Mesenchymal stem cells(MSCs)are adult stem cells that exist in bone marrow,fat,cord blood,bone,muscle and other tissues.MSCs not only have the unique self-renewal ability and multidirectional differentiation potential of stem cells,but also have the function of immune regulation.Arginine is a conditionally essential amino acid,and its metabolic regulation is essential for maintaining cell function and overall health.In MSCs,arginine metabolism may have a certain effect on cell proliferation,differentiation,inflammatory response,and tumor development.This article summarizes the effects of arginine metabolism on the differentiation,inflammation,immunity,and tumor development in different types of MSCs,discusses new strategies for the treatment of metabolic syndrome,and provides new ideas for the treatment of inflammatory diseases and tumors by MSCs from the perspective of arginine metabolism.

Mesenchymal stem cells(MSCs)are adult stem cells that exist in bone marrow,fat,cord blood,bone,muscle and other tissues.MSCs not only have the unique self-renewal ability and multidirectional differentiation potential of stem cells,but also have the function of immune regulation.Arginine is a conditionally essential amino acid,and its metabolic regulation is essential for maintaining cell function and overall health.In MSCs,arginine metabolism may have a certain effect on cell proliferation,differentiation,inflammatory response,and tumor development.This article summarizes the effects of arginine metabolism on the differentiation,inflammation,immunity,and tumor development in different types of MSCs,discusses new strategies for the treatment of metabolic syndrome,and provides new ideas for the treatment of inflammatory diseases and tumors by MSCs from the perspective of arginine metabolism.

Objective:To analyze the group heterogeneity of different types of self-management ability of patients with nonalcoholic fatty liver disease (NAFLD) through potential category analysis, and to explore the differences of nursing interventions among different types of people, so as to provide reference for intervention research.Methods:From March to August 2021, NAFLD patients undergoing physical examination and hospitalization in the First Affiliated Hospital of Xinjiang Medical University were selected as the research object by convenience sampling. The General Information Questionnaire, Health Promoting Lifestyle Profile-Ⅱ (HPLP-Ⅱ) and Self-management Behavior Scale for Patients with NAFLD were used to investigate the patients, and the height and weight of the patients were also measured. A total of 1 189 questionnaires were distributed and 1 124 valid questionnaires were recovered.Results:Self-management ability of NAFLD patients were divided into five types, including good self-management group (32.03%) , lack of self-management-medium level psychological cognition group (23.84%) , lack of health promoting behavior group (11.30%) , lack of disease-cognition-life management group (27.31%) , serious lack of self-management-medium level stress group (5.52%) . Taking the good self-management group as a reference, the results showed that age, marital status, occupation, education level, average monthly income, treatment methods, smoking, body mass index (BMI) , sleep quality, and concomitant diseases were the influencing factors that caused the potential category differences of self-management behavior in NAFLD patients, and the differences were statistically significant ( P<0.05) . Conclusions:Each potential category of NAFLD patients' self-management ability has specificity, which suggests that the formulation of nursing interventions for NAFLD patients in the future should be based on the heterogeneity of various types of groups, so as to improve the effectiveness of self-management intervention.

OBJECTIVE:To evaluate the characteristics and regularity of adverse drug reactions (ADR) in children's hospital. METHODS:The clinical drug use and ADR of 3 653 children during 2006～2008 in our hospital were analyzed statistically by designing a child medication registration form. RESULTS:The incidence of 498 ADR cases was about 13.63%; ADR were mostly occurred in 1～3 year-old children(36.14%); 71.29% were caused by intravenously; 66.87% were induced by antibiotics; ADR were more common in spring and winter. CONCLUSION:The drugs have a dual nature. Moreover,children belong to a special group. The measures such as strictly mastering clinical indications,reducing irrational drug use,sufficient therapy and avoiding or reducing the occurrence of ADR can guarantee children grow healthily.