Objective To study the main pathogenic bacteria and drug sensitivity in patients with chronic sup-purative otitis media and patients with middle ear cholesteatoma in Xinjiang ,and to provide evidence for reasonable u-sing antibiotics for the two diseases .Methods We performed a retrospective analysis of the middle ear secretion bac-terial culture results of 409 patients with chronic suppurative otitis media and middle ear cholesteatoma at our hospi-tal from January 2008 to December 2013 .Results ①There were 361 strains of microbes isolated from 409 patients , and 16 of them were fungi ,and 245 were bacteria .There was a statistical significance of the pathogen detection rate about G+ and G- bacteria between chronic suppurative otitis media and middle ear cholesteatoma (χ2 =12 .216 ,P=0 .000) .②Staphylococcus aureus(in 78 of 254 ears ,30 .7% ) ,pseudomonas aeruginosa(in 46 of 254 ears ,18 .1% ) , coagulase-negative staphylococcus(in 42 of 254 ears ,16 .5% ) ,and proteus mirabilis(in 20 of 254 ears ,7 .87% ) were the most frequently insolated pathogens in chronic suppurative otitis media ,while staphylococcus aureus(in 26 of 107 ears ,24 .30% ) ,pseudomonas aeruginosa(in 17 of 107 ears ,15 .9% ) ,coagulase-negative staphylococcus (in 16 of 107 ears ,15 .0% ) ,and proteus mirabilis(in 14 of 107 ears ,13 .1% ) were the most frequently insolated patho-gens in middle ear cholesteatoma .③Staphylococcus aureus and coagulase -negative staphylococcus were all sensi-tive to quinoline nupu ting /dalfopristin ,teicoplanin ,vancomycin ,and moxifloxacin .The sensitivity of coagulase -negative staphylococcus to gentamicin ,trimethoprim -sulfamethoxazole ,and erythromycin in the middle ear chol-esteatoma were higher than those of in chronic suppurative otitis media .The sensitivity of pseudomonas aeruginosa to ceftazidime ,and imipenem were lower in the middle ear cholesteatoma .The drug sensitivity of pseudomonas aeruginosa ,proteus to trimethoprim/sulfamethoxazole and cefazolin was higher in middle ear cholesteatoma .Conclu-sion There are differences between chronic suppurative otitis media (active) and middle ear cholesteatoma about G+ ,G- bacteria detection rate .Staphylococcus aureus ,coagulase-negative staphylococcus ,pseudomonas aerugi-nosa ,and proteus mirabilis are the main pathogenic bacteria in these two chronic otitis media .There is a difference of some commonly used antimicrobial sensitivity in these two kinds of otitis media ,which is more obvious in pseudo-monas aeruginosa and proteus mirabilis .

OBJECTIVE: To study the correlation between the bacterial biofilm formation and bacterial culture in chronic otitis media. METHOD: As a prospective reserch, we used scanning electron microscopy to examinate patients samples which collected from 32 cases of patients with chronic suppurative otitis media and middle ear cholesteatoma in the operations, and performed the middle ear secretions bacterial culture. According to the different types of chronic otitis media group, we analysised the relationship between chronic otitis media bacterial biofilm formation and the bacterial culture results. RESULT: Chronic suppurative otitis media (activity) and middle ear cholesteatoma bacterial biofilm formation rate were 87.5%, 81.3%, chi-square (P > 0.05). Compared bacterial biofilm results with the results of bacterial cultured in chronic otitis media, sensitivity was 70.37%, specificity was 60.00%, the misdiagnosis rate was 40.00%, the missed diagnosis was 29.63%, positive predictive value was 90. 46%, negative predictive value was 27.27%, accuracy was 68.75%. Youden index was 30. 37%, and Pearson correlation coefficient was 0.232 (P > 0.05). CONCLUSION Chronic suppurative otitis media (activity) and middle ear cholesteatoma bacteria had a higher biofilm formation rate. The routine bacterial culture results can't reflecte bacterial biofilm formation in chronic otitis media. We need to explore more reliable experimental methods to accurately reveal the infection status of chronic otitis media.
Adolescent ; Adult ; Bacteria ; growth & development ; Biofilms ; Cholesteatoma, Middle Ear ; microbiology ; Chronic Disease ; Female ; Humans ; Male ; Middle Aged ; Otitis Media, Suppurative ; microbiology ; Sensitivity and Specificity ; Young Adult

OBJECTIVE: To evaluate the treatment policy for non-Hodgkin's lymphoma of the nasal cavity and nasopharynx. METHOD: Twenty patients with pathologically confirmed non-Hodgkin's lymphoma of nasal cavity and nasopharynx,treated from Jan. 2006 to Oct. 2010, were retrospectively reviewed. RESULT: The 3-year overall survival and complete response rates for all patients were 78% and 47% respectively. The 3-year overall survival rates for patients treated with chemotherapy and patients treated with chemotherapy plus radiotherapy were 75% and 82% respectively. The estimates of complete response for patients receiving chemotherapy alone and for patients receiving chemotherapy plus radiotherapy were 37% and 55%, respectively. The 3-year overall survival rates for patients who achieved complete response and patients who did not were 89% and 70%, respectively. The 3-year overall survival rates for patients in stage IE and stage II E were 92% and 57%, respectively. CONCLUSION There was no significant difference between chemotherapy alone and chemotherapy plus radiotherapy for the treatment of non-Hodgkin's lymphoma of the nasal cavity and nasopharynx. The 3-year overall survival rate for patients in stage IE was much higher than in stage II E. Early treatment is very important to improve the survival rate of the patients.
Adult ; Female ; Humans ; Lymphoma, Non-Hodgkin ; therapy ; Male ; Nasal Cavity ; Nasopharyngeal Neoplasms ; therapy ; Nose Neoplasms ; therapy ; Retrospective Studies ; Survival Rate

OBJECTIVE: Discussion of lung function changes in patients with allergic rhinitis and its clinical significance. METHOD: Using UNICAP100 allergen detector testing 64 patients of allergic rhinitis without asthma symptoms, testing the value of serum total IgE and using immunofluorescence methods for testing inhalation allergen, simultaneously checking the pulmonary function and bronchial provocation. Checking the lung function of 64 patients with non-symptoms of allergic rhinitis in other departments (control group), lung function were compared into two groups of patients. RESULT: In the allergic rhinitis group, 37 patients had abnormal lung function (57.81%), 8 cases in them had obstructive pulmonary ventilation, 12 cases had small airway dysfunction, 31 cases had increased airway resistance respectively. In the control group 15 patients (23.44%) had pulmonary function abnormalities, 2 cases had obstructive pulmonary ventilation, 4 cases had small airway dysfunction, 11 cases had increased airway resistance respectively. Changes in lung function compared in the two groups was statistically significant (P < 0.05). Allergic rhinitis patients with abnormal lung function bronchial provocation test positive rate was significantly higher than the normal lung function in patients with allergic rhinitis, there had statistically significant difference between the two groups (P < 0.05). CONCLUSION After checking the lung function of non-asthmatic symptom patients with allergic rhinitis, we could find abnormal lung function patients of allergic rhinitis and do bronchial provocation test in them, there has important clinical significance of early detection and treatment the patients of allergic rhinitis with bronchial asthma.
Adult ; Bronchial Hyperreactivity ; physiopathology ; Case-Control Studies ; Female ; Humans ; Male ; Nasal Septum ; abnormalities ; Peak Expiratory Flow Rate ; Respiratory Function Tests ; Rhinitis, Allergic, Perennial ; physiopathology

OBJECTIVE To evaluate the efficacy of radiofrequency ablation on treatment of compensatory turbinate hypertrophy.METHODS A total of 105 patients enrolled in the study.Fifty cases only accepted the relocation of inferior turbinate and 55 cases accepted radiofrequency ablation of inferior turbinate during nasal septum deviation surgery under nasal endoscope.The preoperative and postoperative nasal obstructions were assessed with visual analogue scale(VAS).RESULTS The outcome of 105 patients undergoing different operation for below 1 months,3～6 months,above 6 months after operation were recorded.The results of treatment group were better than that of the control group.CONCLUSION The use of radiofrequency ablation for the treatment of compensatory turbinate hypertrophy is an effective method for reducing symptoms of nasal obstruction after relocation of inferior turbinate.

OBJECTIVE To evaluate the efficacy and the recovery of laryngeal functions of various kinds of partial laryngectomy for glottic carcinoma.METHODS The clinical data of 75 patients with glottic carcinoma who underwent partial laryngectomy in our department from Jan. 1997 to Dec. 2006 were retrospectively analyzed. Seventy one cases were male and 4 cases were female. There were 6 kinds of surgical methods for those patients. CO2 laser assisted vocal cordectomy was operated on in 12 cases,vocal cordectomy through laryngofissure in 18 cases,vertical partial laryngectomy in 33 cases,frontal partial laryngectomy in 5 cases,extended vertical partial laryngectomy in 4 cases,and CHEP in 2 cases. RESULTS The overall 3 and 5 year survival rates of the patients were 97.3% and 94.6% respectively. The 3 and 5 year survival rates in 48 cases with stage T1/T2 were 97.9% and 97.9% and those in 27 cases with stage T3/T4 were 92.5% and 85.1%. All of the patients restored the phonation and swallowing function. The decannulation rate was 92.1%(58/63). The decannulation rate of the patients within one month after operation was 85.2% CONCLUSION Partial laryngectomy is the first choice of the radical treatments for glottic carcinoma. Strict indications,correct procedure and surgical repair methods are the keys to ensure the efficacy and preservation of laryngeal function.

0.05).But for the patients with wide-base vocal cord polyps,the effective rate of self-retaining laryngoscope group was higher than that of electronic laryngoscope(P