time points(all P>0.05); and the incidence of adverse events during the treatment period of the two groups was not statistically significant(P>0.05). After treatment for 1 a and removing the orthokeratology lens for 2 wk, there was no significant difference in the uncorrected visual acuity(LogMAR)between the study group and the control group before treatment(P>0.05), and the uncorrected visual acuity of the control group was better than that before treatment(P<0.05).CONCLUSION: Repeated low-energy red light combined with visual training can effectively improve the choroid, control the axial length growth, effectively correct the vision of the cornea, and does not affect the tear film function, with high safety.

Objective: To construct an index system of public health risk assessment for air pollution emergency, so as to provide a tool of evaluating the public health risks of air pollution emergency. Methods: Index system of public health risk assessment for air pollution emergency was established through literature review and group discussions. The index system was determined through two rounds of Delphi expert consultations involving specialists in environmental health, toxicology, epidemiology, health emergency response, and atmospheric monitoring. The effectiveness of the consultation was evaluated by positive coefficient, authority coefficient and coordination coefficient. The weights of index were determined using a combination weighting method of the expert scoring method and the entropy weight method. Results: Fifteen experts participated in the consultation, including 11 males and 4 females. There were 8 experts with a doctor degree, 6 experts with a master degree, 1 experts with a bachelor degree. A total of 11 experts with senior professional titles, and 4 experts with associate senior professional titles. The average work experience was (23.73±10.48) years. The expert positive coefficients for the two rounds of consultations were 83.33% and 100%, respectively. The expert authority coefficients were 0.794 and 0.811, respectively. The coefficients of variation for the importance, feasibility, and sensitivity scores of each index in the two rounds of comsultations were 0.097 to 0.352, 0.078 to 0.478, 0.115 to 0.388, and 0.049 to 0.133, 0.052 to 0.153, 0.049 to 0.178, respectively. The Kendall's coefficients of concordance were 0.237 and 0.440 (both with P<0.05) for the two rounds of consultations. The constructed assessment index system included "likelihood" "hazard" "vulnerability" "controllability" with comprehensive weights of 0.206 7, 0.059 6, 0.378 1, and 0.355 5, respectively. Among the 13 second indicators, "monitoring capability" had the highest comprehensive weight of 0.192 6. Among the 40 tertiary indicators, "real-time monitoring of atmospheric pollutants" "retrospective evaluation of early forecasting results" "types, quantities, and combined effects of atmospheric pollutants" "exposure modes of the population to atmospheric pollutants" had relatively high comprehensive weights of 0.089 5, 0.043 1, 0.041 1 and 0.040 3, respectively. Conclusion The constructed index system of public health risk assessment for air pollution emergency can be applied to the public health risk assessment for air pollution emergencies.

BACKGROUND: The American Heart Association recently released a new cardiovascular health (CVH) metric, Life's Essential 8 (LE8), for health promotion. However, the association between LE8 scores and the risk of chronic kidney disease (CKD) remains uncertain. We aimed to explore the association of LE8 scores with new-onset CKD and examine whether socioeconomic deprivation and genetic risk modify this association. METHODS: A total of 286,908 participants from UK Biobank and without prior CKD were included between 2006 and 2010. CVH was categorized using LE8 scores: low (LE8 scores <50), moderate (LE8 scores ≥50 but <80), and high (LE8 scores ≥80). The study outcome was new-onset CKD, ascertained by data linkage with primary care, hospital inpatient, and death data. Cox proportional hazard regression models were used to investigate the association between CVH categories and new-onset CKD. RESULTS: During a median follow-up of 12.5 years, 8857 (3.1%) participants developed new-onset CKD. Compared to the low CVH group, the moderate (adjusted hazards ratio [HR], 0.50; 95% confidence interval [CI]: 0.47-0.53) and high CVH (adjusted HR, 0.31; 95% CI: 0.27-0.34) groups had a significantly lower risk of developing new-onset CKD. The population-attributable risk associated with high vs. intermediate or low CVH scores was 40.3%. Participants who were least deprived ( vs.  most deprived; adjusted HR, 0.75; 95% CI: 0.71-0.79) and with low genetic risk of CKD ( vs.  high genetic risk; adjusted HR, 0.89; 95% CI: 0.85-0.94) had a significantly lower risk of developing new-onset CKD. However, socioeconomic deprivation and genetic risks of CKD did not significantly modify the relationship between LE8 scores and new-onset CKD (both P -interaction >0.05). CONCLUSION Achieving a higher LE8 score was associated with a lower risk of developing new-onset CKD, regardless of socioeconomic deprivation and genetic risks of CKD.
Humans ; Renal Insufficiency, Chronic/epidemiology* ; Male ; Female ; Middle Aged ; Genetic Predisposition to Disease/genetics* ; Aged ; Risk Factors ; Adult ; Proportional Hazards Models ; Socioeconomic Factors

Objective:To assess the association between temperature and risk of animal injury, and identifying vulnerable populations.Methods:Based on a time-stratified case-crossover design, the number of animal injuries monitored in hospitals of Guangdong Provincial Injury Surveillance System in 2011 and 2015-2016 was included, and the daily meteorological data were derived from the fifth generation of European ReAnalysis-Land, which was produced by the European Centre for Medium-Range Weather Forecasts. Conditional logistic regression combined with a distributed lagged nonlinear model was applied to analyze the association of temperature and animal-specific injuries. We also conducted stratified analysis by region, sex, age, occupation, and location of injury occurrence.Results:There was an almost linear relationship between temperature and the occurrence of animal injury. The excess risk ( ER) of animal injury was 2.65% (95% CI: 2.27%-3.04%) for a 1 ℃ rise in temperature with much higher risk of occurrence ( ER=9.34%, 95% CI: 7.57%-11.13%) for non-mammalian injury than that for mammalian injuries ( ER=2.30%, 95% CI: 1.90%-2.70%). Stratified analysis revealed that the occurrence of animal injury was more susceptible to temperature influences in urban ( ER=2.78%, 95% CI: 2.35%-3.21%), female ( ER=2.71%, 95% CI: 2.16%-3.27%), the elderly aged 60 years and above ( ER=3.05%, 95% CI: 1.65%- 4.47%), farmer ( ER=4.66%, 95% CI: 3.03%-6.32%) and agricultural area ( ER=10.63%, 95% CI: 7.57%-13.79%) than their correspondents. In terms of mammalian injury, dog bites showed the highest risk ( ER=2.71%, 95% CI: 2.12%-3.30%). In terms of non-mammalian,snake injuries were highly influenced by temperature ( ER=16.74%, 95% CI: 11.33%-22.40%). Conclusions:The ambient temperature rises could increase the risk of animal injury with much higher risk for non-mammalian than that for mammalian injuries. Our findings suggest that global warming may increase the risk and disease burden from animal injuries.

Objective To construct a Nomogram prediction model for prognosis of retinopathy of prematurity(ROP)based on serological markers and to validate the predictive value of the model.Methods A total of 195 ROP pa-tients(390 eyes)admitted to the Second Hospital of Hebei Medical University from January 2022 to January 2024 were se-lected.After 3-month follow-up post-treatment,the patients were divided into poor-prognosis(n=41)and good-prognosis(n=154)groups.General data and pre-treatment serological markers[vascular endothelial growth factor(VEGF),insu-lin-like growth factor-1(IGF-1),glutamate(Glu),signal transduction and transcriptional activator 3(STAT3),hypoxic in-ducible factor 3α(HIF-3α)]were compared between the two groups.LASSO-Logistic regression was used to identify risk factors for poor prognosis in ROP patients.A Nomogram prediction model for poor prognosis in ROP patients was construc-ted based on these factors.The predictive value of the model was validated using receiver operating characteristic(ROC)curves,calibration curves,and decision-curve analysis.Results The 1-min Apgar score,5-min Apgar score,proportion of severe disease,proportion of bronchopulmonary dysplasia(BPD),proportion of sepsis,and pre-treatment serum levels of VEGF,Glu,STAT3,and HIF-3α were higher in the poor-prognosis group than in the good-prognosis group,while gesta-tional age,birth weight,and serum IGF-1 levels were lower(all P＜0.05).LASSO-Logistic regression analysis showed that gestational age,disease severity,BPD,sepsis,and pre-treatment serum levels of VEGF,IGF-1,Glu,STAT3,and HIF-3αwere risk factors for poor prognosis in ROP patients(all P＜0.05).A Nomogram prediction model for poor prognosis in ROP patients was constructed based on these factors.The model had an area under the curve(AUC)of 0.943(95％CI:0.907-0.978)for predicting poor prognosis,indicating high predictive efficacy.The model had good calibration,with good con-sistency between predicted and actual results,and demonstrated good clinical utility in predicting poor prognosis in ROP patients.Conclusion Serum levels of VEGF,IGF-1,Glu,STAT3,and HIF-3α are all prognostic factors for ROP pa-tients.The Nomogram prediction model for ROP prognosis based on these serological markers has high application value.

Objective:To assess the association between temperature and risk of animal injury, and identifying vulnerable populations.Methods:Based on a time-stratified case-crossover design, the number of animal injuries monitored in hospitals of Guangdong Provincial Injury Surveillance System in 2011 and 2015-2016 was included, and the daily meteorological data were derived from the fifth generation of European ReAnalysis-Land, which was produced by the European Centre for Medium-Range Weather Forecasts. Conditional logistic regression combined with a distributed lagged nonlinear model was applied to analyze the association of temperature and animal-specific injuries. We also conducted stratified analysis by region, sex, age, occupation, and location of injury occurrence.Results:There was an almost linear relationship between temperature and the occurrence of animal injury. The excess risk ( ER) of animal injury was 2.65% (95% CI: 2.27%-3.04%) for a 1 ℃ rise in temperature with much higher risk of occurrence ( ER=9.34%, 95% CI: 7.57%-11.13%) for non-mammalian injury than that for mammalian injuries ( ER=2.30%, 95% CI: 1.90%-2.70%). Stratified analysis revealed that the occurrence of animal injury was more susceptible to temperature influences in urban ( ER=2.78%, 95% CI: 2.35%-3.21%), female ( ER=2.71%, 95% CI: 2.16%-3.27%), the elderly aged 60 years and above ( ER=3.05%, 95% CI: 1.65%- 4.47%), farmer ( ER=4.66%, 95% CI: 3.03%-6.32%) and agricultural area ( ER=10.63%, 95% CI: 7.57%-13.79%) than their correspondents. In terms of mammalian injury, dog bites showed the highest risk ( ER=2.71%, 95% CI: 2.12%-3.30%). In terms of non-mammalian,snake injuries were highly influenced by temperature ( ER=16.74%, 95% CI: 11.33%-22.40%). Conclusions:The ambient temperature rises could increase the risk of animal injury with much higher risk for non-mammalian than that for mammalian injuries. Our findings suggest that global warming may increase the risk and disease burden from animal injuries.

Objective To construct a Nomogram prediction model for prognosis of retinopathy of prematurity(ROP)based on serological markers and to validate the predictive value of the model.Methods A total of 195 ROP pa-tients(390 eyes)admitted to the Second Hospital of Hebei Medical University from January 2022 to January 2024 were se-lected.After 3-month follow-up post-treatment,the patients were divided into poor-prognosis(n=41)and good-prognosis(n=154)groups.General data and pre-treatment serological markers[vascular endothelial growth factor(VEGF),insu-lin-like growth factor-1(IGF-1),glutamate(Glu),signal transduction and transcriptional activator 3(STAT3),hypoxic in-ducible factor 3α(HIF-3α)]were compared between the two groups.LASSO-Logistic regression was used to identify risk factors for poor prognosis in ROP patients.A Nomogram prediction model for poor prognosis in ROP patients was construc-ted based on these factors.The predictive value of the model was validated using receiver operating characteristic(ROC)curves,calibration curves,and decision-curve analysis.Results The 1-min Apgar score,5-min Apgar score,proportion of severe disease,proportion of bronchopulmonary dysplasia(BPD),proportion of sepsis,and pre-treatment serum levels of VEGF,Glu,STAT3,and HIF-3α were higher in the poor-prognosis group than in the good-prognosis group,while gesta-tional age,birth weight,and serum IGF-1 levels were lower(all P＜0.05).LASSO-Logistic regression analysis showed that gestational age,disease severity,BPD,sepsis,and pre-treatment serum levels of VEGF,IGF-1,Glu,STAT3,and HIF-3αwere risk factors for poor prognosis in ROP patients(all P＜0.05).A Nomogram prediction model for poor prognosis in ROP patients was constructed based on these factors.The model had an area under the curve(AUC)of 0.943(95％CI:0.907-0.978)for predicting poor prognosis,indicating high predictive efficacy.The model had good calibration,with good con-sistency between predicted and actual results,and demonstrated good clinical utility in predicting poor prognosis in ROP patients.Conclusion Serum levels of VEGF,IGF-1,Glu,STAT3,and HIF-3α are all prognostic factors for ROP pa-tients.The Nomogram prediction model for ROP prognosis based on these serological markers has high application value.