Objective: To investigate the serotypes and antimicrobial resistance profiles of Salmonella isolates from foodborne disease patients in Danzhou City, Hainan Province, so as to provide the evidence for improving regional prevention and control strategies for foodborne diseases. Methods: Salmonella strains were isolated from stool or anal swab specimens of patients with foodborne diarrhea treated at Hainan Western Central Hospital and Danzhou People's Hospital from 2022 to 2025. After identification, slide agglutination tests were performed for serotyping. The microbroth dilution method was used to detect antimicrobial resistance of Salmonella strains. Results: A total of 927 specimens were collected, and 87 Salmonella strains were isolated, with a detection rate of 9.38%. Nineteen serotypes were identified, dominated by Salmonella Typhimurium (35 strains, 40.23%), Salmonella Weltevreden (17 strains, 19.54%) and Salmonella Enteritidis (6 strains, 6.90%). Antimicrobial susceptibility testing showed that 64 strains were resistant, with an overall resistance rate of 73.56%, and 54 strains were multidrug-resistant, with a multidrug resistance rate of 62.07%. The resistance rate to tetracycline was relatively high at 65.52%. A total of 38 resistance patterns were identified, covering 1 to 8 antimicrobial agents. The predominant multidrug resistance patterns were chloramphenicol-trimethoprim-sulfamethoxazole-tetracycline-ampicillin-sulbactam and chloramphenicol-trimethoprim-sulfamethoxazole-tetracycline-streptomycin-ampicillin-sulbactam, identified in 8 (12.50%) and 5 (7.81%) isolates, respectively. Conclusions The predominant Salmonella serotypes isolated from foodborne disease patients in Danzhou City are Salmonella Typhimurium, Salmonella Weltevreden and Salmonella Enteritidis. The strains exhibit severe antimicrobial resistance and multidrug resistance, especially against tetracycline. It is necessary to strengthen antimicrobial resistance surveillance and promote rational use of antibiotics.

Objective : To investigate the prevalence of negative emotions in hospitalized youth patients with type 2 diabetes(T2DM) and its correlation with coping strategies and psychological resilience. Methods : 141 youth T2DM patients who met the research standards were selected. Blood glucose related indicators, blood pressure, body mass index(BMI), diabetes chronic complications screening results and other data were collected. The basic information and disease related information questionnaire, self-rating depression scale(SDS), self-rating anxiety scale(SAS), diabetes distress scale(DDS), medical coping modes questionnaire(MCMQ) and Connor-Davidson resilience scale(CD-RISC) were completed. Results: Among 141 hospitalized youth T2DM patients, 37.6% were combined with depression, 32.6% were combined with anxiety, and 35.5% were combined with diabetic distress(DD). Univariate analysis showed that systolic blood pressure(P<0.01), educational level, and the form of hospitalization expenses(P<0.05) were significantly correlated with depression. Marital status(P<0.01), family residence, blood glucose monitoring methods, and the last fasting blood glucose(P<0.05) were significantly correlated with anxiety. BMI, whether it was first diagnosed or treated(P<0.01), gender, occupation, disease course, weekly blood glucose monitoring frequency, and the presence of chronic complications(P<0.05) were significantly correlated with DD. In multivariate analysis, systolic blood pressure(P<0.01), educational level, and the form of hospitalization expenses were significantly correlated with depression, marital status(P<0.05) was significantly correlated with anxiety; BMI and weekly blood glucose monitoring frequency(P<0.01) were significantly correlated with DD. SDS, SAS, total scores and dimensions of DDS were negatively correlated with the total score and dimensions of CD-RISC(rs=-0.182--0.467, P<0.05 or 0.01), and positively correlated with the yielding coping strategies(rs=0.177-0.271,P<0.05 or 0.01). SAS,total scores and dimensions of DDS were positively correlated with avoiding coping strategies(rs=0.237-0.419,P<0.05 or 0.01). The total and dimensions of CD-RISC were positively correlated with facing coping strategies(rs=0.215-0.349,P<0.05 or 0.01),and negatively correlated with yielding coping strategies(rs=-0.234--0.325,P<0.01). Conclusion More than 30% of hospitalized youth T2DM may experience negative emotions such as depression,anxiety,and DD. The occurrence of negative emotions in such patients may be related to disease management or socio-economic issues such as systolic blood pressure,educational level,hospitalization expenses,marital status,BMI,and frequency of blood glucose monitoring,as well as decreased psychological resilience and negative coping strategies.