Objective To investigate the efficacy and safety of Shuganjieyu capsule combined with repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression.Methods Eighty outpatients and inpatients with depression who sought medical care in the Department of Mental Health,Second Hospital Affiliated to Lanzhou University were randomly divided into 2 groups,the study group and the control group,each consisting of 40 patients.The study group was treated with Shuganjieyu capsule combined with rTMS,while the control group received selective serotonin-reuptake inhibitors (SSRIs).Clinical efficacy and rate of adverse reactions were evaluated before treatment and 1,2,4 and 6 courses after treatment,by using Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS).Results After 4 courses of treatment,total efficacy rate of the study group was 92.5％,while that of the control group was 90.0％.No statistical significance could be noted when comparisons were made between them (P ＞ 0.05).After 1 to 2 courses of treatment,HAMD scores of the study group were significantly lower than those of the control group (P ＜ 0.05).However,after 3 and 6 courses of treatment,there were no statistical differences in treatment efficacy (P ＞ 0.05).After 6 courses of treatment,the descending rate in the severe depression patients of the study group was (57.0 ± 17.0) ％,which was obviously lower than that of the control group (62.0 ± 19.0) ％.Statistical significance could be noted when comparisons were made between them (P ＜ 0.05).Evaluations of TESS scores in the 1st,2nd,4th,and 6th week after treatment indicated that the rate of adverse reactions in the control group was 42.5％,which was significantly higher than that of the study group (7.5％).Statistical significance could be found when comparisons were made between them (P ＜ 0.01).Conclusion Treatment by ShuganJieyu capsule combined with repetitive transcranial magnetic stimulation (rTMS) has the advantages of faster efficacy,better safty and less adverse reactions in the treatment of depression,and could produce better effect on those patients with mild and moderate depression.

Objective To investigate the efficacy and safety of Shuganjieyu capsule combined with repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression.Methods Eighty outpatients and inpatients with depression who sought medical care in the Department of Mental Health,Second Hospital Affiliated to Lanzhou University were randomly divided into 2 groups,the study group and the control group,each consisting of 40 patients.The study group was treated with Shuganjieyu capsule combined with rTMS,while the control group received selective serotonin-reuptake inhibitors (SSRIs).Clinical efficacy and rate of adverse reactions were evaluated before treatment and 1,2,4 and 6 courses after treatment,by using Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS).Results After 4 courses of treatment,total efficacy rate of the study group was 92.5％,while that of the control group was 90.0％.No statistical significance could be noted when comparisons were made between them (P ＞ 0.05).After 1 to 2 courses of treatment,HAMD scores of the study group were significantly lower than those of the control group (P ＜ 0.05).However,after 3 and 6 courses of treatment,there were no statistical differences in treatment efficacy (P ＞ 0.05).After 6 courses of treatment,the descending rate in the severe depression patients of the study group was (57.0 ± 17.0) ％,which was obviously lower than that of the control group (62.0 ± 19.0) ％.Statistical significance could be noted when comparisons were made between them (P ＜ 0.05).Evaluations of TESS scores in the 1st,2nd,4th,and 6th week after treatment indicated that the rate of adverse reactions in the control group was 42.5％,which was significantly higher than that of the study group (7.5％).Statistical significance could be found when comparisons were made between them (P ＜ 0.01).Conclusion Treatment by ShuganJieyu capsule combined with repetitive transcranial magnetic stimulation (rTMS) has the advantages of faster efficacy,better safty and less adverse reactions in the treatment of depression,and could produce better effect on those patients with mild and moderate depression.

Treatment resistant depression is a common and severe mental disorder associated with significant burden of disease .Most individuals receiving conventional pharmacotheraphy fail to achieve and sustain remission.So this is still one of the difficult challenges for the psychiatrist .Much of the research pro-vided indications that the efficacy of treatment for the disease was not optimistic, but the treatment was still made great progress .The common treatments for this disease included pharmacotherapy,psychotherapy,elec-troconvulsive therapy(ECT),transcranial magnetic stimulation (TMS),magnetic resonance guided focused ultrasound surgery( MRgFUS) ,deep brain stimulation ( DBS) ,aerobic exercise,light therapy and so on.Each therapeutic strategy has its own features, and could be suitable or unsuitable in some situations.The high rates of non-remission with first-line treatment strategies make the combination of antidepressant and non-drug treatments to be the new trend of the treatments for treatment resistant depression in the future.

Objective To study the relationship between sensation seeking,personality characteristics and health-risk behaviors of medical freshmen.Methods Sensation Seeking Scale ( SSS),Eysenck Personality Questionnaire( EPQ),Adolescent Health-Risk Behaviors Questionnaire were applied in this survey to 384 freshmen from two medical colleges.Results ① The health risk behaviors were comnmon in the medical college freshmen (5.2％,48.2％ ),and the score of health risk behaviors had a significant difference between boys and girls,boys risk behaviors were much more than girls(P＜ 0.05 ).②The correlations between the risk behaviors (such as smoking,drinking,fighting,suicidal ideas,using internet too long,poor eating behavior,lack of physical exercise) and sensation seeking personality traits were strong.The health-risk behaviors were all correlated with extraversion(E)and neuroticism (N) significantly( 66.78 ± 10.29 vs 60.57 ± 9.09,t =2.54,P ＜ 0.01 ;7.11 ± 3.23 vs 5.33 ±2.89,t =2.81,P ＜ 0.05 ).③The results of logistic regression analysis showed that male mother' s high education level,sensation seeking,Eysenck' s P,N dimension were effective prediction factors of freshmen ' s health-risk behaviors.Conclusion Medical college freshmen who have higher levels of sensation seeking,Eysenck' s P,N dimension are more prone to health risk behaviors.