Objective To analyze the application effect of pharmacists' participation in the maintenance and manage-ment of smart pharmaceutical platform.Methods The prescriptions of Shunde Hospital of Guangzhou University of Chinese Med-icine from January 2023 to June 2024 were divided into blank group(from January 2023 to March 2023,305 411 traditional man-ual prescriptions were reviewed)and control group(from January 2024 to March 2024).The original rule review of the smart pharmacy platform system was adopted,339 042 copies),and the experimental group(from April 2024 to June 2024,the rule review after pharmacists participated in maintenance management was adopted,317 902 copies).The prescription qualification rate,the proportion of unreasonable prescriptions,the false positive rate,the proportion of manual review prescriptions,and the rate of filling prescriptions were evaluated,and the management effectiveness of the three groups was compared.Results The qualified rate of prescription in the experimental group and the control group was 99.52％ and 99.60％,respectively,which were higher than 98.74％ in the blank group,and there was a difference between the experimental group and the control group(P＜0.05).Among the irrational prescription types in the experimental group,the proportion of unsuitable administration route,in-complete clinical diagnosis,unsuitable indications and unsuitable usage and dosage were 16.57％,29.42％,20.55％ and 33.46％,and 23.28％,15.74％,30.38％ and 30.50％ in the control group.There were significant differences between 40.08％,27.11％,19.91％ and 12.9％ in blank group(P＜0.05).The false positive rate and manual prescription review ra-tio of the experimental group were 0.40％ and 0.88％,respectively,lower than 0.70％and 1.10％of the control group,and the prescription return rate of 0.78％ was higher than 0.10％ of the control group(P＜0.05).Conclusion Pharmacists' par-ticipation in the maintenance and management of smart pharmacy platform has high application value and can improve the drug safety of patients.

Objective:To explore the categories and characteristics of health behaviors of community residents in Dongfang City, Hainan Province, and to analyze the influencing factors of different categories.Methods:From March to May 2023, 795 community residents of Dongfang City were selected for the study using a simple random sampling method. General Information Questionnaire, Chinese version Short of Health Promotion Lifestyle Profile-Ⅱ, Health Conception Scale, and Self-rated Abilities for Health Practice Scale were used to conduct the survey. Cluster analysis was used to explore the health behavior categories of community residents, and a decision tree model was applied to analyze the influencing factors of different categories.Results:A total of 830 questionnaires were distributed, and 795 valid questionnaires were recovered, with a valid recovery rate of 95.78%. The health behaviors of 795 community residents in Dongfang City were divided into four categories of comprehensive behavior group (26.04%, 207/795), healthy behavior group (37.23%, 296/795), risky behavior group (18.99%, 151/795), and poor health behavior group (17.74%, 141/795). The decision tree model showed that exercise efficacy, gender, ethnicity, and clinical health concepts were the factors influencing different health behavior categories of community residents in Dongfang City ( P<0.05), with exercise efficacy being the core factor. Conclusions:There is heterogeneity in the health behavior of community residents in Dongfang City. Community healthcare workers can implement targeted health promotion measures according to the behavioral characteristics of the population.

Objective To analyze the application effect of pharmacists' participation in the maintenance and manage-ment of smart pharmaceutical platform.Methods The prescriptions of Shunde Hospital of Guangzhou University of Chinese Med-icine from January 2023 to June 2024 were divided into blank group(from January 2023 to March 2023,305 411 traditional man-ual prescriptions were reviewed)and control group(from January 2024 to March 2024).The original rule review of the smart pharmacy platform system was adopted,339 042 copies),and the experimental group(from April 2024 to June 2024,the rule review after pharmacists participated in maintenance management was adopted,317 902 copies).The prescription qualification rate,the proportion of unreasonable prescriptions,the false positive rate,the proportion of manual review prescriptions,and the rate of filling prescriptions were evaluated,and the management effectiveness of the three groups was compared.Results The qualified rate of prescription in the experimental group and the control group was 99.52％ and 99.60％,respectively,which were higher than 98.74％ in the blank group,and there was a difference between the experimental group and the control group(P＜0.05).Among the irrational prescription types in the experimental group,the proportion of unsuitable administration route,in-complete clinical diagnosis,unsuitable indications and unsuitable usage and dosage were 16.57％,29.42％,20.55％ and 33.46％,and 23.28％,15.74％,30.38％ and 30.50％ in the control group.There were significant differences between 40.08％,27.11％,19.91％ and 12.9％ in blank group(P＜0.05).The false positive rate and manual prescription review ra-tio of the experimental group were 0.40％ and 0.88％,respectively,lower than 0.70％and 1.10％of the control group,and the prescription return rate of 0.78％ was higher than 0.10％ of the control group(P＜0.05).Conclusion Pharmacists' par-ticipation in the maintenance and management of smart pharmacy platform has high application value and can improve the drug safety of patients.

Objective:To explore the categories and characteristics of health behaviors of community residents in Dongfang City, Hainan Province, and to analyze the influencing factors of different categories.Methods:From March to May 2023, 795 community residents of Dongfang City were selected for the study using a simple random sampling method. General Information Questionnaire, Chinese version Short of Health Promotion Lifestyle Profile-Ⅱ, Health Conception Scale, and Self-rated Abilities for Health Practice Scale were used to conduct the survey. Cluster analysis was used to explore the health behavior categories of community residents, and a decision tree model was applied to analyze the influencing factors of different categories.Results:A total of 830 questionnaires were distributed, and 795 valid questionnaires were recovered, with a valid recovery rate of 95.78%. The health behaviors of 795 community residents in Dongfang City were divided into four categories of comprehensive behavior group (26.04%, 207/795), healthy behavior group (37.23%, 296/795), risky behavior group (18.99%, 151/795), and poor health behavior group (17.74%, 141/795). The decision tree model showed that exercise efficacy, gender, ethnicity, and clinical health concepts were the factors influencing different health behavior categories of community residents in Dongfang City ( P<0.05), with exercise efficacy being the core factor. Conclusions:There is heterogeneity in the health behavior of community residents in Dongfang City. Community healthcare workers can implement targeted health promotion measures according to the behavioral characteristics of the population.

Objective:To explore the evaluation value of sequential organ failure assessment (SOFA) score at different time points in the prognosis of patients with severe pneumonia combined with acute respiratory distress syndrome (ARDS).Methods:A retrospective cohort study method was conducted, including patients with severe pneumonia and ARDS admitted to the emergency intensive care unit (ICU) of General Hospital of Ningxia Medical University from January 2015 to December 2019. General clinical data such as gender, age, and the SOFA scores at 1, 2, 3, and 7 days after admission were recorded. According to the diagnostic test, the prognostic evaluation value of SOFA score in patients with severe pneumonia combined with ARDS at different time points and different ages was analyzed.Results:A total of 88 cases were included in this study, eventually, 42 cases were survived and 46 cases died, the mortality was 52.27%. The age of the death group was significantly older than the survival group (years old: 60.67±14.66 vs. 51.91±15.97), the SOFA score at each time point were significantly higher than those in the survival group (9.83±3.50 vs. 7.54±2.67, 9.98±3.75 vs. 7.48±2.92, 10.84±4.14 vs. 7.23±2.94, 11.71±4.03 vs. 6.51±3.22, respectively at 1, 2, 3, 7 days after admission, all P < 0.01). The receiver operator characteristic curve (ROC curve) showed that the SOFA score at 1, 2, 3, and 7 days after admission had a certain predictive value for the prognosis of patients with severe pneumonia combined with ARDS (all P < 0.01), and with the prolong of ICU stay, the area under ROC curve (AUC) of SOFA score had gradually increased. On the 7th day after admission, the SOFA score had the highest sensitivity in predicting severe pneumonia combined with ARDS patients, which was 92.86%, and the specificity was the highest on the 3rd day after admission, which was 88.10%. The AUC in day 7 was significantly higher than day 2 (0.85 vs. 0.72) , there was no statistically significant difference of AUC at other time points. After stratifying by age, the diagnostic of sensitivity, specificity, accuracy, and AUC of SOFA score for the prognosis had gradually increased, and the predictive value was better. However, only on day 3 after admission, the AUC of SOFA score was significantly higher than day 1 (0.80 vs. 0.77, P < 0.05), and there was no significant difference in AUC at other time points. In patients older than 60 years old, the AUC of the SOFA score predicting the prognosis of patients was relatively small on day 1 and day 2 (0.67, 0.68, respectively), the ability was poor. There was no statistically significant difference in the AUC of SOFA scores at each time point in evaluating the prognosis of patients. The trends over time of patients at different ages and time points showed that regardless of age, the SOFA scores of the patients in the death group showed an upward trend, while showed a downward trend in the survival group, the difference reached the largest on the 7th day after admission, and the death group was significantly higher than the survival group (age < 60 years old: 12.50 vs. 6.69; age≥60 years old: 11.58 vs. 6.21). Conclusion:The initial SOFA score has a certain value in the evaluation of prognosis of severe pneumonia patients combined with ARDS, but the effect is poor for elderly patients.

【Objective】 To investigate the epidemiology of HTLV by conducting HTLV nucleic acid detection among voluntary blood donors, so as to provide basis for the decision making of blood screening strategy. 【Methods】 The HTLV blood nucleic acid(NAT) screening platform was established based on the existing NAT for HBV / HCV / HIV screening. HTLV (type 1 + 2) detection was carried out in 5 368 blood donors, and the results were analyzed. 【Results】 No NAT-yielding of HTLV- 1, -2 type was found in a total of 5 368 voluntary blood donor from January to August 2019. 【Conclusion】 Qianxinan, currently, is very low epidemic or non epidemic as none of HTLV infections was found among blood donors and no significant differences in the epidemiology of HTLV were notable between the counties and cities. It, however, still needs further investigation in the future.

Objective To verify the feasibility and safety of stomach tumor marker localization based on magnetic tracer technique in dogs.Methods Six male Beagle dogs were examined by gastroscopy.Then tracer magnets were sent to the "tumor" locations assumed in advance and fixed near the "tumors" by endoscopic soft tissue clamp.Laparoscopic gastric tumor localization was performed under general anesthesia 24 hours later.The tracer magnet was placed near the tumor on the surface of the stomach through the operating hole after the conventional establishment of laparoscope puncture parallel mirror to explore the tracer magnet.After the two magnets were attracted,the location of the tracer magnet seen under the laparoscope was the location of the gastric tumor,so as to complete the labeling and positioning of the lesion.Results All the 6 Beagle dogs were successfully implanted with tracer magnets under gastroscopy.Twenty-four hours after the gastroscopy,the pursuit magnet was successfully implanted during laparoscopic surgery.The two magnets automatically attracted each other and formed a sandwich structure of "tracer magnet-gastric wall-pursuit magnet ",which completed the location and identification of gastric tumor under the laparoscopy.Conclusion Gastroscopy combined with laparoscopy based on magnetic tracer technique is simple,accurate,safe and feasible.

Objective:To design magnets to locate colorectal neoplasms based on magnetic tracer technology, and to test its feasibility and safety by animal experiments.Methods:The magnets used for endoscopic localization of colorectal tumors consist of a tracer magnet and a pursuit magnet, both of which are ring-shaped Nd-Fe-B magnets. Eight healthy Beagle dogs were used as animal models. Tumor locations were assumed in the different parts of the colon and rectum under colonoscopy. The tracer magnet was sent to the hypothetical tumors by endoscopic soft tissue clamp and fixed near the tumors. After 24 hours, laparoscopic surgery was performed under general anesthesia. The pursuit magnet was inserted near the resected colon or rectum through the main operating hole. The tracer magnet was absorbed to the pursuit magnet to identify the location of tumors.Results:The tracer magnet and pursuit magnet were successfully designed and processed. The suction force between the tracer magnet and the pursuit magnet at zero distance was 16 N. All the 8 Beagle dogs successfully received indwelling of magnets under colonoscopy, and no magnets fell off after 24 hours. After the placement of pursuit magnet under laparoscopy, the two magnets attracted each other rapidly and accurately, and successfully completed localization of tumor site without any damage during the operation.Conclusion:Colonoscopy combined with laparoscopy for colorectal neoplasms localization based on magnetic tracer technique is simple, accurate, safe and feasible.

Objective:To study the feasibility of establishing gastrointestinal anastomosis by magnetic compression technique in rabbits.Methods:Ten healthy New Zealand rabbits were selected as models for gastrointestinal anastomosis by magnetic compression technique. Daughter and parent magnets suitable for gastrointestinal anastomosis in rabbits were designed and manufactured. A daughter magnet was inserted into the stomach through the purse fistula in the lack of blood vessel area of gastric body, and was pushed into the duodenum along the intestinal tract. And then a parent magnet was inserted through the stomach fistula. The daughter and parent magnets were automatically attracted and pressed the gastric and intestinal walls after they were adjusted in the proper position. The stomach fistula was closed with purse string suture. After ischemia, necrosis, detachment of the tissues between magnets, gastrointestinal anastomosis was established, and the magnets and necrotic tissues were expelled together from the body through the digestive tract. Survival of experimental animals was observed. Anastomotic specimens were obtained one month after operation. The blasting pressure of anastomotic stoma was measured, and the healing of anastomotic stoma was observed with naked eyes.Results:According to the pre-designed operative route, 10 New Zealand rabbits all successfully completed the operation and survived one month after surgery. No complications occurred during perioperative period. The operation time was 35.80±4.71 min (range 28.00-43.00 min), and the magnet discharge time was 11.40±1.56 days (range 9.00-14.00 days). Anastomotic specimens were obtained one month after the operation. Gross observation showed that the anastomotic stoma of gastrointestinal bypass anastomosis healed well, and the surrounding tissues adhered slightly. The anastomotic bursting pressure was 103.00±7.95 mmHg (range 94.00-113.00 mmHg) (1 mmHg=0.133 kPa).Conclusion:The establishment of gastrointestinal anastomosis by magnetic compression technique in rabbits is simple and effective.

Objective To systematically review the clinical effects of Shuxuetong and Low-molecular-weight Heparin(LMWH)in patients with deep vein thrombosis (DVT)in lower limbs.Methods The CNKI,Wanfang,VIP,SinoMed,PubMed,EMBASE,and ISI Web of Science databases were electronically searched from inception to February 3th,2017,to collect the randomized clinical trials on the clinical effects of Shuxuetong and LMWH on DVT in lower limbs.Two investigators independently screened the literatures,extracted data and assessed the quality of enrolled studies.All analyses were performed using the Stata 11.0 software.Results Twenty studies involving 1 515 patients were finally included.The meta-analysis results showed that the total effective rate was significantly higher in Shuxuetong group than in LMWH drug control group(RR =1.22,95 ％ CI:1.13-1.32,P ＜ 0.001).The subgroup analysis showed that there was no significant difference in total effective rate between the Shuxuetong alone group and LMWH alone control group(RR =1.05,95％ CI:0.98-1.12,P =0.136).However,the total effective rate was significantly higher in Shuxuetong combined with LMWH group than in LMWH alone control group(RR =1.30,95％CI:1.18-1.44,P ＜ 0.001).Conclusions Shuxuetong combined with LMWH has better clinical effects than do LMWH alone group in treating patients with DVT in lower limbs.